Centre d'Information et de documentation du CRA Rhône-Alpes
CRA
Informations pratiques
-
Adresse
Centre d'information et de documentation
du CRA Rhône-Alpes
Centre Hospitalier le Vinatier
bât 211
95, Bd Pinel
69678 Bron CedexHoraires
Lundi au Vendredi
9h00-12h00 13h30-16h00Contact
Tél: +33(0)4 37 91 54 65
Mail
Fax: +33(0)4 37 91 54 37
-
Résultat de la recherche
2 recherche sur le mot-clé 'neurocognitive functioning'
Affiner la recherche Générer le flux rss de la recherche
Partager le résultat de cette recherche Faire une suggestion
Single nucleotide polymorphism heritability and differential patterns of genetic overlap between inattention and four neurocognitive factors in youth / Lauren MICALIZZI in Development and Psychopathology, 33-1 (February 2021)
[article]
Titre : Single nucleotide polymorphism heritability and differential patterns of genetic overlap between inattention and four neurocognitive factors in youth Type de document : Texte imprimé et/ou numérique Auteurs : Lauren MICALIZZI, Auteur ; Leslie A. BRICK, Auteur ; Marisa E. MARRACCINI, Auteur ; Chelsie E. BENCA-BACHMAN, Auteur ; Rohan H. C. PALMER, Auteur ; Valerie S. KNOPIK, Auteur Article en page(s) : p.76-86 Langues : Anglais (eng) Mots-clés : Gcta adolescence genetics heritability inattention neurocognitive functioning Index. décimale : PER Périodiques Résumé : Theoretical models of attention-deficit/hyperactivity disorder implicate neurocognitive dysfunction, yet neurocognitive functioning covers a range of abilities that may not all be linked with inattention. This study (a) investigated the single nucleotide polymorphism (SNP) heritability (h2SNP) of inattention and aspects of neurocognitive efficiency (memory, social cognition, executive function, and complex cognition) based on additive genome-wide effects; (b) examined if there were shared genetic effects among inattention and each aspect of neurocognitive efficiency; and (c) conducted an exploratory genome-wide association study to identify genetic regions associated with inattention. The sample included 3,563 participants of the Philadelphia Neurodevelopmental Cohort, a general population sample aged 8-21 years who completed the Penn Neurocognitive Battery. Data on inattention was obtained with the Kiddie Schedule of Affective Disorders (adapted). Genomic relatedness matrix restricted maximum likelihood was implemented in genome-wide complex trait analysis. Analyses revealed significant h2SNP for inattention (20%, SE = 0.08), social cognition (13%, SE = 0.08), memory (17%, SE = 0.08), executive function (25%, SE = 0.08), and complex cognition (24%, SE = 0.08). There was a positive genetic correlation (0.67, SE = 0.37) and a negative residual covariance (-0.23, SE = 0.06) between inattention and social cognition. No SNPs reached genome-wide significance for inattention. Results suggest specificity in genetic overlap among inattention and different aspects of neurocognitive efficiency. En ligne : http://dx.doi.org/10.1017/s0954579419001573 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=442
in Development and Psychopathology > 33-1 (February 2021) . - p.76-86[article] Single nucleotide polymorphism heritability and differential patterns of genetic overlap between inattention and four neurocognitive factors in youth [Texte imprimé et/ou numérique] / Lauren MICALIZZI, Auteur ; Leslie A. BRICK, Auteur ; Marisa E. MARRACCINI, Auteur ; Chelsie E. BENCA-BACHMAN, Auteur ; Rohan H. C. PALMER, Auteur ; Valerie S. KNOPIK, Auteur . - p.76-86.
