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Salivary testosterone in male and female youth with and without autism spectrum disorder: considerations of development, sex, and diagnosis / Rachael A. MUSCATELLO in Molecular Autism, 13 (2022)
[article]
Titre : Salivary testosterone in male and female youth with and without autism spectrum disorder: considerations of development, sex, and diagnosis Type de document : Texte imprimé et/ou numérique Auteurs : Rachael A. MUSCATELLO, Auteur ; Emma RAFATJOO, Auteur ; Karan K. MIRPURI, Auteur ; Ahra KIM, Auteur ; Simon VANDEKAR, Auteur ; Blythe A. CORBETT, Auteur Article en page(s) : 37 p. Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnosis Autistic Disorder Female Humans Longitudinal Studies Male Sexual Development Testosterone Adolescence Androgen Autism Pubertal development Index. décimale : PER Périodiques Résumé : BACKGROUND: Puberty is characterized by significant physical, hormonal, and psychological changes, which may be especially challenging for individuals with autism spectrum disorder (ASD). Although the etiology of ASD remains uncertain, studies suggest imbalances in hormones, such as testosterone, may modulate the autism phenotype. While differences in fetal and postnatal testosterone have been reported, there is limited literature regarding testosterone variations during adolescence in ASD. We investigated morning salivary testosterone levels in youth with ASD and typical development (TD) to explore hypothesized differences, expecting elevated hormonal levels in ASD compared to TD. METHODS: Youth with ASD (n=140) and TD (n=104), ages 10 to 13Â years, were enrolled as part of a longitudinal study on pubertal development. Pubertal stage was determined by gold standard physical examination, and salivary testosterone was collected in the morning immediately upon waking and 30 min after waking and averaged across 3 days. Diagnostic (ASD/TD) and sex (male/female) differences, as well as interactions with age and puberty, were examined using robust linear mixed effect models. RESULTS: Youth with ASD showed significantly elevated testosterone concentrations compared to same-age TD peers. After the inclusion of natural cubic splines to account for nonlinearity in age, a significant age-by-sex interaction emerged with distinct developmental slopes for males and females. At younger ages, females had higher testosterone, until about 11.5Â years of age, when levels began to plateau, while male testosterone concentrations continued to rapidly increase and surpass females. As expected, more advanced pubertal development was associated with elevated testosterone. In contrast, no significant effect of parent-reported social communication symptoms was observed. LIMITATIONS: Limitations include an unequal sex distribution, non-representative sample (e.g., cognition and race/ethnicity), and inability to examine afternoon/evening testosterone due to detection limits. CONCLUSIONS: Testosterone may play a unique role in the presentation of ASD, especially during periods of dynamic hormonal changes including puberty. Inherent developmental (age, puberty) and sex-based (male, female) factors play a more prominent role in changes in testosterone levels during adolescence. Even so, future research is warranted to determine the differential expression and impact of exposure to excess testosterone during the pubertal transition for youth with ASD. En ligne : http://dx.doi.org/10.1186/s13229-022-00515-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491
in Molecular Autism > 13 (2022) . - 37 p.[article] Salivary testosterone in male and female youth with and without autism spectrum disorder: considerations of development, sex, and diagnosis [Texte imprimé et/ou numérique] / Rachael A. MUSCATELLO, Auteur ; Emma RAFATJOO, Auteur ; Karan K. MIRPURI, Auteur ; Ahra KIM, Auteur ; Simon VANDEKAR, Auteur ; Blythe A. CORBETT, Auteur . - 37 p.
Langues : Anglais (eng)
in Molecular Autism > 13 (2022) . - 37 p.
