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Touch and olfaction/taste differentiate children carrying a 16p11.2 deletion from children with ASD / Joana Maria Almeida OSORIO in Molecular Autism, 12 (2021)
[article]
Titre : Touch and olfaction/taste differentiate children carrying a 16p11.2 deletion from children with ASD Type de document : Texte imprimé et/ou numérique Auteurs : Joana Maria Almeida OSORIO, Auteur ; Borja RODRIGUEZ-HERREROS, Auteur ; David ROMASCANO, Auteur ; Vincent JUNOD, Auteur ; Aline HABEGGER, Auteur ; Aurélie PAIN, Auteur ; Sonia RICHETIN, Auteur ; Paola YU, Auteur ; Bertrand ISIDOR, Auteur ; Lionel VAN MALDERGEM, Auteur ; Linda PONS, Auteur ; Sabine MANIFICAT, Auteur ; Nadia CHABANE, Auteur ; Marine JEQUIER GYGAX, Auteur ; Anne Manuela MAILLARD, Auteur Article en page(s) : 8p. Langues : Anglais (eng) Mots-clés : 16p11.2 deletion Autism spectrum disorder (ASD) Children Copy number variants (CNV) Olfaction Sensory processing Sensory processing measure (SPM) Touch Index. décimale : PER Périodiques Résumé : BACKGROUND: Sensory processing atypicalities are frequent in Autism Spectrum Disorder (ASD) and neurodevelopmental disorders (NDD). Different domains of sensory processing appear to be differentially altered in these disorders. In this study, we explored the sensory profile of two clinical cohorts, in comparison with a sample of typically developing children. METHODS: Behavioral responses to sensory stimuli were assessed using the Sensory Processing Measure (parent-report questionnaire). We included 121 ASD children, 17 carriers of the 16p11.2 deletion (Del 16p11.2) and 45 typically developing (TD) children. All participants were aged between 2 and 12 years. Additional measures included the Tactile Defensiveness and Discrimination Test-Revised, Wechsler Intelligence Scales and Autism Diagnostic Observation Schedule (ADOS-2). Statistical analyses included MANCOVA and regression analyses. RESULTS: ASD children score significantly higher on all SPM subscales compared to TD. Del16p11.2 also scored higher than TD on all subscales except for tactile and olfactory/taste processing, in which they score similarly to TD. When assessing sensory modulation patterns (hyper-, hypo-responsiveness and seeking), ASD did not significantly differ from del16p11.2. Both groups had significantly higher scores across all patterns than the TD group. There was no significant association between the SPM Touch subscale and the TDDT-R. LIMITATIONS: Sensory processing was assessed using a parent-report questionnaire. Even though it captures observable behavior, a questionnaire does not assess sensory processing in all its complexity. The sample size of the genetic cohort and the small subset of ASD children with TDDT-R data render some of our results exploratory. Divergence between SPM Touch and TDDT-R raises important questions about the nature of the process that is assessed. CONCLUSIONS: Touch and olfaction/taste seem to be particularly affected in ASD children compared to del16p11.2. These results indicate that parent report measures can provide a useful perspective on behavioral expression. Sensory phenotyping, when combined with neurobiological and psychophysical methods, might have the potential to provide a better understanding of the sensory processing in ASD and in other NDD. En ligne : http://dx.doi.org/10.1186/s13229-020-00410-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=442
in Molecular Autism > 12 (2021) . - 8p.[article] Touch and olfaction/taste differentiate children carrying a 16p11.2 deletion from children with ASD [Texte imprimé et/ou numérique] / Joana Maria Almeida OSORIO, Auteur ; Borja RODRIGUEZ-HERREROS, Auteur ; David ROMASCANO, Auteur ; Vincent JUNOD, Auteur ; Aline HABEGGER, Auteur ; Aurélie PAIN, Auteur ; Sonia RICHETIN, Auteur ; Paola YU, Auteur ; Bertrand ISIDOR, Auteur ; Lionel VAN MALDERGEM, Auteur ; Linda PONS, Auteur ; Sabine MANIFICAT, Auteur ; Nadia CHABANE, Auteur ; Marine JEQUIER GYGAX, Auteur ; Anne Manuela MAILLARD, Auteur . - 8p.
Langues : Anglais (eng)
in Molecular Autism > 12 (2021) . - 8p.
