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Atypical sensory processing in adolescents with an autism spectrum disorder and their non-affected siblings / Wouter DE LA MARCHE in Research in Autism Spectrum Disorders, 6-2 (April-June 2012)
[article]
Titre : Atypical sensory processing in adolescents with an autism spectrum disorder and their non-affected siblings Type de document : Texte imprimé et/ou numérique Auteurs : Wouter DE LA MARCHE, Auteur ; Jean STEYAERT, Auteur ; Ilse L.J. NOENS, Auteur Année de publication : 2012 Article en page(s) : p.639-645 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder Adolescents Siblings Sensory profile Intermediate phenotype Index. décimale : PER Périodiques Résumé : Atypical sensory processing is common in autism spectrum disorders (ASD). Specific profiles have been proposed in different age groups, but no study has focused specifically on adolescents. Identifying traits of ASD that are shared by individuals with ASD and their non-affected family members can shed light on the genetic underpinnings of ASD. Eighty adolescents with ASD (64 boys, 16 girls), 56 non-affected adolescent siblings (21 boys, 35 girls) and 33 adolescent controls (18 boys, 15 girls) filled out the Adolescent/Adult Sensory Profile, a self-report questionnaire resulting in four sensory quadrants according to Dunn's model of sensory processing. Adolescents with ASD differed significantly from controls on the quadrants Sensation Seeking and Sensation Avoidance. On quadrant 2 (Sensation Seeking) siblings scored significantly lower than controls and significantly higher than ASD. These results confirm the presence of atypical sensory processing in adolescents with ASD. We argue that reduced Sensation Seeking might be a candidate for an intermediate phenotype. En ligne : http://dx.doi.org/10.1016/j.rasd.2011.09.014 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=150
in Research in Autism Spectrum Disorders > 6-2 (April-June 2012) . - p.639-645[article] Atypical sensory processing in adolescents with an autism spectrum disorder and their non-affected siblings [Texte imprimé et/ou numérique] / Wouter DE LA MARCHE, Auteur ; Jean STEYAERT, Auteur ; Ilse L.J. NOENS, Auteur . - 2012 . - p.639-645.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 6-2 (April-June 2012) . - p.639-645
Mots-clés : Autism spectrum disorder Adolescents Siblings Sensory profile Intermediate phenotype Index. décimale : PER Périodiques Résumé : Atypical sensory processing is common in autism spectrum disorders (ASD). Specific profiles have been proposed in different age groups, but no study has focused specifically on adolescents. Identifying traits of ASD that are shared by individuals with ASD and their non-affected family members can shed light on the genetic underpinnings of ASD. Eighty adolescents with ASD (64 boys, 16 girls), 56 non-affected adolescent siblings (21 boys, 35 girls) and 33 adolescent controls (18 boys, 15 girls) filled out the Adolescent/Adult Sensory Profile, a self-report questionnaire resulting in four sensory quadrants according to Dunn's model of sensory processing. Adolescents with ASD differed significantly from controls on the quadrants Sensation Seeking and Sensation Avoidance. On quadrant 2 (Sensation Seeking) siblings scored significantly lower than controls and significantly higher than ASD. These results confirm the presence of atypical sensory processing in adolescents with ASD. We argue that reduced Sensation Seeking might be a candidate for an intermediate phenotype. En ligne : http://dx.doi.org/10.1016/j.rasd.2011.09.014 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=150 Atypical Development of Attentional Control Associates with Later Adaptive Functioning, Autism and ADHD Traits / Alexandra HENDRY in Journal of Autism and Developmental Disorders, 50-11 (November 2020)
[article]
