Centre d'Information et de documentation du CRA Rhône-Alpes
CRA
Informations pratiques
-
Adresse
Centre d'information et de documentation
du CRA Rhône-Alpes
Centre Hospitalier le Vinatier
bât 211
95, Bd Pinel
69678 Bron CedexHoraires
Lundi au Vendredi
9h00-12h00 13h30-16h00Contact
Tél: +33(0)4 37 91 54 65
Mail
Fax: +33(0)4 37 91 54 37
-
Résultat de la recherche
2 recherche sur le mot-clé 'oxytocin receptor gene'
Affiner la recherche Générer le flux rss de la recherche
Partager le résultat de cette recherche Faire une suggestion
Oxytocin receptor gene (OXTR) DNA methylation is associated with autism and related social traits – A systematic review / Matthijs MOERKERKE in Research in Autism Spectrum Disorders, 85 (July 2021)
[article]
Titre : Oxytocin receptor gene (OXTR) DNA methylation is associated with autism and related social traits – A systematic review Type de document : Texte imprimé et/ou numérique Auteurs : Matthijs MOERKERKE, Auteur ; Marie-Laure BONTE, Auteur ; Nicky DANIELS, Auteur ; Viktoria CHUBAR, Auteur ; Kaat ALAERTS, Auteur ; Jean STEYAERT, Auteur ; Bart BOETS, Auteur Article en page(s) : 101785 Langues : Anglais (eng) Mots-clés : Oxytocin receptor gene Epigenetics DNA methylation Autism Social behaviour Index. décimale : PER Périodiques Résumé : There is emerging evidence implicating oxytocin receptor gene (OXTR) DNA methylation (DNAm) in social behaviour. This review investigated its association with autism spectrum disorder (ASD) characteristics and related social dimensions, both in individuals with and without ASD. Twelve articles investigating OXTR DNAm in relation to ASD, social perception/cognition and social anxiety were included. We found that hypermethylation is associated with (i) higher quantitative autism traits in adults, reflecting a higher incidence of autism characteristics, (ii) increased brain activity while performing social tasks (indicating a higher need for resources) and (iii) decreased functional connectivity. (iv) Contradictory, hypomethylation was found to be present in children (especially boys) with ASD and was also associated with more social anxiety. While the included studies displayed a large variability, for example in terms of population characteristics, analysed OXTR DNAm regions, and adopted scales/questionnaires, an initial developmental pattern of results emerged, suggesting an association between hypermethylation of OXTR and autism traits in adults. Nonetheless, future studies are warranted to corroborate these initial conclusions. En ligne : https://doi.org/10.1016/j.rasd.2021.101785 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=458
in Research in Autism Spectrum Disorders > 85 (July 2021) . - 101785[article] Oxytocin receptor gene (OXTR) DNA methylation is associated with autism and related social traits – A systematic review [Texte imprimé et/ou numérique] / Matthijs MOERKERKE, Auteur ; Marie-Laure BONTE, Auteur ; Nicky DANIELS, Auteur ; Viktoria CHUBAR, Auteur ; Kaat ALAERTS, Auteur ; Jean STEYAERT, Auteur ; Bart BOETS, Auteur . - 101785.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 85 (July 2021) . - 101785
Mots-clés : Oxytocin receptor gene Epigenetics DNA methylation Autism Social behaviour Index. décimale : PER Périodiques Résumé : There is emerging evidence implicating oxytocin receptor gene (OXTR) DNA methylation (DNAm) in social behaviour. This review investigated its association with autism spectrum disorder (ASD) characteristics and related social dimensions, both in individuals with and without ASD. Twelve articles investigating OXTR DNAm in relation to ASD, social perception/cognition and social anxiety were included. We found that hypermethylation is associated with (i) higher quantitative autism traits in adults, reflecting a higher incidence of autism characteristics, (ii) increased brain activity while performing social tasks (indicating a higher need for resources) and (iii) decreased functional connectivity. (iv) Contradictory, hypomethylation was found to be present in children (especially boys) with ASD and was also associated with more social anxiety. While the included studies displayed a large variability, for example in terms of population characteristics, analysed OXTR DNAm regions, and adopted scales/questionnaires, an initial developmental pattern of results emerged, suggesting an association between hypermethylation of OXTR and autism traits in adults. Nonetheless, future studies are warranted to corroborate these initial conclusions. En ligne : https://doi.org/10.1016/j.rasd.2021.101785 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=458 Cumulative Risk of the Oxytocin Receptor Gene Interacts with Prenatal Exposure to Oxytocin Receptor Antagonist to Predict Children's Social Communication Development / E. FRIEDLANDER in Autism Research, 12-7 (July 2019)
[article]
