Centre d'Information et de documentation du CRA Rhône-Alpes
CRA
Informations pratiques
-
Adresse
Centre d'information et de documentation
du CRA Rhône-Alpes
Centre Hospitalier le Vinatier
bât 211
95, Bd Pinel
69678 Bron CedexHoraires
Lundi au Vendredi
9h00-12h00 13h30-16h00Contact
Tél: +33(0)4 37 91 54 65
Mail
Fax: +33(0)4 37 91 54 37
-
Résultat de la recherche
4 recherche sur le mot-clé 'temporal cortex'
Affiner la recherche Générer le flux rss de la recherche
Partager le résultat de cette recherche Faire une suggestion
Variability in post-error behavioral adjustment is associated with functional abnormalities in the temporal cortex in children with ADHD / Simona SPINELLI in Journal of Child Psychology and Psychiatry, 52-7 (July 2011)
[article]
Titre : Variability in post-error behavioral adjustment is associated with functional abnormalities in the temporal cortex in children with ADHD Type de document : Texte imprimé et/ou numérique Auteurs : Simona SPINELLI, Auteur ; Roma A. VASA, Auteur ; Suresh JOEL, Auteur ; Tess E. NELSON, Auteur ; James J. PEKAR, Auteur ; Stewart H. MOSTOFSKY, Auteur Année de publication : 2011 Article en page(s) : p.808-816 Langues : Anglais (eng) Mots-clés : Error processing variability temporal cortex medial frontal cortex ADD/ADHD child fMRI brain imaging distractibility emotion regulation reaction time Index. décimale : PER Périodiques Résumé : Background: Error processing is reflected, behaviorally, by slower reaction times (RT) on trials immediately following an error (post-error). Children with attention-deficit hyperactivity disorder (ADHD) fail to show RT slowing and demonstrate increased intra-subject variability (ISV) on post-error trials. The neural correlates of these behavioral deficits remain unclear. The dorsal anterior cingulate cortex (ACC) and lateral prefrontal cortex (PFC) are key regions implicated in error processing and subsequent behavioral adjustment. We hypothesized that children with ADHD, compared to typically developing (TD) controls, would exhibit reduced PFC activation during post-error (versus post-correct inhibition) trials and reduced dACC activation during error (versus correct inhibition) trials.
Methods: Using functional Magnetic Resonance Imaging (fMRI) and a Go/No-Go task, we analyzed the neural correlates of error processing in 13 children with ADHD and 17 TD children.
Results: Behaviorally, children with ADHD showed similar RT slowing but increased ISV compared to controls. The post-error contrast revealed a relative increase in blood-oxygen-level dependent (BOLD) signal in the middle/inferior temporal cortex (TempC), the ACC/supplementary motor area (SMA) and the somatosensory/auditory cortex (AudC) in children with ADHD compared to controls. Importantly, in the ADHD group, increased post-error temporal cortex activity was associated with lower ISV. During error (versus correct inhibition) trials, no between-group differences were detected. However, in children with ADHD lower ISV was associated with decreased insula and increased precentral gyrus activity.
Conclusions: In children with ADHD, post-error neural activity suggests, first, a shift of attention towards task-irrelevant stimuli (AudC), and second, a recruitment of compensatory regions that resolve stimulus conflict (TempC) and improve response selection/execution (ACC/SMA). ADHD children with higher temporal cortex activation showed lower ISV, suggesting that functional abnormalities in the compensatory temporal regions contribute to increased variability. Moreover, increased ISV may be related to an over-sensitivity to negative outcomes during error trials in ADHD (insula correlation).En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02356.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=126
in Journal of Child Psychology and Psychiatry > 52-7 (July 2011) . - p.808-816[article] Variability in post-error behavioral adjustment is associated with functional abnormalities in the temporal cortex in children with ADHD [Texte imprimé et/ou numérique] / Simona SPINELLI, Auteur ; Roma A. VASA, Auteur ; Suresh JOEL, Auteur ; Tess E. NELSON, Auteur ; James J. PEKAR, Auteur ; Stewart H. MOSTOFSKY, Auteur . - 2011 . - p.808-816.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 52-7 (July 2011) . - p.808-816
Mots-clés : Error processing variability temporal cortex medial frontal cortex ADD/ADHD child fMRI brain imaging distractibility emotion regulation reaction time Index. décimale : PER Périodiques Résumé : Background: Error processing is reflected, behaviorally, by slower reaction times (RT) on trials immediately following an error (post-error). Children with attention-deficit hyperactivity disorder (ADHD) fail to show RT slowing and demonstrate increased intra-subject variability (ISV) on post-error trials. The neural correlates of these behavioral deficits remain unclear. The dorsal anterior cingulate cortex (ACC) and lateral prefrontal cortex (PFC) are key regions implicated in error processing and subsequent behavioral adjustment. We hypothesized that children with ADHD, compared to typically developing (TD) controls, would exhibit reduced PFC activation during post-error (versus post-correct inhibition) trials and reduced dACC activation during error (versus correct inhibition) trials.
