31 recherche sur le mot-clé 'plasticity'

Atypical rapid audio-visual temporal recalibration in autism spectrum disorders / Jean‐Paul NOEL in Autism Research, 10-1 (January 2017)  

Public ISBD [article]  inAutism Research > 10-1 (January 2017) . - p.121-129 Titre : Atypical rapid audio-visual temporal recalibration in autism spectrum disorders Type de document : texte imprimé Auteurs : Jean‐Paul NOEL, Auteur ; Matthew A. DE NIEAR, Auteur ; Ryan A. STEVENSON, Auteur ; David ALAIS, Auteur ; Mark T. WALLACE, Auteur Article en page(s) : p.121-129 Langues : Anglais (eng) Mots-clés : autism  multisensory  audio-visual  plasticity  recalibration Index. décimale : PER Périodiques Résumé : Changes in sensory and multisensory function are increasingly recognized as a common phenotypic characteristic of Autism Spectrum Disorders (ASD). Furthermore, much recent evidence suggests that sensory disturbances likely play an important role in contributing to social communication weaknesses—one of the core diagnostic features of ASD. An established sensory disturbance observed in ASD is reduced audiovisual temporal acuity. In the current study, we substantially extend these explorations of multisensory temporal function within the framework that an inability to rapidly recalibrate to changes in audiovisual temporal relations may play an important and under-recognized role in ASD. In the paradigm, we present ASD and typically developing (TD) children and adolescents with asynchronous audiovisual stimuli of varying levels of complexity and ask them to perform a simultaneity judgment (SJ). In the critical analysis, we test audiovisual temporal processing on trial t as a condition of trial t − 1. The results demonstrate that individuals with ASD fail to rapidly recalibrate to audiovisual asynchronies in an equivalent manner to their TD counterparts for simple and non-linguistic stimuli (i.e., flashes and beeps, hand-held tools), but exhibit comparable rapid recalibration for speech stimuli. These results are discussed in terms of prior work showing a speech-specific deficit in audiovisual temporal function in ASD, and in light of current theories of autism focusing on sensory noise and stability of perceptual representations. En ligne : http://dx.doi.org/10.1002/aur.1633 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303 [article] Atypical rapid audio-visual temporal recalibration in autism spectrum disorders [texte imprimé] / Jean‐Paul NOEL, Auteur ; Matthew A. DE NIEAR, Auteur ; Ryan A. STEVENSON, Auteur ; David ALAIS, Auteur ; Mark T. WALLACE, Auteur . - p.121-129. Langues : Anglais (eng) in Autism Research > 10-1 (January 2017) . - p.121-129 Mots-clés : autism  multisensory  audio-visual  plasticity  recalibration Index. décimale : PER Périodiques Résumé : Changes in sensory and multisensory function are increasingly recognized as a common phenotypic characteristic of Autism Spectrum Disorders (ASD). Furthermore, much recent evidence suggests that sensory disturbances likely play an important role in contributing to social communication weaknesses—one of the core diagnostic features of ASD. An established sensory disturbance observed in ASD is reduced audiovisual temporal acuity. In the current study, we substantially extend these explorations of multisensory temporal function within the framework that an inability to rapidly recalibrate to changes in audiovisual temporal relations may play an important and under-recognized role in ASD. In the paradigm, we present ASD and typically developing (TD) children and adolescents with asynchronous audiovisual stimuli of varying levels of complexity and ask them to perform a simultaneity judgment (SJ). In the critical analysis, we test audiovisual temporal processing on trial t as a condition of trial t − 1. The results demonstrate that individuals with ASD fail to rapidly recalibrate to audiovisual asynchronies in an equivalent manner to their TD counterparts for simple and non-linguistic stimuli (i.e., flashes and beeps, hand-held tools), but exhibit comparable rapid recalibration for speech stimuli. These results are discussed in terms of prior work showing a speech-specific deficit in audiovisual temporal function in ASD, and in light of current theories of autism focusing on sensory noise and stability of perceptual representations. En ligne : http://dx.doi.org/10.1002/aur.1633 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303

