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Brain structure abnormalities in adolescent girls with conduct disorder / Graeme FAIRCHILD in Journal of Child Psychology and Psychiatry, 54-1 (January 2013)
[article]
Titre : Brain structure abnormalities in adolescent girls with conduct disorder Type de document : Texte imprimé et/ou numérique Auteurs : Graeme FAIRCHILD, Auteur ; Cindy C. HAGAN, Auteur ; Nicholas D. WALSH, Auteur ; Luca PASSAMONTI, Auteur ; Andrew J. CALDER, Auteur ; Ian M. GOODYER, Auteur Article en page(s) : 86-95 Langues : Anglais (eng) Mots-clés : Conduct disorder callous-unemotional traits voxel-based morphometry anterior insula amygdala sex differences Index. décimale : PER Périodiques Résumé : Background: Conduct disorder (CD) in female adolescents is associated with a range of negative outcomes, including teenage pregnancy and antisocial personality disorder. Although recent studies have documented changes in brain structure and function in male adolescents with CD, there have been no neuroimaging studies of female adolescents with CD. Our primary objective was to investigate whether female adolescents with CD show changes in grey matter volume. Our secondary aim was to assess for sex differences in the relationship between CD and brain structure. Methods: Female adolescents with CD (n = 22) and healthy control participants matched in age, performance IQ and handedness (n = 20) underwent structural magnetic resonance imaging. Group comparisons of grey matter volume were performed using voxel-based morphometry. We also tested for sex differences using archive data obtained from male CD and control participants. Results: Female adolescents with CD showed reduced bilateral anterior insula and right striatal grey matter volumes compared with healthy controls. Aggressive CD symptoms were negatively correlated with right dorsolateral prefrontal cortex volume, whereas callous-unemotional traits were positively correlated with bilateral orbitofrontal cortex volume. The sex differences analyses revealed a main effect of diagnosis on right amygdala volume (reflecting reduced amygdala volume in the combined CD group relative to controls) and sex-by-diagnosis interactions in bilateral anterior insula. Conclusions: We observed structural abnormalities in brain regions involved in emotion processing, reward and empathy in female adolescents with CD, which broadly overlap with those reported in previous studies of CD in male adolescents. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02617.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=186
in Journal of Child Psychology and Psychiatry > 54-1 (January 2013) . - 86-95[article] Brain structure abnormalities in adolescent girls with conduct disorder [Texte imprimé et/ou numérique] / Graeme FAIRCHILD, Auteur ; Cindy C. HAGAN, Auteur ; Nicholas D. WALSH, Auteur ; Luca PASSAMONTI, Auteur ; Andrew J. CALDER, Auteur ; Ian M. GOODYER, Auteur . - 86-95.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 54-1 (January 2013) . - 86-95
Mots-clés : Conduct disorder callous-unemotional traits voxel-based morphometry anterior insula amygdala sex differences Index. décimale : PER Périodiques Résumé : Background: Conduct disorder (CD) in female adolescents is associated with a range of negative outcomes, including teenage pregnancy and antisocial personality disorder. Although recent studies have documented changes in brain structure and function in male adolescents with CD, there have been no neuroimaging studies of female adolescents with CD. Our primary objective was to investigate whether female adolescents with CD show changes in grey matter volume. Our secondary aim was to assess for sex differences in the relationship between CD and brain structure. Methods: Female adolescents with CD (n = 22) and healthy control participants matched in age, performance IQ and handedness (n = 20) underwent structural magnetic resonance imaging. Group comparisons of grey matter volume were performed using voxel-based morphometry. We also tested for sex differences using archive data obtained from male CD and control