82 recherche sur le mot-clé 'twins'

EU-AIMS Longitudinal European Autism Project (LEAP): the autism twin cohort / Johan ISAKSSON in Molecular Autism, 9 (2018)  

Public ISBD [article]  inMolecular Autism > 9 (2018) . - 26p. Titre : EU-AIMS Longitudinal European Autism Project (LEAP): the autism twin cohort Type de document : texte imprimé Auteurs : Johan ISAKSSON, Auteur ; Kristiina TAMMIMIES, Auteur ; Janina NEUFELD, Auteur ; Elodie CAUVET, Auteur ; Karl LUNDIN, Auteur ; Jan K. BUITELAAR, Auteur ; Eva LOTH, Auteur ; Declan G.M. MURPHY, Auteur ; Will SPOOREN, Auteur ; Sven BÖLTE, Auteur Article en page(s) : 26p. Langues : Anglais (eng) Mots-clés : Adolescent  Autistic Disorder/diagnosis/epidemiology/genetics  Child  Cohort Studies  Europe  Female  Humans  Longitudinal Studies  Male  Phenotype  Twins, Dizygotic/statistics & numerical data  Twins, Monozygotic/statistics & numerical data  adhd  Autism spectrum disorder  Biomarkers  Brain  Cognition  Genetics  Intervention  Twins Index. décimale : PER Périodiques Résumé : EU-AIMS is the largest European research program aiming to identify stratification biomarkers and novel interventions for autism spectrum disorder (ASD). Within the program, the Longitudinal European Autism Project (LEAP) has recruited and comprehensively phenotyped a rare sample of 76 monozygotic and dizygotic twins, discordant, or concordant for ASD plus 30 typically developing twins. The aim of this letter is to complete previous descriptions of the LEAP case-control sample, clinically characterize, and investigate the suitability of the sample for ASD twin-control analyses purposes and share some 'lessons learnt.' Among the twins, a diagnosis of ASD is associated with increased symptom levels of ADHD, higher rates of intellectual disability, and lower family income. For the future, we conclude that the LEAP twin cohort offers multiple options for analyses of genetic and shared and non-shared environmental factors to generate new hypotheses for the larger cohort of LEAP singletons, but particularly cross-validate and refine evidence from it. En ligne : https://dx.doi.org/10.1186/s13229-018-0212-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=371 [article] EU-AIMS Longitudinal European Autism Project (LEAP): the autism twin cohort [texte imprimé] / Johan ISAKSSON, Auteur ; Kristiina TAMMIMIES, Auteur ; Janina NEUFELD, Auteur ; Elodie CAUVET, Auteur ; Karl LUNDIN, Auteur ; Jan K. BUITELAAR, Auteur ; Eva LOTH, Auteur ; Declan G.M. MURPHY, Auteur ; Will SPOOREN, Auteur ; Sven BÖLTE, Auteur . - 26p. Langues : Anglais (eng) in Molecular Autism > 9 (2018) . - 26p. Mots-clés : Adolescent  Autistic Disorder/diagnosis/epidemiology/genetics  Child  Cohort Studies  Europe  Female  Humans  Longitudinal Studies  Male  Phenotype  Twins, Dizygotic/statistics & numerical data  Twins, Monozygotic/statistics & numerical data  adhd  Autism spectrum disorder  Biomarkers  Brain  Cognition  Genetics  Intervention  Twins Index. décimale : PER Périodiques Résumé : EU-AIMS is the largest European research program aiming to identify stratification biomarkers and novel interventions for autism spectrum disorder (ASD). Within the program, the Longitudinal European Autism Project (LEAP) has recruited and comprehensively phenotyped a rare sample of 76 monozygotic and dizygotic twins, discordant, or concordant for ASD plus 30 typically developing twins. The aim of this letter is to complete previous descriptions of the LEAP case-control sample, clinically characterize, and investigate the suitability of the sample for ASD twin-control analyses purposes and share some 'lessons learnt.' Among the twins, a diagnosis of ASD is associated with increased symptom levels of ADHD, higher rates of intellectual disability, and lower family income. For the future, we conclude that the LEAP twin cohort offers multiple options for analyses of genetic and shared and non-shared environmental factors to generate new hypotheses for the larger cohort of LEAP singletons, but particularly cross-validate and refine evidence from it. En ligne : https://dx.doi.org/10.1186/s13229-018-0212-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=371

