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High rates of parkinsonism in adults with autism / S. STARKSTEIN in Journal of Neurodevelopmental Disorders, 7-1 (December 2015)
[article]
Titre : High rates of parkinsonism in adults with autism Type de document : Texte imprimé et/ou numérique Auteurs : S. STARKSTEIN, Auteur ; S. GELLAR, Auteur ; M. PARLIER, Auteur ; L. PAYNE, Auteur ; J. PIVEN, Auteur Article en page(s) : p.29 Langues : Anglais (eng) Mots-clés : adults autism movement disorders parkinsonism parkinson's disease Index. décimale : PER Périodiques Résumé : BACKGROUND: While it is now recognized that autism spectrum disorder (ASD) is typically a life-long condition, there exist only a handful of systematic studies on middle-aged and older adults with this condition. METHODS: We first performed a structured examination of parkinsonian motor signs in a hypothesis-generating, pilot study (study I) of 19 adults with ASD over 49 years of age. Observing high rates of parkinsonism in those off atypical neuroleptics (2/12, 17 %) in comparison to published population rates for Parkinson's disease and parkinsonism, we examined a second sample of 37 adults with ASD, over 39 years of age, using a structured neurological assessment for parkinsonism. RESULTS: Twelve of the 37 subjects (32 %) met the diagnostic criteria for parkinsonism; however, of these, 29 subjects were on atypical neuroleptics, complicating interpretation of the findings. Two of eight (25 %) subjects not taking atypical neuroleptic medications met the criteria for parkinsonism. Combining subjects who were not currently taking atypical neuroleptic medications, across both studies, we conservatively classified 4/20 (20 %) with parkinsonism. CONCLUSIONS: We find a high frequency of parkinsonism among ASD individuals older than 39 years. If high rates of parkinsonism and potentially Parkinson's disease are confirmed in subsequent studies of ASD, this observation has important implications for understanding the neurobiology of autism and treatment of manifestations in older adults. Given the prevalence of autism in school-age children, the recognition of its life-long natural history, and the recognition of the aging of western societies, these findings also support the importance of further systematic study of other aspects of older adults with autism. En ligne : http://dx.doi.org/10.1186/s11689-015-9125-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=348
in Journal of Neurodevelopmental Disorders > 7-1 (December 2015) . - p.29[article] High rates of parkinsonism in adults with autism [Texte imprimé et/ou numérique] / S. STARKSTEIN, Auteur ; S. GELLAR, Auteur ; M. PARLIER, Auteur ; L. PAYNE, Auteur ; J. PIVEN, Auteur . - p.29.
Langues : Anglais (eng)
in Journal of Neurodevelopmental Disorders > 7-1 (December 2015) . - p.29
Mots-clés : adults autism movement disorders parkinsonism parkinson's disease Index. décimale : PER Périodiques Résumé : BACKGROUND: While it is now recognized that autism spectrum disorder (ASD) is typically a life-long condition, there exist only a handful of systematic studies on middle-aged and older adults with this condition. METHODS: We first performed a structured examination of parkinsonian motor signs in a hypothesis-generating, pilot study (study I) of 19 adults with ASD over 49 years of age. Observing high rates of parkinsonism in those off atypical neuroleptics (2/12, 17 %) in comparison to published population rates for Parkinson's disease and parkinsonism, we examined a second sample of 37 adults with ASD, over 39 years of age, using a structured neurological assessment for parkinsonism. RESULTS: Twelve of the 37 subjects (32 %) met the diagnostic criteria for parkinsonism; however, of these, 29 subjects were on atypical neuroleptics, complicating interpretation of the findings. Two of eight (25 %) subjects not taking atypical neuroleptic medications met the criteria for parkinsonism. Combining subjects who were not currently taking atypical neuroleptic medications, across both studies, we conservatively classified 4/20 (20 %) with parkinsonism. CONCLUSIONS: We find a high frequency of parkinsonism among ASD individuals older than 39 years. If high rates of parkinsonism and potentially Parkinson's disease are confirmed in subsequent studies of ASD, this observation has important implications for understanding the neurobiology of autism and treatment of manifestations in older adults. Given the prevalence of autism in school-age children, the recognition of its life-long natural history, and the recognition of the aging of western societies, these findings also support the importance of further systematic study of other aspects of older adults with autism. En ligne : http://dx.doi.org/10.1186/s11689-015-9125-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=348 Self-reported parkinsonism features in older autistic adults: A descriptive study / H. M. GEURTS in Autism, 26-1 (January 2022)
[article]
Titre : Self-reported parkinsonism features in older autistic adults: A descriptive study Type de document : Texte imprimé et/ou numérique Auteurs : H. M. GEURTS, Auteur ; G. A. MCQUAID, Auteur ; Sander BEGEER, Auteur ; Gregory L. WALLACE, Auteur Article en page(s) : p.217-229 Langues : Anglais (eng) Mots-clés : autism medication old-age parkinsonism self-report Index. décimale : PER Périodiques Résumé : Autistic adults without a suspected intellectual disability reported several motor features such as having tremors, and stiffness in one's legs which are considered to be part of a complex of motor features called parkinsonism. This so-called parkinsonism was remarkably prevalent in middle-aged and older autistic adults in two independent studies (Dutch study: 50-81 years, 183 males, 113 females, all adulthood diagnoses; the USA study: 50-83 years, 110 females, 109 males, majority adulthood diagnosis). Parkinsonism can be part of the progressive motor disease-Parkinson's disease. Therefore, it is important that future studies, including in-person neurological assessment, determine if (and if so, why) autistic adults who report these motor features are at increased risk for developing Parkinson's disease. En ligne : http://dx.doi.org/10.1177/13623613211020183 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=451
in Autism > 26-1 (January 2022) . - p.217-229[article] Self-reported parkinsonism features in older autistic adults: A descriptive study [Texte imprimé et/ou numérique] / H. M. GEURTS, Auteur ; G. A. MCQUAID, Auteur ; Sander BEGEER, Auteur ; Gregory L. WALLACE, Auteur . - p.217-229.