Mots-clés : 16p11.2 deletion Autism spectrum disorder (ASD) Children Copy number variants (CNV) Olfaction Sensory processing Sensory processing measure (SPM) Touch Index. décimale : PER Périodiques Résumé : BACKGROUND: Sensory processing atypicalities are frequent in Autism Spectrum Disorder (ASD) and neurodevelopmental disorders (NDD). Different domains of sensory processing appear to be differentially altered in these disorders. In this study, we explored the sensory profile of two clinical cohorts, in comparison with a sample of typically developing children. METHODS: Behavioral responses to sensory stimuli were assessed using the Sensory Processing Measure (parent-report questionnaire). We included 121 ASD children, 17 carriers of the 16p11.2 deletion (Del 16p11.2) and 45 typically developing (TD) children. All participants were aged between 2 and 12 years. Additional measures included the Tactile Defensiveness and Discrimination Test-Revised, Wechsler Intelligence Scales and Autism Diagnostic Observation Schedule (ADOS-2). Statistical analyses included MANCOVA and regression analyses. RESULTS: ASD children score significantly higher on all SPM subscales compared to TD. Del16p11.2 also scored higher than TD on all subscales except for tactile and olfactory/taste processing, in which they score similarly to TD. When assessing sensory modulation patterns (hyper-, hypo-responsiveness and seeking), ASD did not significantly differ from del16p11.2. Both groups had significantly higher scores across all patterns than the TD group. There was no significant association between the SPM Touch subscale and the TDDT-R. LIMITATIONS: Sensory processing was assessed using a parent-report questionnaire. Even though it captures observable behavior, a questionnaire does not assess sensory processing in all its complexity. The sample size of the genetic cohort and the small subset of ASD children with TDDT-R data render some of our results exploratory. Divergence between SPM Touch and TDDT-R raises important questions about the nature of the process that is assessed. CONCLUSIONS: Touch and olfaction/taste seem to be particularly affected in ASD children compared to del16p11.2. These results indicate that parent report measures can provide a useful perspective on behavioral expression. Sensory phenotyping, when combined with neurobiological and psychophysical methods, might have the potential to provide a better understanding of the sensory processing in ASD and in other NDD. En ligne : http://dx.doi.org/10.1186/s13229-020-00410-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=442 Olfactory Detection Thresholds and Adaptation in Adults with Autism Spectrum Condition / Teresa TAVASSOLI in Journal of Autism and Developmental Disorders, 42-6 (June 2012)
[article]
Titre : Olfactory Detection Thresholds and Adaptation in Adults with Autism Spectrum Condition Type de document : Texte imprimé et/ou numérique Auteurs : Teresa TAVASSOLI, Auteur ; Simon BARON-COHEN, Auteur Année de publication : 2012 Article en page(s) : p.905-909 Langues : Anglais (eng) Mots-clés : Autism Spectrum Condition Olfaction Olfactory detection and adaptation Index. décimale : PER Périodiques Résumé : Sensory issues have been widely reported in Autism Spectrum Conditions (ASC). Since olfaction is one of the least investigated senses in ASC, the current studies explore olfactory detection thresholds and adaptation to olfactory stimuli in adults with ASC. 80 participants took part, 38 (18 females, 20 males) with ASC and 42 control participants (20 males, 22 females). A subgroup of participants (N = 19 in each group) also conducted an adaptation task. Standardized “Sniffin’ Sticks” were used to measure olfactory detection levels and adaptation. Adults with and without ASC showed similar olfactory detection thresholds, and similar adaptation to an olfactory stimulus. Since diminished adaptation in ASC has been previously suggested, future research needs to examine adaptation in other modalities as well. En ligne : http://dx.doi.org/10.1007/s10803-011-1321-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=156
in Journal of Autism and Developmental Disorders > 42-6 (June 2012) . - p.905-909[article] Olfactory Detection Thresholds and Adaptation in Adults with Autism Spectrum Condition [Texte imprimé et/ou numérique] / Teresa TAVASSOLI, Auteur ; Simon BARON-COHEN, Auteur . - 2012 . - p.905-909.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 42-6 (June 2012) . - p.905-909