Eating Problems in Autistic Females and Males: A Co-twin Control Study / Karl LUNDIN REMNÉLIUS in Journal of Autism and Developmental Disorders, 52-7 (July 2022)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 52-7 (July 2022) . - p.3153-3168 Titre : Eating Problems in Autistic Females and Males: A Co-twin Control Study Type de document : texte imprimé Auteurs : Karl LUNDIN REMNÉLIUS, Auteur ; Janina NEUFELD, Auteur ; Johan ISAKSSON, Auteur ; Sven BÖLTE, Auteur Article en page(s) : p.3153-3168 Langues : Anglais (eng) Mots-clés : Adolescent  Adult  Autism Spectrum Disorder/genetics  Autistic Disorder/genetics  Diseases in Twins/genetics  Female  Humans  Male  Twins, Dizygotic  Twins, Monozygotic  Autism  Co-twin control design  Eating  Gender differences  lecturer for Medice and Roche. He receives royalties for textbooks and diagnostic  tools from Hogrefe. KLR, JN, and JI have no conflicts of interest to declare that  are relevant to the content of this article. Index. décimale : PER Périodiques Résumé : This study investigated the association between autism and self-reported eating problems and the influence of gender on the association, in a sample of adolescent and adult twins (N=192). Autistic traits and autism diagnosis were associated with both total and specific eating problems, including selective eating and sensory sensitivity during mealtimes. Interaction effects indicated a stronger association between autistic traits and total eating problems in females, as well as more difficulties with eating in social contexts among autistic females. In within-pair analyses, where unmeasured confounders including genes and shared environment are implicitly controlled for, the association was lost within monozygotic pairs, which might further indicate a genetic influence on the relationship between autism and eating problems. En ligne : http://dx.doi.org/10.1007/s10803-021-05198-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477 [article] Eating Problems in Autistic Females and Males: A Co-twin Control Study [texte imprimé] / Karl LUNDIN REMNÉLIUS, Auteur ; Janina NEUFELD, Auteur ; Johan ISAKSSON, Auteur ; Sven BÖLTE, Auteur . - p.3153-3168. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 52-7 (July 2022) . - p.3153-3168 Mots-clés : Adolescent  Adult  Autism Spectrum Disorder/genetics  Autistic Disorder/genetics  Diseases in Twins/genetics  Female  Humans  Male  Twins, Dizygotic  Twins, Monozygotic  Autism  Co-twin control design  Eating  Gender differences  lecturer for Medice and Roche. He receives royalties for textbooks and diagnostic  tools from Hogrefe. KLR, JN, and JI have no conflicts of interest to declare that  are relevant to the content of this article. Index. décimale : PER Périodiques Résumé : This study investigated the association between autism and self-reported eating problems and the influence of gender on the association, in a sample of adolescent and adult twins (N=192). Autistic traits and autism diagnosis were associated with both total and specific eating problems, including selective eating and sensory sensitivity during mealtimes. Interaction effects indicated a stronger association between autistic traits and total eating problems in females, as well as more difficulties with eating in social contexts among autistic females. In within-pair analyses, where unmeasured confounders including genes and shared environment are implicitly controlled for, the association was lost within monozygotic pairs, which might further indicate a genetic influence on the relationship between autism and eating problems. En ligne : http://dx.doi.org/10.1007/s10803-021-05198-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477

