Familial risk analysis of the association between attention-deficit/hyperactivity disorder and psychoactive substance use disorder in female adolescents: a controlled study / Joseph BIEDERMAN in Journal of Child Psychology and Psychiatry, 50-3 (March 2009)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 50-3 (March 2009) . - p.352-358 Titre : Familial risk analysis of the association between attention-deficit/hyperactivity disorder and psychoactive substance use disorder in female adolescents: a controlled study Type de document : Texte imprimé et/ou numérique Auteurs : Joseph BIEDERMAN, Auteur ; Michael C. MONUTEAUX, Auteur ; Stephen V. FARAONE, Auteur ; Carter R. PETTY, Auteur ; Eric MICK, Auteur ; Allison CLARKE, Auteur ; Kristina TEN HAAGEN, Auteur Année de publication : 2009 Article en page(s) : p.352-358 Langues : Anglais (eng) Mots-clés : ADHD substance-use female family-risk Index. décimale : PER Périodiques Résumé : Background: A robust and bi-directional comorbidity between attention-deficit/hyperactivity disorder (ADHD) and psychoactive substance use disorder (PSUD, alcohol or drug abuse, or dependence) has been consistently reported in the literature. However, this literature has been based almost exclusively on male only samples and, therefore, the findings may not generalize to females. Methods: First-degree relatives from a large sample of pediatrically and psychiatrically referred girls with (123 probands, 403 relatives) and without ADHD (112 probands, 359 relatives) were comprehensively assessed by blind raters with structured diagnostic interviews. Familial risk analysis examined the risks in first-degree relatives for ADHD and PSUD (alcohol or drug abuse or dependence) after stratifying probands by the presence and absence of these disorders. Results: ADHD in the proband significantly increased the risk for ADHD in relatives independently of the comorbidity with PSUD. PSUD in the proband was associated with a significantly increased risk for PSUD in relatives regardless of ADHD status. There was no evidence of co-segregation or non-random mating in the families of probands with ADHD and PSUD. Conclusions: Patterns of familial risk analysis suggest that the association between ADHD and PSUD in adolescent females is most consistent with the hypothesis that these disorders are independently transmitted, although the hypothesis of variable expressivity could not be ruled out. These findings are consistent with previously reported patterns of familial associations between ADHD and PSUD found in adolescent males. Longer follow-up periods are needed to more fully clarify the relationship between ADHD and PSUD, as well as provide adequate power for separate analyses of alcohol and drug use. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.02040.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=720 [article] Familial risk analysis of the association between attention-deficit/hyperactivity disorder and psychoactive substance use disorder in female adolescents: a controlled study [Texte imprimé et/ou numérique] / Joseph BIEDERMAN, Auteur ; Michael C. MONUTEAUX, Auteur ; Stephen V. FARAONE, Auteur ; Carter R. PETTY, Auteur ; Eric MICK, Auteur ; Allison CLARKE, Auteur ; Kristina TEN HAAGEN, Auteur . - 2009 . - p.352-358. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 50-3 (March 2009) . - p.352-358 Mots-clés : ADHD substance-use female family-risk Index. décimale : PER Périodiques Résumé : Background: A robust and bi-directional comorbidity between attention-deficit/hyperactivity disorder (ADHD) and psychoactive substance use disorder (PSUD, alcohol or drug abuse, or dependence) has been consistently reported in the literature. However, this literature has been based almost exclusively on male only samples and, therefore, the findings may not generalize to females. Methods: First-degree relatives from a large sample of pediatrically and psychiatrically referred girls with (123 probands, 403 relatives) and without ADHD (112 probands, 359 relatives) were comprehensively assessed by blind raters with structured diagnostic interviews. Familial risk analysis examined the risks in first-degree relatives for ADHD and PSUD (alcohol or drug abuse or dependence) after stratifying probands by the presence and absence of these disorders. Results: ADHD in the proband significantly increased the risk for ADHD in relatives independently of the comorbidity with PSUD. PSUD in the proband was associated with a significantly increased risk for PSUD in relatives regardless of ADHD status. There was no evidence of co-segregation or non-random mating in the families of probands with ADHD and PSUD. Conclusions: Patterns of familial risk analysis suggest that the association between ADHD and PSUD in adolescent females is most consistent with the hypothesis that these disorders are independently transmitted, although the hypothesis of variable expressivity could not be ruled out. These findings are consistent with previously reported patterns of familial associations between ADHD and PSUD found in adolescent males. Longer follow-up periods are needed to more fully clarify the relationship between ADHD and PSUD, as well as provide adequate power for separate analyses of alcohol and drug use. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.02040.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=720

