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Otitis media, antibiotics, and risk of autism spectrum disorder / T. WIMBERLEY in Autism Research, 11-10 (October 2018)
[article]
Titre : Otitis media, antibiotics, and risk of autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : T. WIMBERLEY, Auteur ; E. AGERBO, Auteur ; C. B. PEDERSEN, Auteur ; Soeren DALSGAARD, Auteur ; H. T. HORSDAL, Auteur ; P. B. MORTENSEN, Auteur ; W. K. THOMPSON, Auteur ; O. KOHLER-FORSBERG, Auteur ; R. H. YOLKEN, Auteur Article en page(s) : p.1432-1440 Langues : Anglais (eng) Mots-clés : antibiotics autism spectrum disorder epidemiology otitis media Index. décimale : PER Périodiques Résumé : Otitis media infections and antibiotic treatment have been linked to the risk of developing autism spectrum disorder. Broad-spectrum antibiotics may alter the composition of the gut flora microbiota, which is hypothesized to be involved in the regulation of the immune system. This study examines the interplay among otitis media, antibiotics, and the subsequent risk of developing autism. Based on the entire Danish population, 780,547 children were followed from birth (January 1, 1997 to December 31, 2008) until December 31, 2012. We calculated adjusted hazard ratios and absolute risks of autism with 95% confidence intervals (CIs) related to previous otitis media diagnoses and antibiotic prescriptions redeemed at Danish pharmacies. The absolute risk of autism before age 10 was increased among children with otitis media (1.2% for females and 3.3% for males) and in children who had redeemed an antibiotic prescription (0.6% and 2.7% for females and males) compared to children without a history of otitis media and antibiotics usage (0.4% for females and 1.9% for males). Similarly, we found an increased hazard ratio of autism associated with otitis media (1.83 95% CI 1.71-1.95) and antibiotics usage (1.29 95% CI 1.17-1.43). A history of both otitis media and antibiotic treatment did not further increase the risk of autism. Although the risk of autism was associated with otitis media and treatment with antibiotics, we found little evidence of a synergistic effect between otitis media infections and treatment with antibiotics. Autism Res 2018, 11: 1432-1440. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: We investigated whether otitis media ear infections and antibiotic treatment were associated with autism spectrum disorder. Autism was more common in children who had had an otitis media infection or who had been treated with antibiotics. Given the observational nature of our data, our study cannot be used to conclude that otitis media or use of antibiotics cause autism, as our findings may be subject to unobserved confounding. En ligne : http://dx.doi.org/10.1002/aur.2015 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=369
in Autism Research > 11-10 (October 2018) . - p.1432-1440[article] Otitis media, antibiotics, and risk of autism spectrum disorder [Texte imprimé et/ou numérique] / T. WIMBERLEY, Auteur ; E. AGERBO, Auteur ; C. B. PEDERSEN, Auteur ; Soeren DALSGAARD, Auteur ; H. T. HORSDAL, Auteur ; P. B. MORTENSEN, Auteur ; W. K. THOMPSON, Auteur ; O. KOHLER-FORSBERG, Auteur ; R. H. YOLKEN, Auteur . - p.1432-1440.
