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Auditory event-related potentials and associations with sensory patterns in children with autism spectrum disorder, developmental delay, and typical development / Franc C L. DONKERS in Autism, 24-5 (July 2020)
[article]
Titre : Auditory event-related potentials and associations with sensory patterns in children with autism spectrum disorder, developmental delay, and typical development Type de document : Texte imprimé et/ou numérique Auteurs : Franc C L. DONKERS, Auteur ; Mike CARLSON, Auteur ; Sarah E. SCHIPUL, Auteur ; Aysenil BELGER, Auteur ; Grace T. BARANEK, Auteur Article en page(s) : p.1093-1110 Langues : Anglais (eng) Mots-clés : autism spectrum disorders development sensory impairments interest. Index. décimale : PER Périodiques Résumé : Atypical sensory response patterns are common in children with autism and developmental delay. Expanding on previous work, this observational electroencephalogram study assessed auditory event-related potentials and their associations with clinically evaluated sensory response patterns in children with autism spectrum disorder (n?=?28), developmental delay (n?=?17), and typical development (n?=?39). Attention-orienting P3a responses were attenuated in autism spectrum disorder relative to both developmental delay and typical development, but early sensory N2 responses were attenuated in both autism spectrum disorder and developmental delay relative to typical development. Attenuated event-related potentials involving N2 or P3a components, or a P1?×?N2 interaction, were related to more severe hyporesponsive or sensory-seeking response patterns across children with autism spectrum disorder and developmental delay. Thus, although attentional disruptions may be unique to autism spectrum disorder, sensory disruptions appear across developmental delay and are associated with atypical sensory behaviors. En ligne : http://dx.doi.org/10.1177/1362361319893196 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=426
in Autism > 24-5 (July 2020) . - p.1093-1110[article] Auditory event-related potentials and associations with sensory patterns in children with autism spectrum disorder, developmental delay, and typical development [Texte imprimé et/ou numérique] / Franc C L. DONKERS, Auteur ; Mike CARLSON, Auteur ; Sarah E. SCHIPUL, Auteur ; Aysenil BELGER, Auteur ; Grace T. BARANEK, Auteur . - p.1093-1110.
Langues : Anglais (eng)
in Autism > 24-5 (July 2020) . - p.1093-1110
Mots-clés : autism spectrum disorders development sensory impairments interest. Index. décimale : PER Périodiques Résumé : Atypical sensory response patterns are common in children with autism and developmental delay. Expanding on previous work, this observational electroencephalogram study assessed auditory event-related potentials and their associations with clinically evaluated sensory response patterns in children with autism spectrum disorder (n?=?28), developmental delay (n?=?17), and typical development (n?=?39). Attention-orienting P3a responses were attenuated in autism spectrum disorder relative to both developmental delay and typical development, but early sensory N2 responses were attenuated in both autism spectrum disorder and developmental delay relative to typical development. Attenuated event-related potentials involving N2 or P3a components, or a P1?×?N2 interaction, were related to more severe hyporesponsive or sensory-seeking response patterns across children with autism spectrum disorder and developmental delay. Thus, although attentional disruptions may be unique to autism spectrum disorder, sensory disruptions appear across developmental delay and are associated with atypical sensory behaviors. En ligne : http://dx.doi.org/10.1177/1362361319893196 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=426 California Autism Prevalence by County and Race/Ethnicity: Declining Trends Among Wealthy Whites / Cynthia NEVISON in Journal of Autism and Developmental Disorders, 50-11 (November 2020)
[article]
Titre : California Autism Prevalence by County and Race/Ethnicity: Declining Trends Among Wealthy Whites Type de document : Texte imprimé et/ou numérique Auteurs : Cynthia NEVISON, Auteur ; William PARKER, Auteur Article en page(s) : p.4011-4021 Langues : Anglais (eng) Mots-clés : Asian Autism spectrum disorder Black California County Hispanic Income Prevalence Race/ethnicity Silicon Valley Time trends White or financial relationships that could be construed as a potential conflict of interest. Index. décimale : PER Périodiques Résumé : County-level ASD prevalence was estimated using an age-resolved snapshot from the California Department of Developmental Services (DDS) for birth years 1993-2013. ASD prevalence increased among all children across birth years 1993-2000 but plateaued or declined thereafter among whites from wealthy counties. In contrast, ASD rates increased continuously across 1993-2013 among whites from lower income counties and Hispanics from all counties. Both white ASD prevalence and rate of change in prevalence were inversely correlated to county income from birth year 2000-2013 but not 1993-2000. These disparate trends within the dataset suggest that wealthy white parents, starting around 2000, may have begun opting out of DDS in favor of private care and/or making changes that effectively lowered their children's risk of ASD. En ligne : http://dx.doi.org/10.1007/s10803-020-04460-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=432