participants. Results: Female adolescents with CD showed reduced bilateral anterior insula and right striatal grey matter volumes compared with healthy controls. Aggressive CD symptoms were negatively correlated with right dorsolateral prefrontal cortex volume, whereas callous-unemotional traits were positively correlated with bilateral orbitofrontal cortex volume. The sex differences analyses revealed a main effect of diagnosis on right amygdala volume (reflecting reduced amygdala volume in the combined CD group relative to controls) and sex-by-diagnosis interactions in bilateral anterior insula. Conclusions: We observed structural abnormalities in brain regions involved in emotion processing, reward and empathy in female adolescents with CD, which broadly overlap with those reported in previous studies of CD in male adolescents. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02617.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=186 Dysfunctional representation of expected value is associated with reinforcement-based decision-making deficits in adolescents with conduct problems / Stuart F. WHITE in Journal of Child Psychology and Psychiatry, 57-8 (August 2016)
[article]
Titre : Dysfunctional representation of expected value is associated with reinforcement-based decision-making deficits in adolescents with conduct problems Type de document : Texte imprimé et/ou numérique Auteurs : Stuart F. WHITE, Auteur ; Patrick M. TYLER, Auteur ; Anna K. ERWAY, Auteur ; Mary L. BOTKIN, Auteur ; Venkata KOLLI, Auteur ; Harma MEFFERT, Auteur ; Kayla POPE, Auteur ; James R. BLAIR, Auteur Article en page(s) : p.938-946 Langues : Anglais (eng) Mots-clés : Conduct problems decision-making anterior insula expected value prediction error Index. décimale : PER Périodiques Résumé : Background Previous work has shown that patients with conduct problems (CP) show impairments in reinforcement-based decision-making. However, studies with patients have not previously demonstrated any relationships between impairment in any of the neurocomputations underpinning reinforcement-based decision-making and specific symptom sets [e.g. level of CP and/or callous-unemotional (CU) traits]. Methods Seventy-two youths [20 female, mean age = 13.81 (SD = 2.14), mean IQ = 102.34 (SD = 10.99)] from a residential treatment program and the community completed a passive avoidance task while undergoing functional MRI. Results Greater levels of CP were associated with poorer task performance. Reduced representation of expected values (EV) when making avoidance responses within bilateral anterior insula cortex/inferior frontal gyrus (AIC/iFG) and striatum was associated with greater levels of CP but not CU traits. Conclusions The current data indicate that difficulties in the use of value information to motivate decisions to avoid suboptimal choices are associated with increased levels of CP (though not severity of CU traits). Moreover, they account for the behavioral deficits observed during reinforcement-based decision-making in youth with CP. In short, an individual's relative failure to utilize value information within AIC/iFG to avoid bad choices is associated with elevated levels of CP. En ligne : http://dx.doi.org/10.1111/jcpp.12557 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=292
in Journal of Child Psychology and Psychiatry > 57-8 (August 2016) . - p.938-946[article] Dysfunctional representation of expected value is associated with reinforcement-based decision-making deficits in adolescents with conduct problems [Texte imprimé et/ou numérique] / Stuart F. WHITE, Auteur ; Patrick M. TYLER, Auteur ; Anna K. ERWAY, Auteur ; Mary L. BOTKIN, Auteur ; Venkata KOLLI, Auteur ; Harma MEFFERT, Auteur ; Kayla POPE, Auteur ; James R. BLAIR, Auteur . - p.938-946.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 57-8 (August 2016) . - p.938-946