Langues : Anglais (eng)
in Autism Research > 11-10 (October 2018) . - p.1432-1440
Mots-clés : antibiotics autism spectrum disorder epidemiology otitis media Index. décimale : PER Périodiques Résumé : Otitis media infections and antibiotic treatment have been linked to the risk of developing autism spectrum disorder. Broad-spectrum antibiotics may alter the composition of the gut flora microbiota, which is hypothesized to be involved in the regulation of the immune system. This study examines the interplay among otitis media, antibiotics, and the subsequent risk of developing autism. Based on the entire Danish population, 780,547 children were followed from birth (January 1, 1997 to December 31, 2008) until December 31, 2012. We calculated adjusted hazard ratios and absolute risks of autism with 95% confidence intervals (CIs) related to previous otitis media diagnoses and antibiotic prescriptions redeemed at Danish pharmacies. The absolute risk of autism before age 10 was increased among children with otitis media (1.2% for females and 3.3% for males) and in children who had redeemed an antibiotic prescription (0.6% and 2.7% for females and males) compared to children without a history of otitis media and antibiotics usage (0.4% for females and 1.9% for males). Similarly, we found an increased hazard ratio of autism associated with otitis media (1.83 95% CI 1.71-1.95) and antibiotics usage (1.29 95% CI 1.17-1.43). A history of both otitis media and antibiotic treatment did not further increase the risk of autism. Although the risk of autism was associated with otitis media and treatment with antibiotics, we found little evidence of a synergistic effect between otitis media infections and treatment with antibiotics. Autism Res 2018, 11: 1432-1440. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: We investigated whether otitis media ear infections and antibiotic treatment were associated with autism spectrum disorder. Autism was more common in children who had had an otitis media infection or who had been treated with antibiotics. Given the observational nature of our data, our study cannot be used to conclude that otitis media or use of antibiotics cause autism, as our findings may be subject to unobserved confounding. En ligne : http://dx.doi.org/10.1002/aur.2015 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=369 Otitis Media and Related Complications Among Children with Autism Spectrum Disorders / Daniel J. ADAMS in Journal of Autism and Developmental Disorders, 46-5 (May 2016)
[article]
Titre : Otitis Media and Related Complications Among Children with Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Daniel J. ADAMS, Auteur ; Apryl SUSI, Auteur ; Christine R. ERDIE-LALENA, Auteur ; Gregory GORMAN, Auteur ; Elizabeth HISLE-GORMAN, Auteur ; Michael RAJNIK, Auteur ; Marilisa ELROD, Auteur ; Cade M. NYLUND, Auteur Article en page(s) : p.1636-1642 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders Child development disorders, pervasive Otitis media Mastoiditis Index. décimale : PER Périodiques Résumé : Acute otitis media (AOM) symptoms can be masked by communication deficits, common to children with autism spectrum disorders (ASD). We sought to evaluate the association between ASD and otitis media. Using ICD-9-CM diagnostic codes, we performed a retrospective case-cohort study comparing AOM, and otitis-related diagnoses among children with and without ASD. Children with ASD had a significantly increased rate of AOM, otitis media with effusion, otorrhea, and PE tube placement. Children with ASD were more than twice as likely to develop mastoiditis, and to undergo mastoidectomy and tympanoplasty. Children with ASD are more likely to have middle ear infections and otitis-related complications, highlighting the importance of routine middle ear examinations and close attention to hearing impairment in this population. En ligne : http://dx.doi.org/10.1007/s10803-015-2689-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=288
in Journal of Autism and Developmental Disorders > 46-5 (May 2016) . - p.1636-1642[article] Otitis Media and Related Complications Among Children with Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Daniel J. ADAMS, Auteur ; Apryl SUSI, Auteur ; Christine R. ERDIE-LALENA, Auteur ; Gregory GORMAN, Auteur ; Elizabeth HISLE-GORMAN, Auteur ; Michael RAJNIK, Auteur ; Marilisa ELROD, Auteur ; Cade M. NYLUND, Auteur . - p.1636-1642.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 46-5 (May 2016) . - p.1636-1642
Mots-clés : Autism spectrum disorders Child development disorders, pervasive Otitis media Mastoiditis Index. décimale : PER Périodiques Résumé : Acute otitis media (AOM) symptoms can be masked by communication deficits, common to children with autism spectrum disorders (ASD). We sought to evaluate the association between ASD and otitis media. Using ICD-9-CM diagnostic codes, we performed a retrospective case-cohort study comparing AOM, and otitis-related diagnoses among children with and without ASD. Children with ASD had a significantly increased rate of AOM, otitis media with effusion, otorrhea, and PE tube placement. Children with ASD were more than twice as likely to develop mastoiditis, and to undergo mastoidectomy and tympanoplasty. Children with ASD are more likely to have middle ear infections and otitis-related complications, highlighting the importance of routine middle ear examinations and close attention to hearing impairment in this population. En ligne : http://dx.doi.org/10.1007/s10803-015-2689-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=288