Mots-clés : Autism Spectrum Disorder/diagnosis Autistic Disorder Female Humans Longitudinal Studies Male Sexual Development Testosterone Adolescence Androgen Autism Pubertal development Index. décimale : PER Périodiques Résumé : BACKGROUND: Puberty is characterized by significant physical, hormonal, and psychological changes, which may be especially challenging for individuals with autism spectrum disorder (ASD). Although the etiology of ASD remains uncertain, studies suggest imbalances in hormones, such as testosterone, may modulate the autism phenotype. While differences in fetal and postnatal testosterone have been reported, there is limited literature regarding testosterone variations during adolescence in ASD. We investigated morning salivary testosterone levels in youth with ASD and typical development (TD) to explore hypothesized differences, expecting elevated hormonal levels in ASD compared to TD. METHODS: Youth with ASD (n=140) and TD (n=104), ages 10 to 13Â years, were enrolled as part of a longitudinal study on pubertal development. Pubertal stage was determined by gold standard physical examination, and salivary testosterone was collected in the morning immediately upon waking and 30 min after waking and averaged across 3 days. Diagnostic (ASD/TD) and sex (male/female) differences, as well as interactions with age and puberty, were examined using robust linear mixed effect models. RESULTS: Youth with ASD showed significantly elevated testosterone concentrations compared to same-age TD peers. After the inclusion of natural cubic splines to account for nonlinearity in age, a significant age-by-sex interaction emerged with distinct developmental slopes for males and females. At younger ages, females had higher testosterone, until about 11.5Â years of age, when levels began to plateau, while male testosterone concentrations continued to rapidly increase and surpass females. As expected, more advanced pubertal development was associated with elevated testosterone. In contrast, no significant effect of parent-reported social communication symptoms was observed. LIMITATIONS: Limitations include an unequal sex distribution, non-representative sample (e.g., cognition and race/ethnicity), and inability to examine afternoon/evening testosterone due to detection limits. CONCLUSIONS: Testosterone may play a unique role in the presentation of ASD, especially during periods of dynamic hormonal changes including puberty. Inherent developmental (age, puberty) and sex-based (male, female) factors play a more prominent role in changes in testosterone levels during adolescence. Even so, future research is warranted to determine the differential expression and impact of exposure to excess testosterone during the pubertal transition for youth with ASD. En ligne : http://dx.doi.org/10.1186/s13229-022-00515-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491 Salle de bain. De l'argent pour changer / Isabelle MALO in Déclic, 159 (Mai-Juin 2014)
[article]
Titre : Salle de bain. De l'argent pour changer Type de document : Texte imprimé et/ou numérique Auteurs : Isabelle MALO, Auteur Année de publication : 2014 Article en page(s) : p.19 Langues : Français (fre) Index. décimale : PER Périodiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=233
in Déclic > 159 (Mai-Juin 2014) . - p.19[article] Salle de bain. De l'argent pour changer [Texte imprimé et/ou numérique] / Isabelle MALO, Auteur . - 2014 . - p.19.
Langues : Français (fre)
in Déclic > 159 (Mai-Juin 2014) . - p.19
Index. décimale : PER Périodiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=233 Sally J. Rogers and Geraldine Dawson: Review of Early Start Denver Model for Young Children with Autism: Promoting Language, Learning and Engagement / Rhea PAUL in Journal of Autism and Developmental Disorders, 41-7 (July 2011)
[article]
Titre : Sally J. Rogers and Geraldine Dawson: Review of Early Start Denver Model for Young Children with Autism: Promoting Language, Learning and Engagement : Guilford Press, NY, 297 pp Type de document : Texte imprimé et/ou numérique Auteurs : Rhea PAUL, Auteur Année de publication : 2011 Article en page(s) : p.978-980 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1007/s10803-010-1041-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=130
in Journal of Autism and Developmental Disorders > 41-7 (July 2011) . - p.978-980[article] Sally J. Rogers and Geraldine Dawson: Review of Early Start Denver Model for Young Children with Autism: Promoting Language, Learning and Engagement : Guilford Press, NY, 297 pp [Texte imprimé et/ou numérique] / Rhea PAUL, Auteur . - 2011 . - p.978-980.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 41-7 (July 2011) . - p.978-980
Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1007/s10803-010-1041-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=130 Sally Kirk: Hope for the Autism Spectrum: A Mother and Son Journey of Insight and Biomedical Intervention / Mojdeh BAYAT in Journal of Autism and Developmental Disorders, 40-1 (January 2010)
[article]
Titre : Sally Kirk: Hope for the Autism Spectrum: A Mother and Son Journey of Insight and Biomedical Intervention : Jessica Kingsley Publishers, London & Philadelphia, 2008, 431 pp, ISBN 978-1-84310-894-8, $24.95 (hard cover) Type de document : Texte imprimé et/ou numérique Auteurs : Mojdeh BAYAT, Auteur Année de publication : 2010 Article en page(s) : p.130-131 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1007/s10803-009-0779-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=964
in Journal of Autism and Developmental Disorders > 40-1 (January 2010) . - p.130-131[article] Sally Kirk: Hope for the Autism Spectrum: A Mother and Son Journey of Insight and Biomedical Intervention : Jessica Kingsley Publishers, London & Philadelphia, 2008, 431 pp, ISBN 978-1-84310-894-8, $24.95 (hard cover) [Texte imprimé et/ou numérique] / Mojdeh BAYAT, Auteur . - 2010 . - p.130-131.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 40-1 (January 2010) . - p.130-131
Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1007/s10803-009-0779-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=964 Same but Different: 9-Month-Old Infants at Average and High Risk for Autism Look at the Same Facial Features but Process Them Using Different Brain Mechanisms / Alexandra P.F. KEY in Autism Research, 5-4 (August 2012)
[article]
Titre : Same but Different: 9-Month-Old Infants at Average and High Risk for Autism Look at the Same Facial Features but Process Them Using Different Brain Mechanisms Type de document : Texte imprimé et/ou numérique Auteurs : Alexandra P.F. KEY, Auteur ; Wendy L. STONE, Auteur Année de publication : 2012 Article en page(s) : p.253-66 Langues : Anglais (eng) Mots-clés : face processing ERP eye tracking infants ASD Vineland Index. décimale : PER Périodiques Résumé : The study examined whether 9-month-old infants at average vs. high risk for autism spectrum disorder (ASD) process facial features (eyes, mouth) differently and whether such differences are related to infants' social and communicative skills. Eye tracking and visual event-related potentials (ERPs) were recorded in 35 infants (20 average-risk typical infants, 15 high-risk siblings of children with ASD) while they viewed photographs of a smiling unfamiliar female face. On 30% of the trials, the eyes or the mouth of that face was replaced with corresponding features from a different female. There were no group differences in the number, duration, or distribution of fixations, and all infants looked at the eyes and mouth regions equally. However, increased attention to the mouth was associated with weaker receptive communication skills and increased attention to the eyes correlated with better interpersonal skills. ERP results revealed that all infants detected eye and mouth changes but did so using different brain mechanisms. Changes in facial features were associated with changes in activity of the face perception mechanisms (N290) for the average-risk group but not for the high-risk infants. For all infants, correlations between ERP and eye-tracking measures indicated that larger and faster ERPs to feature changes were associated with fewer fixations on the irrelevant regions of stimuli. The size and latency of the ERP responses also correlated with parental reports of receptive and expressive communication skills, suggesting that differences in brain processing of human faces are associated with individual differences in social-communicative behaviors. En ligne : http://dx.doi.org/10.1002/aur.1231 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=179
in Autism Research > 5-4 (August 2012) . - p.253-66[article] Same but Different: 9-Month-Old Infants at Average and High Risk for Autism Look at the Same Facial Features but Process Them Using Different Brain Mechanisms [Texte imprimé et/ou numérique] / Alexandra P.F. KEY, Auteur ; Wendy L. STONE, Auteur . - 2012 . - p.253-66.
Langues : Anglais (eng)
in Autism Research > 5-4 (August 2012) . - p.253-66
Mots-clés : face processing ERP eye tracking infants ASD Vineland Index. décimale : PER Périodiques Résumé : The study examined whether 9-month-old infants at average vs. high risk for autism spectrum disorder (ASD) process facial features (eyes, mouth) differently and whether such differences are related to infants' social and communicative skills. Eye tracking and visual event-related potentials (ERPs) were recorded in 35 infants (20 average-risk typical infants, 15 high-risk siblings of children with ASD) while they viewed photographs of a smiling unfamiliar female face. On 30% of the trials, the eyes or the mouth of that face was replaced with corresponding features from a different female. There were no group differences in the number, duration, or distribution of fixations, and all infants looked at the eyes and mouth regions equally. However, increased attention to the mouth was associated with weaker receptive communication skills and increased attention to the eyes correlated with better interpersonal skills. ERP results revealed that all infants detected eye and mouth changes but did so using different brain mechanisms. Changes in facial features were associated with changes in activity of the face perception mechanisms (N290) for the average-risk group but not for the high-risk infants. For all infants, correlations between ERP and eye-tracking measures indicated that larger and faster ERPs to feature changes were associated with fewer fixations on the irrelevant regions of stimuli. The size and latency of the ERP responses also correlated with parental reports of receptive and expressive communication skills, suggesting that differences in brain processing of human faces are associated with individual differences in social-communicative behaviors. En ligne : http://dx.doi.org/10.1002/aur.1231 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=179 Un samedi à la montagne / Isabelle MALO in Déclic, 157 (Janvier-Février 2014)
PermalinkSandifer syndrome: an overlooked diagnosis? / C. S. NANAYAKKARA in Developmental Medicine & Child Neurology, 27-6 (December 1985)
PermalinkSandifer syndrome: an unappreciated clinical entity / Steven L. WERLIN in Developmental Medicine & Child Neurology, 22-3 (June 1980)
PermalinkSans diagnostic, mon dossier est en souffrance in Déclic, 142 (Juillet-Août 2011)
PermalinkSans Sessad, c’est possible ? / Isabelle MALO in Déclic, 133 (Janvier-Février 2010)
PermalinkSans viande sans risque ? / Anne-Claire PREFOL in Déclic, 177 (Mai-Juin 2017)
PermalinkLa santé mentale des enfants et adolescents intellectuellement surdoués : synthèse des données quantitatives / F. GUENOLE in Approche Neuropsychologique des Apprentissages chez l'Enfant - A.N.A.E., 154 (Juin 2018)
PermalinkSanté mentale, locus de contrôle et estime de soi d'enfants scolarisés en Zone d'Education Prioritaire ou non / Monique ALLES-JARDEL in Approche Neuropsychologique des Apprentissages chez l'Enfant - A.N.A.E., 68 (Septembre 2002)
PermalinkPermalinkSantéBD : penser l’accès aux soins pour personnes avec autisme et tous types de handicap. 70 fiches illustratives et adaptables application tablette / Elisabeth CATAIX-NEGRE in Rééducation Orthophonique, 266 (Juin 2016)
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