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Evidence for interplay between genes and parenting on infant temperament in the first year of life: monoamine oxidase A polymorphism moderates effects of maternal sensitivity on infant anger proneness / Andrew PICKLES in Journal of Child Psychology and Psychiatry, 54-12 (December 2013)
[article]
Titre : Evidence for interplay between genes and parenting on infant temperament in the first year of life: monoamine oxidase A polymorphism moderates effects of maternal sensitivity on infant anger proneness Type de document : Texte imprimé et/ou numérique Auteurs : Andrew PICKLES, Auteur ; Jonathan HILL, Auteur ; Gerome BREEN, Auteur ; John QUINN, Auteur ; Kate ABBOTT, Auteur ; Helen JONES, Auteur ; Helen SHARP, Auteur Article en page(s) : p.1308-1317 Langues : Anglais (eng) Mots-clés : Monoamine oxidase A promoter polymorphism maternal sensitivity infant temperament anger proneness gene by environment interaction Index. décimale : PER Périodiques Résumé : Background The low expression polymorphism of the MAOA gene in interaction with adverse environments (G × E) is associated with antisocial behaviour disorders. These have their origins in early life, but it is not known whether MAOA G × E occurs in infants. We therefore examined whether MAOA G × E predicts infant anger proneness, a temperamental dimension associated with later antisocial behaviour disorders. In contrast to previous studies, we examined MAOA G × E prospectively using an observational measure of a key aspect of the infant environment, maternal sensitivity, at a specified developmental time point. Methods In a stratified epidemiological cohort recruited during pregnancy, we ascertained MAOA status (low vs. high expression alleles) from the saliva of 193 infants, and examined specific predictions to maternal report of infant temperament at 14 months from maternal sensitivity assessed at 29 weeks of age. Results Analyses, weighted to provide general population estimates, indicated a robust interaction between MAOA status and maternal sensitivity in the prediction of infant anger proneness (p = .003) which became stronger once possible confounders for maternal sensitivity were included in the model (p = .0001). The interaction terms were similar in males (p = .010) and females (p = .016), but the effects were different as a consequence of an additional sex of infant by maternal sensitivity interaction. Conclusions This prospective study provides the first evidence of moderation by the MAOA gene of effects of parenting on infant anger proneness, an important early risk for the development of disruptive and aggressive behaviour disorders. En ligne : http://dx.doi.org/10.1111/jcpp.12081 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=219
in Journal of Child Psychology and Psychiatry > 54-12 (December 2013) . - p.1308-1317[article] Evidence for interplay between genes and parenting on infant temperament in the first year of life: monoamine oxidase A polymorphism moderates effects of maternal sensitivity on infant anger proneness [Texte imprimé et/ou numérique] / Andrew PICKLES, Auteur ; Jonathan HILL, Auteur ; Gerome BREEN, Auteur ; John QUINN, Auteur ; Kate ABBOTT, Auteur ; Helen JONES, Auteur ; Helen SHARP, Auteur . - p.1308-1317.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 54-12 (December 2013) . - p.1308-1317
Mots-clés : Monoamine oxidase A promoter polymorphism maternal sensitivity infant temperament anger proneness gene by environment interaction Index. décimale : PER Périodiques Résumé : Background The low expression polymorphism of the MAOA gene in interaction with adverse environments (G × E) is associated with antisocial behaviour disorders. These have their origins in early life, but it is not known whether MAOA G × E occurs in infants. We therefore examined whether MAOA G × E predicts infant anger proneness, a temperamental dimension associated with later antisocial behaviour disorders. In contrast to previous studies, we examined MAOA G × E prospectively using an observational measure of a key aspect of the infant environment, maternal sensitivity, at a specified developmental time point. Methods In a stratified epidemiological cohort recruited during pregnancy, we ascertained MAOA status (low vs. high expression alleles) from the saliva of 193 infants, and examined specific predictions to maternal report of infant temperament at 14 months from maternal sensitivity assessed at 29 