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Early Signs of Autism in Toddlers: A Follow-Up Study in the Danish National Birth Cohort / Sanne LEMCKE in Journal of Autism and Developmental Disorders, 43-10 (October 2013)
[article]
Titre : Early Signs of Autism in Toddlers: A Follow-Up Study in the Danish National Birth Cohort Type de document : Texte imprimé et/ou numérique Auteurs : Sanne LEMCKE, Auteur ; Svend JUUL, Auteur ; Erik T. PARNER, Auteur ; Marlene B. LAURITSEN, Auteur ; Poul THORSEN, Auteur Article en page(s) : p.2366-2375 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder Intellectual disability Early signs Parents’ interview Follow-up study Birth cohort Index. décimale : PER Périodiques Résumé : To identify possible early signs of autism spectrum disorder (ASD) within the Danish National Birth Cohort, we studied prospectively collected interviews from 76,441 mothers about their children’s development and behaviour at 6 and 18 months. In Danish national registries, 720 children with ASD and 231 children with intellectual disability (ID) were identified. At 6 months, associations between early signs and ASD or ID were found only in few areas. At 18 months social, language, and motor skills were delayed, and suspicion of vision and hearing problems were increased for both groups. Signs distinguishing ASD from ID were unclear, and the positive predictive values regarding ASD were below 10 % for individual predictors and aggregated risk scores. En ligne : http://dx.doi.org/10.1007/s10803-013-1785-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=215
in Journal of Autism and Developmental Disorders > 43-10 (October 2013) . - p.2366-2375[article] Early Signs of Autism in Toddlers: A Follow-Up Study in the Danish National Birth Cohort [Texte imprimé et/ou numérique] / Sanne LEMCKE, Auteur ; Svend JUUL, Auteur ; Erik T. PARNER, Auteur ; Marlene B. LAURITSEN, Auteur ; Poul THORSEN, Auteur . - p.2366-2375.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 43-10 (October 2013) . - p.2366-2375
Mots-clés : Autism spectrum disorder Intellectual disability Early signs Parents’ interview Follow-up study Birth cohort Index. décimale : PER Périodiques Résumé : To identify possible early signs of autism spectrum disorder (ASD) within the Danish National Birth Cohort, we studied prospectively collected interviews from 76,441 mothers about their children’s development and behaviour at 6 and 18 months. In Danish national registries, 720 children with ASD and 231 children with intellectual disability (ID) were identified. At 6 months, associations between early signs and ASD or ID were found only in few areas. At 18 months social, language, and motor skills were delayed, and suspicion of vision and hearing problems were increased for both groups. Signs distinguishing ASD from ID were unclear, and the positive predictive values regarding ASD were below 10 % for individual predictors and aggregated risk scores. En ligne : http://dx.doi.org/10.1007/s10803-013-1785-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=215 Performance of the Autism Observation Scale for Infants with community-ascertained infants showing early signs of autism / Kristelle HUDRY in Autism, 25-2 (February 2021)
[article]
Titre : Performance of the Autism Observation Scale for Infants with community-ascertained infants showing early signs of autism Type de document : Texte imprimé et/ou numérique Auteurs : Kristelle HUDRY, Auteur ; Lacey CHETCUTI, Auteur ; Maryam BOUTRUS, Auteur ; Sarah PILLAR, Auteur ; Emma K. BAKER, Auteur ; Stefanie DIMOV, Auteur ; Josephine BARBARO, Auteur ; Jonathan GREEN, Auteur ; Andrew J. O. WHITEHOUSE, Auteur ; Kandice J. VARCIN, Auteur Article en page(s) : p.490-501 Langues : Anglais (eng) Mots-clés : developmental psychology diagnosis early signs individual variability/heterogeneity infants psychometrics Index. décimale : PER Périodiques Résumé : We investigated whether a commonly used research assessment - the Autism Observation Scale for Infants (AOSI) - accurately measures autism behaviours among infants showing early signs of autism identified within the community. The AOSI is often included in studies tracking the development of infants at increased likelihood of autism, such as the infant siblings of diagnosed children. However, the suitability of this measure has not previously been tested with community-referred infants. We administered the AOSI with infants when aged 9 to 14 months and again 6?months later. Our researchers - independent of the AOSI development team and newly trained on this measure - were able to administer the brief interactive assessment and score it accurately. The infants' AOSI scores were linked to their scores on other established and validated clinical assessments, particularly at the second visit when average age was 18?months. Stronger correspondence of AOSI and other scores at this second visit suggests early autism behaviours are better established and more consistent by 18?months of age, even though these infants showed clear enough signs of possible autism to prompt referral to our study around 12?months of age. However, the moderate association of AOSI scores over time suggests that, like infant siblings - who mostly do not develop autism - community-identified infants showing early signs may also have variable developmental pathways in early life. En ligne : http://dx.doi.org/10.1177/1362361320965397 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=442
in Autism > 25-2 (February 2021) . - p.490-501[article] Performance of the Autism Observation Scale for Infants with community-ascertained infants showing early signs of autism [Texte imprimé et/ou numérique] / Kristelle HUDRY, Auteur ; Lacey CHETCUTI, Auteur ; Maryam BOUTRUS, Auteur ; Sarah PILLAR, Auteur ; Emma K. BAKER, Auteur ; Stefanie DIMOV, Auteur ; Josephine BARBARO, Auteur ; Jonathan GREEN, Auteur ; Andrew J. O. WHITEHOUSE, Auteur ; Kandice J. VARCIN, Auteur . - p.490-501.
