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Mental disorders in preadolescent children at familial high-risk of schizophrenia or bipolar disorder - a four-year follow-up study: The Danish High Risk and Resilience Study, VIA 11: The Danish High Risk and Resilience Study, VIA 11 / Maja GREGERSEN in Journal of Child Psychology and Psychiatry, 63-9 (September 2022)
[article]
Titre : Mental disorders in preadolescent children at familial high-risk of schizophrenia or bipolar disorder - a four-year follow-up study: The Danish High Risk and Resilience Study, VIA 11: The Danish High Risk and Resilience Study, VIA 11 Type de document : Texte imprimé et/ou numérique Auteurs : Maja GREGERSEN, Auteur ; Anne SØNDERGAARD, Auteur ; Julie Marie BRANDT, Auteur ; Ditte ELLERSGAARD, Auteur ; Sinnika Birkehoj ROHD, Auteur ; Carsten HJORTHØJ, Auteur ; Jessica OHLAND, Auteur ; Mette Falkenberg KRANTZ, Auteur ; Martin WILMS, Auteur ; Anna Krogh ANDREASSEN, Auteur ; Christina Bruun KNUDSEN, Auteur ; Lotte VEDDUM, Auteur ; Aja GREVE, Auteur ; Vibeke BLIKSTED, Auteur ; Ole MORS, Auteur ; Lars CLEMMENSEN, Auteur ; Jens Richardt MØLLEGAARD JEPSEN, Auteur ; Merete NORDENTOFT, Auteur ; Nicoline HEMAGER, Auteur ; Anne Amalie Elgaard THORUP, Auteur Article en page(s) : p.1046-1056 Langues : Anglais (eng) Mots-clés : Bipolar Disorder/epidemiology Child Child, Preschool Denmark/epidemiology Follow-Up Studies Humans Longitudinal Studies Schizophrenia/epidemiology Child and adolescent psychiatry bipolar disorder familial high-risk psychopathology schizophrenia Index. décimale : PER Périodiques Résumé : BACKGROUND: Children at familial high-risk of schizophrenia and bipolar disorder have an elevated prevalence of mental disorders but studies of children within a narrow age range are lacking and there are few conjoint studies of these two groups. Knowledge on their mental health is important for prevention and early intervention. METHODS: The authors examined mental disorders and global functioning in children at familial high-risk of schizophrenia (FHR-SZ) and bipolar disorder (FHR-BP) compared with population-based controls. In a longitudinal cohort study, 450 children (FHR-SZ, n=171; FHR-BP, n=104; controls, n=175), were assessed for Axis I disorders at baseline and four-year follow-up (mean age 11.9, SD 0.2) with the Kiddie Schedule for Affective Disorders and Schizophrenia for School-Age Children and for global functioning with Children's Global Assessment Scale. RESULTS: Cumulative incidence of Any Axis I disorder was elevated by age 11 in children at FHR-SZ (54.4%, OR 3.0, 95% CI 1.9-4.7, p<.001) and children at FHR-BP (52.9%, OR 2.8, 95% CI 1.7-4.7, p<.001) compared with controls (28.6%). Children at FHR-SZ and FHR-BP had higher rates of affective disorders (OR 4.4, 95% CI 1.4-13.5, p=.009; OR 5.1, 95% CI 1.6-16.4, p=.007), anxiety disorders (OR 2.1, 95% CI 1.1-4.0, p=.02; OR 3.0, 95% CI 1.5-6.1, p=.002), and stress and adjustment disorders (OR 3.3, 95% CI 1.4-7.5, p=.006; OR 5.3, 95% CI 2.2-12.4, p<.001). Disruptive behavior disorders (OR 2.8, 95% CI 1.0-7.3, p=.04) and ADHD (OR 2.9, 95% CI 1.6-5.3, p<.001) were elevated in children at FHR-SZ. Both FHR groups had lower global functioning than controls. Cumulative incidence of disorders increased equally across the three groups from early childhood to preadolescence and level of functioning did not change differentially. CONCLUSIONS: Children at FHR-SZ and FHR-BP have an elevated prevalence of mental disorders and poorer functioning than controls. Vulnerability in children at FHR manifests early and remains stable throughout childhood. Early attention toward their mental health and identification of those in need of intervention is warranted. En ligne : http://dx.doi.org/10.1111/jcpp.13548 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=486
