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Effects of Overweight or Obesity on Brain Resting State Functional Connectivity of Children with Autism Spectrum Disorder / Chanaka N. KAHATHUDUWA in Journal of Autism and Developmental Disorders, 49-12 (December 2019)
[article]
Titre : Effects of Overweight or Obesity on Brain Resting State Functional Connectivity of Children with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Chanaka N. KAHATHUDUWA, Auteur ; B. WEST, Auteur ; A. MASTERGEORGE, Auteur Article en page(s) : p.4751-4760 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder Brain Connectome Functional neuroimaging Magnetic resonance imaging Obesity Overweight Index. décimale : PER Périodiques Résumé : Evidence on neurophysiological correlates of coexisting autism spectrum disorders (ASD) and overweight/obesity may elucidate mechanisms leading to the observed greater risk of obesity in children with ASD. An exploratory secondary data analysis was performed on resting state functional magnetic resonance imaging (rs-fMRI) data of children downloaded from the ABIDE Preprocessed database (n = 81). Children with isolated ASD showed hypo-connectivity between anterior and posterior default mode network (DMN) (p = 0.003; FWER). Children with coexisting ASD and overweight/obesity showed hyper-connectivity between anterior and posterior DMN (p = 0.015; FWER). More evidence is needed to confirm these contrasting rs-fMRI connectivity profiles and to explicate causal inferences regarding neurophysiological mechanisms associated with coexisting ASD and overweight/obesity. En ligne : http://dx.doi.org/10.1007/s10803-019-04187-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=411
in Journal of Autism and Developmental Disorders > 49-12 (December 2019) . - p.4751-4760[article] Effects of Overweight or Obesity on Brain Resting State Functional Connectivity of Children with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Chanaka N. KAHATHUDUWA, Auteur ; B. WEST, Auteur ; A. MASTERGEORGE, Auteur . - p.4751-4760.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 49-12 (December 2019) . - p.4751-4760
Mots-clés : Autism spectrum disorder Brain Connectome Functional neuroimaging Magnetic resonance imaging Obesity Overweight Index. décimale : PER Périodiques Résumé : Evidence on neurophysiological correlates of coexisting autism spectrum disorders (ASD) and overweight/obesity may elucidate mechanisms leading to the observed greater risk of obesity in children with ASD. An exploratory secondary data analysis was performed on resting state functional magnetic resonance imaging (rs-fMRI) data of children downloaded from the ABIDE Preprocessed database (n = 81). Children with isolated ASD showed hypo-connectivity between anterior and posterior default mode network (DMN) (p = 0.003; FWER). Children with coexisting ASD and overweight/obesity showed hyper-connectivity between anterior and posterior DMN (p = 0.015; FWER). More evidence is needed to confirm these contrasting rs-fMRI connectivity profiles and to explicate causal inferences regarding neurophysiological mechanisms associated with coexisting ASD and overweight/obesity. En ligne : http://dx.doi.org/10.1007/s10803-019-04187-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=411 PET - CT Scan Shows Decreased Severity of Autism after Autologous Cellular Therapy: A Case Report / Alok SHARMA in Autism - Open Access, 6-2 ([01/03/2016])
[article]
Titre : PET - CT Scan Shows Decreased Severity of Autism after Autologous Cellular Therapy: A Case Report Type de document : Texte imprimé et/ou numérique Auteurs : Alok SHARMA, Auteur ; Hemangi SANE, Auteur ; Nandini GOKULCHANDRAN, Auteur ; Prerna BADHE, Auteur ; Avantika PATIL, Auteur ; Pooja KULKARNI, Auteur ; Amruta PARANJAPE, Auteur Article en page(s) : 6 p. Langues : Anglais (eng) Mots-clés : Autism Stem cell therapy Bone marrow mononuclear cells Autologous Childhood autism Rating scale Functional neuroimaging Neurodevelopmental disorders Index. décimale : PER Périodiques Résumé : PET - CT scan has been recently utilized to detect functional abnormalities in the brain. In autism, the MRI of brain is normal hence, functional neuroimaging techniques such as Positron Emission Tomography – Computer Tomography scan of the brain should be explored. Autism is a complex neurodevelopmental disorder affecting communication, behavior and socialization. Currently, available therapeutic approaches are aimed at symptomatic changes and do not target the core pathology in the brain of autism. Cell therapy has recently emerged as a promising treatment modality for autism. However, the effects of cell therapy need to be monitored by objective