Langues : Anglais (eng)
in Autism > 25-2 (February 2021) . - p.490-501
Mots-clés : developmental psychology diagnosis early signs individual variability/heterogeneity infants psychometrics Index. décimale : PER Périodiques Résumé : We investigated whether a commonly used research assessment - the Autism Observation Scale for Infants (AOSI) - accurately measures autism behaviours among infants showing early signs of autism identified within the community. The AOSI is often included in studies tracking the development of infants at increased likelihood of autism, such as the infant siblings of diagnosed children. However, the suitability of this measure has not previously been tested with community-referred infants. We administered the AOSI with infants when aged 9 to 14 months and again 6?months later. Our researchers - independent of the AOSI development team and newly trained on this measure - were able to administer the brief interactive assessment and score it accurately. The infants' AOSI scores were linked to their scores on other established and validated clinical assessments, particularly at the second visit when average age was 18?months. Stronger correspondence of AOSI and other scores at this second visit suggests early autism behaviours are better established and more consistent by 18?months of age, even though these infants showed clear enough signs of possible autism to prompt referral to our study around 12?months of age. However, the moderate association of AOSI scores over time suggests that, like infant siblings - who mostly do not develop autism - community-identified infants showing early signs may also have variable developmental pathways in early life. En ligne : http://dx.doi.org/10.1177/1362361320965397 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=442 Beyond pass-fail: Examining the potential utility of two thresholds in the autism screening process / M. Y. ROBERTS in Autism Research, 12-1 (January 2019)
[article]
Titre : Beyond pass-fail: Examining the potential utility of two thresholds in the autism screening process Type de document : Texte imprimé et/ou numérique Auteurs : M. Y. ROBERTS, Auteur ; Y. STERN, Auteur ; L. H. HAMPTON, Auteur ; J. M. GRAUZER, Auteur ; A. MILLER, Auteur ; A. LEVIN, Auteur ; B. KORNFELD, Auteur ; M. M. DAVIS, Auteur ; A. KAAT, Auteur ; R. ESTABROOK, Auteur Article en page(s) : p.112-122 Langues : Anglais (eng) Mots-clés : Children autism early detection early signs Index. décimale : PER Périodiques Résumé : Access to early intervention as early in development as possible is critical to maximizing long-term outcomes for children with autism spectrum disorders (ASD). However, despite the fact that ASD can be reliably diagnosed by 24 months, the average age of diagnosis is 2 years later. Waitlists for specialized developmental evaluations are one barrier to early diagnosis. The purpose of this study was to examine one potential approach to reducing wait time for an ASD diagnostic evaluation by examining the utility of using more than one threshold for an autism screening tool, the Screening Tool for Autism in Toddlers and Young Children (STAT). Participants included 171 children between 24 and 36 months of age who received a medical diagnostic evaluation through Illinois' Early Intervention Program. This study directly compared the performance of the STAT when scored: (a) using the original single threshold, (b) using seven equally weighted items using a single threshold, and (c) using all items differentially weighted based on how strongly that item predicts a later ASD diagnosis. In addition, this study explored the potential utility of using two thresholds rather than a single threshold for each scoring method. Results of this study suggest that using a two-threshold logistic regression method has potential psychometric advantages over a single threshold and categorical scoring. Using this approach may reduce the wait time for specialty ASD diagnostic evaluations by maximizing true negatives and true positives, such that specialty evaluations may be reserved for those cases that are more ambiguous or more complex. Autism Research 2019, 12: 112-122. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: This study examined the benefits of using two versus one cutoff score when screening for autism. Results indicate that having two scores and weighting test items based on predictive association with an autism diagnosis is better than using a single score and weighting each item equally. Using such an approach may reduce the wait time for specialty autism diagnostic evaluations, such that specialty evaluations may be reserved for those cases that are more ambiguous or more complex. En ligne : http://dx.doi.org/10.1002/aur.2045 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=376
in Autism Research > 12-1 (January 2019) . - p.112-122[article] Beyond pass-fail: Examining the potential utility of two thresholds in the autism screening process [Texte imprimé et/ou numérique] / M. Y. ROBERTS, Auteur ; Y. STERN, Auteur ; L. H. HAMPTON, Auteur ; J. M. GRAUZER, Auteur ; A. MILLER, Auteur ; A. LEVIN, Auteur ; B. KORNFELD, Auteur ; M. M. DAVIS, Auteur ; A. KAAT, Auteur ; R. ESTABROOK, Auteur . - p.112-122.