in Journal of Child Psychology and Psychiatry > 63-9 (September 2022) . - p.1046-1056[article] Mental disorders in preadolescent children at familial high-risk of schizophrenia or bipolar disorder - a four-year follow-up study: The Danish High Risk and Resilience Study, VIA 11: The Danish High Risk and Resilience Study, VIA 11 [Texte imprimé et/ou numérique] / Maja GREGERSEN, Auteur ; Anne SØNDERGAARD, Auteur ; Julie Marie BRANDT, Auteur ; Ditte ELLERSGAARD, Auteur ; Sinnika Birkehoj ROHD, Auteur ; Carsten HJORTHØJ, Auteur ; Jessica OHLAND, Auteur ; Mette Falkenberg KRANTZ, Auteur ; Martin WILMS, Auteur ; Anna Krogh ANDREASSEN, Auteur ; Christina Bruun KNUDSEN, Auteur ; Lotte VEDDUM, Auteur ; Aja GREVE, Auteur ; Vibeke BLIKSTED, Auteur ; Ole MORS, Auteur ; Lars CLEMMENSEN, Auteur ; Jens Richardt MØLLEGAARD JEPSEN, Auteur ; Merete NORDENTOFT, Auteur ; Nicoline HEMAGER, Auteur ; Anne Amalie Elgaard THORUP, Auteur . - p.1046-1056.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 63-9 (September 2022) . - p.1046-1056
Mots-clés : Bipolar Disorder/epidemiology Child Child, Preschool Denmark/epidemiology Follow-Up Studies Humans Longitudinal Studies Schizophrenia/epidemiology Child and adolescent psychiatry bipolar disorder familial high-risk psychopathology schizophrenia Index. décimale : PER Périodiques Résumé : BACKGROUND: Children at familial high-risk of schizophrenia and bipolar disorder have an elevated prevalence of mental disorders but studies of children within a narrow age range are lacking and there are few conjoint studies of these two groups. Knowledge on their mental health is important for prevention and early intervention. METHODS: The authors examined mental disorders and global functioning in children at familial high-risk of schizophrenia (FHR-SZ) and bipolar disorder (FHR-BP) compared with population-based controls. In a longitudinal cohort study, 450 children (FHR-SZ, n=171; FHR-BP, n=104; controls, n=175), were assessed for Axis I disorders at baseline and four-year follow-up (mean age 11.9, SD 0.2) with the Kiddie Schedule for Affective Disorders and Schizophrenia for School-Age Children and for global functioning with Children's Global Assessment Scale. RESULTS: Cumulative incidence of Any Axis I disorder was elevated by age 11 in children at FHR-SZ (54.4%, OR 3.0, 95% CI 1.9-4.7, p<.001) and children at FHR-BP (52.9%, OR 2.8, 95% CI 1.7-4.7, p<.001) compared with controls (28.6%). Children at FHR-SZ and FHR-BP had higher rates of affective disorders (OR 4.4, 95% CI 1.4-13.5, p=.009; OR 5.1, 95% CI 1.6-16.4, p=.007), anxiety disorders (OR 2.1, 95% CI 1.1-4.0, p=.02; OR 3.0, 95% CI 1.5-6.1, p=.002), and stress and adjustment disorders (OR 3.3, 95% CI 1.4-7.5, p=.006; OR 5.3, 95% CI 2.2-12.4, p<.001). Disruptive behavior disorders (OR 2.8, 95% CI 1.0-7.3, p=.04) and ADHD (OR 2.9, 95% CI 1.6-5.3, p<.001) were elevated in children at FHR-SZ. Both FHR groups had lower global functioning than controls. Cumulative incidence of disorders increased equally across the three groups from early childhood to preadolescence and level of functioning did not change differentially. CONCLUSIONS: Children at FHR-SZ and FHR-BP have an elevated prevalence of mental disorders and poorer functioning than controls. Vulnerability in children at FHR manifests early and remains stable throughout childhood. Early attention toward their mental health and identification of those in need of intervention is warranted. En ligne : http://dx.doi.org/10.1111/jcpp.13548 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=486 Autism spectrum disorder screening with the CBCL/11/2-5: Findings for young children at high risk for autism spectrum disorder / L. A. RESCORLA in Autism, 23-1 (January 2019)
[article]
