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Stoppage in Autism Spectrum Disorders / Therese K. GRØNBORG in Journal of Autism and Developmental Disorders, 45-11 (November 2015)
[article]
Titre : Stoppage in Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Therese K. GRØNBORG, Auteur ; Stefan N. HANSEN, Auteur ; Svend V. NIELSEN, Auteur ; Axel SKYTTHE, Auteur ; Erik T. PARNER, Auteur Article en page(s) : p.3509-3519 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder Sibling recurrence risk Stoppage Index. décimale : PER Périodiques Résumé : Stoppage refers to changes in reproductive behavior following the birth of a child with a severe disease. The presence of stoppage can bias estimates of sibling recurrence risk if not properly addressed. If stoppage occurs non-randomly (differential stoppage), it is possibly an additional source of bias in sibling recurrence risk estimation. This study investigated whether stoppage occurs in Danish families with a firstborn child diagnosed with autism spectrum disorders, and if stoppage was differential. We found that stoppage occurs moderately in Danish families affected by autism spectrum disorders, and that stoppage is differential. However, differential stoppage is a minor source of estimation bias in Danish sibling recurrence risk studies of autism spectrum disorders. En ligne : http://dx.doi.org/10.1007/s10803-015-2497-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270
in Journal of Autism and Developmental Disorders > 45-11 (November 2015) . - p.3509-3519[article] Stoppage in Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Therese K. GRØNBORG, Auteur ; Stefan N. HANSEN, Auteur ; Svend V. NIELSEN, Auteur ; Axel SKYTTHE, Auteur ; Erik T. PARNER, Auteur . - p.3509-3519.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 45-11 (November 2015) . - p.3509-3519
Mots-clés : Autism spectrum disorder Sibling recurrence risk Stoppage Index. décimale : PER Périodiques Résumé : Stoppage refers to changes in reproductive behavior following the birth of a child with a severe disease. The presence of stoppage can bias estimates of sibling recurrence risk if not properly addressed. If stoppage occurs non-randomly (differential stoppage), it is possibly an additional source of bias in sibling recurrence risk estimation. This study investigated whether stoppage occurs in Danish families with a firstborn child diagnosed with autism spectrum disorders, and if stoppage was differential. We found that stoppage occurs moderately in Danish families affected by autism spectrum disorders, and that stoppage is differential. However, differential stoppage is a minor source of estimation bias in Danish sibling recurrence risk studies of autism spectrum disorders. En ligne : http://dx.doi.org/10.1007/s10803-015-2497-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270 Evidence for ASD Recurrence Rates and Reproductive Stoppage From Large UK ASD Research Family Databases / Claire L. WOOD in Autism Research, 8-1 (February 2015)
[article]
Titre : Evidence for ASD Recurrence Rates and Reproductive Stoppage From Large UK ASD Research Family Databases Type de document : Texte imprimé et/ou numérique Auteurs : Claire L. WOOD, Auteur ; Frances WARNELL, Auteur ; Mary JOHNSON, Auteur ; Annette HAMES, Auteur ; Mark S. PEARCE, Auteur ; Helen MCCONACHIE, Auteur ; Jeremy R. PARR, Auteur Article en page(s) : p.73-81 Langues : Anglais (eng) Mots-clés : autism ASD genetics recurrence stoppage Index. décimale : PER Périodiques Résumé : Following a diagnosis of a developmental disorder such as autism spectrum disorder (ASD) in early childhood, parents may decide to have fewer children than previously planned. The tendency for families to halt reproduction after receiving a diagnosis for one child is known as reproductive stoppage. Stoppage may lead to an underestimate of recurrence risk estimates of parents having more than one child with ASD. Using two large UK ASD family databases, we investigated recurrence rates for ASD and evidence for reproductive stoppage for both ASD and undiagnosed ASD/broader autism phenotype in a subgroup of families. Reproductive stoppage was tested for using the Mann–Whitney U-test to disprove the null hypothesis that affected and nonaffected children were distributed randomly by birth order. Dahlberg's later-sib method was used to estimate recurrence risk and take stoppage into account. Data were available from 299 families (660 children) including 327 with ASD. Ten percent of the complete families had more than one child with an ASD. Using Dahlberg's later-sib method, the recurrence risk for ASD was 24.7% overall and 50.0% in families with two or more older siblings with ASD. Children with ASD were born significantly later in families than those without ASD in all sibship combinations. This study shows strong evidence that ASD is associated with reproductive stoppage. These data have important implications for family planning and genetic counseling. Autism Res 2015, 8: 73–81. En ligne : http://dx.doi.org/10.1002/aur.1414 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=256
in Autism Research > 8-1 (February 2015) . - p.73-81[article] Evidence for ASD Recurrence Rates and Reproductive Stoppage From Large UK ASD Research Family Databases [Texte imprimé et/ou numérique] / Claire L. WOOD, Auteur ; Frances WARNELL, Auteur ; Mary JOHNSON, Auteur ; Annette HAMES, Auteur ; Mark S. PEARCE, Auteur ; Helen MCCONACHIE, Auteur ; Jeremy R. PARR, Auteur . - p.73-81.
Langues : Anglais (eng)
in Autism Research > 8-1 (February 2015) . - p.73-81
Mots-clés : autism ASD genetics recurrence stoppage Index. décimale : PER Périodiques Résumé : Following a diagnosis of a developmental disorder such as autism spectrum disorder (ASD) in early childhood, parents may decide to have fewer children than previously planned. The tendency for families to halt reproduction after receiving a diagnosis for one child is known as reproductive stoppage. Stoppage may lead to an underestimate of recurrence risk estimates of parents having more than one child with ASD. Using two large UK ASD family databases, we investigated recurrence rates for ASD and evidence for reproductive stoppage for both ASD and undiagnosed ASD/broader autism phenotype in a subgroup of families. Reproductive stoppage was tested for using the Mann–Whitney U-test to disprove the null hypothesis that affected and nonaffected children were distributed randomly by birth order. Dahlberg's later-sib method was used to estimate recurrence risk and take stoppage into account. Data were available from 299 families (660 children) including 327 with ASD. Ten percent of the complete families had more than one child with an ASD. Using Dahlberg's later-sib method, the recurrence risk for ASD was 24.7% overall and 50.0% in families with two or more older siblings with ASD. Children with ASD were born significantly later in families than those without ASD in all sibship combinations. This study shows strong evidence that ASD is associated with reproductive stoppage. These data have important implications for family planning and genetic counseling. Autism Res 2015, 8: 73–81. En ligne : http://dx.doi.org/10.1002/aur.1414 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=256