Mots-clés : Conduct problems decision-making anterior insula expected value prediction error Index. décimale : PER Périodiques Résumé : Background Previous work has shown that patients with conduct problems (CP) show impairments in reinforcement-based decision-making. However, studies with patients have not previously demonstrated any relationships between impairment in any of the neurocomputations underpinning reinforcement-based decision-making and specific symptom sets [e.g. level of CP and/or callous-unemotional (CU) traits]. Methods Seventy-two youths [20 female, mean age = 13.81 (SD = 2.14), mean IQ = 102.34 (SD = 10.99)] from a residential treatment program and the community completed a passive avoidance task while undergoing functional MRI. Results Greater levels of CP were associated with poorer task performance. Reduced representation of expected values (EV) when making avoidance responses within bilateral anterior insula cortex/inferior frontal gyrus (AIC/iFG) and striatum was associated with greater levels of CP but not CU traits. Conclusions The current data indicate that difficulties in the use of value information to motivate decisions to avoid suboptimal choices are associated with increased levels of CP (though not severity of CU traits). Moreover, they account for the behavioral deficits observed during reinforcement-based decision-making in youth with CP. In short, an individual's relative failure to utilize value information within AIC/iFG to avoid bad choices is associated with elevated levels of CP. En ligne : http://dx.doi.org/10.1111/jcpp.12557 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=292 Mood and neural responses to social rejection do not seem to be altered in resilient adolescents with a history of adversity / Jessica FRITZ in Development and Psychopathology, 32-2 (May 2020)
[article]
Titre : Mood and neural responses to social rejection do not seem to be altered in resilient adolescents with a history of adversity Type de document : Texte imprimé et/ou numérique Auteurs : Jessica FRITZ, Auteur ; Jason STRETTON, Auteur ; Adrian Dahl ASKELUND, Auteur ; Susanne SCHWEIZER, Auteur ; Nicholas D. WALSH, Auteur ; Bernet M. ELZINGA, Auteur ; Ian M. GOODYER, Auteur ; Paul O. WILKINSON, Auteur ; Anne-Laura VAN HARMELEN, Auteur Article en page(s) : p.411-423 Langues : Anglais (eng) Mots-clés : anterior insula dorsal anterior cingulate cortex mental health resilience social rejection social support that could affect this article. Index. décimale : PER Périodiques Résumé : Childhood adversity (CA) increases the risk of subsequent mental health problems. Adolescent social support (from family and/or friends) reduces the risk of mental health problems after CA. However, the mechanisms of this effect remain unclear, and we speculate that they are manifested on neurodevelopmental levels. Therefore, we investigated whether family and/or friendship support at ages 14 and 17 function as intermediate variables for the relationship between CA before age 11 and affective or neural responses to social rejection feedback at age 18. We studied 55 adolescents with normative mental health at age 18 (26 with CA and therefore considered "resilient"), from a longitudinal cohort. Participants underwent a Social Feedback Task in the magnetic resonance imaging scanner. Social rejection feedback activated the dorsal anterior cingulate cortex and the left anterior insula. CA did not predict affective or neural responses to social rejection at age 18. Yet, CA predicted better friendships at age 14 and age 18, when adolescents with and without CA had comparable mood levels. Thus, adolescents with CA and normative mood levels have more adolescent friendship support and seem to have normal mood and neural responses to social rejection. En ligne : http://dx.doi.org/10.1017/s0954579419000178 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=426
in Development and Psychopathology > 32-2 (May 2020) . - p.411-423[article] Mood and neural responses to social rejection do not seem to be altered in resilient adolescents with a history of adversity [Texte imprimé et/ou numérique] / Jessica FRITZ, Auteur ; Jason STRETTON, Auteur ; Adrian Dahl ASKELUND, Auteur ; Susanne SCHWEIZER, Auteur ; Nicholas D. WALSH, Auteur ; Bernet M. ELZINGA, Auteur ; Ian M. GOODYER, Auteur ; Paul O. WILKINSON, Auteur ; Anne-Laura VAN HARMELEN, Auteur . - p.411-423.
