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Neonatal Thyroid Stimulating Hormone and Subsequent Diagnosis of Autism Spectrum Disorders and Intellectual Disability / Jennifer L. AMES in Autism Research, 13-3 (March 2020)
[article]
Titre : Neonatal Thyroid Stimulating Hormone and Subsequent Diagnosis of Autism Spectrum Disorders and Intellectual Disability Type de document : Texte imprimé et/ou numérique Auteurs : Jennifer L. AMES, Auteur ; Gayle C. WINDHAM, Auteur ; Kristen LYALL, Auteur ; Michelle PEARL, Auteur ; Martin KHARRAZI, Auteur ; Cathleen K. YOSHIDA, Auteur ; Judy VAN DE WATER, Auteur ; Paul ASHWOOD, Auteur ; Lisa A. CROEN, Auteur Article en page(s) : p.444-455 Langues : Anglais (eng) Mots-clés : Asd autism intellectual disability neonatal thyroid thyroid-stimulating hormone Index. décimale : PER Périodiques Résumé : Hypothyroid conditions in early life, if left untreated, are associated with adverse neurodevelopmental outcomes, including intellectual disability (ID). However, evidence addressing the role of neonatal thyroid hormone insufficiencies in the altered neurobiology underlying autism spectrum disorders (ASD), particularly among its subphenotypes, is limited. We conducted a population-based, case-control study among a sample of children born during 2000-2003 in Southern California. We examined neonatal thyroid-stimulating hormone (TSH) measured during routine newborn screening among children later diagnosed with ASD (n = 518) or ID (n = 145) and general population (GP) controls (n = 399). TSH was further analyzed in relation to ASD subgroups of intellectual ability and onset type (early-onset ASD vs. ASD with regression) ascertained by expert review of developmental services records. Odds ratios (ORs) of the differences in TSH between groups were obtained from multivariate logistic regression. We examined neonatal TSH as continuous (ln-transformed) and as quartiles. We found no association between continuous neonatal TSH levels and ASD (adj-OR: 1.00, 95% CI: 0.79-1.26) nor ID (adj-OR = 1.01, 95% CI: 0.73-1.40). Among ASD subphenotypes, we observed a suggestive inverse trend between ASD with regression and TSH, though the association only reached statistical significance in the highest TSH quartile (adj-OR: 0.50, 95% CI: 0.26-0.98). While there was little evidence that neonatal TSH is related to overall ASD risk, more work is needed to understand the influence of thyroid hormones on ASD subphenotypes. Autism Res 2020, 13: 444-455. (c) 2019 International Society for Autism Research,Wiley Periodicals, Inc. LAY SUMMARY: Low levels of thyroid hormone at birth can negatively impact brain development. We studied whether newborn levels of thyroid stimulating hormone (TSH) were associated with autism spectrum disorder (ASD) and its subtypes in a sample of children born in California. Newborn TSH was not related to the overall risk of ASD or intellectual disability. However, the relationships of thyroid hormone levels at birth and specific subtypes of ASD, particularly ASD with developmental regression, may need more research. En ligne : http://dx.doi.org/10.1002/aur.2247 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=421
in Autism Research > 13-3 (March 2020) . - p.444-455[article] Neonatal Thyroid Stimulating Hormone and Subsequent Diagnosis of Autism Spectrum Disorders and Intellectual Disability [Texte imprimé et/ou numérique] / Jennifer L. AMES, Auteur ; Gayle C. WINDHAM, Auteur ; Kristen LYALL, Auteur ; Michelle PEARL, Auteur ; Martin KHARRAZI, Auteur ; Cathleen K. YOSHIDA, Auteur ; Judy VAN DE WATER, Auteur ; Paul ASHWOOD, Auteur ; Lisa A. CROEN, Auteur . - p.444-455.
