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Conduct disorder symptomatology is associated with an altered functional connectome in a large national youth sample / Scott TILLEM in Development and Psychopathology, 34-4 (October 2022)
[article]
Titre : Conduct disorder symptomatology is associated with an altered functional connectome in a large national youth sample Type de document : Texte imprimé et/ou numérique Auteurs : Scott TILLEM, Auteur ; May I. CONLEY, Auteur ; Arielle BASKIN-SOMMERS, Auteur Article en page(s) : p.1573-1584 Langues : Anglais (eng) Mots-clés : Adolescent Brain Child Cluster Analysis Conduct Disorder/diagnostic imaging Connectome Humans Magnetic Resonance Imaging/methods conduct disorder graph analysis neural topology neurocognitive functioning subcortical structures Index. décimale : PER Périodiques Résumé : Conduct disorder (CD), characterized by youth antisocial behavior, is associated with a variety of neurocognitive impairments. However, questions remain regarding the neural underpinnings of these impairments. To investigate novel neural mechanisms that may support these neurocognitive abnormalities, the present study applied a graph analysis to resting-state functional magnetic resonance imaging (fMRI) data collected from a national sample of 4,781 youth, ages 9-10, who participated in the baseline session of the Adolescent Brain Cognitive Development(SM) Study (ABCD Study®). Analyses were then conducted to examine the relationships among levels of CD symptomatology, metrics of global topology, node-level metrics for subcortical structures, and performance on neurocognitive assessments. Youth higher on CD displayed higher global clustering (Î2= .039, 95% CI(corrected) [.0027 .0771]), but lower Degree(subcortical) (Î2= -.052, 95% CI(corrected) [-.0916 -.0152]). Youth higher on CD had worse performance on a general neurocognitive assessment (Î2= -.104, 95% CI [-.1328 -.0763]) and an emotion recognition memory assessment (Î2= -.061, 95% CI [-.0919 -.0290]). Finally, global clustering mediated the relationship between CD and general neurocognitive functioning (indirect Î2= -.002, 95% CI [-.0044 -.0002]), and Degree(subcortical) mediated the relationship between CD and emotion recognition memory performance (indirect Î2= -.002, 95% CI [-.0046 -.0005]). CD appears associated with neuro-topological abnormalities and these abnormalities may represent neural mechanisms supporting CD-related neurocognitive disruptions. En ligne : http://dx.doi.org/10.1017/s0954579421000237 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=489
in Development and Psychopathology > 34-4 (October 2022) . - p.1573-1584[article] Conduct disorder symptomatology is associated with an altered functional connectome in a large national youth sample [Texte imprimé et/ou numérique] / Scott TILLEM, Auteur ; May I. CONLEY, Auteur ; Arielle BASKIN-SOMMERS, Auteur . - p.1573-1584.