Mots-clés : Autism Spectrum Condition Olfaction Olfactory detection and adaptation Index. décimale : PER Périodiques Résumé : Sensory issues have been widely reported in Autism Spectrum Conditions (ASC). Since olfaction is one of the least investigated senses in ASC, the current studies explore olfactory detection thresholds and adaptation to olfactory stimuli in adults with ASC. 80 participants took part, 38 (18 females, 20 males) with ASC and 42 control participants (20 males, 22 females). A subgroup of participants (N = 19 in each group) also conducted an adaptation task. Standardized “Sniffin’ Sticks” were used to measure olfactory detection levels and adaptation. Adults with and without ASC showed similar olfactory detection thresholds, and similar adaptation to an olfactory stimulus. Since diminished adaptation in ASC has been previously suggested, future research needs to examine adaptation in other modalities as well. En ligne : http://dx.doi.org/10.1007/s10803-011-1321-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=156 Olfactory Dysfunction in Neurodevelopmental Disorders: A Meta-analytic Review of Autism Spectrum Disorders, Attention Deficit/Hyperactivity Disorder and Obsessive-Compulsive Disorder / Andrew J. D. CROW in Journal of Autism and Developmental Disorders, 50-8 (August 2020)
[article]
Titre : Olfactory Dysfunction in Neurodevelopmental Disorders: A Meta-analytic Review of Autism Spectrum Disorders, Attention Deficit/Hyperactivity Disorder and Obsessive-Compulsive Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Andrew J. D. CROW, Auteur ; Jennica M. JANSSEN, Auteur ; Kayci L. VICKERS, Auteur ; Julia PARISH-MORRIS, Auteur ; Paul J. MOBERG, Auteur ; David R. ROALF, Auteur Article en page(s) : p.2685-2697 Langues : Anglais (eng) Mots-clés : Attention-deficit/hyperactivity disorder Autism spectrum disorders Meta-analysis Obsessive–compulsive disorder Olfaction Index. décimale : PER Périodiques Résumé : Olfactory dysfunction is recognized in neurodevelopmental disorders and may serve as an early indicator of global dysfunction. The present meta-analysis measures olfaction effect sizes in attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorders (ASDs), and obsessive-compulsive disorder (OCD). Meta-analysis included 320 ADHD, 346 ASD, and 208 OCD individuals as compared to 910 controls. Olfactory performance deficits were small-to-moderate and heterogeneous (d?=??-?0.42, 95% CI?=??-?0.59????-?0.25). Meta-analytic results indicate that olfactory dysfunction is evident in individuals with ASD and OCD, with small-to-negligible effects in ADHD. These findings imply olfactory dysfunction is related to clinical phenotype in ASD and OCD, but not ADHD, and warrant inclusion in clinical assessment and evaluation of certain neurodevelopmental disorders. En ligne : http://dx.doi.org/10.1007/s10803-020-04376-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=428
in Journal of Autism and Developmental Disorders > 50-8 (August 2020) . - p.2685-2697[article] Olfactory Dysfunction in Neurodevelopmental Disorders: A Meta-analytic Review of Autism Spectrum Disorders, Attention Deficit/Hyperactivity Disorder and Obsessive-Compulsive Disorder [Texte imprimé et/ou numérique] / Andrew J. D. CROW, Auteur ; Jennica M. JANSSEN, Auteur ; Kayci L. VICKERS, Auteur ; Julia PARISH-MORRIS, Auteur ; Paul J. MOBERG, Auteur ; David R. ROALF, Auteur . - p.2685-2697.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 50-8 (August 2020) . - p.2685-2697
Mots-clés : Attention-deficit/hyperactivity disorder Autism spectrum disorders Meta-analysis Obsessive–compulsive disorder Olfaction Index. décimale : PER Périodiques Résumé : Olfactory dysfunction is recognized in neurodevelopmental disorders and may serve as an early indicator of global dysfunction. The present meta-analysis measures olfaction effect sizes in attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorders (ASDs), and obsessive-compulsive disorder (OCD). Meta-analysis included 320 ADHD, 346 ASD, and 208 OCD individuals as compared to 910 controls. Olfactory performance deficits were small-to-moderate and heterogeneous (d?=??-?0.42, 95% CI?=??-?0.59????-?0.25). Meta-analytic results indicate that olfactory dysfunction is evident in individuals with ASD and OCD, with small-to-negligible effects in ADHD. These findings imply olfactory dysfunction is related to clinical phenotype in ASD and OCD, but not ADHD, and warrant inclusion in clinical assessment and evaluation of certain neurodevelopmental disorders. En ligne : http://dx.doi.org/10.1007/s10803-020-04376-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=428 The relationship of autistic traits to taste and olfactory processing in anorexia nervosa / Emma KINNAIRD in Molecular Autism, 11 (2020)
[article]