Methods: Using functional Magnetic Resonance Imaging (fMRI) and a Go/No-Go task, we analyzed the neural correlates of error processing in 13 children with ADHD and 17 TD children.
Results: Behaviorally, children with ADHD showed similar RT slowing but increased ISV compared to controls. The post-error contrast revealed a relative increase in blood-oxygen-level dependent (BOLD) signal in the middle/inferior temporal cortex (TempC), the ACC/supplementary motor area (SMA) and the somatosensory/auditory cortex (AudC) in children with ADHD compared to controls. Importantly, in the ADHD group, increased post-error temporal cortex activity was associated with lower ISV. During error (versus correct inhibition) trials, no between-group differences were detected. However, in children with ADHD lower ISV was associated with decreased insula and increased precentral gyrus activity.
Conclusions: In children with ADHD, post-error neural activity suggests, first, a shift of attention towards task-irrelevant stimuli (AudC), and second, a recruitment of compensatory regions that resolve stimulus conflict (TempC) and improve response selection/execution (ACC/SMA). ADHD children with higher temporal cortex activation showed lower ISV, suggesting that functional abnormalities in the compensatory temporal regions contribute to increased variability. Moreover, increased ISV may be related to an over-sensitivity to negative outcomes during error trials in ADHD (insula correlation).En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02356.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=126 Childhood abuse and reduced cortical thickness in brain regions involved in emotional processing / Andrea L. GOLD in Journal of Child Psychology and Psychiatry, 57-10 (October 2016)
[article]
Titre : Childhood abuse and reduced cortical thickness in brain regions involved in emotional processing Type de document : Texte imprimé et/ou numérique Auteurs : Andrea L. GOLD, Auteur ; Margaret A. SHERIDAN, Auteur ; Matthew PEVERILL, Auteur ; Daniel S. BUSSO, Auteur ; Hilary K. LAMBERT, Auteur ; Sonia ALVES, Auteur ; Daniel S. PINE, Auteur ; Katie A. MCLAUGHLIN, Auteur Article en page(s) : p.1154-1164 Langues : Anglais (eng) Mots-clés : Abuse childhood adversity ventromedial prefrontal cortex temporal cortex cortical thickness Index. décimale : PER Périodiques Résumé : Background Alterations in gray matter development represent a potential pathway through which childhood abuse is associated with psychopathology. Several prior studies find reduced volume and thickness of prefrontal (PFC) and temporal cortex regions in abused compared with nonabused adolescents, although most prior research is based on adults and volume-based measures. This study tests the hypothesis that child abuse, independent of parental education, predicts reduced cortical thickness in prefrontal and temporal cortices as well as reduced gray mater volume (GMV) in subcortical regions during adolescence. Methods Structural MRI scans were obtained from 21 adolescents exposed to physical and/or sexual abuse and 37 nonabused adolescents (ages 13–20). Abuse was operationalized using dichotomous and continuous measures. We examined associations between abuse and brain structure in several a priori-defined regions, controlling for parental education, age, sex, race, and total brain volume for subcortical GMV. Significance was evaluated at p < .05 with a false discovery rate correction. Results Child abuse exposure and severity were associated with reduced thickness in ventromedial prefrontal cortex (PFC), right lateral orbitofrontal cortex, right inferior frontal gyrus, bilateral parahippocampal gyrus (PHG), left temporal pole, and bilateral inferior, right middle, and right superior temporal gyri. Neither abuse measure predicted cortical surface area or subcortical GMV. Bilateral PHG thickness was inversely related to externalizing symptoms. Conclusions Child abuse, an experience characterized by a high degree of threat, is associated with reduced cortical thickness in ventromedial and ventrolateral PFC and medial and lateral temporal cortex in adolescence. Reduced PHG thickness may be a mediator linking abuse with externalizing psychopathology, although prospective research is needed to evaluate this possibility. En ligne : http://dx.doi.org/10.1111/jcpp.12630 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=295