Langues : Anglais (eng)
in Development and Psychopathology > 34-4 (October 2022) . - p.1573-1584
Mots-clés : Adolescent Brain Child Cluster Analysis Conduct Disorder/diagnostic imaging Connectome Humans Magnetic Resonance Imaging/methods conduct disorder graph analysis neural topology neurocognitive functioning subcortical structures Index. décimale : PER Périodiques Résumé : Conduct disorder (CD), characterized by youth antisocial behavior, is associated with a variety of neurocognitive impairments. However, questions remain regarding the neural underpinnings of these impairments. To investigate novel neural mechanisms that may support these neurocognitive abnormalities, the present study applied a graph analysis to resting-state functional magnetic resonance imaging (fMRI) data collected from a national sample of 4,781 youth, ages 9-10, who participated in the baseline session of the Adolescent Brain Cognitive Development(SM) Study (ABCD Study®). Analyses were then conducted to examine the relationships among levels of CD symptomatology, metrics of global topology, node-level metrics for subcortical structures, and performance on neurocognitive assessments. Youth higher on CD displayed higher global clustering (Î2= .039, 95% CI(corrected) [.0027 .0771]), but lower Degree(subcortical) (Î2= -.052, 95% CI(corrected) [-.0916 -.0152]). Youth higher on CD had worse performance on a general neurocognitive assessment (Î2= -.104, 95% CI [-.1328 -.0763]) and an emotion recognition memory assessment (Î2= -.061, 95% CI [-.0919 -.0290]). Finally, global clustering mediated the relationship between CD and general neurocognitive functioning (indirect Î2= -.002, 95% CI [-.0044 -.0002]), and Degree(subcortical) mediated the relationship between CD and emotion recognition memory performance (indirect Î2= -.002, 95% CI [-.0046 -.0005]). CD appears associated with neuro-topological abnormalities and these abnormalities may represent neural mechanisms supporting CD-related neurocognitive disruptions. En ligne : http://dx.doi.org/10.1017/s0954579421000237 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=489 Multimodal brain imaging in autism spectrum disorder and the promise of twin research / Katell MEVEL in Autism, 19-5 (July 2015)
[article]
Titre : Multimodal brain imaging in autism spectrum disorder and the promise of twin research Type de document : Texte imprimé et/ou numérique Auteurs : Katell MEVEL, Auteur ; Peter FRANSSON, Auteur ; Sven BÖLTE, Auteur Article en page(s) : p.527-541 Langues : Anglais (eng) Mots-clés : autism connectome diffusion tensor imaging monozygotic twins neurodevelopmental disorders resting-state functional magnetic resonance imaging review Index. décimale : PER Périodiques Résumé : Current evidence suggests the phenotype of autism spectrum disorder to be driven by a complex interaction of genetic and environmental factors impacting onto brain maturation, synaptic function, and cortical networks. However, findings are heterogeneous, and the exact neurobiological pathways of autism spectrum disorder still remain poorly understood. The co-twin control or twin-difference design is a potentially powerful tool to disentangle causal genetic and environmental contributions on neurodevelopment in autism spectrum disorder. To this end, monozygotic twins discordant for this condition provide unique means for the maximum control of potentially confounding factors. Unfortunately, only few studies of a rather narrow scope, and limited sample size, have been conducted. In an attempt to highlight the great potential of combining the brain connectome approach with monozygotic twin design, we first give an overview of the existing neurobiological evidence for autism spectrum disorder and its cognitive correlates. Then, a special focus is made onto the brain imaging findings reported within populations of monozygotic twins phenotypically discordant for autism spectrum disorder. Finally, we introduce the brain connectome model and describe an ongoing project using this approach among the largest cohort of monozygotic twins discordant for autism spectrum disorder ever recruited. En ligne : http://dx.doi.org/10.1177/1362361314535510 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=261
in Autism > 19-5 (July 2015) . - p.527-541[article] Multimodal brain imaging in autism spectrum disorder and the promise of twin research [Texte imprimé et/ou numérique] / Katell MEVEL, Auteur ; Peter FRANSSON, Auteur ; Sven BÖLTE, Auteur . - p.527-541.