2D:4D Ratio in Neurodevelopmental Disorders: A Twin Study / Lynnea MYERS in Journal of Autism and Developmental Disorders, 48-9 (September 2018)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 48-9 (September 2018) . - p.3244-3252 Titre : 2D:4D Ratio in Neurodevelopmental Disorders: A Twin Study Type de document : texte imprimé Auteurs : Lynnea MYERS, Auteur ; Annelies VAN'T WESTEINDE, Auteur ; Ralf KUJA-HALKOLA, Auteur ; Kristiina TAMMIMIES, Auteur ; Sven BÖLTE, Auteur Article en page(s) : p.3244-3252 Langues : Anglais (eng) Mots-clés : 2D:4D ratio  Adhd  Autism  Hormones  Neurodevelopmental disorders  Sex  Twins Index. décimale : PER Périodiques Résumé : The second to fourth digit (2D:4D) ratio is of interest in autism spectrum disorder (ASD). Studies on the relationship of this ratio with other neurodevelopmental disorders (NDDs) are lacking. Investigating the association between the ratio and NDDs in twins can provide insight into genetic and/or environmental factors driving the ratio. Hand images were collected in N = 238 twins with NDDs or typical development from 70 monozygotic and 49 dizygotic pairs to examine ratios and their associations to DSM-5 defined categorical NDDs, autistic traits, zygosity, and sex. There were small associations for males between the ratios and any NDD and ADHD diagnoses. Males had lower ratios than females. Future studies exploring the ratio alongside physical anomalies could provide etiological insight into NDDs. En ligne : http://dx.doi.org/10.1007/s10803-018-3588-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368 [article] 2D:4D Ratio in Neurodevelopmental Disorders: A Twin Study [texte imprimé] / Lynnea MYERS, Auteur ; Annelies VAN'T WESTEINDE, Auteur ; Ralf KUJA-HALKOLA, Auteur ; Kristiina TAMMIMIES, Auteur ; Sven BÖLTE, Auteur . - p.3244-3252. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 48-9 (September 2018) . - p.3244-3252 Mots-clés : 2D:4D ratio  Adhd  Autism  Hormones  Neurodevelopmental disorders  Sex  Twins Index. décimale : PER Périodiques Résumé : The second to fourth digit (2D:4D) ratio is of interest in autism spectrum disorder (ASD). Studies on the relationship of this ratio with other neurodevelopmental disorders (NDDs) are lacking. Investigating the association between the ratio and NDDs in twins can provide insight into genetic and/or environmental factors driving the ratio. Hand images were collected in N = 238 twins with NDDs or typical development from 70 monozygotic and 49 dizygotic pairs to examine ratios and their associations to DSM-5 defined categorical NDDs, autistic traits, zygosity, and sex. There were small associations for males between the ratios and any NDD and ADHD diagnoses. Males had lower ratios than females. Future studies exploring the ratio alongside physical anomalies could provide etiological insight into NDDs. En ligne : http://dx.doi.org/10.1007/s10803-018-3588-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368