in Journal of Child Psychology and Psychiatry > 57-10 (October 2016) . - p.1154-1164[article] Childhood abuse and reduced cortical thickness in brain regions involved in emotional processing [Texte imprimé et/ou numérique] / Andrea L. GOLD, Auteur ; Margaret A. SHERIDAN, Auteur ; Matthew PEVERILL, Auteur ; Daniel S. BUSSO, Auteur ; Hilary K. LAMBERT, Auteur ; Sonia ALVES, Auteur ; Daniel S. PINE, Auteur ; Katie A. MCLAUGHLIN, Auteur . - p.1154-1164.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 57-10 (October 2016) . - p.1154-1164
Mots-clés : Abuse childhood adversity ventromedial prefrontal cortex temporal cortex cortical thickness Index. décimale : PER Périodiques Résumé : Background Alterations in gray matter development represent a potential pathway through which childhood abuse is associated with psychopathology. Several prior studies find reduced volume and thickness of prefrontal (PFC) and temporal cortex regions in abused compared with nonabused adolescents, although most prior research is based on adults and volume-based measures. This study tests the hypothesis that child abuse, independent of parental education, predicts reduced cortical thickness in prefrontal and temporal cortices as well as reduced gray mater volume (GMV) in subcortical regions during adolescence. Methods Structural MRI scans were obtained from 21 adolescents exposed to physical and/or sexual abuse and 37 nonabused adolescents (ages 13–20). Abuse was operationalized using dichotomous and continuous measures. We examined associations between abuse and brain structure in several a priori-defined regions, controlling for parental education, age, sex, race, and total brain volume for subcortical GMV. Significance was evaluated at p < .05 with a false discovery rate correction. Results Child abuse exposure and severity were associated with reduced thickness in ventromedial prefrontal cortex (PFC), right lateral orbitofrontal cortex, right inferior frontal gyrus, bilateral parahippocampal gyrus (PHG), left temporal pole, and bilateral inferior, right middle, and right superior temporal gyri. Neither abuse measure predicted cortical surface area or subcortical GMV. Bilateral PHG thickness was inversely related to externalizing symptoms. Conclusions Child abuse, an experience characterized by a high degree of threat, is associated with reduced cortical thickness in ventromedial and ventrolateral PFC and medial and lateral temporal cortex in adolescence. Reduced PHG thickness may be a mediator linking abuse with externalizing psychopathology, although prospective research is needed to evaluate this possibility. En ligne : http://dx.doi.org/10.1111/jcpp.12630 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=295
[article]
Titre : Effective connectivity in autism Type de document : Texte imprimé et/ou numérique Auteurs : Edmund T. ROLLS, Auteur ; Yunyi ZHOU, Auteur ; Wei CHENG, Auteur ; Matthieu GILSON, Auteur ; Gustavo DECO, Auteur ; Jianfeng FENG, Auteur Article en page(s) : p.32-44 Langues : Anglais (eng) Mots-clés : amygdala autism effective connectivity face expression precuneus temporal cortex Index. décimale : PER Périodiques Résumé : The aim was to go beyond functional connectivity, by measuring in the first large-scale study differences in effective, that is directed, connectivity between brain areas in autism compared to controls. Resting-state functional magnetic resonance imaging was analyzed from the Autism Brain Imaging Data Exchange (ABIDE) data set in 394 people with autism spectrum disorder and 473 controls, and effective connectivity (EC) was measured between 94 brain areas. First, in autism, the middle temporal gyrus and other temporal areas had lower effective connectivities to the precuneus and cuneus, and these were correlated with the Autism Diagnostic Observational Schedule total, communication, and social scores. This lower EC from areas implicated in face expression analysis and theory of mind to the precuneus and cuneus implicated in the sense of self may relate to the poor understanding of the implications of face expression inputs for oneself in autism, and to the reduced theory of mind. Second, the hippocampus and amygdala had higher EC to the middle temporal gyrus in autism, and these are thought to be back projections based on anatomical evidence and are weaker than in the other direction. This may be related to increased retrieval of recent and emotional memories in autism. Third, some prefrontal cortex areas had higher EC with each other and with the precuneus and cuneus. Fourth, there was decreased EC from the temporal pole to the ventromedial prefrontal cortex, and there was evidence for lower activity in the ventromedial prefrontal cortex, a brain area implicated in emotion-related decision-making. Autism Res 2020, 13: 32-44. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: To understand autism spectrum disorders better, it may be helpful to understand whether brain systems cause effects on each other differently in people with autism. In this first large-scale neuroimaging investigation of effective connectivity in people with autism, it is shown that parts of the temporal lobe involved in facial expression identification and theory of mind have weaker effects on the precuneus and cuneus implicated in the sense of self. This may relate to the poor understanding of the implications of face expression inputs for oneself in autism, and to the reduced theory of mind. En ligne : http://dx.doi.org/10.1002/aur.2235 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=415
in Autism Research > 13-1 (January 2020) . - p.32-44[article] Effective connectivity in autism [Texte imprimé et/ou numérique] / Edmund T. ROLLS, Auteur ; Yunyi ZHOU, Auteur ; Wei CHENG, Auteur ; Matthieu GILSON, Auteur ; Gustavo DECO, Auteur ; Jianfeng FENG, Auteur . - p.32-44.
Langues : Anglais (eng)
in Autism Research > 13-1 (January 2020) . - p.32-44
Mots-clés : amygdala autism effective connectivity face expression precuneus temporal cortex Index. décimale : PER Périodiques Résumé : The aim was to go beyond functional connectivity, by measuring in the first large-scale study differences in effective, that is directed, connectivity between brain areas in autism compared to controls. Resting-state functional magnetic resonance imaging was analyzed from the Autism Brain Imaging Data Exchange (ABIDE) data set in 394 people with autism spectrum disorder and 473 controls, and effective connectivity (EC) was measured between 94 brain areas. First, in autism, the middle temporal gyrus and other temporal areas had lower effective connectivities to the precuneus and cuneus, and these were correlated with the Autism Diagnostic Observational Schedule total, communication, and social scores. This lower EC from areas implicated in face expression analysis and theory of mind to the precuneus and cuneus implicated in the sense of self may relate to the poor understanding of the implications of face expression inputs for oneself in autism, and to the reduced theory of mind. Second, the hippocampus and amygdala had higher EC to the middle temporal gyrus in autism, and these are thought to be back projections based on anatomical evidence and are weaker than in the other direction. This may be related to increased retrieval of recent and emotional memories in autism. Third, some prefrontal cortex areas had higher EC with each other and with the precuneus and cuneus. Fourth, there was decreased EC from the temporal pole to the ventromedial prefrontal cortex, and there was evidence for lower activity in the ventromedial prefrontal cortex, a brain area implicated in emotion-related decision-making. Autism Res 2020, 13: 32-44. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: To understand autism spectrum disorders better, it may be helpful to understand whether brain systems cause effects on each other differently in people with autism. In this first large-scale neuroimaging investigation of effective connectivity in people with autism, it is shown that parts of the temporal lobe involved in facial expression identification and theory of mind have weaker effects on the precuneus and cuneus implicated in the sense of self. This may relate to the poor understanding of the implications of face expression inputs for oneself in autism, and to the reduced theory of mind. En ligne : http://dx.doi.org/10.1002/aur.2235 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=415 Genetic modifications associated with ketogenic diet treatment in the BTBRT+Tf/J mouse model of autism spectrum disorder / Richelle MYCHASIUK in Autism Research, 10-3 (March 2017)
[article]