Langues : Anglais (eng)
in Autism Research > 13-3 (March 2020) . - p.444-455
Mots-clés : Asd autism intellectual disability neonatal thyroid thyroid-stimulating hormone Index. décimale : PER Périodiques Résumé : Hypothyroid conditions in early life, if left untreated, are associated with adverse neurodevelopmental outcomes, including intellectual disability (ID). However, evidence addressing the role of neonatal thyroid hormone insufficiencies in the altered neurobiology underlying autism spectrum disorders (ASD), particularly among its subphenotypes, is limited. We conducted a population-based, case-control study among a sample of children born during 2000-2003 in Southern California. We examined neonatal thyroid-stimulating hormone (TSH) measured during routine newborn screening among children later diagnosed with ASD (n = 518) or ID (n = 145) and general population (GP) controls (n = 399). TSH was further analyzed in relation to ASD subgroups of intellectual ability and onset type (early-onset ASD vs. ASD with regression) ascertained by expert review of developmental services records. Odds ratios (ORs) of the differences in TSH between groups were obtained from multivariate logistic regression. We examined neonatal TSH as continuous (ln-transformed) and as quartiles. We found no association between continuous neonatal TSH levels and ASD (adj-OR: 1.00, 95% CI: 0.79-1.26) nor ID (adj-OR = 1.01, 95% CI: 0.73-1.40). Among ASD subphenotypes, we observed a suggestive inverse trend between ASD with regression and TSH, though the association only reached statistical significance in the highest TSH quartile (adj-OR: 0.50, 95% CI: 0.26-0.98). While there was little evidence that neonatal TSH is related to overall ASD risk, more work is needed to understand the influence of thyroid hormones on ASD subphenotypes. Autism Res 2020, 13: 444-455. (c) 2019 International Society for Autism Research,Wiley Periodicals, Inc. LAY SUMMARY: Low levels of thyroid hormone at birth can negatively impact brain development. We studied whether newborn levels of thyroid stimulating hormone (TSH) were associated with autism spectrum disorder (ASD) and its subtypes in a sample of children born in California. Newborn TSH was not related to the overall risk of ASD or intellectual disability. However, the relationships of thyroid hormone levels at birth and specific subtypes of ASD, particularly ASD with developmental regression, may need more research. En ligne : http://dx.doi.org/10.1002/aur.2247 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=421 A Descriptive Study on the Neonatal Morbidity Profile of Autism Spectrum Disorders, Including a Comparison with Other Neurodevelopmental Disorders / Hjördis Osk ATLADOTTIR in Journal of Autism and Developmental Disorders, 45-8 (August 2015)
[article]
Titre : A Descriptive Study on the Neonatal Morbidity Profile of Autism Spectrum Disorders, Including a Comparison with Other Neurodevelopmental Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Hjördis Osk ATLADOTTIR, Auteur ; Diana SCHENDEL, Auteur ; Erik T. PARNER, Auteur ; T. B. HENRIKSEN, Auteur Année de publication : 2015 Article en page(s) : p.2429-2442 Langues : Anglais (eng) Mots-clés : Autism Neonatal Hyperkinetic disorder CP Epilepsy Intellectual disability Index. décimale : PER Périodiques Résumé : The aim of this study was to describe the profile of specific neonatal morbidities in children later diagnosed with autism spectrum disorder (ASD), and to compare this profile with the profile of children with hyperkinetic disorder, cerebral palsy, epilepsy or intellectual disability. This is a Danish population based cohort study, including all children born in Denmark from 1994, through 2010, and surviving the first year of life. Children with ASD as a whole have significantly elevated rates of a range of neurologic, respiratory, inflammatory, and metabolic problems in the neonatal period compared to the general population, but there are few if any indicators of a distinctive neonatal morbidity profile in ASD compared to other neurodevelopmental outcomes. En ligne : http://dx.doi.org/10.1007/s10803-015-2408-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=263