Langues : Anglais (eng)
in Autism > 19-5 (July 2015) . - p.527-541
Mots-clés : autism connectome diffusion tensor imaging monozygotic twins neurodevelopmental disorders resting-state functional magnetic resonance imaging review Index. décimale : PER Périodiques Résumé : Current evidence suggests the phenotype of autism spectrum disorder to be driven by a complex interaction of genetic and environmental factors impacting onto brain maturation, synaptic function, and cortical networks. However, findings are heterogeneous, and the exact neurobiological pathways of autism spectrum disorder still remain poorly understood. The co-twin control or twin-difference design is a potentially powerful tool to disentangle causal genetic and environmental contributions on neurodevelopment in autism spectrum disorder. To this end, monozygotic twins discordant for this condition provide unique means for the maximum control of potentially confounding factors. Unfortunately, only few studies of a rather narrow scope, and limited sample size, have been conducted. In an attempt to highlight the great potential of combining the brain connectome approach with monozygotic twin design, we first give an overview of the existing neurobiological evidence for autism spectrum disorder and its cognitive correlates. Then, a special focus is made onto the brain imaging findings reported within populations of monozygotic twins phenotypically discordant for autism spectrum disorder. Finally, we introduce the brain connectome model and describe an ongoing project using this approach among the largest cohort of monozygotic twins discordant for autism spectrum disorder ever recruited. En ligne : http://dx.doi.org/10.1177/1362361314535510 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=261 Testing the extreme male brain hypothesis: Is autism spectrum disorder associated with a more male-typical brain? / L. VAN EIJK in Autism Research, 14-8 (August 2021)
[article]
Titre : Testing the extreme male brain hypothesis: Is autism spectrum disorder associated with a more male-typical brain? Type de document : Texte imprimé et/ou numérique Auteurs : L. VAN EIJK, Auteur ; B. P. ZIETSCH, Auteur Article en page(s) : p.1597-1608 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/complications/diagnostic imaging Autistic Disorder Brain/diagnostic imaging Connectome Female Humans Magnetic Resonance Imaging Male Sex Characteristics autism spectrum disorder brain diseases magnetic resonance imaging masculinity neuroimaging sex characteristics Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is more common in males than females and has been linked to male-typical behavior. Accordingly, the "Extreme Male Brain" hypothesis suggests that ASD is associated with an exaggeratedly male-typical brain. To test this hypothesis, we derived a data-driven measure of individual differences along a male-female dimension based on sex differences in subcortical brain shape (i.e., brain maleness) by training our algorithm on two population samples (Queensland Twin IMaging study and Human Connectome Project; combined N = 2153). We then applied this algorithm to two clinical datasets (Autism Brain Imaging Data Exchange I and II; ASD N = 1060; neurotypical controls N = 1166) to obtain a brain maleness score for each individual, representing maleness of their brain on a male-female continuum. Consistent with the Extreme Male Brain hypothesis, we found a higher mean brain maleness score in the ASD group than in controls (d = 0.20 [0.12-0.29]), parallel to higher scores for control males than control females (d = 1.17 [1.05-1.29]). Further, brain maleness was positively associated with autistic symptoms. We tested the possibility this finding was driven by the ASD group's larger brains than controls (d = 0.17 [0.08-0.25]), given that males had larger brains than females (d = 0.96 [0.84-1.07]). Indeed, after adjusting for differences in brain size, the brain maleness difference between the ASD group and controls disappeared, and no association with autistic symptoms remained (after controlling for multiple comparisons), suggesting greater maleness of the autistic brain is driven by brain size. Brain maleness may be influenced by the same factors that influence brain size. LAY SUMMARY: A popular theory proposes that individuals with autistic spectrum disorder (ASD) have an "extreme male brain", but this has not been subject to rigorous, direct tests. We developed a measure of individual differences along a male-female dimension and then derived this measure for 1060 individuals with ASD and 1166 neurotypical controls. Individuals with ASD had slightly more male-type brains. However, this difference is accounted for by males and individuals with ASD having relatively larger brains than females and controls, respectively. En ligne : http://dx.doi.org/10.1002/aur.2537 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449
in Autism Research > 14-8 (August 2021) . - p.1597-1608[article] Testing the extreme male brain hypothesis: Is autism spectrum disorder associated with a more male-typical brain? [Texte imprimé et/ou numérique] / L. VAN EIJK, Auteur ; B. P. ZIETSCH, Auteur . - p.1597-1608.
