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Association Between DCC Polymorphisms and Susceptibility to Autism Spectrum Disorder / Yan LI in Journal of Autism and Developmental Disorders, 50-10 (October 2020)
[article]
Titre : Association Between DCC Polymorphisms and Susceptibility to Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Yan LI, Auteur ; Shuang QIU, Auteur ; Weijing ZHONG, Auteur ; Yong LI, Auteur ; Yunkai LIU, Auteur ; Yi CHENG, Auteur ; Yawen LIU, Auteur Article en page(s) : p.3800-3809 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder Deleted in colorectal carcinoma gene Haplotype analysis Single nucleotide polymorphisms Susceptibility Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) represents a group of childhood-onset lifelong neuro-developmental disorders. However, the association between single nucleotide polymorphisms (SNPs) in the deleted in colorectal carcinoma (DCC) gene and ASD susceptibility remains unclear. We investigated the association between ASD susceptibility and seven SNPs in DCC on the basis of a case-control study (231 ASD cases and 242 controls) in Chinese Han. We found that there was no association between ASD susceptibility and the seven SNPs in DCC; however, T-A haplotype (rs2229082-rs2270954), T-A-T-C haplotype (rs2229082-rs2270954-rs2292043-rs2292044), C-G-T-C-T haplotype (rs934345-rs17753970-rs2229082-rs2270954-rs2292043), C-G-T-C-T-G haplotype (rs934345-rs17753970-rs2229082-rs2270954-rs2292043-rs2292044), and G-G-T-C-C-C-C haplotype (rs934345-rs17753970-rs2229082-rs2270954-rs2292043-rs2292044-rs16956878) were associated with ASD susceptibility. Our results indicate that the haplotypes formed on the basis of the seven SNPs in DCC may be implicated in ASD. En ligne : http://dx.doi.org/10.1007/s10803-020-04417-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=432
in Journal of Autism and Developmental Disorders > 50-10 (October 2020) . - p.3800-3809[article] Association Between DCC Polymorphisms and Susceptibility to Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Yan LI, Auteur ; Shuang QIU, Auteur ; Weijing ZHONG, Auteur ; Yong LI, Auteur ; Yunkai LIU, Auteur ; Yi CHENG, Auteur ; Yawen LIU, Auteur . - p.3800-3809.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 50-10 (October 2020) . - p.3800-3809
Mots-clés : Autism spectrum disorder Deleted in colorectal carcinoma gene Haplotype analysis Single nucleotide polymorphisms Susceptibility Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) represents a group of childhood-onset lifelong neuro-developmental disorders. However, the association between single nucleotide polymorphisms (SNPs) in the deleted in colorectal carcinoma (DCC) gene and ASD susceptibility remains unclear. We investigated the association between ASD susceptibility and seven SNPs in DCC on the basis of a case-control study (231 ASD cases and 242 controls) in Chinese Han. We found that there was no association between ASD susceptibility and the seven SNPs in DCC; however, T-A haplotype (rs2229082-rs2270954), T-A-T-C haplotype (rs2229082-rs2270954-rs2292043-rs2292044), C-G-T-C-T haplotype (rs934345-rs17753970-rs2229082-rs2270954-rs2292043), C-G-T-C-T-G haplotype (rs934345-rs17753970-rs2229082-rs2270954-rs2292043-rs2292044), and G-G-T-C-C-C-C haplotype (rs934345-rs17753970-rs2229082-rs2270954-rs2292043-rs2292044-rs16956878) were associated with ASD susceptibility. Our results indicate that the haplotypes formed on the basis of the seven SNPs in DCC may be implicated in ASD. En ligne : http://dx.doi.org/10.1007/s10803-020-04417-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=432