Titre : Genetic modifications associated with ketogenic diet treatment in the BTBRT+Tf/J mouse model of autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Richelle MYCHASIUK, Auteur ; Jong M. RHO, Auteur Article en page(s) : p.456-471 Langues : Anglais (eng) Mots-clés : autism spectrum disorder ketogenic diet RNAseq temporal cortex hippocampus mitochondria development Index. décimale : PER Périodiques Résumé : Background: Autism spectrum disorder (ASD) is a prevalent and heterogeneous neurodevelopmental disorder characterized by hallmark behavioral features. The spectrum of disorders that fall within the ASD umbrella encompass a distinct but overlapping symptom complex that likely results from an array of molecular and genetic aberrations rather than a single genetic mutation. The ketogenic diet (KD) is a high-fat low-carbohydrate anti-seizure and neuroprotective diet that has demonstrated efficacy in the treatment of ASD-like behaviors in animal and human studies. Methods: We investigated changes in mRNA and gene expression in the BTBR mouse model of ASD that may contribute to the behavioral phenotype. In addition, we sought to examine changes in gene expression following KD treatment in BTBR mice. Results: Despite significant behavioral abnormalities, expression changes in BTBR mice did not differ substantially from controls; only 33 genes were differentially expressed in the temporal cortex, and 48 in the hippocampus. Examination of these differentially expressed genes suggested deficits in the stress response and in neuronal signaling/communication. After treatment with the KD, both brain regions demonstrated improvements in ASD deficits associated with myelin formation and white matter development. Conclusions: Although our study supports many of the previously known impairments associated with ASD, such as excessive myelin formation and impaired GABAergic transmission, the RNAseq data and pathway analysis utilized here identified new therapeutic targets for analysis, such as Vitamin D pathways and cAMP signaling. En ligne : http://dx.doi.org/10.1002/aur.1682 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304
in Autism Research > 10-3 (March 2017) . - p.456-471[article] Genetic modifications associated with ketogenic diet treatment in the BTBRT+Tf/J mouse model of autism spectrum disorder [Texte imprimé et/ou numérique] / Richelle MYCHASIUK, Auteur ; Jong M. RHO, Auteur . - p.456-471.
Langues : Anglais (eng)
in Autism Research > 10-3 (March 2017) . - p.456-471
Mots-clés : autism spectrum disorder ketogenic diet RNAseq temporal cortex hippocampus mitochondria development Index. décimale : PER Périodiques Résumé : Background: Autism spectrum disorder (ASD) is a prevalent and heterogeneous neurodevelopmental disorder characterized by hallmark behavioral features. The spectrum of disorders that fall within the ASD umbrella encompass a distinct but overlapping symptom complex that likely results from an array of molecular and genetic aberrations rather than a single genetic mutation. The ketogenic diet (KD) is a high-fat low-carbohydrate anti-seizure and neuroprotective diet that has demonstrated efficacy in the treatment of ASD-like behaviors in animal and human studies. Methods: We investigated changes in mRNA and gene expression in the BTBR mouse model of ASD that may contribute to the behavioral phenotype. In addition, we sought to examine changes in gene expression following KD treatment in BTBR mice. Results: Despite significant behavioral abnormalities, expression changes in BTBR mice did not differ substantially from controls; only 33 genes were differentially expressed in the temporal cortex, and 48 in the hippocampus. Examination of these differentially expressed genes suggested deficits in the stress response and in neuronal signaling/communication. After treatment with the KD, both brain regions demonstrated improvements in ASD deficits associated with myelin formation and white matter development. Conclusions: Although our study supports many of the previously known impairments associated with ASD, such as excessive myelin formation and impaired GABAergic transmission, the RNAseq data and pathway analysis utilized here identified new therapeutic targets for analysis, such as Vitamin D pathways and cAMP signaling. En ligne : http://dx.doi.org/10.1002/aur.1682 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304