in Journal of Autism and Developmental Disorders > 50-11 (November 2020) . - p.4011-4021[article] California Autism Prevalence by County and Race/Ethnicity: Declining Trends Among Wealthy Whites [Texte imprimé et/ou numérique] / Cynthia NEVISON, Auteur ; William PARKER, Auteur . - p.4011-4021.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 50-11 (November 2020) . - p.4011-4021
Mots-clés : Asian Autism spectrum disorder Black California County Hispanic Income Prevalence Race/ethnicity Silicon Valley Time trends White or financial relationships that could be construed as a potential conflict of interest. Index. décimale : PER Périodiques Résumé : County-level ASD prevalence was estimated using an age-resolved snapshot from the California Department of Developmental Services (DDS) for birth years 1993-2013. ASD prevalence increased among all children across birth years 1993-2000 but plateaued or declined thereafter among whites from wealthy counties. In contrast, ASD rates increased continuously across 1993-2013 among whites from lower income counties and Hispanics from all counties. Both white ASD prevalence and rate of change in prevalence were inversely correlated to county income from birth year 2000-2013 but not 1993-2000. These disparate trends within the dataset suggest that wealthy white parents, starting around 2000, may have begun opting out of DDS in favor of private care and/or making changes that effectively lowered their children's risk of ASD. En ligne : http://dx.doi.org/10.1007/s10803-020-04460-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=432 Elevated de novo protein synthesis in FMRP-deficient human neurons and its correction by metformin treatment / Kagistia Hana UTAMI in Molecular Autism, 11 (2020)
[article]
Titre : Elevated de novo protein synthesis in FMRP-deficient human neurons and its correction by metformin treatment Type de document : Texte imprimé et/ou numérique Auteurs : Kagistia Hana UTAMI, Auteur ; Nur Amirah Binte Mohammad YUSOF, Auteur ; Jing Eugene KWA, Auteur ; Ulla-Kaisa PETERI, Auteur ; Maija L. CASTRÉN, Auteur ; Mahmoud A. POULADI, Auteur Article en page(s) : 41 p. Langues : Anglais (eng) Mots-clés : Fragile X syndrome Human stem cells Protein synthesis Therapy interest. Index. décimale : PER Périodiques Résumé : FXS is the most common genetic cause of intellectual (ID) and autism spectrum disorders (ASD). FXS is caused by loss of FMRP, an RNA-binding protein involved in the translational regulation of a large number of neuronal mRNAs. Absence of FMRP has been shown to lead to elevated protein synthesis and is thought to be a major cause of the synaptic plasticity and behavioural deficits in FXS. The increase in protein synthesis results in part from abnormal activation of key protein translation pathways downstream of ERK1/2 and mTOR signalling. Pharmacological and genetic interventions that attenuate hyperactivation of these pathways can normalize levels of protein synthesis and improve phenotypic outcomes in animal models of FXS. Several efforts are currently underway to trial this strategy in patients with FXS. To date, elevated global protein synthesis as a result of FMRP loss has not been validated in the context of human neurons. Here, using an isogenic human stem cell-based model, we show that de novo protein synthesis is elevated in FMRP-deficient neural cells. We further show that this increase is associated with elevated ERK1/2 and Akt signalling and can be rescued by metformin treatment. Finally, we examined the effect of normalizing protein synthesis on phenotypic abnormalities in FMRP-deficient neural cells. We find that treatment with metformin attenuates the increase in proliferation of FMRP-deficient neural progenitor cells but not the neuronal deficits in neurite outgrowth. The elevated level of protein synthesis and the normalization of neural progenitor proliferation by metformin treatment were validated in additional control and FXS patient-derived hiPSC lines. Overall, our results validate that loss of FMRP results in elevated de novo protein synthesis in human neurons and suggest that approaches targeting this abnormality are likely to be of partial therapeutic benefit in FXS. En ligne : http://dx.doi.org/10.1186/s13229-020-00350-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=427
in Molecular Autism > 11 (2020) . - 41 p.[article] Elevated de novo protein synthesis in FMRP-deficient human neurons and its correction by metformin treatment [Texte imprimé et/ou numérique] / Kagistia Hana UTAMI, Auteur ; Nur Amirah Binte Mohammad YUSOF, Auteur ; Jing Eugene KWA, Auteur ; Ulla-Kaisa PETERI, Auteur ; Maija L. CASTRÉN, Auteur ; Mahmoud A. POULADI, Auteur . - 41 p.