Titre : Autism spectrum disorder screening with the CBCL/11/2-5: Findings for young children at high risk for autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : L. A. RESCORLA, Auteur ; Breanna WINDER-PATEL, Auteur ; Sarah J. PATERSON, Auteur ; J. PANDEY, Auteur ; J. J. WOLFF, Auteur ; Robert T. SCHULTZ, Auteur ; J. PIVEN, Auteur Article en page(s) : p.29-38 Langues : Anglais (eng) Mots-clés : autism spectrum disorder screening baby sibling paradigm CBCL/11/2-5 Diagnostic and Statistical Manual of Mental Disorders-Pervasive Developmental Problems scale familial high-risk modified checklist rating-scales toddlers identification cbcl Psychology Index. décimale : PER Périodiques Résumé : The screening power of the CBCL/11/2-5's Withdrawn and Diagnostic and Statistical Manual of Mental Disorders-Pervasive Developmental Problems (DSM-PDP) scales to identify children diagnosed with autism spectrum disorder at 24 months was tested in a longitudinal, familial high-risk study. Participants were 56 children at high risk for autism spectrum disorder due to an affected older sibling (high-risk group) and 26 low-risk children with a typically developing older sibling (low-risk group). At 24 months, 13 of the 56 high-risk children were diagnosed with autism spectrum disorder, whereas the other 43 were not. The high-risk children diagnosed with autism spectrum disorder group had significantly higher scores on the CBCL/11/2-5's Diagnostic and Statistical Manual of Mental Disorders-Pervasive Developmental Problems and Withdrawn scales than children in the low-risk and high-risk children not diagnosed with autism spectrum disorder groups (eta p2>0.50). Receiver operating characteristic analyses yielded very high area under the curve values (0.91 and 0.89), and a cut point of T > 60 yielded sensitivity of 77% and specificity of 97% to 99% between the high-risk children diagnosed with autism spectrum disorder and the combination of low-risk and high-risk children not diagnosed with autism spectrum disorder. Consistent with several previous studies, the CBCL/11/2-5's Diagnostic and Statistical Manual of Mental Disorders-Pervasive Developmental Problems scale and the Withdrawn syndrome differentiated well between children diagnosed with autism spectrum disorder and those not diagnosed. En ligne : http://dx.doi.org/10.1177/1362361317718482 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=379
in Autism > 23-1 (January 2019) . - p.29-38[article] Autism spectrum disorder screening with the CBCL/11/2-5: Findings for young children at high risk for autism spectrum disorder [Texte imprimé et/ou numérique] / L. A. RESCORLA, Auteur ; Breanna WINDER-PATEL, Auteur ; Sarah J. PATERSON, Auteur ; J. PANDEY, Auteur ; J. J. WOLFF, Auteur ; Robert T. SCHULTZ, Auteur ; J. PIVEN, Auteur . - p.29-38.
Langues : Anglais (eng)
in Autism > 23-1 (January 2019) . - p.29-38
Mots-clés : autism spectrum disorder screening baby sibling paradigm CBCL/11/2-5 Diagnostic and Statistical Manual of Mental Disorders-Pervasive Developmental Problems scale familial high-risk modified checklist rating-scales toddlers identification cbcl Psychology Index. décimale : PER Périodiques Résumé : The screening power of the CBCL/11/2-5's Withdrawn and Diagnostic and Statistical Manual of Mental Disorders-Pervasive Developmental Problems (DSM-PDP) scales to identify children diagnosed with autism spectrum disorder at 24 months was tested in a longitudinal, familial high-risk study. Participants were 56 children at high risk for autism spectrum disorder due to an affected older sibling (high-risk group) and 26 low-risk children with a typically developing older sibling (low-risk group). At 24 months, 13 of the 56 high-risk children were diagnosed with autism spectrum disorder, whereas the other 43 were not. The high-risk children diagnosed with autism spectrum disorder group had significantly higher scores on the CBCL/11/2-5's Diagnostic and Statistical Manual of Mental Disorders-Pervasive Developmental Problems and Withdrawn scales than children in the low-risk and high-risk children not diagnosed with autism spectrum disorder groups (eta p2>0.50). Receiver operating characteristic analyses yielded very high area under the curve values (0.91 and 0.89), and a cut point of T > 60 yielded sensitivity of 77% and specificity of 97% to 99% between the high-risk children diagnosed with autism spectrum disorder and the combination of low-risk