Langues : Anglais (eng)
in Development and Psychopathology > 32-2 (May 2020) . - p.411-423
Mots-clés : anterior insula dorsal anterior cingulate cortex mental health resilience social rejection social support that could affect this article. Index. décimale : PER Périodiques Résumé : Childhood adversity (CA) increases the risk of subsequent mental health problems. Adolescent social support (from family and/or friends) reduces the risk of mental health problems after CA. However, the mechanisms of this effect remain unclear, and we speculate that they are manifested on neurodevelopmental levels. Therefore, we investigated whether family and/or friendship support at ages 14 and 17 function as intermediate variables for the relationship between CA before age 11 and affective or neural responses to social rejection feedback at age 18. We studied 55 adolescents with normative mental health at age 18 (26 with CA and therefore considered "resilient"), from a longitudinal cohort. Participants underwent a Social Feedback Task in the magnetic resonance imaging scanner. Social rejection feedback activated the dorsal anterior cingulate cortex and the left anterior insula. CA did not predict affective or neural responses to social rejection at age 18. Yet, CA predicted better friendships at age 14 and age 18, when adolescents with and without CA had comparable mood levels. Thus, adolescents with CA and normative mood levels have more adolescent friendship support and seem to have normal mood and neural responses to social rejection. En ligne : http://dx.doi.org/10.1017/s0954579419000178 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=426 Neural and Behavioral Responses During Self-Evaluative Processes Differ in Youth With and Without Autism / Jennifer H. PFEIFER in Journal of Autism and Developmental Disorders, 43-2 (February 2013)
[article]
Titre : Neural and Behavioral Responses During Self-Evaluative Processes Differ in Youth With and Without Autism Type de document : Texte imprimé et/ou numérique Auteurs : Jennifer H. PFEIFER, Auteur ; Junaid S. MERCHANT, Auteur ; Natalie L. COLICH, Auteur ; Leanna M. HERNANDEZ, Auteur ; Jeff D. RUDIE, Auteur ; Mirella DAPRETTO, Auteur Article en page(s) : p.272-285 Langues : (Eng) Mots-clés : Autism Self Ventral mPFC Anterior insula Middle cingulate cortex Development Index. décimale : PER Périodiques Résumé : This fMRI study investigated neural responses while making appraisals of self and other, across the social and academic domains, in children and adolescents with and without autism spectrum disorders (ASD). Compared to neurotypical youth, those with ASD exhibited hypoactivation of ventromedial prefrontal cortex during self-appraisals. Responses in middle cingulate cortex (MCC) and anterior insula (AI) also distinguished between groups. Stronger activity in MCC and AI during self-appraisals was associated with better social functioning in the ASD group. Although self-appraisals were significantly more positive in the neurotypical group, positivity was unrelated to brain activity in these regions. Together, these results suggest that multiple brain regions support making self-appraisals in neurotypical development, and function atypically in youth with ASD. En ligne : http://dx.doi.org/10.1007/s10803-012-1563-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=188
in Journal of Autism and Developmental Disorders > 43-2 (February 2013) . - p.272-285[article] Neural and Behavioral Responses During Self-Evaluative Processes Differ in Youth With and Without Autism [Texte imprimé et/ou numérique] / Jennifer H. PFEIFER, Auteur ; Junaid S. MERCHANT, Auteur ; Natalie L. COLICH, Auteur ; Leanna M. HERNANDEZ, Auteur ; Jeff D. RUDIE, Auteur ; Mirella DAPRETTO, Auteur . - p.272-285.
Langues : (Eng)
in Journal of Autism and Developmental Disorders > 43-2 (February 2013) . - p.272-285
Mots-clés : Autism Self Ventral mPFC Anterior insula Middle cingulate cortex Development Index. décimale : PER Périodiques Résumé : This fMRI study investigated neural responses while making appraisals of self and other, across the social and academic domains, in children and adolescents with and without autism spectrum disorders (ASD). Compared to neurotypical youth, those with ASD exhibited hypoactivation of ventromedial prefrontal cortex during self-appraisals. Responses in middle cingulate cortex (MCC) and anterior insula (AI) also distinguished between groups. Stronger activity in MCC and AI during self-appraisals was associated with better social functioning in the ASD group. Although self-appraisals were significantly more positive in the neurotypical group, positivity was unrelated to brain activity in these regions. Together, these results suggest that multiple brain regions support making self-appraisals in neurotypical development, and function atypically in youth with ASD. En ligne : http://dx.doi.org/10.1007/s10803-012-1563-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=188 Neural correlates of emotion processing during observed self-face recognition in individuals with autism spectrum disorders / Tomoyo MORITA in Research in Autism Spectrum Disorders, 26 (June 2016)