Langues : Anglais (eng)
in Molecular Autism > 11 (2020) . - 41 p.
Mots-clés : Fragile X syndrome Human stem cells Protein synthesis Therapy interest. Index. décimale : PER Périodiques Résumé : FXS is the most common genetic cause of intellectual (ID) and autism spectrum disorders (ASD). FXS is caused by loss of FMRP, an RNA-binding protein involved in the translational regulation of a large number of neuronal mRNAs. Absence of FMRP has been shown to lead to elevated protein synthesis and is thought to be a major cause of the synaptic plasticity and behavioural deficits in FXS. The increase in protein synthesis results in part from abnormal activation of key protein translation pathways downstream of ERK1/2 and mTOR signalling. Pharmacological and genetic interventions that attenuate hyperactivation of these pathways can normalize levels of protein synthesis and improve phenotypic outcomes in animal models of FXS. Several efforts are currently underway to trial this strategy in patients with FXS. To date, elevated global protein synthesis as a result of FMRP loss has not been validated in the context of human neurons. Here, using an isogenic human stem cell-based model, we show that de novo protein synthesis is elevated in FMRP-deficient neural cells. We further show that this increase is associated with elevated ERK1/2 and Akt signalling and can be rescued by metformin treatment. Finally, we examined the effect of normalizing protein synthesis on phenotypic abnormalities in FMRP-deficient neural cells. We find that treatment with metformin attenuates the increase in proliferation of FMRP-deficient neural progenitor cells but not the neuronal deficits in neurite outgrowth. The elevated level of protein synthesis and the normalization of neural progenitor proliferation by metformin treatment were validated in additional control and FXS patient-derived hiPSC lines. Overall, our results validate that loss of FMRP results in elevated de novo protein synthesis in human neurons and suggest that approaches targeting this abnormality are likely to be of partial therapeutic benefit in FXS. En ligne : http://dx.doi.org/10.1186/s13229-020-00350-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=427 Impact of childhood maltreatment and resilience on behavioral and neural patterns of inhibitory control during emotional distraction / Lauren A. DEMERS in Development and Psychopathology, 34-4 (October 2022)
[article]
Titre : Impact of childhood maltreatment and resilience on behavioral and neural patterns of inhibitory control during emotional distraction Type de document : Texte imprimé et/ou numérique Auteurs : Lauren A. DEMERS, Auteur ; Ruskin H. HUNT, Auteur ; Dante CICCHETTI, Auteur ; Julia E. COHEN-GILBERT, Auteur ; Fred A. ROGOSCH, Auteur ; Sheree L. TOTH, Auteur ; Kathleen M. THOMAS, Auteur Article en page(s) : p.1260-1271 Langues : Anglais (eng) Mots-clés : Adult Attention Brain/diagnostic imaging Child Child Abuse/psychology Emotional Regulation Emotions/physiology Humans Magnetic Resonance Imaging childhood maltreatment emotion impulsivity inhibitory control prefrontal cortex interest. Index. décimale : PER Périodiques Résumé : Exposure to childhood maltreatment (CM) may disrupt typical development of neural systems underlying impulse control and emotion regulation. Yet resilient outcomes are observed in some individuals exposed to CM. Individual differences in adult functioning may result from variation in inhibitory control in the context of emotional distractions, underpinned by cognitive-affective brain circuits. Thirty-eight healthy adults with a history of substantiated CM and 34 nonmaltreated adults from the same longitudinal sample performed a Go/No-Go task in which task-relevant stimuli (letters) were presented at the center of task-irrelevant, negative, or neutral images, while undergoing functional magnetic resonance imaging. The comparison group, but