Langues : Anglais (eng)
in Autism Research > 14-8 (August 2021) . - p.1597-1608
Mots-clés : Autism Spectrum Disorder/complications/diagnostic imaging Autistic Disorder Brain/diagnostic imaging Connectome Female Humans Magnetic Resonance Imaging Male Sex Characteristics autism spectrum disorder brain diseases magnetic resonance imaging masculinity neuroimaging sex characteristics Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is more common in males than females and has been linked to male-typical behavior. Accordingly, the "Extreme Male Brain" hypothesis suggests that ASD is associated with an exaggeratedly male-typical brain. To test this hypothesis, we derived a data-driven measure of individual differences along a male-female dimension based on sex differences in subcortical brain shape (i.e., brain maleness) by training our algorithm on two population samples (Queensland Twin IMaging study and Human Connectome Project; combined N = 2153). We then applied this algorithm to two clinical datasets (Autism Brain Imaging Data Exchange I and II; ASD N = 1060; neurotypical controls N = 1166) to obtain a brain maleness score for each individual, representing maleness of their brain on a male-female continuum. Consistent with the Extreme Male Brain hypothesis, we found a higher mean brain maleness score in the ASD group than in controls (d = 0.20 [0.12-0.29]), parallel to higher scores for control males than control females (d = 1.17 [1.05-1.29]). Further, brain maleness was positively associated with autistic symptoms. We tested the possibility this finding was driven by the ASD group's larger brains than controls (d = 0.17 [0.08-0.25]), given that males had larger brains than females (d = 0.96 [0.84-1.07]). Indeed, after adjusting for differences in brain size, the brain maleness difference between the ASD group and controls disappeared, and no association with autistic symptoms remained (after controlling for multiple comparisons), suggesting greater maleness of the autistic brain is driven by brain size. Brain maleness may be influenced by the same factors that influence brain size. LAY SUMMARY: A popular theory proposes that individuals with autistic spectrum disorder (ASD) have an "extreme male brain", but this has not been subject to rigorous, direct tests. We developed a measure of individual differences along a male-female dimension and then derived this measure for 1060 individuals with ASD and 1166 neurotypical controls. Individuals with ASD had slightly more male-type brains. However, this difference is accounted for by males and individuals with ASD having relatively larger brains than females and controls, respectively. En ligne : http://dx.doi.org/10.1002/aur.2537 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449 Altered functional connectivity of the amygdaloid input nuclei in adolescents and young adults with autism spectrum disorder: a resting state fMRI study / A. RAUSCH in Molecular Autism, 7 (2016)
[article]
Titre : Altered functional connectivity of the amygdaloid input nuclei in adolescents and young adults with autism spectrum disorder: a resting state fMRI study Type de document : Texte imprimé et/ou numérique Auteurs : A. RAUSCH, Auteur ; W. ZHANG, Auteur ; K. V. HAAK, Auteur ; M. MENNES, Auteur ; E. J. HERMANS, Auteur ; E. VAN OORT, Auteur ; G. VAN WINGEN, Auteur ; Christian F. BECKMANN, Auteur ; Jan K. BUITELAAR, Auteur ; W. B. GROEN, Auteur Article en page(s) : 13p. Langues : Anglais (eng) Mots-clés : Adolescent Afferent Pathways/pathology/physiopathology Amygdala/pathology/physiopathology Autism Spectrum Disorder/pathology/physiopathology Basolateral Nuclear Complex/pathology/physiopathology Central Amygdaloid Nucleus/pathology/physiopathology Connectome Efferent Pathways/pathology/physiopathology Emotions Female Humans Image Processing, Computer-Assisted Magnetic Resonance Imaging Male Models, Neurological Models, Psychological Neocortex/pathology/physiopathology Nerve Net/pathology/physiopathology Signal-To-Noise Ratio Social Perception Surveys and Questionnaires Temporal Lobe/pathology/physiopathology Young Adult Amygdala Autism spectrum disorder Centromedial Connectivity Input-output Laterobasal Nuclei Superficial Index. décimale : PER Périodiques Résumé : BACKGROUND: Amygdala dysfunction is hypothesized to underlie the social deficits