Titre : The relationship of autistic traits to taste and olfactory processing in anorexia nervosa Type de document : Texte imprimé et/ou numérique Auteurs : Emma KINNAIRD, Auteur ; Catherine STEWART, Auteur ; Kate TCHANTURIA, Auteur Article en page(s) : 25 p. Langues : Anglais (eng) Mots-clés : Anorexia nervosa Autism Eating disorders Olfaction Sensory Taste Index. décimale : PER Périodiques Résumé : BACKGROUND: There is a heightened prevalence of autism in anorexia nervosa (AN) compared to the general population. Autistic people with AN experience a longer illness duration and poorer treatment outcomes. Whether sensory differences in autism could contribute to altered taste and smell as a potential maintaining factor in AN is under-explored. The aim of this study was to explore whether autistic traits are associated with taste and olfaction differences in AN. METHODS: The study recruited n = 40 people with AN, and n = 40 healthy controls (HC). Smell sensitivity was measured using the Sniffin' Sticks test. Taste sensitivity was measured using taste strips. Participants self-rated their autistic traits using the Autism Spectrum Quotient. RESULTS: There were no significant differences on taste and olfactory outcomes between people with AN and HC. These findings did not change after controlling for the heightened levels of autistic traits in the AN group. No relationship between taste and smell outcomes and autistic traits were identified within the AN group. LIMITATIONS: The current study is not able to draw conclusions about taste and smell processing in co-occurring autism and AN as it only measured levels of autistic traits, rather than comparing people with and without an autism diagnosis. CONCLUSIONS: No significant associations between autistic traits and taste and smell processing in AN were identified. Future research should consider further exploring this area, including by comparing autistic women to women with AN. En ligne : http://dx.doi.org/10.1186/s13229-020-00331-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=427
in Molecular Autism > 11 (2020) . - 25 p.[article] The relationship of autistic traits to taste and olfactory processing in anorexia nervosa [Texte imprimé et/ou numérique] / Emma KINNAIRD, Auteur ; Catherine STEWART, Auteur ; Kate TCHANTURIA, Auteur . - 25 p.
Langues : Anglais (eng)
in Molecular Autism > 11 (2020) . - 25 p.
Mots-clés : Anorexia nervosa Autism Eating disorders Olfaction Sensory Taste Index. décimale : PER Périodiques Résumé : BACKGROUND: There is a heightened prevalence of autism in anorexia nervosa (AN) compared to the general population. Autistic people with AN experience a longer illness duration and poorer treatment outcomes. Whether sensory differences in autism could contribute to altered taste and smell as a potential maintaining factor in AN is under-explored. The aim of this study was to explore whether autistic traits are associated with taste and olfaction differences in AN. METHODS: The study recruited n = 40 people with AN, and n = 40 healthy controls (HC). Smell sensitivity was measured using the Sniffin' Sticks test. Taste sensitivity was measured using taste strips. Participants self-rated their autistic traits using the Autism Spectrum Quotient. RESULTS: There were no significant differences on taste and olfactory outcomes between people with AN and HC. These findings did not change after controlling for the heightened levels of autistic traits in the AN group. No relationship between taste and smell outcomes and autistic traits were identified within the AN group. LIMITATIONS: The current study is not able to draw conclusions about taste and smell processing in co-occurring autism and AN as it only measured levels of autistic traits, rather than comparing people with and without an autism diagnosis. CONCLUSIONS: No significant associations between autistic traits and taste and smell processing in AN were identified. Future research should consider further exploring this area, including by comparing autistic women to women with AN. En ligne : http://dx.doi.org/10.1186/s13229-020-00331-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=427 Assessment of olfactory detection thresholds in children with autism spectrum disorders using a pulse ejection system / H. KUMAZAKI in Molecular Autism, 7 (2016)
[article]
Titre : Assessment of olfactory detection thresholds in children with autism spectrum disorders using a pulse ejection system Type de document : Texte imprimé et/ou numérique Auteurs : H. KUMAZAKI, Auteur ; T. MURAMATSU, Auteur ; T. X. FUJISAWA, Auteur ; M. MIYAO, Auteur ; E. MATSUURA, Auteur ; K. OKADA, Auteur ; H. KOSAKA, Auteur ; A. TOMODA, Auteur ; M. MIMURA, Auteur Article en page(s) : 6p. Langues : Anglais (eng) Mots-clés : Adolescent Aerosols Autism Spectrum Disorder/physiopathology/psychology Caproates Case-Control Studies Child Diagnostic Equipment Equipment Design Female Humans Hypesthesia/etiology/physiopathology/psychology Male Odorants Olfactory Perception/physiology Pentanols Pulsatile Flow Sensory Thresholds/physiology Autism spectrum disorder Laboratory-based studies Olfaction Olfactory detection threshold Pulse ejection system