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Cerebellar gray matter differentiates children with early language delay in autism / Anila M. D'MELLO in Autism Research, 9-11 (November 2016)
[article]
Titre : Cerebellar gray matter differentiates children with early language delay in autism Type de document : Texte imprimé et/ou numérique Auteurs : Anila M. D'MELLO, Auteur ; Dorothea M. MOORE, Auteur ; Deana CROCETTI, Auteur ; Stewart H. MOSTOFSKY, Auteur ; Catherine J. STOODLEY, Auteur Article en page(s) : p.1191-1204 Langues : Anglais (eng) Mots-clés : autism cerebellum early language delay voxel-based morphometry ADOS imaging Index. décimale : PER Périodiques Résumé : Early language delay (ELD) is one of the earliest indicators of autism spectrum disorder (ASD), and predicts later cognitive and behavioral outcomes. We aimed to determine the neural correlates of ELD in autism, and examine the relationships between gray matter (GM), age of first word/phrase, and core ASD symptoms. We used voxel-based morphometry to examine whole-brain differences in GM in 8–13 year old children with autism (n?=?13 ELD; n?=?22 non-ELD) and 35 age-matched typically developing (TD) children. Multiple regression analyses examined the relationships between GM, age of first word/phrase, and autism diagnostic observation schedule (ADOS) scores. Composite age of first word/phrase negatively correlated with GM throughout the cerebellum. Both ASD groups (ELD and non-ELD) had reduced GM in right cerebellar Crus I/II when compared to TD children. Left cerebellar Crus I/II was the only region in the brain that differentiated ELD and non-ELD children, with ELD children showing reduced GM relative to both non-ELD and TD groups. Group×score interactions converged in left Crus I/II, such that the non-ELD group showed poorer ADOS scores with increasing GM, whereas the ELD group showed poorer ADOS scores as GM decreased. Reduced GM in right cerebellar Crus I/I was related ASD diagnosis, while children with ELD showed additional reduced GM in left Crus I/II. These findings highlight the importance of specific cerebellar networks in both ASD and early language development, and suggest that bilateral disruption in cerebellar regions that interconnect with fronto-parietal networks could impact language acquisition in ASD. En ligne : http://dx.doi.org/10.1002/aur.1622 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=297
in Autism Research > 9-11 (November 2016) . - p.1191-1204[article] Cerebellar gray matter differentiates children with early language delay in autism [Texte imprimé et/ou numérique] / Anila M. D'MELLO, Auteur ; Dorothea M. MOORE, Auteur ; Deana CROCETTI, Auteur ; Stewart H. MOSTOFSKY, Auteur ; Catherine J. STOODLEY, Auteur . - p.1191-1204.
Langues : Anglais (eng)
in Autism Research > 9-11 (November 2016) . - p.1191-1204
Mots-clés : autism cerebellum early language delay voxel-based morphometry ADOS imaging Index. décimale : PER Périodiques Résumé : Early language delay (ELD) is one of the earliest indicators of autism spectrum disorder (ASD), and predicts later cognitive and behavioral outcomes. We aimed to determine the neural correlates of ELD in autism, and examine the relationships between gray matter (GM), age of first word/phrase, and core ASD symptoms. We used voxel-based morphometry to examine whole-brain differences in GM in 8–13 year old children with autism (n?=?13 ELD; n?=?22 non-ELD) and 35 age-matched typically developing (TD) children. Multiple regression analyses examined the relationships between GM, age of first word/phrase, and autism diagnostic observation schedule (ADOS) scores. Composite age of first word/phrase negatively correlated with GM throughout the cerebellum. Both ASD groups (ELD and non-ELD) had reduced GM in right cerebellar Crus I/II when compared to TD children. Left cerebellar Crus I/II was the only region in the brain that differentiated ELD and non-ELD children, with ELD children showing reduced GM relative to both non-ELD and TD groups. Group×score interactions converged in left Crus I/II, such that the non-ELD group showed poorer ADOS scores with increasing GM, whereas the ELD group showed poorer ADOS scores as GM decreased. Reduced GM in right cerebellar Crus I/I was related ASD diagnosis, while children with ELD showed additional reduced GM in left Crus I/II. These findings highlight the importance of specific cerebellar networks in both ASD and early language development, and suggest that bilateral disruption in cerebellar regions that interconnect with fronto-parietal networks could impact language acquisition in ASD. En ligne : http://dx.doi.org/10.1002/aur.1622 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=297 Syntax and Morphology in Danish-Speaking Children with Autism Spectrum Disorder / Cecilia BRYNSKOV in Journal of Autism and Developmental Disorders, 47-2 (February 2017)
[article]
Titre : Syntax and Morphology in Danish-Speaking Children with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Cecilia BRYNSKOV, Auteur ; Inge-Marie EIGSTI, Auteur ; Meta JØRGENSEN, Auteur ; Sanne LEMCKE, Auteur ; Ocke-Schwen BOHN, Auteur ; Peter KRØJGAARD, Auteur Article en page(s) : p.373-383 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder Vocabulary Syntax Morphology Sentence repetition Early language delay Index. décimale : PER Périodiques Résumé : The current study examined delays in syntax and morphology, and vocabulary, in autism spectrum disorder (ASD). Children ages 4–6 years with ASD (n?=?21) and typical development (n?=?21), matched on nonverbal mental age, completed five language tasks. The ASD group had significant delays in both syntax and morphology, and vocabulary measures, with significant within-group heterogeneity; furthermore, syntactic and morphological measures were impaired even for subgroups matched on vocabulary. Children in the ASD group without early language delay showed syntactic and morphological impairment, with intact performance on vocabulary and sentence repetition. Findings indicate that syntactic and morphological impairments are a significant concern for high-functioning children with ASD, and may be overlooked if language evaluation focuses exclusively on vocabulary. En ligne : http://dx.doi.org/10.1007/s10803-016-2962-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303
in Journal of Autism and Developmental Disorders > 47-2 (February 2017) . - p.373-383[article] Syntax and Morphology in Danish-Speaking Children with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Cecilia BRYNSKOV, Auteur ; Inge-Marie EIGSTI, Auteur ; Meta JØRGENSEN, Auteur ; Sanne LEMCKE, Auteur ; Ocke-Schwen BOHN, Auteur ; Peter KRØJGAARD, Auteur . - p.373-383.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 47-2 (February 2017) . - p.373-383
Mots-clés : Autism spectrum disorder Vocabulary Syntax Morphology Sentence repetition Early language delay Index. décimale : PER Périodiques Résumé : The current study examined delays in syntax and morphology, and vocabulary, in autism spectrum disorder (ASD). Children ages 4–6 years with ASD (n?=?21) and typical development (n?=?21), matched on nonverbal mental age, completed five language tasks. The ASD group had significant delays in both syntax and morphology, and vocabulary measures, with significant within-group heterogeneity; furthermore, syntactic and morphological measures were impaired even for subgroups matched on vocabulary. Children in the ASD group without early language delay showed syntactic and morphological impairment, with intact performance on vocabulary and sentence repetition. Findings indicate that syntactic and morphological impairments are a significant concern for high-functioning children with ASD, and may be overlooked if language evaluation focuses exclusively on vocabulary. En ligne : http://dx.doi.org/10.1007/s10803-016-2962-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303