in Journal of Autism and Developmental Disorders > 45-8 (August 2015) . - p.2429-2442[article] A Descriptive Study on the Neonatal Morbidity Profile of Autism Spectrum Disorders, Including a Comparison with Other Neurodevelopmental Disorders [Texte imprimé et/ou numérique] / Hjördis Osk ATLADOTTIR, Auteur ; Diana SCHENDEL, Auteur ; Erik T. PARNER, Auteur ; T. B. HENRIKSEN, Auteur . - 2015 . - p.2429-2442.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 45-8 (August 2015) . - p.2429-2442
Mots-clés : Autism Neonatal Hyperkinetic disorder CP Epilepsy Intellectual disability Index. décimale : PER Périodiques Résumé : The aim of this study was to describe the profile of specific neonatal morbidities in children later diagnosed with autism spectrum disorder (ASD), and to compare this profile with the profile of children with hyperkinetic disorder, cerebral palsy, epilepsy or intellectual disability. This is a Danish population based cohort study, including all children born in Denmark from 1994, through 2010, and surviving the first year of life. Children with ASD as a whole have significantly elevated rates of a range of neurologic, respiratory, inflammatory, and metabolic problems in the neonatal period compared to the general population, but there are few if any indicators of a distinctive neonatal morbidity profile in ASD compared to other neurodevelopmental outcomes. En ligne : http://dx.doi.org/10.1007/s10803-015-2408-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=263 The Role of Prenatal, Obstetric and Neonatal Factors in the Development of Autism / Linda DODDS in Journal of Autism and Developmental Disorders, 41-7 (July 2011)
[article]
Titre : The Role of Prenatal, Obstetric and Neonatal Factors in the Development of Autism Type de document : Texte imprimé et/ou numérique Auteurs : Linda DODDS, Auteur ; Deshayne B. FELL, Auteur ; Sarah SHEA, Auteur ; B. Anthony ARMSON, Auteur ; Alexander C. ALLEN, Auteur ; Susan E. BRYSON, Auteur Année de publication : 2011 Article en page(s) : p.891-902 Langues : Anglais (eng) Mots-clés : Autism Cohort Prenatal Pregnancy Neonatal Epidemiology Index. décimale : PER Périodiques Résumé : We conducted a linked database cohort study of infants born between 1990 and 2002 in Nova Scotia, Canada. Diagnoses of autism were identified from administrative databases with relevant diagnostic information to 2005. A factor representing genetic susceptibility was defined as having an affected sibling or a mother with a history of a psychiatric or neurologic condition. Among 129,733 children, there were 924 children with an autism diagnosis. The results suggest that among those with low genetic susceptibility, some maternal and obstetric factors may have an independent role in autism etiology whereas among genetically susceptible children, these factors appear to play a lesser role. The role of pre-pregnancy obesity and excessive weight gain during pregnancy on autism risk require further investigation. En ligne : http://dx.doi.org/10.1007/s10803-010-1114-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=130
in Journal of Autism and Developmental Disorders > 41-7 (July 2011) . - p.891-902[article] The Role of Prenatal, Obstetric and Neonatal Factors in the Development of Autism [Texte imprimé et/ou numérique] / Linda DODDS, Auteur ; Deshayne B. FELL, Auteur ; Sarah SHEA, Auteur ; B. Anthony ARMSON, Auteur ; Alexander C. ALLEN, Auteur ; Susan E. BRYSON, Auteur . - 2011 . - p.891-902.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 41-7 (July 2011) . - p.891-902