and high-risk children not diagnosed with autism spectrum disorder. Consistent with several previous studies, the CBCL/11/2-5's Diagnostic and Statistical Manual of Mental Disorders-Pervasive Developmental Problems scale and the Withdrawn syndrome differentiated well between children diagnosed with autism spectrum disorder and those not diagnosed. En ligne : http://dx.doi.org/10.1177/1362361317718482 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=379 A Combined Study on the Use of the Child Behavior Checklist 1½-5 for Identifying Autism Spectrum Disorders at 18 Months / Natasha CHERICONI in Journal of Autism and Developmental Disorders, 51-11 (November 2021)
[article]
Titre : A Combined Study on the Use of the Child Behavior Checklist 1½-5 for Identifying Autism Spectrum Disorders at 18 Months Type de document : Texte imprimé et/ou numérique Auteurs : Natasha CHERICONI, Auteur ; Giulia BALBONI, Auteur ; V. COSTANZO, Auteur ; A. MANCINI, Auteur ; M. PROSPERI, Auteur ; R. LASALA, Auteur ; Raffaella TANCREDI, Auteur ; M. L. SCATTONI, Auteur ; F. MURATORI, Auteur ; Fabio APICELLA, Auteur Article en page(s) : p.3829-3842 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnosis Checklist Child Child Behavior Humans Male Siblings Autism spectrum disorder screening Baby sibling paradigm Cbcl 1½-5 Familial high-risk Index. décimale : PER Périodiques Résumé : The capacity of the Child Behavior Checklist 1½-5 (CBCL 1½-5) to identify children with autism spectrum disorder (ASD) at 18 months was tested on 37 children clinically referred for ASD and 46 children at elevated likelihood of developing ASD due to having an affected brother/sister. At 30 months the clinically referred children all received a confirmatory diagnosis, and 10 out of 46 siblings received a diagnosis of ASD. CBCL 1½-5 profiles were compared with a group of matched children with typical development (effect of cognitive level controlled for). The capacity of the CBCL 1½-5 DSM Oriented-Pervasive Developmental Problems scale to differentiate correctly between children diagnosed with ASD and children with typical development appeared dependent on group ascertainment methodology. En ligne : http://dx.doi.org/10.1007/s10803-020-04838-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=453
in Journal of Autism and Developmental Disorders > 51-11 (November 2021) . - p.3829-3842[article] A Combined Study on the Use of the Child Behavior Checklist 1½-5 for Identifying Autism Spectrum Disorders at 18 Months [Texte imprimé et/ou numérique] / Natasha CHERICONI, Auteur ; Giulia BALBONI, Auteur ; V. COSTANZO, Auteur ; A. MANCINI, Auteur ; M. PROSPERI, Auteur ; R. LASALA, Auteur ; Raffaella TANCREDI, Auteur ; M. L. SCATTONI, Auteur ; F. MURATORI, Auteur ; Fabio APICELLA, Auteur . - p.3829-3842.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 51-11 (November 2021) . - p.3829-3842
Mots-clés : Autism Spectrum Disorder/diagnosis Checklist Child Child Behavior Humans Male Siblings Autism spectrum disorder screening Baby sibling paradigm Cbcl 1½-5 Familial high-risk Index. décimale : PER Périodiques Résumé : The capacity of the Child Behavior Checklist 1½-5 (CBCL 1½-5) to identify children with autism spectrum disorder (ASD) at 18 months was tested on 37 children clinically referred for ASD and 46 children at elevated likelihood of developing ASD due to having an affected brother/sister. At 30 months the clinically referred children all received a confirmatory diagnosis, and 10 out of 46 siblings received a diagnosis of ASD. CBCL 1½-5 profiles were compared with a group of matched children with typical development (effect of cognitive level controlled for). The capacity of the CBCL 1½-5 DSM Oriented-Pervasive Developmental Problems scale to differentiate correctly between children diagnosed with ASD and children with typical development appeared dependent on group ascertainment methodology. En ligne : http://dx.doi.org/10.1007/s10803-020-04838-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=453