imaging. In this study, we present the case of a 6 year old boy with autism treated with intrathecal administration of autologous bone marrow mononuclear cells and monitored with Positron Emission Tomography – Computer Tomography scan. On regular follow up at 3 and 6 months, significant social, behavioral and communication improvements were observed. On outcome measures, the Indian Scale for Assessment of Autism score pre -intervention improved from 113 to 97, Functional Independence Measure improved significantly from 42 to 50 and Childhood Autism Rating Scale improved from 42.5 to 35.5. The severity of illness on Clinical Global Impression scale showed a change from a score of 5 (markedly ill) to 4 (moderately ill). Global improvement graded on the CGI scale was 2 (much improved). The efficacy index on Childhood Autism Rating Scale showed moderate therapeutic effect (score 5). Interestingly, Positron Emission Tomography - Computer Tomography comparisons at 6 months revealed improved metabolism of the previously hypometabolic areas of the brain which correlated well with clinical improvements. No adverse events were reported. En ligne : https://dx.doi.org/10.4172/2165-7890.1000169 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=410
in Autism - Open Access > 6-2 [01/03/2016] . - 6 p.[article] PET - CT Scan Shows Decreased Severity of Autism after Autologous Cellular Therapy: A Case Report [Texte imprimé et/ou numérique] / Alok SHARMA, Auteur ; Hemangi SANE, Auteur ; Nandini GOKULCHANDRAN, Auteur ; Prerna BADHE, Auteur ; Avantika PATIL, Auteur ; Pooja KULKARNI, Auteur ; Amruta PARANJAPE, Auteur . - 6 p.
Langues : Anglais (eng)
in Autism - Open Access > 6-2 [01/03/2016] . - 6 p.
Mots-clés : Autism Stem cell therapy Bone marrow mononuclear cells Autologous Childhood autism Rating scale Functional neuroimaging Neurodevelopmental disorders Index. décimale : PER Périodiques Résumé : PET - CT scan has been recently utilized to detect functional abnormalities in the brain. In autism, the MRI of brain is normal hence, functional neuroimaging techniques such as Positron Emission Tomography – Computer Tomography scan of the brain should be explored. Autism is a complex neurodevelopmental disorder affecting communication, behavior and socialization. Currently, available therapeutic approaches are aimed at symptomatic changes and do not target the core pathology in the brain of autism. Cell therapy has recently emerged as a promising treatment modality for autism. However, the effects of cell therapy need to be monitored by objective imaging. In this study, we present the case of a 6 year old boy with autism treated with intrathecal administration of autologous bone marrow mononuclear cells and monitored with Positron Emission Tomography – Computer Tomography scan. On regular follow up at 3 and 6 months, significant social, behavioral and communication improvements were observed. On outcome measures, the Indian Scale for Assessment of Autism score pre -intervention improved from 113 to 97, Functional Independence Measure improved significantly from 42 to 50 and Childhood Autism Rating Scale improved from 42.5 to 35.5. The severity of illness on Clinical Global Impression scale showed a change from a score of 5 (markedly ill) to 4 (moderately ill). Global improvement graded on the CGI scale was 2 (much improved). The efficacy index on Childhood Autism Rating Scale showed moderate therapeutic effect (score 5). Interestingly, Positron Emission Tomography - Computer Tomography comparisons at 6 months revealed improved metabolism of the previously hypometabolic areas of the brain which correlated well with clinical improvements. No adverse events were reported. En ligne : https://dx.doi.org/10.4172/2165-7890.1000169 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=410 Research Review: Constraining heterogeneity: the social brain and its development in autism spectrum disorder / Kevin A. PELPHREY in Journal of Child Psychology and Psychiatry, 52-6 (June 2011)
[article]
