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Spectrum or subtypes? A latent profile analysis of restricted and repetitive behaviours in autism / Lidan ZHENG in Research in Autism Spectrum Disorders, 57 (January 2019)
[article]
Titre : Spectrum or subtypes? A latent profile analysis of restricted and repetitive behaviours in autism Type de document : Texte imprimé et/ou numérique Auteurs : Lidan ZHENG, Auteur ; Rachel GROVE, Auteur ; Valsamma EAPEN, Auteur Article en page(s) : p.46-54 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder Restricted and repetitive interests and behaviours Latent profile analysis DSM-5 Clinical subtypes Index. décimale : PER Périodiques Résumé : Background Autism Spectrum Disorder (ASD) is a heterogeneous condition. One way of understanding this heterogeneity is by investigating whether homogenous subgroups within the autism population exist. Some studies have attempted to do this by looking at social and communication skills. However, few studies have looked at subtyping using restricted and repetitive behaviours. While restricted and repetitive behaviours form part of the core features of autism, their presentation is diverse across different individuals on the spectrum. The aim of this study was to determine if restricted and repetitive behaviours could be used to identify potential subtypes of autism. Method This study used unsupervised clustering algorithms to differentiate subgroups of individuals on the autism spectrum based on their scores on the Repetitive Behaviour Scale-Revised (RBS-R). Results Three groups were found that reported low, medium and high levels of restricted and repetitive behaviours. These groups also differed on a range of clinical measures including problematic behaviours, autistic traits and adaptive behaviours. Conclusions Our findings indicate that subgroups of individuals with autism can be identified based on their level of restricted and repetitive behaviours. This highlights that restricted and repetitive behaviours may be best understood under a dimensional continuum of severity. This has implications for our understanding of the non-social characteristics of autism. En ligne : https://doi.org/10.1016/j.rasd.2018.10.003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=371
in Research in Autism Spectrum Disorders > 57 (January 2019) . - p.46-54[article] Spectrum or subtypes? A latent profile analysis of restricted and repetitive behaviours in autism [Texte imprimé et/ou numérique] / Lidan ZHENG, Auteur ; Rachel GROVE, Auteur ; Valsamma EAPEN, Auteur . - p.46-54.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 57 (January 2019) . - p.46-54
Mots-clés : Autism spectrum disorder Restricted and repetitive interests and behaviours Latent profile analysis DSM-5 Clinical subtypes Index. décimale : PER Périodiques Résumé : Background Autism Spectrum Disorder (ASD) is a heterogeneous condition. One way of understanding this heterogeneity is by investigating whether homogenous subgroups within the autism population exist. Some studies have attempted to do this by looking at social and communication skills. However, few studies have looked at subtyping using restricted and repetitive behaviours. While restricted and repetitive behaviours form part of the core features of autism, their presentation is diverse across different individuals on the spectrum. The aim of this study was to determine if restricted and repetitive behaviours could be used to identify potential subtypes of autism. Method This study used unsupervised clustering algorithms to differentiate subgroups of individuals on the autism spectrum based on their scores on the Repetitive Behaviour Scale-Revised (RBS-R). Results Three groups were found that reported low, medium and high levels of restricted and repetitive behaviours. These groups also differed on a range of clinical measures including problematic behaviours, autistic traits and adaptive behaviours. Conclusions Our findings indicate that subgroups of individuals with autism can be identified based on their level of restricted and repetitive behaviours. This highlights that restricted and repetitive behaviours may be best understood under a dimensional continuum of severity. This has implications for our understanding of the non-social characteristics of autism. En ligne : https://doi.org/10.1016/j.rasd.2018.10.003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=371 Cognitive dysfunction is worse among pediatric patients with bipolar disorder Type I than Type II / Lindsay S. SCHENKEL in Journal of Child Psychology and Psychiatry, 53-7 (July 2012)
[article]
Titre : Cognitive dysfunction is worse among pediatric patients with bipolar disorder Type I than Type II Type de document : Texte imprimé et/ou numérique Auteurs : Lindsay S. SCHENKEL, Auteur ; Amy E. WEST, Auteur ; Rachel H. JACOBS, Auteur ; John A. SWEENEY, Auteur ; Mani N. PAVULURI, Auteur Année de publication : 2012 Article en page(s) : p.775-781 Langues : Anglais (eng) Mots-clés : Pediatric bipolar disorder neurocognitive function bipolar I disorder bipolar II disorder clinical subtypes Index. décimale : PER Périodiques Résumé : Background: Impaired profiles of neurocognitive function have been consistently demonstrated among pediatric patients with bipolar disorder (BD), and may aid in the identification of endophenotypes across subtypes of the disorder. This study aims to determine phenotypic cognitive profiles of patients with BD Type I and II.