Titre : Atypical Development of Attentional Control Associates with Later Adaptive Functioning, Autism and ADHD Traits Type de document : Texte imprimé et/ou numérique Auteurs : Alexandra HENDRY, Auteur ; Emily J. H. JONES, Auteur ; Rachael BEDFORD, Auteur ; Linn ANDERSSON KONKE, Auteur ; Jannath BEGUM ALI, Auteur ; Sven B?LTE, Auteur ; Karin C. BROCKI, Auteur ; Ellen DEMURIE, Auteur ; Mark H. JOHNSON, Auteur ; Mirjam K. J. PIJL, Auteur ; Herbert ROEYERS, Auteur ; Tony CHARMAN, Auteur Article en page(s) : p.4085-4105 Langues : Anglais (eng) Mots-clés : Adhd Attention Atypical development Autism Infant Intermediate phenotype lecturer for Shire/Takeda, Medice, Roche, Eli Lilly, Prima Psychiatry, and SB Education and Psychological Consulting AB. He receives royalties for text books and diagnostic tools from Huber/Hogrefe, Kohlhammer and UTB. Charman discloses that he has served as a consultant to F. Hoffmann-La Roche Ltd and has received royalties from Sage Publications and Guilford Publications. All other authors report no conflict of interest. Index. décimale : PER Périodiques Résumé : Autism is frequently associated with difficulties with top-down attentional control, which impact on individuals' mental health and quality of life. The developmental processes involved in these attentional difficulties are not well understood. Using a data-driven approach, 2 samples (N?=?294 and 412) of infants at elevated and typical likelihood of autism were grouped according to profiles of parent report of attention at 10, 15 and 25 months. In contrast to the normative profile of increases in attentional control scores between infancy and toddlerhood, a minority (7-9%) showed plateauing attentional control scores between 10 and 25 months. Consistent with pre-registered hypotheses, plateaued growth of attentional control was associated with elevated autism and ADHD traits, and lower adaptive functioning at age 3 years. En ligne : http://dx.doi.org/10.1007/s10803-020-04465-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=432
in Journal of Autism and Developmental Disorders > 50-11 (November 2020) . - p.4085-4105[article] Atypical Development of Attentional Control Associates with Later Adaptive Functioning, Autism and ADHD Traits [Texte imprimé et/ou numérique] / Alexandra HENDRY, Auteur ; Emily J. H. JONES, Auteur ; Rachael BEDFORD, Auteur ; Linn ANDERSSON KONKE, Auteur ; Jannath BEGUM ALI, Auteur ; Sven B?LTE, Auteur ; Karin C. BROCKI, Auteur ; Ellen DEMURIE, Auteur ; Mark H. JOHNSON, Auteur ; Mirjam K. J. PIJL, Auteur ; Herbert ROEYERS, Auteur ; Tony CHARMAN, Auteur . - p.4085-4105.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 50-11 (November 2020) . - p.4085-4105
Mots-clés : Adhd Attention Atypical development Autism Infant Intermediate phenotype lecturer for Shire/Takeda, Medice, Roche, Eli Lilly, Prima Psychiatry, and SB Education and Psychological Consulting AB. He receives royalties for text books and diagnostic tools from Huber/Hogrefe, Kohlhammer and UTB. Charman discloses that he has served as a consultant to F. Hoffmann-La Roche Ltd and has received royalties from Sage Publications and Guilford Publications. All other authors report no conflict of interest. Index. décimale : PER Périodiques Résumé : Autism is frequently associated with difficulties with top-down attentional control, which impact on individuals' mental health and quality of life. The developmental processes involved in these attentional difficulties are not well understood. Using a data-driven approach, 2 samples (N?=?294 and 412) of infants at elevated and typical likelihood of autism were grouped according to profiles of parent report of attention at 10, 15 and 25 months. In contrast to the normative profile of increases in attentional control scores between infancy and toddlerhood, a minority (7-9%) showed plateauing attentional control scores between 10 and 25 months. Consistent with pre-registered hypotheses, plateaued growth of attentional control was associated with elevated autism and ADHD traits, and lower adaptive functioning at age 3 years. En ligne : http://dx.doi.org/10.1007/s10803-020-04465-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=432 Executive functioning and local-global visual processing: candidate endophenotypes for autism spectrum disorder? / Lien VAN EYLEN in Journal of Child Psychology and Psychiatry, 58-3 (March 2017)
[article]
Titre : Executive functioning and local-global visual processing: candidate endophenotypes for autism spectrum disorder? Type de document : Texte imprimé et/ou numérique Auteurs : Lien VAN EYLEN, Auteur ; Bart BOETS, Auteur ; Nele COSEMANS, Auteur ; Hilde PEETERS, Auteur ; Jean STEYAERT, Auteur ; Johan WAGEMANS, Auteur ; Ilse NOENS, Auteur Article en page(s) : p.258-269 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder relatives intermediate phenotype executive functioning central coherence Index. décimale : PER Périodiques Résumé : Background Heterogeneity within autism spectrum disorder (ASD) hampers insight in the etiology and stimulates the search for endophenotypes. Endophenotypes should meet several criteria, the most important being the association with ASD and the higher occurrence rate in