Titre : Research Review: Constraining heterogeneity: the social brain and its development in autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Kevin A. PELPHREY, Auteur ; Sarah SHULTZ, Auteur ; Caitlin M. HUDAC, Auteur ; Brent C. VANDER WYK, Auteur Année de publication : 2011 Article en page(s) : p.631-644 Langues : Anglais (eng) Mots-clés : Social perception social cognition autism functional neuroimaging social brain Index. décimale : PER Périodiques Résumé : The expression of autism spectrum disorder (ASD) is highly heterogeneous, owing to the complex interactions between genes, the brain, and behavior throughout development. Here we present a model of ASD that implicates an early and initial failure to develop the specialized functions of one or more of the set of neuroanatomical structures involved in social information processing (i.e., the ‘social brain’). From this early and primary disruption, abnormal brain development is canalized because the individual with an ASD must develop in a highly social world without the specialized neural systems that would ordinarily allow him or her to partake in the fabric of social life, which is woven from the thread of opportunities for social reciprocity and the tools of social engagement. This brain canalization gives rise to other characteristic behavioral deficits in ASD including deficits in communication, restricted interests, and repetitive behaviors. We propose that focused efforts to explore the brain mechanisms underlying the core, pathognomic deficits in the development of mechanisms for social engagement in ASD will greatly elucidate our understanding and treatment of this complex, devastating family of neurodevelopmental disorders. In particular, developmental studies (i.e., longitudinal studies of young children with and without ASD, as well as infants at increased risk for being identified with ASD) of the neural circuitry supporting key aspects of social information processing are likely to provide important insights into the underlying components of the full-syndrome of ASD. These studies could also contribute to the identification of developmental brain endophenotypes to facilitate genetic studies. The potential for this kind of approach is illustrated via examples of functional neuroimaging research from our own laboratory implicating the posterior superior temporal sulcus (STS) as a key player in the set of neural structures giving rise to ASD. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02349.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=126
in Journal of Child Psychology and Psychiatry > 52-6 (June 2011) . - p.631-644[article] Research Review: Constraining heterogeneity: the social brain and its development in autism spectrum disorder [Texte imprimé et/ou numérique] / Kevin A. PELPHREY, Auteur ; Sarah SHULTZ, Auteur ; Caitlin M. HUDAC, Auteur ; Brent C. VANDER WYK, Auteur . - 2011 . - p.631-644.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 52-6 (June 2011) . - p.631-644
Mots-clés : Social perception social cognition autism functional neuroimaging social brain Index. décimale : PER Périodiques Résumé : The expression of autism spectrum disorder (ASD) is highly heterogeneous, owing to the complex interactions between genes, the brain, and behavior throughout development. Here we present a model of ASD that implicates an early and initial failure to develop the specialized functions of one or more of the set of neuroanatomical structures involved in social information processing (i.e., the ‘social brain’). From this early and primary disruption, abnormal brain development is canalized because the individual with an ASD must develop in a highly social world without the specialized neural systems that would ordinarily allow him or her to partake in the fabric of social life, which is woven from the thread of opportunities for social reciprocity and the tools of social engagement. This brain canalization gives rise to other characteristic behavioral deficits in ASD including deficits in communication, restricted interests, and repetitive behaviors. We propose that focused efforts to explore the brain mechanisms underlying the core, pathognomic deficits in the development of mechanisms for social engagement in ASD will greatly elucidate our understanding and treatment of this complex, devastating family of neurodevelopmental disorders. In particular, developmental studies (i.e., longitudinal studies of young children with and without ASD, as well as infants at increased risk for being identified with ASD) of the neural circuitry supporting key aspects of social information processing are likely to provide important insights into the underlying components of the full-syndrome of ASD. These studies could also contribute to the identification of developmental brain endophenotypes to facilitate genetic studies. The potential for this kind of approach is illustrated via examples of functional neuroimaging research from our own laboratory implicating the posterior superior temporal sulcus (STS) as a key player in the set of neural structures giving rise to ASD. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02349.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=126 Neurobehavioral correlates of impaired emotion recognition in pediatric PTSD / Sara A. HEYN in Development and Psychopathology, 34-3 (August 2022)
[article]