observed in autism spectrum disorders (ASD). However, the neurobiological basis of this hypothesis is underspecified because it is unknown whether ASD relates to abnormalities of the amygdaloid input or output nuclei. Here, we investigated the functional connectivity of the amygdaloid social-perceptual input nuclei and emotion-regulation output nuclei in ASD versus controls. METHODS: We collected resting state functional magnetic resonance imaging (fMRI) data, tailored to provide optimal sensitivity in the amygdala as well as the neocortex, in 20 adolescents and young adults with ASD and 25 matched controls. We performed a regular correlation analysis between the entire amygdala (EA) and the whole brain and used a partial correlation analysis to investigate whole-brain functional connectivity uniquely related to each of the amygdaloid subregions. RESULTS: Between-group comparison of regular EA correlations showed significantly reduced connectivity in visuospatial and superior parietal areas in ASD compared to controls. Partial correlation analysis revealed that this effect was driven by the left superficial and right laterobasal input subregions, but not the centromedial output nuclei. CONCLUSIONS: These results indicate reduced connectivity of specifically the amygdaloid sensory input channels in ASD, suggesting that abnormal amygdalo-cortical connectivity can be traced down to the socio-perceptual pathways. En ligne : http://dx.doi.org/10.1186/s13229-015-0060-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=329
in Molecular Autism > 7 (2016) . - 13p.[article] Altered functional connectivity of the amygdaloid input nuclei in adolescents and young adults with autism spectrum disorder: a resting state fMRI study [Texte imprimé et/ou numérique] / A. RAUSCH, Auteur ; W. ZHANG, Auteur ; K. V. HAAK, Auteur ; M. MENNES, Auteur ; E. J. HERMANS, Auteur ; E. VAN OORT, Auteur ; G. VAN WINGEN, Auteur ; Christian F. BECKMANN, Auteur ; Jan K. BUITELAAR, Auteur ; W. B. GROEN, Auteur . - 13p.
Langues : Anglais (eng)
in Molecular Autism > 7 (2016) . - 13p.
Mots-clés : Adolescent Afferent Pathways/pathology/physiopathology Amygdala/pathology/physiopathology Autism Spectrum Disorder/pathology/physiopathology Basolateral Nuclear Complex/pathology/physiopathology Central Amygdaloid Nucleus/pathology/physiopathology Connectome Efferent Pathways/pathology/physiopathology Emotions Female Humans Image Processing, Computer-Assisted Magnetic Resonance Imaging Male Models, Neurological Models, Psychological Neocortex/pathology/physiopathology Nerve Net/pathology/physiopathology Signal-To-Noise Ratio Social Perception Surveys and Questionnaires Temporal Lobe/pathology/physiopathology Young Adult Amygdala Autism spectrum disorder Centromedial Connectivity Input-output Laterobasal Nuclei Superficial Index. décimale : PER Périodiques Résumé : BACKGROUND: Amygdala dysfunction is hypothesized to underlie the social deficits observed in autism spectrum disorders (ASD). However, the neurobiological basis of this hypothesis is underspecified because it is unknown whether ASD relates to abnormalities of the amygdaloid input or output nuclei. Here, we investigated the functional connectivity of the amygdaloid social-perceptual input nuclei and emotion-regulation output nuclei in ASD versus controls. METHODS: We collected resting state functional magnetic resonance imaging (fMRI) data, tailored to provide optimal sensitivity in the amygdala as well as the neocortex, in 20 adolescents and young adults with ASD and 25 matched controls. We performed a regular correlation analysis between the entire amygdala (EA) and the whole brain and used a partial correlation analysis to investigate whole-brain functional connectivity uniquely related to each of the amygdaloid subregions. RESULTS: Between-group comparison of regular EA correlations showed significantly reduced connectivity in visuospatial and superior parietal areas in ASD compared to controls. Partial correlation analysis revealed that this effect was driven by the left superficial and right laterobasal input subregions, but not the centromedial output nuclei. CONCLUSIONS: These results indicate reduced connectivity of specifically the amygdaloid sensory input channels in ASD, suggesting that abnormal amygdalo-cortical connectivity can be traced down to the socio-perceptual pathways. En ligne : http://dx.doi.org/10.1186/s13229-015-0060-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=329 Commentary: Developmental connectomics to advance our understanding of typical and atypical brain development – a commentary on Vértes and Bullmore () / Alice M. GRAHAM in Journal of Child Psychology and Psychiatry, 56-3 (March 2015)