Aetiological overlap between anxiety and attention deficit hyperactivity symptom dimensions in adolescence / Giorgia MICHELINI in Journal of Child Psychology and Psychiatry, 56-4 (April 2015)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 56-4 (April 2015) . - p.423-431 Titre : Aetiological overlap between anxiety and attention deficit hyperactivity symptom dimensions in adolescence Type de document : texte imprimé Auteurs : Giorgia MICHELINI, Auteur ; Thalia C. ELEY, Auteur ; Alice M. GREGORY, Auteur ; Tom A. MCADAMS, Auteur Article en page(s) : p.423-431 Langues : Anglais (eng) Mots-clés : Anxiety  ADH problems  genetics  twins  adolescence Index. décimale : PER Périodiques Résumé : Background Anxiety and attention-deficit/hyperactivity (ADH) problems are common in adolescence, often co-occur, and are characterised by high heterogeneity in their phenotypic expressions. Although it is known that anxiety and ADH problems correlate, the relationships between subtypes of anxiety and ADH problems have been scarcely investigated. Methods Using a large population sample of adolescent twins and siblings we explored the phenotypic and aetiological association between anxiety subtypes (panic/agoraphobia, separation anxiety, social anxiety, physical injury fears, obsessive-compulsive symptoms and generalised anxiety) and the two ADH dimensions (attention problems and hyperactivity/impulsivity). Both phenotypes were assessed using self-report questionnaires. Results The association between ADH problems and anxiety could be entirely attributed to attention problems, not hyperactivity/impulsivity. Most of the correlations between anxiety subtypes and attention problems showed an approximately equal role of genetic and nonshared environmental factors. Conclusions The high heterogeneity within anxiety and ADH problems should be taken into account in order to better understand comorbidity between them. En ligne : http://dx.doi.org/10.1111/jcpp.12318 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260 [article] Aetiological overlap between anxiety and attention deficit hyperactivity symptom dimensions in adolescence [texte imprimé] / Giorgia MICHELINI, Auteur ; Thalia C. ELEY, Auteur ; Alice M. GREGORY, Auteur ; Tom A. MCADAMS, Auteur . - p.423-431. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 56-4 (April 2015) . - p.423-431 Mots-clés : Anxiety  ADH problems  genetics  twins  adolescence Index. décimale : PER Périodiques Résumé : Background Anxiety and attention-deficit/hyperactivity (ADH) problems are common in adolescence, often co-occur, and are characterised by high heterogeneity in their phenotypic expressions. Although it is known that anxiety and ADH problems correlate, the relationships between subtypes of anxiety and ADH problems have been scarcely investigated. Methods Using a large population sample of adolescent twins and siblings we explored the phenotypic and aetiological association between anxiety subtypes (panic/agoraphobia, separation anxiety, social anxiety, physical injury fears, obsessive-compulsive symptoms and generalised anxiety) and the two ADH dimensions (attention problems and hyperactivity/impulsivity). Both phenotypes were assessed using self-report questionnaires. Results The association between ADH problems and anxiety could be entirely attributed to attention problems, not hyperactivity/impulsivity. Most of the correlations between anxiety subtypes and attention problems showed an approximately equal role of genetic and nonshared environmental factors. Conclusions The high heterogeneity within anxiety and ADH problems should be taken into account in order to better understand comorbidity between them. En ligne : http://dx.doi.org/10.1111/jcpp.12318 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260