Langues : Anglais (eng)
in Autism > 26-1 (January 2022) . - p.217-229
Mots-clés : autism medication old-age parkinsonism self-report Index. décimale : PER Périodiques Résumé : Autistic adults without a suspected intellectual disability reported several motor features such as having tremors, and stiffness in one's legs which are considered to be part of a complex of motor features called parkinsonism. This so-called parkinsonism was remarkably prevalent in middle-aged and older autistic adults in two independent studies (Dutch study: 50-81 years, 183 males, 113 females, all adulthood diagnoses; the USA study: 50-83 years, 110 females, 109 males, majority adulthood diagnosis). Parkinsonism can be part of the progressive motor disease-Parkinson's disease. Therefore, it is important that future studies, including in-person neurological assessment, determine if (and if so, why) autistic adults who report these motor features are at increased risk for developing Parkinson's disease. En ligne : http://dx.doi.org/10.1177/13623613211020183 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=451 Motor Disturbance in ASD: A Pilot Study Showing Hypokinetic Behavior? / M. A. L. MOSTERT-KERCKHOFFS in Journal of Autism and Developmental Disorders, 50-2 (February 2020)
[article]
Titre : Motor Disturbance in ASD: A Pilot Study Showing Hypokinetic Behavior? Type de document : Texte imprimé et/ou numérique Auteurs : M. A. L. MOSTERT-KERCKHOFFS, Auteur ; A. E. WILLEMS, Auteur ; D. E. TENBACK, Auteur ; J. P. KONING, Auteur ; P. VAN HARTEN, Auteur ; W. G. STAAL, Auteur Article en page(s) : p.415-428 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder Dyskinesia Motor disturbance Parkinsonism Index. décimale : PER Périodiques Résumé : Data supporting theoretical models linking autism spectrum disorders (ASD) to motor disturbance are inconclusive. In the present study, children and adolescents with ASD (n = 44) were compared with a matched group of typically developing individuals (n = 49) on both instrumental and observational assessments of motor abnormalities. No group differences were found in the instrumental data. However, more bradykinetic motor behavior was found using an observational scale in the ASD groups. More rigid motor behavior was found in the adolescents with ASD but not in the children. Individuals with ASD show significantly more hypokinetic behavior, which may not be strictly dopaminergic in origin, but may reflect a weak central coherency in neuronal networks related to the motor system in which developmental changes are present. En ligne : http://dx.doi.org/10.1007/s10803-019-04171-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=416
in Journal of Autism and Developmental Disorders > 50-2 (February 2020) . - p.415-428[article] Motor Disturbance in ASD: A Pilot Study Showing Hypokinetic Behavior? [Texte imprimé et/ou numérique] / M. A. L. MOSTERT-KERCKHOFFS, Auteur ; A. E. WILLEMS, Auteur ; D. E. TENBACK, Auteur ; J. P. KONING, Auteur ; P. VAN HARTEN, Auteur ; W. G. STAAL, Auteur . - p.415-428.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 50-2 (February 2020) . - p.415-428
Mots-clés : Autism spectrum disorder Dyskinesia Motor disturbance Parkinsonism Index. décimale : PER Périodiques Résumé : Data supporting theoretical models linking autism spectrum disorders (ASD) to motor disturbance are inconclusive. In the present study, children and adolescents with ASD (n = 44) were compared with a matched group of typically developing individuals (n = 49) on both instrumental and observational assessments of motor abnormalities. No group differences were found in the instrumental data. However, more bradykinetic motor behavior was found using an observational scale in the ASD groups. More rigid motor behavior was found in the adolescents with ASD but not in the children. Individuals with ASD show significantly more hypokinetic behavior, which may not be strictly dopaminergic in origin, but may reflect a weak central coherency in neuronal networks related to the motor system in which developmental changes are present. En ligne : http://dx.doi.org/10.1007/s10803-019-04171-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=416