not the maltreated group, made increased inhibitory control errors in the context of negative, but not neutral, distractor images. In addition, the comparison group had greater right inferior frontal gyrus and bilateral frontal pole activation during inhibitory control blocks with negative compared to neutral background images relative to the CM group. Across the full sample, greater adaptive functioning in everyday contexts was associated with superior inhibitory control and greater right frontal pole activation. Results suggest that resilience following early adversity is associated with enhanced attention and behavioral regulation in the context of task-irrelevant negative emotional stimuli in a laboratory setting. En ligne : http://dx.doi.org/10.1017/s0954579421000055 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488
in Development and Psychopathology > 34-4 (October 2022) . - p.1260-1271[article] Impact of childhood maltreatment and resilience on behavioral and neural patterns of inhibitory control during emotional distraction [Texte imprimé et/ou numérique] / Lauren A. DEMERS, Auteur ; Ruskin H. HUNT, Auteur ; Dante CICCHETTI, Auteur ; Julia E. COHEN-GILBERT, Auteur ; Fred A. ROGOSCH, Auteur ; Sheree L. TOTH, Auteur ; Kathleen M. THOMAS, Auteur . - p.1260-1271.
Langues : Anglais (eng)
in Development and Psychopathology > 34-4 (October 2022) . - p.1260-1271
Mots-clés : Adult Attention Brain/diagnostic imaging Child Child Abuse/psychology Emotional Regulation Emotions/physiology Humans Magnetic Resonance Imaging childhood maltreatment emotion impulsivity inhibitory control prefrontal cortex interest. Index. décimale : PER Périodiques Résumé : Exposure to childhood maltreatment (CM) may disrupt typical development of neural systems underlying impulse control and emotion regulation. Yet resilient outcomes are observed in some individuals exposed to CM. Individual differences in adult functioning may result from variation in inhibitory control in the context of emotional distractions, underpinned by cognitive-affective brain circuits. Thirty-eight healthy adults with a history of substantiated CM and 34 nonmaltreated adults from the same longitudinal sample performed a Go/No-Go task in which task-relevant stimuli (letters) were presented at the center of task-irrelevant, negative, or neutral images, while undergoing functional magnetic resonance imaging. The comparison group, but not the maltreated group, made increased inhibitory control errors in the context of negative, but not neutral, distractor images. In addition, the comparison group had greater right inferior frontal gyrus and bilateral frontal pole activation during inhibitory control blocks with negative compared to neutral background images relative to the CM group. Across the full sample, greater adaptive functioning in everyday contexts was associated with superior inhibitory control and greater right frontal pole activation. Results suggest that resilience following early adversity is associated with enhanced attention and behavioral regulation in the context of task-irrelevant negative emotional stimuli in a laboratory setting. En ligne : http://dx.doi.org/10.1017/s0954579421000055 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488 Incremental Utility of 24-Month Autism Spectrum Disorder Screening After Negative 18-Month Screening / Yael G. DAI in Journal of Autism and Developmental Disorders, 50-6 (June 2020)
[article]