Langues : Anglais (eng)
in Development and Psychopathology > 33-1 (February 2021) . - p.76-86
Mots-clés : Gcta adolescence genetics heritability inattention neurocognitive functioning Index. décimale : PER Périodiques Résumé : Theoretical models of attention-deficit/hyperactivity disorder implicate neurocognitive dysfunction, yet neurocognitive functioning covers a range of abilities that may not all be linked with inattention. This study (a) investigated the single nucleotide polymorphism (SNP) heritability (h2SNP) of inattention and aspects of neurocognitive efficiency (memory, social cognition, executive function, and complex cognition) based on additive genome-wide effects; (b) examined if there were shared genetic effects among inattention and each aspect of neurocognitive efficiency; and (c) conducted an exploratory genome-wide association study to identify genetic regions associated with inattention. The sample included 3,563 participants of the Philadelphia Neurodevelopmental Cohort, a general population sample aged 8-21 years who completed the Penn Neurocognitive Battery. Data on inattention was obtained with the Kiddie Schedule of Affective Disorders (adapted). Genomic relatedness matrix restricted maximum likelihood was implemented in genome-wide complex trait analysis. Analyses revealed significant h2SNP for inattention (20%, SE = 0.08), social cognition (13%, SE = 0.08), memory (17%, SE = 0.08), executive function (25%, SE = 0.08), and complex cognition (24%, SE = 0.08). There was a positive genetic correlation (0.67, SE = 0.37) and a negative residual covariance (-0.23, SE = 0.06) between inattention and social cognition. No SNPs reached genome-wide significance for inattention. Results suggest specificity in genetic overlap among inattention and different aspects of neurocognitive efficiency. En ligne : http://dx.doi.org/10.1017/s0954579419001573 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=442 Conduct disorder symptomatology is associated with an altered functional connectome in a large national youth sample / Scott TILLEM in Development and Psychopathology, 34-4 (October 2022)
[article]
Titre : Conduct disorder symptomatology is associated with an altered functional connectome in a large national youth sample Type de document : Texte imprimé et/ou numérique Auteurs : Scott TILLEM, Auteur ; May I. CONLEY, Auteur ; Arielle BASKIN-SOMMERS, Auteur Article en page(s) : p.1573-1584 Langues : Anglais (eng) Mots-clés : Adolescent Brain Child Cluster Analysis Conduct Disorder/diagnostic imaging Connectome Humans Magnetic Resonance Imaging/methods conduct disorder graph analysis neural topology neurocognitive functioning subcortical structures Index. décimale : PER Périodiques Résumé : Conduct disorder (CD), characterized by youth antisocial behavior, is associated with a variety of neurocognitive impairments. However, questions remain regarding the neural underpinnings of these impairments. To investigate novel neural mechanisms that may support these neurocognitive abnormalities, the present study applied a graph analysis to resting-state functional magnetic resonance imaging (fMRI) data collected from a national sample of 4,781 youth, ages 9-10, who participated in the baseline session of the Adolescent Brain Cognitive Development(SM) Study (ABCD Study®). Analyses were then conducted to examine the relationships among levels of CD symptomatology, metrics of global topology, node-level metrics for subcortical structures, and performance on neurocognitive assessments. Youth higher on CD displayed higher global clustering (Î2= .039, 95% CI(corrected) [.0027 .0771]), but lower Degree(subcortical) (Î2= -.052, 95% CI(corrected) [-.0916 -.0152]). Youth higher on CD had worse performance on a general neurocognitive assessment (Î2= -.104, 95% CI [-.1328 -.0763]) and an emotion recognition memory assessment (Î2= -.061, 95% CI [-.0919 -.0290]). Finally, global clustering mediated the relationship between CD and general neurocognitive functioning (indirect Î2= -.002, 95% CI [-.0044 -.0002]), and Degree(subcortical) mediated the relationship between CD and emotion recognition memory performance (indirect Î2= -.002, 95% CI [-.0046 -.0005]). CD appears associated with neuro-topological abnormalities and these abnormalities may represent neural mechanisms supporting CD-related neurocognitive disruptions. En ligne : http://dx.doi.org/10.1017/s0954579421000237 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=489
in Development and Psychopathology > 34-4 (October 2022) . - p.1573-1584[article] Conduct disorder symptomatology is associated with an altered functional connectome in a large national youth sample [Texte imprimé et/ou numérique] / Scott TILLEM, Auteur ; May I. CONLEY, Auteur ; Arielle BASKIN-SOMMERS, Auteur . - p.1573-1584.
Langues : Anglais (eng)
in Development and Psychopathology > 34-4 (October 2022) . - p.1573-1584
Mots-clés : Adolescent Brain Child Cluster Analysis Conduct Disorder/diagnostic imaging Connectome Humans Magnetic Resonance Imaging/methods conduct disorder graph analysis neural topology neurocognitive functioning subcortical structures Index. décimale : PER Périodiques Résumé : Conduct disorder (CD), characterized by youth antisocial behavior, is associated with a variety of neurocognitive impairments. However, questions remain regarding the neural underpinnings of these impairments. To investigate novel neural mechanisms that may support these neurocognitive abnormalities, the present study applied a graph analysis to resting-state functional magnetic resonance imaging (fMRI) data collected from a national sample of 4,781 youth, ages 9-10, who participated in the baseline session of the Adolescent Brain Cognitive Development(SM) Study (ABCD Study®). Analyses were then conducted to examine the relationships among levels of CD symptomatology, metrics of global topology, node-level metrics for subcortical structures, and performance on neurocognitive assessments. Youth higher on CD displayed higher global clustering (Î2= .039, 95% CI(corrected) [.0027 .0771]), but lower Degree(subcortical) (Î2= -.052, 95% CI(corrected) [-.0916 -.0152]). Youth higher on CD had worse performance on a general neurocognitive assessment (Î2= -.104, 95% CI [-.1328 -.0763]) and an emotion recognition memory assessment (Î2= -.061, 95% CI [-.0919 -.0290]). Finally, global clustering mediated the relationship between CD and general neurocognitive functioning (indirect Î2= -.002, 95% CI [-.0044 -.0002]), and Degree(subcortical) mediated the relationship between CD and emotion recognition memory performance (indirect Î2= -.002, 95% CI [-.0046 -.0005]). CD appears associated with neuro-topological abnormalities and these abnormalities may represent neural mechanisms supporting CD-related neurocognitive disruptions. En ligne : http://dx.doi.org/10.1017/s0954579421000237 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=489