weeks of age. Results Analyses, weighted to provide general population estimates, indicated a robust interaction between MAOA status and maternal sensitivity in the prediction of infant anger proneness (p = .003) which became stronger once possible confounders for maternal sensitivity were included in the model (p = .0001). The interaction terms were similar in males (p = .010) and females (p = .016), but the effects were different as a consequence of an additional sex of infant by maternal sensitivity interaction. Conclusions This prospective study provides the first evidence of moderation by the MAOA gene of effects of parenting on infant anger proneness, an important early risk for the development of disruptive and aggressive behaviour disorders. En ligne : http://dx.doi.org/10.1111/jcpp.12081 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=219 Using the PDD Behavior Inventory as a Level 2 Screener: A Classification and Regression Trees Analysis / Ira L. COHEN in Journal of Autism and Developmental Disorders, 46-9 (September 2016)
[article]
Titre : Using the PDD Behavior Inventory as a Level 2 Screener: A Classification and Regression Trees Analysis Type de document : Texte imprimé et/ou numérique Auteurs : Ira L. COHEN, Auteur ; Xudong LIU, Auteur ; Melissa HUDSON, Auteur ; Jennifer GILLIS, Auteur ; Rachel N. S. CAVALARI, Auteur ; Raymond G. ROMANCZYK, Auteur ; Bernard Z. KARMEL, Auteur ; Judith M. GARDNER, Auteur Article en page(s) : p.3006-3022 Langues : Anglais (eng) Mots-clés : Level 2 screeners Autism Spectrum Disorder Decision trees Data mining Machine learning Seizures Monoamine Oxidase A Genotype Phenotype Subgroups Index. décimale : PER Périodiques Résumé : In order to improve discrimination accuracy between Autism Spectrum Disorder (ASD) and similar neurodevelopmental disorders, a data mining procedure, Classification and Regression Trees (CART), was used on a large multi-site sample of PDD Behavior Inventory (PDDBI) forms on children with and without ASD. Discrimination accuracy exceeded 80 %, generalized to an independent validation set, and generalized across age groups and sites, and agreed well with ADOS classifications. Parent PDDBIs yielded better results than teacher PDDBIs but, when CART predictions agreed across informants, sensitivity increased. Results also revealed three subtypes of ASD: minimally verbal, verbal, and atypical; and two, relatively common subtypes of non-ASD children: social pragmatic problems and good social skills. These subgroups corresponded to differences in behavior profiles and associated bio-medical findings. En ligne : http://dx.doi.org/10.1007/s10803-016-2843-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=292
in Journal of Autism and Developmental Disorders > 46-9 (September 2016) . - p.3006-3022[article] Using the PDD Behavior Inventory as a Level 2 Screener: A Classification and Regression Trees Analysis [Texte imprimé et/ou numérique] / Ira L. COHEN, Auteur ; Xudong LIU, Auteur ; Melissa HUDSON, Auteur ; Jennifer GILLIS, Auteur ; Rachel N. S. CAVALARI, Auteur ; Raymond G. ROMANCZYK, Auteur ; Bernard Z. KARMEL, Auteur ; Judith M. GARDNER, Auteur . - p.3006-3022.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 46-9 (September 2016) . - p.3006-3022
Mots-clés : Level 2 screeners Autism Spectrum Disorder Decision trees Data mining Machine learning Seizures Monoamine Oxidase A Genotype Phenotype Subgroups Index. décimale : PER Périodiques Résumé : In order to improve discrimination accuracy between Autism Spectrum Disorder (ASD) and similar neurodevelopmental disorders, a data mining procedure, Classification and Regression Trees (CART), was used on a large multi-site sample of PDD Behavior Inventory (PDDBI) forms on children with and without ASD. Discrimination accuracy exceeded 80 %, generalized to an independent validation set, and generalized across age groups and sites, and agreed well with ADOS classifications. Parent PDDBIs yielded better results than teacher PDDBIs but, when CART predictions agreed across informants, sensitivity increased. Results also revealed three subtypes of ASD: minimally verbal, verbal, and atypical; and two, relatively common subtypes of non-ASD children: social pragmatic problems and good social skills. These subgroups corresponded to differences in behavior profiles and associated bio-medical findings. En ligne : http://dx.doi.org/10.1007/s10803-016-2843-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=292