Centre d'Information et de documentation du CRA Rhône-Alpes
CRA
Informations pratiques
-
Adresse
Centre d'information et de documentation
du CRA Rhône-Alpes
Centre Hospitalier le Vinatier
bât 211
95, Bd Pinel
69678 Bron CedexHoraires
Lundi au Vendredi
9h00-12h00 13h30-16h00Contact
Tél: +33(0)4 37 91 54 65
Mail
Fax: +33(0)4 37 91 54 37
-
Résultat de la recherche
2 recherche sur le mot-clé 'Gene–environment interactions'
Affiner la recherche Générer le flux rss de la recherche
Partager le résultat de cette recherche Faire une suggestion
Commentary: Beyond stressful life events and depression? – reflections on Bogdan et al. () / Jay BELSKY in Journal of Child Psychology and Psychiatry, 55-5 (May 2014)
[article]
Titre : Commentary: Beyond stressful life events and depression? – reflections on Bogdan et al. () Type de document : Texte imprimé et/ou numérique Auteurs : Jay BELSKY, Auteur Article en page(s) : p.458-459 Mots-clés : Gene–environment interactions stressful life events 5-HTTLPR early childhood developmental plasticity depression Index. décimale : PER Périodiques Résumé : In light of continuing disagreement, even at the meta-analytic level, as to whether the gene- × -environment (G×E) interaction involving 5-HTTLPR and stressful life events (SLEs) predicts depression, Bogdan and associates (this issue, Bogdan et al., 2014) sought to extend research on what has become a highly controversial general (GxE) and specific (5HTTLPR X SLEs) arena of inquiry. Thus, rather than seeking to replicate this specific GXE interaction in another sample of adolescents or adults, these investigators shifted the developmental focus–to very young children, aged 3-5 years of age. This re-direction was motivated by the kindling hypothesis which stipulates that the earliest episodes of depression might be especially sensitive to environmental adversity, with later episodes very much dependent on earlier ones and less a function of later-life environmental provocation. Thus, the investigators reasoned that the controversial G×E interaction might actually prove more evident and exert a more pronounced impact early in childhood than at older ages where they have been so extensively studied. En ligne : http://dx.doi.org/10.1111/jcpp.12238 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=231
in Journal of Child Psychology and Psychiatry > 55-5 (May 2014) . - p.458-459[article] Commentary: Beyond stressful life events and depression? – reflections on Bogdan et al. () [Texte imprimé et/ou numérique] / Jay BELSKY, Auteur . - p.458-459.
in Journal of Child Psychology and Psychiatry > 55-5 (May 2014) . - p.458-459
Mots-clés : Gene–environment interactions stressful life events 5-HTTLPR early childhood developmental plasticity depression Index. décimale : PER Périodiques Résumé : In light of continuing disagreement, even at the meta-analytic level, as to whether the gene- × -environment (G×E) interaction involving 5-HTTLPR and stressful life events (SLEs) predicts depression, Bogdan and associates (this issue, Bogdan et al., 2014) sought to extend research on what has become a highly controversial general (GxE) and specific (5HTTLPR X SLEs) arena of inquiry. Thus, rather than seeking to replicate this specific GXE interaction in another sample of adolescents or adults, these investigators shifted the developmental focus–to very young children, aged 3-5 years of age. This re-direction was motivated by the kindling hypothesis which stipulates that the earliest episodes of depression might be especially sensitive to environmental adversity, with later episodes very much dependent on earlier ones and less a function of later-life environmental provocation. Thus, the investigators reasoned that the controversial G×E interaction might actually prove more evident and exert a more pronounced impact early in childhood than at older ages where they have been so extensively studied. En ligne : http://dx.doi.org/10.1111/jcpp.12238 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=231 Commentary: G × E in child psychiatry and psychology: a broadening of the scope of enquiry as prompted by Munafò et al. (2014) / Michael RUTTER in Journal of Child Psychology and Psychiatry, 55-10 (October 2014)
[article]
Titre : Commentary: G × E in child psychiatry and psychology: a broadening of the scope of enquiry as prompted by Munafò et al. (2014) Type de document : Texte imprimé et/ou numérique Auteurs : Michael RUTTER, Auteur Article en page(s) : p.1102-1104 Langues : Anglais (eng) Mots-clés : Gene–environment interactions G × E correlations biological pathways child mental health disorders Index. décimale : PER Périodiques Résumé : The accompanying Practitioner Review by Munafò et al. (2014) presents two main arguments: (1) that there are few (if any) examples of G × E in psychiatry so it cannot aid gene discovery, and (2) that genome-wide association studies (GWAS) are already yielding important findings. With respect to the supposed weakness of G × E research, they fail to mention any of the substantial body of evidence in support of G × E – see various chapters in Dodge and Rutter (2011). En ligne : http://dx.doi.org/10.1111/jcpp.12309 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=238
in Journal of Child Psychology and Psychiatry > 55-10 (October 2014) . - p.1102-1104[article] Commentary: G × E in child psychiatry and psychology: a broadening of the scope of enquiry as prompted by Munafò et al. (2014) [Texte imprimé et/ou numérique] / Michael RUTTER, Auteur . - p.1102-1104.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 55-10 (October 2014) . - p.1102-1104
Mots-clés : Gene–environment interactions G × E correlations biological pathways child mental health disorders Index. décimale : PER Périodiques Résumé : The accompanying Practitioner Review by Munafò et al. (2014) presents two main arguments: (1) that there are few (if any) examples of G × E in psychiatry so it cannot aid gene discovery, and (2) that genome-wide association studies (GWAS) are already yielding important findings. With respect to the supposed weakness of G × E research, they fail to mention any of the substantial body of evidence in support of G × E – see various chapters in Dodge and Rutter (2011). En ligne : http://dx.doi.org/10.1111/jcpp.12309 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=238