Aetiology of shame and its association with adolescent depression and anxiety: results from a prospective twin and sibling study / M. NIKOLIĆ in Journal of Child Psychology and Psychiatry, 63-1 (January 2022)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 63-1 (January 2022) . - p.99-108 Titre : Aetiology of shame and its association with adolescent depression and anxiety: results from a prospective twin and sibling study Type de document : texte imprimé Auteurs : M. NIKOLIĆ, Auteur ; Laurie J. HANNIGAN, Auteur ; Georgina KREBS, Auteur ; Abram STERNE, Auteur ; Alice M. GREGORY, Auteur ; Thalia C. ELEY, Auteur Article en page(s) : p.99-108 Langues : Anglais (eng) Mots-clés : Adolescent  Anxiety/epidemiology/genetics  Child  Depression/epidemiology/genetics  Female  Humans  Male  Prospective Studies  Shame  Siblings  Young Adult  Adolescence  anxiety  depression  twins Index. décimale : PER Périodiques Résumé : BACKGROUND: Shame is considered a maladaptive self-conscious emotion that commonly co-occurs alongside depression and anxiety. Little is known, however, about the aetiology of shame and its associations with depression and anxiety. We estimated, for the first time, genetic and environmental influences on shame and on its associations with depression and anxiety in adolescence. METHODS: The sample was twin and sibling pairs from the Genesis 1219 Study (Time 1, N = 2,685; males 42.8%, M(age)  = 14.95, SD = 1.67, age range: 12-21; Time 2, N = 1618; males 39.7%, M(age)  = 16.97, SD = 1.64, age range: 14-23). Participants completed validated questionnaires to measure shame (at Time 1), depression and anxiety (at Times 1 and 2). RESULTS: Shame was moderately to strongly associated with concurrent depression and anxiety. Prospectively, shame was significantly associated with an increase in depression, but not anxiety. Genetic analyses revealed that shame was moderately heritable with substantial nonshared environmental influence. The associations between shame and concurrent depression and anxiety were primarily accounted for by overlapping genetic influences. Prospectively, the association between shame and later depression was primarily accounted for by genetic and nonshared environmental influences shared with earlier depression. The unique association between shame and later depression was mostly explained by common nonshared environmental influences. CONCLUSIONS: The findings offer novel evidence regarding aetiology of shame-although moderately heritable, shame in adolescents may also result from nonshared environmental factors. Genetic and nonshared environmental influences contribute to the co-occurrence of shame with depression and anxiety. En ligne : http://dx.doi.org/10.1111/jcpp.13465 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456 [article] Aetiology of shame and its association with adolescent depression and anxiety: results from a prospective twin and sibling study [texte imprimé] / M. NIKOLIĆ, Auteur ; Laurie J. HANNIGAN, Auteur ; Georgina KREBS, Auteur ; Abram STERNE, Auteur ; Alice M. GREGORY, Auteur ; Thalia C. ELEY, Auteur . - p.99-108. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 63-1 (January 2022) . - p.99-108 Mots-clés : Adolescent  Anxiety/epidemiology/genetics  Child  Depression/epidemiology/genetics  Female  Humans  Male  Prospective Studies  Shame  Siblings  Young Adult  Adolescence  anxiety  depression  twins Index. décimale : PER Périodiques Résumé : BACKGROUND: Shame is considered a maladaptive self-conscious emotion that commonly co-occurs alongside depression and anxiety. Little is known, however, about the aetiology of shame and its associations with depression and anxiety. We estimated, for the first time, genetic and environmental influences on shame and on its associations with depression and anxiety in adolescence. METHODS: The sample was twin and sibling pairs from the Genesis 1219 Study (Time 1, N = 2,685; males 42.8%, M(age)  = 14.95, SD = 1.67, age range: 12-21; Time 2, N = 1618; males 39.7%, M(age)  = 16.97, SD = 1.64, age range: 14-23). Participants completed validated questionnaires to measure shame (at Time 1), depression and anxiety (at Times 1 and 2). RESULTS: Shame was moderately to strongly associated with concurrent depression and anxiety. Prospectively, shame was significantly associated with an increase in depression, but not anxiety. Genetic analyses revealed that shame was moderately heritable with substantial nonshared environmental influence. The associations between shame and concurrent depression and anxiety were primarily accounted for by overlapping genetic influences. Prospectively, the association between shame and later depression was primarily accounted for by genetic and nonshared environmental influences shared with earlier depression. The unique association between shame and later depression was mostly explained by common nonshared environmental influences. CONCLUSIONS: The findings offer novel evidence regarding aetiology of shame-although moderately heritable, shame in adolescents may also result from nonshared environmental factors. Genetic and nonshared environmental influences contribute to the co-occurrence of shame with depression and anxiety. En ligne : http://dx.doi.org/10.1111/jcpp.13465 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456

Associations between conduct problems in childhood and adverse outcomes in emerging adulthood: a longitudinal Swedish nationwide twin cohort / Paul LICHTENSTEIN in Journal of Child Psychology and Psychiatry, 61-7 (July 2020)  

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Associations between psychiatric polygenic risk scores and general and specific psychopathology symptoms in childhood and adolescence between and within dizygotic twin pairs / Cen CHEN in Journal of Child Psychology and Psychiatry, 63-12 (December 2022)  

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Autism Spectrum Disorder and Mental Health Problems: Patterns of Difficulties and Longitudinal Trajectories in a Population-Based Twin Sample / Emma COLVERT in Journal of Autism and Developmental Disorders, 52-3 (March 2022)  

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Autism spectrum disorder and obstetric optimality: a twin study and meta-analysis of sibling studies / Sandra GÓMEZ-VALLEJO in Journal of Child Psychology and Psychiatry, 62-11 (November 2021)  

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Autism spectrum disorders and coexisting disorders in a nationwide Swedish twin study / Sebastian LUNDSTROM in Journal of Child Psychology and Psychiatry, 56-6 (June 2015)  

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