Mots-clés : Autism Cohort Prenatal Pregnancy Neonatal Epidemiology Index. décimale : PER Périodiques Résumé : We conducted a linked database cohort study of infants born between 1990 and 2002 in Nova Scotia, Canada. Diagnoses of autism were identified from administrative databases with relevant diagnostic information to 2005. A factor representing genetic susceptibility was defined as having an affected sibling or a mother with a history of a psychiatric or neurologic condition. Among 129,733 children, there were 924 children with an autism diagnosis. The results suggest that among those with low genetic susceptibility, some maternal and obstetric factors may have an independent role in autism etiology whereas among genetically susceptible children, these factors appear to play a lesser role. The role of pre-pregnancy obesity and excessive weight gain during pregnancy on autism risk require further investigation. En ligne : http://dx.doi.org/10.1007/s10803-010-1114-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=130 Impaired Gas Exchange at Birth and Risk of Intellectual Disability and Autism: A Meta-analysis / Amirhossein MODABBERNIA in Journal of Autism and Developmental Disorders, 46-5 (May 2016)
[article]
Titre : Impaired Gas Exchange at Birth and Risk of Intellectual Disability and Autism: A Meta-analysis Type de document : Texte imprimé et/ou numérique Auteurs : Amirhossein MODABBERNIA, Auteur ; Josephine MOLLON, Auteur ; Paolo BOFFETTA, Auteur ; Abraham REICHENBERG, Auteur Article en page(s) : p.1847-1859 Langues : Anglais (eng) Mots-clés : Asphyxia Autism Hypoxia Intellectual disability Neonatal Perinatal Index. décimale : PER Périodiques Résumé : We conducted meta-analyses of 67 studies on the association between neonatal proxies of impaired gas exchange and intellectual disability (ID) or autism spectrum disorders (ASD). Neonatal acidosis was associated with an odds ratio (OR) of 3.55 [95 % confidence interval (95 % CI) 2.23–5.49] for ID and an OR of 1.10 (95 % CI 0.91–1.31) for ASD. Children with a 5-min Apgar score of <7 had an OR of 5.39 (95 % CI 3.84–7.55) for ID and an OR of 1.67 (95 % CI 1.34–2.09) for ASD. O2 treatment was associated with an OR of 4.32 (95 % CI 3.23–5.78) for ID and an OR of 2.02 (95 % CI 1.45 to 2.83) for ASD. Our meta-analysis demonstrates an increased risk of ID and (to a lesser extent) ASD in children with neonatal hypoxia. Moreover, our findings raise the possibility that concomitant ID might account for the observed association between the gas exchange proxies and ASD. En ligne : http://dx.doi.org/10.1007/s10803-016-2717-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=288
in Journal of Autism and Developmental Disorders > 46-5 (May 2016) . - p.1847-1859[article] Impaired Gas Exchange at Birth and Risk of Intellectual Disability and Autism: A Meta-analysis [Texte imprimé et/ou numérique] / Amirhossein MODABBERNIA, Auteur ; Josephine MOLLON, Auteur ; Paolo BOFFETTA, Auteur ; Abraham REICHENBERG, Auteur . - p.1847-1859.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 46-5 (May 2016) . - p.1847-1859
Mots-clés : Asphyxia Autism Hypoxia Intellectual disability Neonatal Perinatal Index. décimale : PER Périodiques Résumé : We conducted meta-analyses of 67 studies on the association between neonatal proxies of impaired gas exchange and intellectual disability (ID) or autism spectrum disorders (ASD). Neonatal acidosis was associated with an odds ratio (OR) of 3.55 [95 % confidence interval (95 % CI) 2.23–5.49] for ID and an OR of 1.10 (95 % CI 0.91–1.31) for ASD. Children with a 5-min Apgar score of <7 had an OR of 5.39 (95 % CI 3.84–7.55) for ID and an OR of 1.67 (95 % CI 1.34–2.09) for ASD. O2 treatment was associated with an OR of 4.32 (95 % CI 3.23–5.78) for ID and an OR of 2.02 (95 % CI 1.45 to 2.83) for ASD. Our meta-analysis demonstrates an increased risk of ID and (to a lesser extent) ASD in children with neonatal hypoxia. Moreover, our findings raise the possibility that concomitant ID might account for the observed association between the gas exchange proxies and ASD. En ligne : http://dx.doi.org/10.1007/s10803-016-2717-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=288