Cumulative-genetic plasticity, parenting and adolescent self-regulation / Jay BELSKY in Journal of Child Psychology and Psychiatry, 52-5 (May 2011)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 52-5 (May 2011) . - p.619-626 Titre : Cumulative-genetic plasticity, parenting and adolescent self-regulation Type de document : texte imprimé Auteurs : Jay BELSKY, Auteur ; Kevin M. BEAVER, Auteur Année de publication : 2011 Article en page(s) : p.619-626 Langues : Anglais (eng) Mots-clés : Self-control  self-regulation  plasticity  G×E  parenting Index. décimale : PER Périodiques Résumé : Background:  The capacity to control or regulate one’s emotions, cognitions and behavior is central to competent functioning, with limitations in these abilities associated with developmental problems. Parenting appears to influence such self-regulation. Here the differential-susceptibility hypothesis is tested that the more putative ‘plasticity alleles’ adolescents carry, the more positively and negatively influenced they will be by, respectively, supportive and unsupportive parenting. Methods:  One thousand, five hundred and eighty-six (1586) adolescents (n = 754 males; n = 832 females) enrolled in the American Add Health project were scored in terms of how many of 5 putative ‘plasticity alleles’ they carried – the 10R allele of DAT1, the A1 allele of DRD2, the 7R allele of DRD4, the short allele of 5HTTLPR, and the 2R/3R alleles of MAOA. Then the effect of the resultant index (ranging from 0 to 5) of cumulative-genetic plasticity in moderating effects of parenting on adolescent self-regulation was evaluated. Results:  Consistent with differential susceptibility, the more plasticity alleles males (but not females) carried, the more and less self-regulation they manifested under, respectively, supportive and unsupportive parenting conditions. Conclusion:  Adolescent males appear to vary for genetic reasons in their susceptibility to parenting vis-à-vis self-regulation, perhaps due to epistatic and/or epigenetic processes. G×E research may benefit from compositing candidate genes. To afford comparative evaluation of differential-susceptibility vs. diathesis-stress models of environmental action, future G×E work should focus on positive as well as negative environmental conditions and developmental outcomes. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02327.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=121 [article] Cumulative-genetic plasticity, parenting and adolescent self-regulation [texte imprimé] / Jay BELSKY, Auteur ; Kevin M. BEAVER, Auteur . - 2011 . - p.619-626. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 52-5 (May 2011) . - p.619-626 Mots-clés : Self-control  self-regulation  plasticity  G×E  parenting Index. décimale : PER Périodiques Résumé : Background:  The capacity to control or regulate one’s emotions, cognitions and behavior is central to competent functioning, with limitations in these abilities associated with developmental problems. Parenting appears to influence such self-regulation. Here the differential-susceptibility hypothesis is tested that the more putative ‘plasticity alleles’ adolescents carry, the more positively and negatively influenced they will be by, respectively, supportive and unsupportive parenting. Methods:  One thousand, five hundred and eighty-six (1586) adolescents (n = 754 males; n = 832 females) enrolled in the American Add Health project were scored in terms of how many of 5 putative ‘plasticity alleles’ they carried – the 10R allele of DAT1, the A1 allele of DRD2, the 7R allele of DRD4, the short allele of 5HTTLPR, and the 2R/3R alleles of MAOA. Then the effect of the resultant index (ranging from 0 to 5) of cumulative-genetic plasticity in moderating effects of parenting on adolescent self-regulation was evaluated. Results:  Consistent with differential susceptibility, the more plasticity alleles males (but not females) carried, the more and less self-regulation they manifested under, respectively, supportive and unsupportive parenting conditions. Conclusion:  Adolescent males appear to vary for genetic reasons in their susceptibility to parenting vis-à-vis self-regulation, perhaps due to epistatic and/or epigenetic processes. G×E research may benefit from compositing candidate genes. To afford comparative evaluation of differential-susceptibility vs. diathesis-stress models of environmental action, future G×E work should focus on positive as well as negative environmental conditions and developmental outcomes. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02327.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=121

Development of Local Circuits in Mammalian Visual Cortex / Lawrence C. KATZ in Annual Review of Neuroscience, 15 (1992)

Public ISBD [article]  inAnnual Review of Neuroscience > 15 (1992) . - p.31-56 Titre : Development of Local Circuits in Mammalian Visual Cortex Type de document : texte imprimé Auteurs : Lawrence C. KATZ, Auteur ; Edward M. CALLAWAY, Auteur Année de publication : 1992 Article en page(s) : p.31-56 Langues : Anglais (eng) Mots-clés : Plasticity - Intrinsic circuits - Pathfinding - Horizontal connections - Activity Index. décimale : PER Périodiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=370 [article] Development of Local Circuits in Mammalian Visual Cortex [texte imprimé] / Lawrence C. KATZ, Auteur ; Edward M. CALLAWAY, Auteur . - 1992 . - p.31-56. Langues : Anglais (eng) in Annual Review of Neuroscience > 15 (1992) . - p.31-56 Mots-clés : Plasticity - Intrinsic circuits - Pathfinding - Horizontal connections - Activity Index. décimale : PER Périodiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=370