[article]
Titre : Neural correlates of emotion processing during observed self-face recognition in individuals with autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Tomoyo MORITA, Auteur ; Hirotaka KOSAKA, Auteur ; Daisuke N. SAITO, Auteur ; Takeshi FUJII, Auteur ; Makoto ISHITOBI, Auteur ; Toshio MUNESUE, Auteur ; Keisuke INOHARA, Auteur ; Hidehiko OKAZAWA, Auteur ; Ryusuke KAKIGI, Auteur ; Norihiro SADATO, Auteur Article en page(s) : p.16-32 Langues : Anglais (eng) Mots-clés : Anterior cingulate cortex Anterior insula Autism spectrum disorder (ASD) Being observed Embarrassment Functional magnetic resonance imaging Self-face Index. décimale : PER Périodiques Résumé : When exposed to self-face images, individuals often experience embarrassment, which is enhanced by being observed. This self-evaluative emotion is related to activity in the right anterior insula and the functional connectivity between the anterior cingulate and prefrontal cortices. Coupling between cognitive evaluation of self-face images and emotional response to them (cognitive–emotional coupling) is weaker in individuals with autism spectrum disorder (ASD), in parallel with reduced activity of the right insula. To determine whether self-evaluative emotions of individuals with ASD are less strongly impacted by observation, we conducted functional MRI in 14 adult men with ASD and 18 age-matched control men while the participants viewed self-face images. Increased embarrassment upon observation was positively correlated with increased activity in the right anterior insula in the control group, but not in the ASD group. In addition, awareness of being observed enhanced cognitive–emotional coupling in the controls but not in the ASD group. The coupling was correlated with the functional connectivity between the anterior cingulate and medial prefrontal cortices. These results suggest that the reduced impact of observation on embarrassment induced by self-face images in individuals with ASD is related to impairment in the right anterior insula, which is involved in creating subjective feelings, and the anterior cingulate cortex, which acts as a hub for integrating information from others during self-face evaluation. En ligne : http://dx.doi.org/10.1016/j.rasd.2016.02.011 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=285
in Research in Autism Spectrum Disorders > 26 (June 2016) . - p.16-32[article] Neural correlates of emotion processing during observed self-face recognition in individuals with autism spectrum disorders [Texte imprimé et/ou numérique] / Tomoyo MORITA, Auteur ; Hirotaka KOSAKA, Auteur ; Daisuke N. SAITO, Auteur ; Takeshi FUJII, Auteur ; Makoto ISHITOBI, Auteur ; Toshio MUNESUE, Auteur ; Keisuke INOHARA, Auteur ; Hidehiko OKAZAWA, Auteur ; Ryusuke KAKIGI, Auteur ; Norihiro SADATO, Auteur . - p.16-32.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 26 (June 2016) . - p.16-32
Mots-clés : Anterior cingulate cortex Anterior insula Autism spectrum disorder (ASD) Being observed Embarrassment Functional magnetic resonance imaging Self-face Index. décimale : PER Périodiques Résumé : When exposed to self-face images, individuals often experience embarrassment, which is enhanced by being observed. This self-evaluative emotion is related to activity in the right anterior insula and the functional connectivity between the anterior cingulate and prefrontal cortices. Coupling between cognitive evaluation of self-face images and emotional response to them (cognitive–emotional coupling) is weaker in individuals with autism spectrum disorder (ASD), in parallel with reduced activity of the right insula. To determine whether self-evaluative emotions of individuals with ASD are less strongly impacted by observation, we conducted functional MRI in 14 adult men with ASD and 18 age-matched control men while the participants viewed self-face images. Increased embarrassment upon observation was positively correlated with increased activity in the right anterior insula in the control group, but not in the ASD group. In addition, awareness of being observed enhanced cognitive–emotional coupling in the controls but not in the ASD group. The coupling was correlated with the functional connectivity between the anterior cingulate and medial prefrontal cortices. These results suggest that the reduced impact of observation on embarrassment induced by self-face images in individuals with ASD is related to impairment in the right anterior insula, which is involved in creating subjective feelings, and the anterior cingulate cortex, which acts as a hub for integrating information from others during self-face evaluation. En ligne : http://dx.doi.org/10.1016/j.rasd.2016.02.011 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=285 Autism spectrum disorder and interoception: Abnormalities in global integration? / T. R. HATFIELD in Autism, 23-1 (January 2019)
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