[article]
Titre : Commentary: Developmental connectomics to advance our understanding of typical and atypical brain development – a commentary on Vértes and Bullmore () Type de document : Texte imprimé et/ou numérique Auteurs : Alice M. GRAHAM, Auteur ; Damien A. FAIR, Auteur Article en page(s) : p.321-323 Langues : Anglais (eng) Mots-clés : Brain development neuropsychiatric disorders neuroimaging connectome DOHad Index. décimale : PER Périodiques Résumé : Vértes and Bullmore's article lays a framework for applying connectomics, the study of brain function from the perspective of underlying network organization, to advance understanding of healthy and maladaptive brain development. They elucidate the power of connectomics for bridging both different levels of analysis (e.g. from synapses to brain regions) and multiple academic fields. In this commentary, we highlight important themes and remaining questions stemming from Vértes and Bullmore's work, including: (a) the application of connectomics in the context of integrating analyses across multiple spatial and temporal dimensions, (b) the extent to which connectomics might be applied in translational and clinical studies of development, (c) growth connectomics and the Developmental Origins of Health and Disease (DOHaD) hypothesis, and (d) the importance and complexity of sound methodological practices in applying connectomics to developmental and clinical science. Ongoing work in these areas will be important for fulfilling the promise of connectomics as a bridge between neuroscience, developmental science, and translational and clinical research. En ligne : http://dx.doi.org/10.1111/jcpp.12400 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260
in Journal of Child Psychology and Psychiatry > 56-3 (March 2015) . - p.321-323[article] Commentary: Developmental connectomics to advance our understanding of typical and atypical brain development – a commentary on Vértes and Bullmore () [Texte imprimé et/ou numérique] / Alice M. GRAHAM, Auteur ; Damien A. FAIR, Auteur . - p.321-323.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 56-3 (March 2015) . - p.321-323
Mots-clés : Brain development neuropsychiatric disorders neuroimaging connectome DOHad Index. décimale : PER Périodiques Résumé : Vértes and Bullmore's article lays a framework for applying connectomics, the study of brain function from the perspective of underlying network organization, to advance understanding of healthy and maladaptive brain development. They elucidate the power of connectomics for bridging both different levels of analysis (e.g. from synapses to brain regions) and multiple academic fields. In this commentary, we highlight important themes and remaining questions stemming from Vértes and Bullmore's work, including: (a) the application of connectomics in the context of integrating analyses across multiple spatial and temporal dimensions, (b) the extent to which connectomics might be applied in translational and clinical studies of development, (c) growth connectomics and the Developmental Origins of Health and Disease (DOHaD) hypothesis, and (d) the importance and complexity of sound methodological practices in applying connectomics to developmental and clinical science. Ongoing work in these areas will be important for fulfilling the promise of connectomics as a bridge between neuroscience, developmental science, and translational and clinical research. En ligne : http://dx.doi.org/10.1111/jcpp.12400 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260 Effects of Overweight or Obesity on Brain Resting State Functional Connectivity of Children with Autism Spectrum Disorder / Chanaka N. KAHATHUDUWA in Journal of Autism and Developmental Disorders, 49-12 (December 2019)
PermalinkNeuroanatomie fonctionnelle du langage : un nouveau schéma connectomique / Sylvie MORITZ-GASSER in Rééducation Orthophonique, 274 (Juin 2018)
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