The influence of sex on the course and psychiatric correlates of ADHD from childhood to adolescence: A longitudinal study / Michael C. MONUTEAUX in Journal of Child Psychology and Psychiatry, 51-3 (March 2010)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 51-3 (March 2010) . - p.233-241 Titre : The influence of sex on the course and psychiatric correlates of ADHD from childhood to adolescence: A longitudinal study Type de document : Texte imprimé et/ou numérique Auteurs : Michael C. MONUTEAUX, Auteur ; Joseph BIEDERMAN, Auteur ; Stephen V. FARAONE, Auteur ; Eric MICK, Auteur Année de publication : 2010 Article en page(s) : p.233-241 Langues : Anglais (eng) Mots-clés : ADHD growth-curve sex longitudinal structural-equation model Index. décimale : PER Périodiques Résumé : Background: Little is known about the influence of sex on the course of attention-deficit/hyperactivity disorder (ADHD) and its comorbid psychiatric conditions. The purpose of this study was to examine the effect of sex on the course and psychiatric correlates of ADHD from childhood into adolescence. Methods: Two identically designed, longitudinal, case–control family studies of male and female probands with and without ADHD and their siblings were combined. All subjects were blindly assessed with structured diagnostic interviews. Among subjects with a lifetime history of ADHD (n = 471, mean age 11.5 ± 4.3 years at baseline), we used linear growth curve models to estimate the effect of time on the change in ADHD symptoms, and whether this effect differed by sex. We also we examined the effect of sex on the association between ADHD and the longitudinal progression of comorbid psychopathology using structural equation models. Results: We found no evidence that sex moderated the effect of age on ADHD symptoms; in both genders, age exhibited a similar effect on the decline of ADHD symptoms. However, the female sample demonstrated greater stability in comorbid psychopathology from childhood into adolescence. Furthermore, we found that the stability of comorbid psychopathology in females remained significant after accounting for the correlation between adolescent psychopathology and adolescent ADHD. In males, childhood and adolescent comorbid psychopathology were no longer correlated when adolescent ADHD was taken into account. Conclusions: Our findings indicate that while the course of ADHD across childhood and adolescence did not differ between males and females, patterns of psychiatric comorbidity were conditional on sex. Future studies should explicitly test how sex modifies the associations between ADHD and risk factors and ADHD and associated functional outcomes. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02152.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=988 [article] The influence of sex on the course and psychiatric correlates of ADHD from childhood to adolescence: A longitudinal study [Texte imprimé et/ou numérique] / Michael C. MONUTEAUX, Auteur ; Joseph BIEDERMAN, Auteur ; Stephen V. FARAONE, Auteur ; Eric MICK, Auteur . - 2010 . - p.233-241. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 51-3 (March 2010) . - p.233-241 Mots-clés : ADHD growth-curve sex longitudinal structural-equation model Index. décimale : PER Périodiques Résumé : Background: Little is known about the influence of sex on the course of attention-deficit/hyperactivity disorder (ADHD) and its comorbid psychiatric conditions. The purpose of this study was to examine the effect of sex on the course and psychiatric correlates of ADHD from childhood into adolescence. Methods: Two identically designed, longitudinal, case–control family studies of male and female probands with and without ADHD and their siblings were combined. All subjects were blindly assessed with structured diagnostic interviews. Among subjects with a lifetime history of ADHD (n = 471, mean age 11.5 ± 4.3 years at baseline), we used linear growth curve models to estimate the effect of time on the change in ADHD symptoms, and whether this effect differed by sex. We also we examined the effect of sex on the association between ADHD and the longitudinal progression of comorbid psychopathology using structural equation models. Results: We found no evidence that sex moderated the effect of age on ADHD symptoms; in both genders, age exhibited a similar effect on the decline of ADHD symptoms. However, the female sample demonstrated greater stability in comorbid psychopathology from childhood into adolescence. Furthermore, we found that the stability of comorbid psychopathology in females remained significant after accounting for the correlation between adolescent psychopathology and adolescent ADHD. In males, childhood and adolescent comorbid psychopathology were no longer correlated when adolescent ADHD was taken into account. Conclusions: Our findings indicate that while the course of ADHD across childhood and adolescence did not differ between males and females, patterns of psychiatric comorbidity were conditional on sex. Future studies should explicitly test how sex modifies the associations between ADHD and risk factors and ADHD and associated functional outcomes. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02152.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=988

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