Titre : Neurobehavioral correlates of impaired emotion recognition in pediatric PTSD Type de document : Texte imprimé et/ou numérique Auteurs : Sara A. HEYN, Auteur ; Collin SCHMIT, Auteur ; Taylor J. KEDING, Auteur ; Richard WOLF, Auteur ; Ryan J. HERRINGA, Auteur Article en page(s) : p.946-956 Langues : Anglais (eng) Mots-clés : adolescent emotion functional neuroimaging posttraumatic stress disorders Index. décimale : PER Périodiques Résumé : Despite broad evidence suggesting that adversity-exposed youth experience an impaired ability to recognize emotion in others, the underlying biological mechanisms remains elusive. This study uses a multimethod approach to target the neurological substrates of this phenomenon in a well-phenotyped sample of youth meeting diagnostic criteria for posttraumatic stress disorder (PTSD). Twenty-one PTSD-afflicted youth and 23 typically developing (TD) controls completed clinical interview schedules, an emotion recognition task with eye-tracking, and an implicit emotion processing task during functional magnetic resonance imaging )fMRI). PTSD was associated with decreased accuracy in identification of angry, disgust, and neutral faces as compared to TD youth. Of note, these impairments occurred despite the normal deployment of visual attention in youth with PTSD relative to TD youth. Correlation with a related fMRI task revealed a group by accuracy interaction for amygdala “hippocampus functional connectivity (FC) for angry expressions, where TD youth showed a positive relationship between anger accuracy and amygdala “hippocampus FC; this relationship was reversed in youth with PTSD. These findings are a novel characterization of impaired threat recognition within a well-phenotyped population of severe pediatric PTSD. Further, the differential amygdala “hippocampus FC identified in youth with PTSD may imply aberrant efficiency of emotional contextualization circuits. En ligne : http://dx.doi.org/10.1017/S0954579420001704 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=485
in Development and Psychopathology > 34-3 (August 2022) . - p.946-956[article] Neurobehavioral correlates of impaired emotion recognition in pediatric PTSD [Texte imprimé et/ou numérique] / Sara A. HEYN, Auteur ; Collin SCHMIT, Auteur ; Taylor J. KEDING, Auteur ; Richard WOLF, Auteur ; Ryan J. HERRINGA, Auteur . - p.946-956.
Langues : Anglais (eng)
in Development and Psychopathology > 34-3 (August 2022) . - p.946-956
Mots-clés : adolescent emotion functional neuroimaging posttraumatic stress disorders Index. décimale : PER Périodiques Résumé : Despite broad evidence suggesting that adversity-exposed youth experience an impaired ability to recognize emotion in others, the underlying biological mechanisms remains elusive. This study uses a multimethod approach to target the neurological substrates of this phenomenon in a well-phenotyped sample of youth meeting diagnostic criteria for posttraumatic stress disorder (PTSD). Twenty-one PTSD-afflicted youth and 23 typically developing (TD) controls completed clinical interview schedules, an emotion recognition task with eye-tracking, and an implicit emotion processing task during functional magnetic resonance imaging )fMRI). PTSD was associated with decreased accuracy in identification of angry, disgust, and neutral faces as compared to TD youth. Of note, these impairments occurred despite the normal deployment of visual attention in youth with PTSD relative to TD youth. Correlation with a related fMRI task revealed a group by accuracy interaction for amygdala “hippocampus functional connectivity (FC) for angry expressions, where TD youth showed a positive relationship between anger accuracy and amygdala “hippocampus FC; this relationship was reversed in youth with PTSD. These findings are a novel characterization of impaired threat recognition within a well-phenotyped population of severe pediatric PTSD. Further, the differential amygdala “hippocampus FC identified in youth with PTSD may imply aberrant efficiency of emotional contextualization circuits. En ligne : http://dx.doi.org/10.1017/S0954579420001704 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=485 Bidirectional links between adolescent brain function and substance use moderated by cognitive control / Jungmeen KIM-SPOON in Journal of Child Psychology and Psychiatry, 62-4 (April 2021)
[article]