Langues : Anglais (eng)
in Autism Research > 12-1 (January 2019) . - p.112-122
Mots-clés : Children autism early detection early signs Index. décimale : PER Périodiques Résumé : Access to early intervention as early in development as possible is critical to maximizing long-term outcomes for children with autism spectrum disorders (ASD). However, despite the fact that ASD can be reliably diagnosed by 24 months, the average age of diagnosis is 2 years later. Waitlists for specialized developmental evaluations are one barrier to early diagnosis. The purpose of this study was to examine one potential approach to reducing wait time for an ASD diagnostic evaluation by examining the utility of using more than one threshold for an autism screening tool, the Screening Tool for Autism in Toddlers and Young Children (STAT). Participants included 171 children between 24 and 36 months of age who received a medical diagnostic evaluation through Illinois' Early Intervention Program. This study directly compared the performance of the STAT when scored: (a) using the original single threshold, (b) using seven equally weighted items using a single threshold, and (c) using all items differentially weighted based on how strongly that item predicts a later ASD diagnosis. In addition, this study explored the potential utility of using two thresholds rather than a single threshold for each scoring method. Results of this study suggest that using a two-threshold logistic regression method has potential psychometric advantages over a single threshold and categorical scoring. Using this approach may reduce the wait time for specialty ASD diagnostic evaluations by maximizing true negatives and true positives, such that specialty evaluations may be reserved for those cases that are more ambiguous or more complex. Autism Research 2019, 12: 112-122. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: This study examined the benefits of using two versus one cutoff score when screening for autism. Results indicate that having two scores and weighting test items based on predictive association with an autism diagnosis is better than using a single score and weighting each item equally. Using such an approach may reduce the wait time for specialty autism diagnostic evaluations, such that specialty evaluations may be reserved for those cases that are more ambiguous or more complex. En ligne : http://dx.doi.org/10.1002/aur.2045 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=376 Infants at-risk for autism spectrum disorder: Patterns of vocalizations at 14 months / Dunia GARRIDO in Autism Research, 10-8 (August 2017)
[article]
Titre : Infants at-risk for autism spectrum disorder: Patterns of vocalizations at 14 months Type de document : Texte imprimé et/ou numérique Auteurs : Dunia GARRIDO, Auteur ; Linda R. WATSON, Auteur ; Gloria CARBALLO, Auteur ; Rocio GARCIA-RETAMERO, Auteur ; Elizabeth R. CRAIS, Auteur Article en page(s) : p.1372-1383 Langues : Anglais (eng) Mots-clés : autism at-risk early signs speech vocalizations Index. décimale : PER Périodiques Résumé : Differences in the early development of children are crucial for early detection of autism spectrum disorder (ASD). Previous studies have shown large differences between children later diagnosed with ASD and their typically developing peers in the early use of canonical vocalizations (i.e., vocalizations that include well-formed consonant–vowel syllables) and the use of vocalizations for communicative purposes. In this prospective study, we examined the extent to which infant vocalizations at 14 months would predict Autism Diagnostic Observation Schedule (ADOS) diagnostic symptom groups, that is, Autism, Spectrum, and Non-ASD, for 82 community-identified at-risk infants at 23 months. Thirty-minute video samples were coded with the intention to categorize and quantify speech (canonical/noncanonical and directed/nondirected) and nonspeech vocalizations (atypical, distress, and pleasure vocalizations). Our results revealed that more canonical directed (OR?=?1.039, P?=?.036), and fewer noncanonical directed (OR=.607, P?=?.002) and noncanonical nondirected (OR?=?1.200, P?=?.049) vocalizations were associated with a greater likelihood of being in the Non-ASD group versus the Autism group, with no variables significantly predicting Autism versus Spectrum group membership. Despite some statistically significant findings, models performed poorly in classifying children into correct ASD symptom group at age 23 months based on vocalizations at 14 months. Thus, the utility of infant vocalizations alone for predicting toddler clinical outcomes among infants initially identified at an elevated risk for ASD appears limited; however, considering the structure and function of early vocalizations combined with other early developmental and behavioral features may improve the confidence for clinicians in making an early diagnosis of ASD. En ligne : http://dx.doi.org/10.1002/aur.1788 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=310