Index. décimale : PER Périodiques Résumé : BACKGROUND: Atypical responsiveness to olfactory stimuli has been reported as the strongest predictor of social impairment in children with autism spectrum disorders (ASD). However, previous laboratory-based sensory psychophysical studies that have aimed to investigate olfactory sensitivity in children with ASD have produced inconsistent results. The methodology of these studies is limited by several factors, and more sophisticated approaches are required to produce consistent results. METHODS: We measured olfactory detection thresholds in children with ASD and typical development (TD) using a pulse ejection system-a newly developed methodology designed to resolve problems encountered in previous studies. The two odorants used as stimuli were isoamyl acetate and allyl caproate. RESULTS: Forty-three participants took part in this study: 23 (6 females, 17 males) children with ASD and 20 with TD (6 females, 14 males). Olfactory detection thresholds of children with ASD were significantly higher than those of TD children with both isoamyl acetate (2.85 +/- 0.28 vs 1.57 +/- 0.15; p < 0.001) and allyl caproate ( 3.30 +/- 0.23 vs 1.17 +/- 0.08; p < 0.001). CONCLUSIONS: We found impaired olfactory detection thresholds in children with ASD. Our results contribute to a better understanding of the olfactory abnormalities that children with ASD experience. Considering the role and effect that odors play in our daily lives, insensitivity to some odorants might have a tremendous impact on children with ASD. Future studies of olfactory processing in ASD may reveal important links between brain function, clinically relevant behavior, and treatment. En ligne : http://dx.doi.org/10.1186/s13229-016-0071-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=328
in Molecular Autism > 7 (2016) . - 6p.[article] Assessment of olfactory detection thresholds in children with autism spectrum disorders using a pulse ejection system [Texte imprimé et/ou numérique] / H. KUMAZAKI, Auteur ; T. MURAMATSU, Auteur ; T. X. FUJISAWA, Auteur ; M. MIYAO, Auteur ; E. MATSUURA, Auteur ; K. OKADA, Auteur ; H. KOSAKA, Auteur ; A. TOMODA, Auteur ; M. MIMURA, Auteur . - 6p.
Langues : Anglais (eng)
in Molecular Autism > 7 (2016) . - 6p.
Mots-clés : Adolescent Aerosols Autism Spectrum Disorder/physiopathology/psychology Caproates Case-Control Studies Child Diagnostic Equipment Equipment Design Female Humans Hypesthesia/etiology/physiopathology/psychology Male Odorants Olfactory Perception/physiology Pentanols Pulsatile Flow Sensory Thresholds/physiology Autism spectrum disorder Laboratory-based studies Olfaction Olfactory detection threshold Pulse ejection system Index. décimale : PER Périodiques Résumé : BACKGROUND: Atypical responsiveness to olfactory stimuli has been reported as the strongest predictor of social impairment in children with autism spectrum disorders (ASD). However, previous laboratory-based sensory psychophysical studies that have aimed to investigate olfactory sensitivity in children with ASD have produced inconsistent results. The methodology of these studies is limited by several factors, and more sophisticated approaches are required to produce consistent results. METHODS: We measured olfactory detection thresholds in children with ASD and typical development (TD) using a pulse ejection system-a newly developed methodology designed to resolve problems encountered in previous studies. The two odorants used as stimuli were isoamyl acetate and allyl caproate. RESULTS: Forty-three participants took part in this study: 23 (6 females, 17 males) children with ASD and 20 with TD (6 females, 14 males). Olfactory detection thresholds of children with ASD were significantly higher than those of TD children with both isoamyl acetate (2.85 +/- 0.28 vs 1.57 +/- 0.15; p < 0.001) and allyl caproate ( 3.30 +/- 0.23 vs 1.17 +/- 0.08; p < 0.001). CONCLUSIONS: We found impaired olfactory detection thresholds in children with ASD. Our results contribute to a better understanding of the olfactory abnormalities that children with ASD experience. Considering the role and effect that odors play in our daily lives, insensitivity to some odorants might have a tremendous impact on children with ASD. Future studies of olfactory processing in ASD may reveal important links between brain function, clinically relevant behavior, and treatment. En ligne : http://dx.doi.org/10.1186/s13229-016-0071-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=328 Les débuts de la perception et de la cognition chez le jeune enfant / Arlette STRERI
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PermalinkHyper nauséeux et troubles de l'oralité chez l'enfant / Catherine SENEZ in Rééducation Orthophonique, 220 (Décembre 2004)
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