Titre : Bidirectional links between adolescent brain function and substance use moderated by cognitive control Type de document : Texte imprimé et/ou numérique Auteurs : Jungmeen KIM-SPOON, Auteur ; Toria HERD, Auteur ; Alexis BRIEANT, Auteur ; Kristin M. PEVIANI, Auteur ; Nina LAUHARATANAHIRUN, Auteur ; Jacob LEE, Auteur ; Kirby DEATER-DECKARD, Auteur ; Warren K. BICKEL, Auteur ; Brooks KING-CASAS, Auteur Article en page(s) : p.427-436 Langues : Anglais (eng) Mots-clés : Neural risk processing cognitive control functional neuroimaging insula activation neurotoxic effects substance use Index. décimale : PER Périodiques Résumé : BACKGROUND: No clear consensus exists as to whether neurodevelopmental abnormalities among substance users reflect predisposing neural risk factors, neurotoxic effects of substances, or both. Using a longitudinal design, we examined developmental patterns of the bidirectional links between neural mechanisms and substance use throughout adolescence. METHOD: 167 adolescents (aged 13-14 years at Time 1, 53% male) were assessed annually four times. Risk-related neural processing was assessed by blood-oxygen-level-dependent responses in the insula during a lottery choice task, cognitive control by behavioral performance during the Multi-Source Interference Task, and substance use by adolescents' self-reported cigarette, alcohol, and marijuana use. RESULTS: Latent change score modeling indicated that greater substance use predicted increased insula activation during risk processing, but the effects of insula activation on changes in substance use were not significant. The coupling effect from substance use to insula activation was particularly strong for adolescents with low cognitive control, which supports the theorized moderating role of cognitive control. CONCLUSIONS: Our results elucidate how substance use may alter brain development to be biased toward maladaptive decision-making, particularly among adolescents with poor cognitive control. Furthermore, the current findings underscore that cognitive control may be an important target in the prevention and treatment of adolescent substance use given its moderating role in the neuroadaptive effects of substance use on brain development. En ligne : http://dx.doi.org/10.1111/jcpp.13285 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=445
in Journal of Child Psychology and Psychiatry > 62-4 (April 2021) . - p.427-436[article] Bidirectional links between adolescent brain function and substance use moderated by cognitive control [Texte imprimé et/ou numérique] / Jungmeen KIM-SPOON, Auteur ; Toria HERD, Auteur ; Alexis BRIEANT, Auteur ; Kristin M. PEVIANI, Auteur ; Nina LAUHARATANAHIRUN, Auteur ; Jacob LEE, Auteur ; Kirby DEATER-DECKARD, Auteur ; Warren K. BICKEL, Auteur ; Brooks KING-CASAS, Auteur . - p.427-436.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 62-4 (April 2021) . - p.427-436
Mots-clés : Neural risk processing cognitive control functional neuroimaging insula activation neurotoxic effects substance use Index. décimale : PER Périodiques Résumé : BACKGROUND: No clear consensus exists as to whether neurodevelopmental abnormalities among substance users reflect predisposing neural risk factors, neurotoxic effects of substances, or both. Using a longitudinal design, we examined developmental patterns of the bidirectional links between neural mechanisms and substance use throughout adolescence. METHOD: 167 adolescents (aged 13-14 years at Time 1, 53% male) were assessed annually four times. Risk-related neural processing was assessed by blood-oxygen-level-dependent responses in the insula during a lottery choice task, cognitive control by behavioral performance during the Multi-Source Interference Task, and substance use by adolescents' self-reported cigarette, alcohol, and marijuana use. RESULTS: Latent change score modeling indicated that greater substance use predicted increased insula activation during risk processing, but the effects of insula activation on changes in substance use were not significant. The coupling effect from substance use to insula activation was particularly strong for adolescents with low cognitive control, which supports the theorized moderating role of cognitive control. CONCLUSIONS: Our results elucidate how substance use may alter brain development to be biased toward maladaptive decision-making, particularly among adolescents with poor cognitive control. Furthermore, the current findings underscore that cognitive control may be an important target in the prevention and treatment of adolescent substance use given its moderating role in the neuroadaptive effects of substance use on brain development. En ligne : http://dx.doi.org/10.1111/jcpp.13285 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=445 Longitudinal pathways linking family risk, neural risk processing, delay discounting, and adolescent substance use / J. KIM-SPOON in Journal of Child Psychology and Psychiatry, 60-6 (June 2019)
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