Methods: Subjects (N = 79) consisted of BD I (n = 27) and BD II (n = 19) patients and demographic and intellectually matched healthy controls (HC; n = 33) that completed a battery of neurocognitive tasks.
Results: Bipolar disorder Type I patients performed significantly more poorly compared to HC on all domains of cognitive function including attention, executive function, working memory, visual memory, and verbal learning and memory. BD I patients also performed more poorly compared to BD II patients on all domains of cognitive functioning with the exception of working memory, whereas BD II patients did poorly relative to HC only on verbal learning and memory.
Conclusions: Findings from the current study indicate that BD I patients are characterized by more severe cognitive impairment relative to BD II patients who show an intermediate pattern of performance between BD I patients and HC. Verbal learning and memory may effectively differentiate pediatric BD patients and controls, regardless of the subtype of BD, and may serve as a cognitive endophenotype for the disorder. Additionally, these findings move us closer to developing effective cognitive interventions tailored to specific subtypes of pediatric BD patients.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02519.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=166
in Journal of Child Psychology and Psychiatry > 53-7 (July 2012) . - p.775-781[article] Cognitive dysfunction is worse among pediatric patients with bipolar disorder Type I than Type II [Texte imprimé et/ou numérique] / Lindsay S. SCHENKEL, Auteur ; Amy E. WEST, Auteur ; Rachel H. JACOBS, Auteur ; John A. SWEENEY, Auteur ; Mani N. PAVULURI, Auteur . - 2012 . - p.775-781.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 53-7 (July 2012) . - p.775-781
Mots-clés : Pediatric bipolar disorder neurocognitive function bipolar I disorder bipolar II disorder clinical subtypes Index. décimale : PER Périodiques Résumé : Background: Impaired profiles of neurocognitive function have been consistently demonstrated among pediatric patients with bipolar disorder (BD), and may aid in the identification of endophenotypes across subtypes of the disorder. This study aims to determine phenotypic cognitive profiles of patients with BD Type I and II.
Methods: Subjects (N = 79) consisted of BD I (n = 27) and BD II (n = 19) patients and demographic and intellectually matched healthy controls (HC; n = 33) that completed a battery of neurocognitive tasks.
Results: Bipolar disorder Type I patients performed significantly more poorly compared to HC on all domains of cognitive function including attention, executive function, working memory, visual memory, and verbal learning and memory. BD I patients also performed more poorly compared to BD II patients on all domains of cognitive functioning with the exception of working memory, whereas BD II patients did poorly relative to HC only on verbal learning and memory.
Conclusions: Findings from the current study indicate that BD I patients are characterized by more severe cognitive impairment relative to BD II patients who show an intermediate pattern of performance between BD I patients and HC. Verbal learning and memory may effectively differentiate pediatric BD patients and controls, regardless of the subtype of BD, and may serve as a cognitive endophenotype for the disorder. Additionally, these findings move us closer to developing effective cognitive interventions tailored to specific subtypes of pediatric BD patients.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02519.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=166