in Autism Research > 10-8 (August 2017) . - p.1372-1383[article] Infants at-risk for autism spectrum disorder: Patterns of vocalizations at 14 months [Texte imprimé et/ou numérique] / Dunia GARRIDO, Auteur ; Linda R. WATSON, Auteur ; Gloria CARBALLO, Auteur ; Rocio GARCIA-RETAMERO, Auteur ; Elizabeth R. CRAIS, Auteur . - p.1372-1383.
Langues : Anglais (eng)
in Autism Research > 10-8 (August 2017) . - p.1372-1383
Mots-clés : autism at-risk early signs speech vocalizations Index. décimale : PER Périodiques Résumé : Differences in the early development of children are crucial for early detection of autism spectrum disorder (ASD). Previous studies have shown large differences between children later diagnosed with ASD and their typically developing peers in the early use of canonical vocalizations (i.e., vocalizations that include well-formed consonant–vowel syllables) and the use of vocalizations for communicative purposes. In this prospective study, we examined the extent to which infant vocalizations at 14 months would predict Autism Diagnostic Observation Schedule (ADOS) diagnostic symptom groups, that is, Autism, Spectrum, and Non-ASD, for 82 community-identified at-risk infants at 23 months. Thirty-minute video samples were coded with the intention to categorize and quantify speech (canonical/noncanonical and directed/nondirected) and nonspeech vocalizations (atypical, distress, and pleasure vocalizations). Our results revealed that more canonical directed (OR?=?1.039, P?=?.036), and fewer noncanonical directed (OR=.607, P?=?.002) and noncanonical nondirected (OR?=?1.200, P?=?.049) vocalizations were associated with a greater likelihood of being in the Non-ASD group versus the Autism group, with no variables significantly predicting Autism versus Spectrum group membership. Despite some statistically significant findings, models performed poorly in classifying children into correct ASD symptom group at age 23 months based on vocalizations at 14 months. Thus, the utility of infant vocalizations alone for predicting toddler clinical outcomes among infants initially identified at an elevated risk for ASD appears limited; however, considering the structure and function of early vocalizations combined with other early developmental and behavioral features may improve the confidence for clinicians in making an early diagnosis of ASD. En ligne : http://dx.doi.org/10.1002/aur.1788 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=310 A Six-Minute Measure of Vocalizations in Toddlers with Autism Spectrum Disorder / Elena J. TENENBAUM in Autism Research, 13-8 (August 2020)
[article]
Titre : A Six-Minute Measure of Vocalizations in Toddlers with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Elena J. TENENBAUM, Auteur ; Kimberly L. H. CARPENTER, Auteur ; Maura SABATOS-DEVITO, Auteur ; Jordan HASHEMI, Auteur ; Saritha VERMEER, Auteur ; Guillermo SAPIRO, Auteur ; Geraldine DAWSON, Auteur Article en page(s) : p.1373-1382 Langues : Anglais (eng) Mots-clés : developmental psychology early detection early signs infants language Index. décimale : PER Périodiques Résumé : To improve early identification of autism spectrum disorder (ASD), we need objective, reliable, and accessible measures. To that end, a previous study demonstrated that a tablet-based application (app) that assessed several autism risk behaviors distinguished between toddlers with ASD and non-ASD toddlers. Using vocal data collected during this study, we investigated whether vocalizations uttered during administration of this app can distinguish among toddlers aged 16-31?months with typical development (TD), language or developmental delay (DLD), and ASD. Participant's visual and vocal responses were recorded using the camera and microphone in a tablet while toddlers watched movies designed to elicit behaviors associated with risk for ASD. Vocalizations were then coded offline. Results showed that (a) children with ASD and DLD were less likely to produce words during app administration than TD participants; (b) the ratio of syllabic vocalizations to all vocalizations was higher among TD than ASD or DLD participants; and (c) the rates of nonsyllabic vocalizations were higher in the ASD group than in either the TD or DLD groups. Those producing more nonsyllabic vocalizations were 24 times more likely to be diagnosed