Evidence of hyper-plasticity in adults with Autism Spectrum Disorder / J.F. WILSON in Research in Autism Spectrum Disorders, 43-44 (November 2017)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 43-44 (November 2017) . - p.40-52 Titre : Evidence of hyper-plasticity in adults with Autism Spectrum Disorder Type de document : texte imprimé Auteurs : J.F. WILSON, Auteur ; V. LODHIA, Auteur ; D.P. COURTNEY, Auteur ; Ian KIRK, Auteur ; J.P. HAMM, Auteur Article en page(s) : p.40-52 Langues : Anglais (eng) Mots-clés : Long-term potentiation  Autism spectrum disorder  Plasticity  Visual evoked potentials  EEG Index. décimale : PER Périodiques Résumé : AbstractBackground Long-term potentiation (LTP) is a form of synaptic plasticity involved in learning and memory. Abnormal levels of LTP have been suggested to contribute to symptoms in a number of disorders, and here we examined the extent to which LTP may be affected in autism spectrum disorders (ASD). While animal models of ASD have suggested LTP may be atypical, the results have been inconsistent in terms of the direction of abnormality. Method In the present study a paradigm for non-invasively eliciting LTP in humans was utilized to test a group of adults with ASD and matched controls. This paradigm uses high-frequency visual stimulation as the LTP-inducing stimulus, and the effect of LTP is reflected by an increase in amplitude of the visually-elicited N1b component of the visual evoked potential (VEP). Result Main effects for Hemisphere and Tetanus were found. While Group interactions were not found, a Group by Tetanus interaction was approaching significance and was determined to be weak evidence against the null ((pH0|D = 0.44) therefore, LTP effects were explored within groups for the N1 component. It was found that the ASD group had a greater N1 amplitude compared to controls. Conclusion Our results showed that the ASD group had greater N1 amplitude post-tetanus over the right hemisphere compared to controls and demonstrate elevated LTP. These results support the notion of enhanced perceptual functioning, as elevated LTP may be related to superior visual processing due to overspecialised neural networks in ASD. En ligne : https://doi.org/10.1016/j.rasd.2017.09.005 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=327 [article] Evidence of hyper-plasticity in adults with Autism Spectrum Disorder [texte imprimé] / J.F. WILSON, Auteur ; V. LODHIA, Auteur ; D.P. COURTNEY, Auteur ; Ian KIRK, Auteur ; J.P. HAMM, Auteur . - p.40-52. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 43-44 (November 2017) . - p.40-52 Mots-clés : Long-term potentiation  Autism spectrum disorder  Plasticity  Visual evoked potentials  EEG Index. décimale : PER Périodiques Résumé : AbstractBackground Long-term potentiation (LTP) is a form of synaptic plasticity involved in learning and memory. Abnormal levels of LTP have been suggested to contribute to symptoms in a number of disorders, and here we examined the extent to which LTP may be affected in autism spectrum disorders (ASD). While animal models of ASD have suggested LTP may be atypical, the results have been inconsistent in terms of the direction of abnormality. Method In the present study a paradigm for non-invasively eliciting LTP in humans was utilized to test a group of adults with ASD and matched controls. This paradigm uses high-frequency visual stimulation as the LTP-inducing stimulus, and the effect of LTP is reflected by an increase in amplitude of the visually-elicited N1b component of the visual evoked potential (VEP). Result Main effects for Hemisphere and Tetanus were found. While Group interactions were not found, a Group by Tetanus interaction was approaching significance and was determined to be weak evidence against the null ((pH0|D = 0.44) therefore, LTP effects were explored within groups for the N1 component. It was found that the ASD group had a greater N1 amplitude compared to controls. Conclusion Our results showed that the ASD group had greater N1 amplitude post-tetanus over the right hemisphere compared to controls and demonstrate elevated LTP. These results support the notion of enhanced perceptual functioning, as elevated LTP may be related to superior visual processing due to overspecialised neural networks in ASD. En ligne : https://doi.org/10.1016/j.rasd.2017.09.005 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=327