Titre : Incremental Utility of 24-Month Autism Spectrum Disorder Screening After Negative 18-Month Screening Type de document : Texte imprimé et/ou numérique Auteurs : Yael G. DAI, Auteur ; Lauren E. MILLER, Auteur ; Riane K. RAMSEY, Auteur ; Diana L. ROBINS, Auteur ; Deborah A. FEIN, Auteur ; Thyde DUMONT-MATHIEU, Auteur Article en page(s) : p.2030-2040 Langues : Anglais (eng) Mots-clés : 18 Months 24 Months Autism Spectrum Disorder Early identification M-chat Screening which receives royalties from companies that incorporate the M-CHAT(-R) into commercial products. Data in the current study are from the freely available version of the M-CHAT(-R). The remaining authors declare that they have no conflict of interest. Index. décimale : PER Périodiques Résumé : The American Academy of Pediatrics recommends Autism Spectrum Disorder (ASD) screening at 18 and 24 months. However, utility of rescreening at 24 months, after a negative 18-month screening, remains unknown. We identified cases of ASD detected at 24 months after a negative 18-month screening (i.e., Catch-24 group; n?=?10) and compared them to toddlers detected by 18-month screening (i.e., Early Diagnosis group; n?=?203). Repeated ASD-specific screening at 24 months detected children who were missed at their 18-month screening. Thus, our findings support repeated screening for ASD at both 18 and 24 months in order to maximize identification of toddlers with ASD and other neurodevelopmental disorders who require intervention. En ligne : http://dx.doi.org/10.1007/s10803-019-03959-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=425
in Journal of Autism and Developmental Disorders > 50-6 (June 2020) . - p.2030-2040[article] Incremental Utility of 24-Month Autism Spectrum Disorder Screening After Negative 18-Month Screening [Texte imprimé et/ou numérique] / Yael G. DAI, Auteur ; Lauren E. MILLER, Auteur ; Riane K. RAMSEY, Auteur ; Diana L. ROBINS, Auteur ; Deborah A. FEIN, Auteur ; Thyde DUMONT-MATHIEU, Auteur . - p.2030-2040.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 50-6 (June 2020) . - p.2030-2040
Mots-clés : 18 Months 24 Months Autism Spectrum Disorder Early identification M-chat Screening which receives royalties from companies that incorporate the M-CHAT(-R) into commercial products. Data in the current study are from the freely available version of the M-CHAT(-R). The remaining authors declare that they have no conflict of interest. Index. décimale : PER Périodiques Résumé : The American Academy of Pediatrics recommends Autism Spectrum Disorder (ASD) screening at 18 and 24 months. However, utility of rescreening at 24 months, after a negative 18-month screening, remains unknown. We identified cases of ASD detected at 24 months after a negative 18-month screening (i.e., Catch-24 group; n?=?10) and compared them to toddlers detected by 18-month screening (i.e., Early Diagnosis group; n?=?203). Repeated ASD-specific screening at 24 months detected children who were missed at their 18-month screening. Thus, our findings support repeated screening for ASD at both 18 and 24 months in order to maximize identification of toddlers with ASD and other neurodevelopmental disorders who require intervention. En ligne : http://dx.doi.org/10.1007/s10803-019-03959-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=425 Iterative redesign of a caregiver-mediated intervention for use in educational settings / Karen BEARSS in Autism, 26-3 (April 2022)
PermalinkModel Teachers or Model Students? A Comparison of Video Modelling Interventions for Improving Reading Fluency and Comprehension in Children with Autism / Rachael EGARR in Journal of Autism and Developmental Disorders, 52-8 (August 2022)
PermalinkPeri-Pregnancy Cannabis Use and Autism Spectrum Disorder in the Offspring: Findings from the Study to Explore Early Development / Carolyn G. DIGUISEPPI in Journal of Autism and Developmental Disorders, 52-11 (November 2022)
PermalinkA Pilot Randomised Control Trial of Digitally-Mediated Social Stories for Children on the Autism Spectrum / R. HANRAHAN in Journal of Autism and Developmental Disorders, 50-12 (December 2020)
PermalinkA Randomized, Community-Based Feasibility Trial of Modified ESDM for Toddlers with Suspected Autism / Pat MIRENDA in Journal of Autism and Developmental Disorders, 52-12 (December 2022)
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