with ASD. These results lend support to previous findings that early vocalizations might be useful in identifying risk for ASD in toddlers and demonstrate the feasibility of using a scalable tablet-based app for assessing vocalizations in the context of a routine pediatric visit. LAY SUMMARY: Although parents often report symptoms of autism spectrum disorder (ASD) in infancy, we are not yet reliably diagnosing ASD until much later in development. A previous study tested a tablet-based application (app) that recorded behaviors we know are associated with ASD to help identify children at risk for the disorder. Here we measured how children vocalize while they watched the movies presented on the tablet. Children with ASD were less likely to produce words, less likely to produce speechlike sounds, and more likely to produce atypical sounds while watching these movies. These measures, combined with other behaviors measured by the app, might help identify which children should be evaluated for ASD. Autism Res 2020, 13: 1373-1382. © 2020 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.2293 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=430
in Autism Research > 13-8 (August 2020) . - p.1373-1382[article] A Six-Minute Measure of Vocalizations in Toddlers with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Elena J. TENENBAUM, Auteur ; Kimberly L. H. CARPENTER, Auteur ; Maura SABATOS-DEVITO, Auteur ; Jordan HASHEMI, Auteur ; Saritha VERMEER, Auteur ; Guillermo SAPIRO, Auteur ; Geraldine DAWSON, Auteur . - p.1373-1382.
Langues : Anglais (eng)
in Autism Research > 13-8 (August 2020) . - p.1373-1382
Mots-clés : developmental psychology early detection early signs infants language Index. décimale : PER Périodiques Résumé : To improve early identification of autism spectrum disorder (ASD), we need objective, reliable, and accessible measures. To that end, a previous study demonstrated that a tablet-based application (app) that assessed several autism risk behaviors distinguished between toddlers with ASD and non-ASD toddlers. Using vocal data collected during this study, we investigated whether vocalizations uttered during administration of this app can distinguish among toddlers aged 16-31?months with typical development (TD), language or developmental delay (DLD), and ASD. Participant's visual and vocal responses were recorded using the camera and microphone in a tablet while toddlers watched movies designed to elicit behaviors associated with risk for ASD. Vocalizations were then coded offline. Results showed that (a) children with ASD and DLD were less likely to produce words during app administration than TD participants; (b) the ratio of syllabic vocalizations to all vocalizations was higher among TD than ASD or DLD participants; and (c) the rates of nonsyllabic vocalizations were higher in the ASD group than in either the TD or DLD groups. Those producing more nonsyllabic vocalizations were 24 times more likely to be diagnosed with ASD. These results lend support to previous findings that early vocalizations might be useful in identifying risk for ASD in toddlers and demonstrate the feasibility of using a scalable tablet-based app for assessing vocalizations in the context of a routine pediatric visit. LAY SUMMARY: Although parents often report symptoms of autism spectrum disorder (ASD) in infancy, we are not yet reliably diagnosing ASD until much later in development. A previous study tested a tablet-based application (app) that recorded behaviors we know are associated with ASD to help identify children at risk for the disorder. Here we measured how children vocalize while they watched the movies presented on the tablet. Children with ASD were less likely to produce words, less likely to produce speechlike sounds, and more likely to produce atypical sounds while watching these movies. These measures, combined with other behaviors measured by the app, might help identify which children should be evaluated for ASD. Autism Res 2020, 13: 1373-1382. © 2020 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.2293 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=430 Onset patterns in autism: Variation across informants, methods, and timing / Sally OZONOFF in Autism Research, 11-5 (May 2018)
PermalinkResponse to changing contingencies in infants at high and low risk for autism spectrum disorder / Jessie B. NORTHRUP in Autism Research, 10-7 (July 2017)
PermalinkScreening for autism spectrum disorder in a naturalistic home setting using the systematic observation of red flags (SORF) at 18-24 months / Deanna DOW in Autism Research, 13-1 (January 2020)
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