Heterogeneity and plasticity in the development of language: a 17-year follow-up of children referred early for possible autism / Andrew PICKLES in Journal of Child Psychology and Psychiatry, 55-12 (December 2014)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 55-12 (December 2014) . - p.1354-1362 Titre : Heterogeneity and plasticity in the development of language: a 17-year follow-up of children referred early for possible autism Type de document : texte imprimé Auteurs : Andrew PICKLES, Auteur ; Deborah K. ANDERSON, Auteur ; Catherine LORD, Auteur Article en page(s) : p.1354-1362 Langues : Anglais (eng) Mots-clés : Early intervention  heterogeneity  language impairment  plasticity Index. décimale : PER Périodiques Résumé : Background Delayed, abnormal language is a common feature of autism and language therapy often a significant component of recommended treatment. However, as with other disorders with a language component, we know surprisingly little about the language trajectories and how varied these might be across different children. Thus, we know little about how and when language problems might resolve, whether there are periods of relative stability or lack of change and what periods might offer more favourable circumstances for intervention. Methods Expressive and receptive language was measured on six occasions between age 2 and 19 on a cohort of 192 children initially referred for autism. Latent class growth models were fitted to characterize the patterns of heterogeneous development. Results Latent class growth analysis identified seven classes. Between age 6 and 19, all classes tracked in parallel. Between ages 2 and 6, development was more heterogeneous with considerable variation in relative progress. In all groups, receptive and expressive language developed very largely in tandem. Conclusions The results confirmed previous analysis of children with specific language impairment where progress beyond age 6 was remarkably uniform. Greater variation was evident before this age with some groups making clearly better or worse progress compared to others. While this developmental heterogeneity may simply be a reflection of variation in preexisting and unchanging biological disposition, it may also reflect, at least in part, greater sensitivity in the early years to environments that are more or less supportive of language development. These findings contribute to the case for the importance of early intervention. En ligne : http://dx.doi.org/10.1111/jcpp.12269 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=243 [article] Heterogeneity and plasticity in the development of language: a 17-year follow-up of children referred early for possible autism [texte imprimé] / Andrew PICKLES, Auteur ; Deborah K. ANDERSON, Auteur ; Catherine LORD, Auteur . - p.1354-1362. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 55-12 (December 2014) . - p.1354-1362 Mots-clés : Early intervention  heterogeneity  language impairment  plasticity Index. décimale : PER Périodiques Résumé : Background Delayed, abnormal language is a common feature of autism and language therapy often a significant component of recommended treatment. However, as with other disorders with a language component, we know surprisingly little about the language trajectories and how varied these might be across different children. Thus, we know little about how and when language problems might resolve, whether there are periods of relative stability or lack of change and what periods might offer more favourable circumstances for intervention. Methods Expressive and receptive language was measured on six occasions between age 2 and 19 on a cohort of 192 children initially referred for autism. Latent class growth models were fitted to characterize the patterns of heterogeneous development. Results Latent class growth analysis identified seven classes. Between age 6 and 19, all classes tracked in parallel. Between ages 2 and 6, development was more heterogeneous with considerable variation in relative progress. In all groups, receptive and expressive language developed very largely in tandem. Conclusions The results confirmed previous analysis of children with specific language impairment where progress beyond age 6 was remarkably uniform. Greater variation was evident before this age with some groups making clearly better or worse progress compared to others. While this developmental heterogeneity may simply be a reflection of variation in preexisting and unchanging biological disposition, it may also reflect, at least in part, greater sensitivity in the early years to environments that are more or less supportive of language development. These findings contribute to the case for the importance of early intervention. En ligne : http://dx.doi.org/10.1111/jcpp.12269 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=243

Learning and Memory in the Vestibulo-Ocular Reflex / Sascha DU LAC in Annual Review of Neuroscience, 18 (1995)

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Measuring the Plasticity of Social Approach: A Randomized Controlled Trial of the Effects of the PEERS Intervention on EEG Asymmetry in Adolescents with Autism Spectrum Disorders / Amy Vaughan VAN HECKE in Journal of Autism and Developmental Disorders, 45-2 (February 2015)  

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Nitric Oxide and Synaptic Function / Erin M. SCHUMAN in Annual Review of Neuroscience, 17 (1994)

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Oxytocin-induced increase in N,N-dimethylglycine and time course of changes in oxytocin efficacy for autism social core symptoms / Yasuhiko KATO in Molecular Autism, 12 (2021)  

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Plasticity of temporal binding in children with autism spectrum disorder: A single case experimental design perceptual training study / Jacob I. FELDMAN in Research in Autism Spectrum Disorders, 74 (June 2020)  

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