Titre : Cumulative Risk of the Oxytocin Receptor Gene Interacts with Prenatal Exposure to Oxytocin Receptor Antagonist to Predict Children's Social Communication Development Type de document : Texte imprimé et/ou numérique Auteurs : E. FRIEDLANDER, Auteur ; N. YIRMIYA, Auteur ; E. LAIBA, Auteur ; A. HAREL-GADASSI, Auteur ; M. YAARI, Auteur ; O. FELDSTEIN, Auteur ; D. MANKUTA, Auteur ; S. ISRAEL, Auteur Année de publication : 2019 Article en page(s) : p.1087-1100 Langues : Anglais (eng) Mots-clés : Oxtr autism spectrum disorder gene-environment interaction oxytocin oxytocin receptor antagonist oxytocin receptor gene Index. décimale : PER Périodiques Résumé : Compelling evidence for the far-reaching role of oxytocin (OT) in social cognition and affiliative behaviors set the basis for examining the association between genetic variation in the OT receptor (OXTR) gene and risk for autism spectrum disorder (ASD). In the current study, gene-environment interaction between OXTR and prenatal exposure to either OT or OXTR antagonist (OXTRA) in predicting early social communication development was examined. One hundred and fifty-three children (age: M = 4.32, SD = 1.07) were assigned to four groups based on prenatal history: children whose mothers prenatally received OXTRA and Nifedipine to delay preterm labor (n = 27); children whose mothers received Nifedipine only to delay preterm labor (n = 35); children whose mothers received OT for labor augmentation (n = 56), and a no intervention group (n = 35). Participants completed a developmental assessment of intelligence quotient (IQ), adaptive behavior, and social communication abilities. DNA was extracted via buccal swab. A genetic risk score was calculated based on four OXTR single nucleotide polymorphisms (rs53576, rs237887, rs1042778, and rs2254298) previously reported to be associated with ASD symptomatology. OXTRrisk-allele dosage was associated with more severe autism diagnostics observation schedule (ADOS) scores only in the OXTRA group. In contrast, in the Nifedipine, OT, and no intervention groups, OXTRrisk-allele dosage was not associated with children's ADOS scores. These findings highlight the importance of both genetic and environmental pathways of OT in signaling early social development and raise the need for further research in this field. Autism Res 2019, 12: 1087-1100. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: In the current study, we examined if the association between prenatal exposure to an oxytocin receptor antagonist (OXTRA) and autism spectrum disorder (ASD) related impairments are dependent on an individual's genetic background for the oxytocin receptor gene (OXTR). Children who carried a greater number of risk alleles for the OXTR gene and whose mothers received OXTRA to delay preterm labor showed more ASD-related impairments. The results highlight the importance of both genetic and environmental pathways of oxytocin in shaping early social development. En ligne : http://dx.doi.org/10.1002/aur.2111 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=402
in Autism Research > 12-7 (July 2019) . - p.1087-1100[article] Cumulative Risk of the Oxytocin Receptor Gene Interacts with Prenatal Exposure to Oxytocin Receptor Antagonist to Predict Children's Social Communication Development [Texte imprimé et/ou numérique] / E. FRIEDLANDER, Auteur ; N. YIRMIYA, Auteur ; E. LAIBA, Auteur ; A. HAREL-GADASSI, Auteur ; M. YAARI, Auteur ; O. FELDSTEIN, Auteur ; D. MANKUTA, Auteur ; S. ISRAEL, Auteur . - 2019 . - p.1087-1100.
Langues : Anglais (eng)
in Autism Research > 12-7 (July 2019) . - p.1087-1100
Mots-clés : Oxtr autism spectrum disorder gene-environment interaction oxytocin oxytocin receptor antagonist oxytocin receptor gene Index. décimale : PER Périodiques Résumé : Compelling evidence for the far-reaching role of oxytocin (OT) in social cognition and affiliative behaviors set the basis for examining the association between genetic variation in the OT receptor (OXTR) gene and risk for autism spectrum disorder (ASD). In the current study, gene-environment interaction between OXTR and prenatal exposure to either OT or OXTR antagonist (OXTRA) in predicting early social communication development was examined. One hundred and fifty-three children (age: M = 4.32, SD = 1.07) were assigned to four groups based on prenatal history: children whose mothers prenatally received OXTRA and Nifedipine to delay preterm labor (n = 27); children whose mothers received Nifedipine only to delay preterm labor (n = 35); children whose mothers received OT for labor augmentation (n = 56), and a no intervention group (n = 35). Participants completed a developmental assessment of intelligence quotient (IQ), adaptive behavior, and social communication abilities. DNA was extracted via buccal swab. A genetic risk score was calculated based on four OXTR single nucleotide polymorphisms (rs53576, rs237887, rs1042778, and rs2254298) previously reported to be associated with ASD symptomatology. OXTRrisk-allele dosage was associated with more severe autism diagnostics observation schedule (ADOS) scores only in the OXTRA group. In contrast, in the Nifedipine, OT, and no intervention groups, OXTRrisk-allele dosage was not associated with children's ADOS scores. These findings highlight the importance of both genetic and environmental pathways of OT in signaling early social development and raise the need for further research in this field. Autism Res 2019, 12: 1087-1100. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: In the current study, we examined if the association between prenatal exposure to an oxytocin receptor antagonist (OXTRA) and autism spectrum disorder (ASD) related impairments are dependent on an individual's genetic background for the oxytocin receptor gene (OXTR). Children who carried a greater number of risk alleles for the OXTR gene and whose mothers received OXTRA to delay preterm labor showed more ASD-related impairments. The results highlight the importance of both genetic and environmental pathways of oxytocin in shaping early social development. En ligne : http://dx.doi.org/10.1002/aur.2111 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=402