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Altered Metabolic Characteristics in Plasma of Young Boys with Autism Spectrum Disorder / Lei WANG in Journal of Autism and Developmental Disorders, 52-11 (November 2022)
[article]
Titre : Altered Metabolic Characteristics in Plasma of Young Boys with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Lei WANG, Auteur ; Ruixuan ZHENG, Auteur ; Ying XU, Auteur ; Ziyun ZHOU, Auteur ; Ping GUAN, Auteur ; Yanling WU, Auteur ; Jian ZHOU, Auteur ; Zaohuo CHENG, Auteur ; Lili ZHANG, Auteur Article en page(s) : p.4897-4907 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnosis Biomarkers Child Choline Chromatography, Liquid Humans Male Ornithine Tandem Mass Spectrometry Autism Spectrum Disorder (ASD) Liquid chromatography-tandem mass spectrometry (LC-MS/MS) Metabolic profile Plasma Index. décimale : PER Périodiques Résumé : Autism Spectrum Disorder (ASD) is a serious neurodevelopmental disorder with no clinical biomarker. This study used untargeted metabolomic analysis to identify metabolic characteristics in plasma that can distinguish ASD children. 29 boys with ASD (3.02 Â+ 0.67Â years) and 30 typically developing (TD) boys (3.13 Â+ 0.46Â years) were recruited. Developmental and behavioral assessments were conducted in ASD group. Samples of plasma were analyzed using liquid chromatography-tandem mass spectrometry (LC-MS/MS). The association between metabolite concentration and scale score was assessed by Spearman rank correlation. Altered metabolic characteristics were found in boys with ASD. In Receiver Operating Characteristic (ROC) analysis, ornithine had the highest AUC (Area under ROC) value. Furthermore, the concentration of choline and ornithine was negatively correlated with ABC-language score in ASD group. En ligne : http://dx.doi.org/10.1007/s10803-021-05364-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=489
in Journal of Autism and Developmental Disorders > 52-11 (November 2022) . - p.4897-4907[article] Altered Metabolic Characteristics in Plasma of Young Boys with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Lei WANG, Auteur ; Ruixuan ZHENG, Auteur ; Ying XU, Auteur ; Ziyun ZHOU, Auteur ; Ping GUAN, Auteur ; Yanling WU, Auteur ; Jian ZHOU, Auteur ; Zaohuo CHENG, Auteur ; Lili ZHANG, Auteur . - p.4897-4907.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 52-11 (November 2022) . - p.4897-4907
Mots-clés : Autism Spectrum Disorder/diagnosis Biomarkers Child Choline Chromatography, Liquid Humans Male Ornithine Tandem Mass Spectrometry Autism Spectrum Disorder (ASD) Liquid chromatography-tandem mass spectrometry (LC-MS/MS) Metabolic profile Plasma Index. décimale : PER Périodiques Résumé : Autism Spectrum Disorder (ASD) is a serious neurodevelopmental disorder with no clinical biomarker. This study used untargeted metabolomic analysis to identify metabolic characteristics in plasma that can distinguish ASD children. 29 boys with ASD (3.02 Â+ 0.67Â years) and 30 typically developing (TD) boys (3.13 Â+ 0.46Â years) were recruited. Developmental and behavioral assessments were conducted in ASD group. Samples of plasma were analyzed using liquid chromatography-tandem mass spectrometry (LC-MS/MS). The association between metabolite concentration and scale score was assessed by Spearman rank correlation. Altered metabolic characteristics were found in boys with ASD. In Receiver Operating Characteristic (ROC) analysis, ornithine had the highest AUC (Area under ROC) value. Furthermore, the concentration of choline and ornithine was negatively correlated with ABC-language score in ASD group. En ligne : http://dx.doi.org/10.1007/s10803-021-05364-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=489 Oxytocin levels tend to be lower in autistic children: A meta-analysis of 31 studies / S. JOHN in Autism, 25-8 (November 2021)
[article]
Titre : Oxytocin levels tend to be lower in autistic children: A meta-analysis of 31 studies Type de document : Texte imprimé et/ou numérique Auteurs : S. JOHN, Auteur ; A. V. JAEGGI, Auteur Article en page(s) : p.2152-2161 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder Autistic Disorder Child Humans Interpersonal Relations Oxytocin/blood autism blood meta-analysis oxytocin oxytocin levels plasma saliva serum Index. décimale : PER Périodiques Résumé : Oxytocin is a hormone that mediates interpersonal relationships through enhancing social recognition, social memory, and reducing stress. It is released centrally into the cerebrospinal fluid, as well as peripherally into the blood, where it can easily be measured. Some studies indicate that the oxytocin system with its social implications might be different in people with autism spectrum disorder. With summarizing evidence of 31 studies, this meta-analysis suggests that children with autism spectrum disorder have lower blood oxytocin levels compared to neurotypical individuals. This might not be the case for adults with autism spectrum disorder, where we could not find a difference. Our findings motivate further exploration of the oxytocin system in children with autism spectrum disorder. This could lead to therapeutic options in treating autism spectrum disorder in childhood. En ligne : http://dx.doi.org/10.1177/13623613211034375 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=451
in Autism > 25-8 (November 2021) . - p.2152-2161[article] Oxytocin levels tend to be lower in autistic children: A meta-analysis of 31 studies [Texte imprimé et/ou numérique] / S. JOHN, Auteur ; A. V. JAEGGI, Auteur . - p.2152-2161.
Langues : Anglais (eng)
in Autism > 25-8 (November 2021) . - p.2152-2161
Mots-clés : Autism Spectrum Disorder Autistic Disorder Child Humans Interpersonal Relations Oxytocin/blood autism blood meta-analysis oxytocin oxytocin levels plasma saliva serum Index. décimale : PER Périodiques Résumé : Oxytocin is a hormone that mediates interpersonal relationships through enhancing social recognition, social memory, and reducing stress. It is released centrally into the cerebrospinal fluid, as well as peripherally into the blood, where it can easily be measured. Some studies indicate that the oxytocin system with its social implications might be different in people with autism spectrum disorder. With summarizing evidence of 31 studies, this meta-analysis suggests that children with autism spectrum disorder have lower blood oxytocin levels compared to neurotypical individuals. This might not be the case for adults with autism spectrum disorder, where we could not find a difference. Our findings motivate further exploration of the oxytocin system in children with autism spectrum disorder. This could lead to therapeutic options in treating autism spectrum disorder in childhood. En ligne : http://dx.doi.org/10.1177/13623613211034375 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=451