unaffected ASD relatives than in the general population. We evaluated these criteria for executive functioning (EF) and local-global (L-G) visual processing. Methods By administering an extensive cognitive battery which increases the validity of the measures, we examined which of the cognitive anomalies shown by ASD probands also occur in their unaffected relatives (n = 113) compared to typically developing (TD) controls (n = 100). Microarrays were performed, so we could exclude relatives from probands with a de novo mutation in a known ASD susceptibility copy number variant, thus increasing the probability that genetic risk variants are shared by the ASD relatives. An overview of studies investigating EF and L-G processing in ASD relatives was also provided. Results For EF, ASD relatives – like ASD probands – showed impairments in response inhibition, cognitive flexibility and generativity (specifically, ideational fluency), and EF impairments in daily life. For L-G visual processing, the ASD relatives showed no anomalies on the tasks, but they reported more attention to detail in daily life. Group differences were similar for siblings and for parents of ASD probands, and yielded larger effect sizes in a multiplex subsample. The group effect sizes for the comparison between ASD probands and TD individuals were generally larger than those of the ASD relatives compared to TD individuals. Conclusions Impaired cognitive flexibility, ideational fluency and response inhibition are strong candidate endophenotypes for ASD. They could help to delineate etiologically more homogeneous subgroups, which is clinically important to allow assigning ASD probands to different, more targeted, interventions. En ligne : http://dx.doi.org/10.1111/jcpp.12637 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303
in Journal of Child Psychology and Psychiatry > 58-3 (March 2017) . - p.258-269[article] Executive functioning and local-global visual processing: candidate endophenotypes for autism spectrum disorder? [Texte imprimé et/ou numérique] / Lien VAN EYLEN, Auteur ; Bart BOETS, Auteur ; Nele COSEMANS, Auteur ; Hilde PEETERS, Auteur ; Jean STEYAERT, Auteur ; Johan WAGEMANS, Auteur ; Ilse NOENS, Auteur . - p.258-269.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 58-3 (March 2017) . - p.258-269
Mots-clés : Autism spectrum disorder relatives intermediate phenotype executive functioning central coherence Index. décimale : PER Périodiques Résumé : Background Heterogeneity within autism spectrum disorder (ASD) hampers insight in the etiology and stimulates the search for endophenotypes. Endophenotypes should meet several criteria, the most important being the association with ASD and the higher occurrence rate in unaffected ASD relatives than in the general population. We evaluated these criteria for executive functioning (EF) and local-global (L-G) visual processing. Methods By administering an extensive cognitive battery which increases the validity of the measures, we examined which of the cognitive anomalies shown by ASD probands also occur in their unaffected relatives (n = 113) compared to typically developing (TD) controls (n = 100). Microarrays were performed, so we could exclude relatives from probands with a de novo mutation in a known ASD susceptibility copy number variant, thus increasing the probability that genetic risk variants are shared by the ASD relatives. An overview of studies investigating EF and L-G processing in ASD relatives was also provided. Results For EF, ASD relatives – like ASD probands – showed impairments in response inhibition, cognitive flexibility and generativity (specifically, ideational fluency), and EF impairments in daily life. For L-G visual processing, the ASD relatives showed no anomalies on the tasks, but they reported more attention to detail in daily life. Group differences were similar for siblings and for parents of ASD probands, and yielded larger effect sizes in a multiplex subsample. The group effect sizes for the comparison between ASD probands and TD individuals were generally larger than those of the ASD relatives compared to TD individuals. Conclusions Impaired cognitive flexibility, ideational fluency and response inhibition are strong candidate endophenotypes for ASD. They could help to delineate etiologically more homogeneous subgroups, which is clinically important to allow assigning ASD probands to different, more targeted, interventions. En ligne : http://dx.doi.org/10.1111/jcpp.12637 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303