Annual Research Review: Perspectives on progress in ADHD science - from characterization to cause / Edmund J. S. SONUGA-BARKE in Journal of Child Psychology and Psychiatry, 64-4 (April 2023)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 64-4 (April 2023) . - p.506-532 Titre : Annual Research Review: Perspectives on progress in ADHD science - from characterization to cause Type de document : Texte imprimé et/ou numérique Auteurs : Edmund J. S. SONUGA-BARKE, Auteur ; Stephen P. BECKER, Auteur ; Sven BÖLTE, Auteur ; Francisco Xavier CASTELLANOS, Auteur ; Barbara FRANKE, Auteur ; Jeffrey H. NEWCORN, Auteur ; Joel T. NIGG, Auteur ; Luis Augusto ROHDE, Auteur ; Emily SIMONOFF, Auteur Article en page(s) : p.506-532 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The science of attention-deficit/hyperactivity disorder (ADHD) is motivated by a translational goal - the discovery and exploitation of knowledge about the nature of ADHD to the benefit of those individuals whose lives it affects. Over the past fifty years, scientific research has made enormous strides in characterizing the ADHD condition and in understanding its correlates and causes. However, the translation of these scientific insights into clinical benefits has been limited. In this review, we provide a selective and focused survey of the scientific field of ADHD, providing our personal perspectives on what constitutes the scientific consensus, important new leads to be highlighted, and the key outstanding questions to be addressed going forward. We cover two broad domains - clinical characterization and, risk factors, causal processes and neuro-biological pathways. Part one focuses on the developmental course of ADHD, co-occurring characteristics and conditions, and the functional impact of living with ADHD - including impairment, quality of life, and stigma. In part two, we explore genetic and environmental influences and putative mediating brain processes. In the final section, we reflect on the future of the ADHD construct in the light of cross-cutting scientific themes and recent conceptual reformulations that cast ADHD traits as part of a broader spectrum of neurodivergence. En ligne : https://doi.org/10.1111/jcpp.13696 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=501 [article] Annual Research Review: Perspectives on progress in ADHD science - from characterization to cause [Texte imprimé et/ou numérique] / Edmund J. S. SONUGA-BARKE, Auteur ; Stephen P. BECKER, Auteur ; Sven BÖLTE, Auteur ; Francisco Xavier CASTELLANOS, Auteur ; Barbara FRANKE, Auteur ; Jeffrey H. NEWCORN, Auteur ; Joel T. NIGG, Auteur ; Luis Augusto ROHDE, Auteur ; Emily SIMONOFF, Auteur . - p.506-532. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 64-4 (April 2023) . - p.506-532 Index. décimale : PER Périodiques Résumé : The science of attention-deficit/hyperactivity disorder (ADHD) is motivated by a translational goal - the discovery and exploitation of knowledge about the nature of ADHD to the benefit of those individuals whose lives it affects. Over the past fifty years, scientific research has made enormous strides in characterizing the ADHD condition and in understanding its correlates and causes. However, the translation of these scientific insights into clinical benefits has been limited. In this review, we provide a selective and focused survey of the scientific field of ADHD, providing our personal perspectives on what constitutes the scientific consensus, important new leads to be highlighted, and the key outstanding questions to be addressed going forward. We cover two broad domains - clinical characterization and, risk factors, causal processes and neuro-biological pathways. Part one focuses on the developmental course of ADHD, co-occurring characteristics and conditions, and the functional impact of living with ADHD - including impairment, quality of life, and stigma. In part two, we explore genetic and environmental influences and putative mediating brain processes. In the final section, we reflect on the future of the ADHD construct in the light of cross-cutting scientific themes and recent conceptual reformulations that cast ADHD traits as part of a broader spectrum of neurodivergence. En ligne : https://doi.org/10.1111/jcpp.13696 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=501

Assessing medication effects in the MTA study using neuropsychological outcomes / Jeffery N. EPSTEIN in Journal of Child Psychology and Psychiatry, 47-5 (May 2006)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 47-5 (May 2006) . - p.446–456 Titre : Assessing medication effects in the MTA study using neuropsychological outcomes Type de document : Texte imprimé et/ou numérique Auteurs : Jeffery N. EPSTEIN, Auteur ; Peter S. JENSEN, Auteur ; John S. MARCH, Auteur ; Jeffrey H. NEWCORN, Auteur ; William E. PELHAM, Auteur ; Joanne B. SEVERE, Auteur ; James M. SWANSON, Auteur ; Karen WELLS, Auteur ; Benedetto VITIELLO, Auteur ; Betsy HOZA, Auteur ; Stephen P. HINSHAW, Auteur ; Kimberly HOAGWOOD, Auteur ; C. Keith CONNERS, Auteur ; Aaron S. HERVEY, Auteur ; Simon T. TONEV, Auteur ; L. Eugene ARNOLD, Auteur ; Howard B. ABIKOFF, Auteur ; Glen ELLIOTT, Auteur ; Laurence L. GREENHILL, Auteur ; Lily HECHTMAN, Auteur ; Timothy WIGAL, Auteur Année de publication : 2006 Article en page(s) : p.446–456 Langues : Anglais (eng) Mots-clés : ADHD/ADD go/no-go-test stimulants reaction-time distributions neuropsychology pharmacology Index. décimale : PER Périodiques Résumé : Background: While studies have increasingly investigated deficits in reaction time (RT) and RT variability in children with attention deficit/hyperactivity disorder (ADHD), few studies have examined the effects of stimulant medication on these important neuropsychological outcome measures. Methods: 316 children who participated in the Multimodal Treatment Study of Children with ADHD (MTA) completed the Conners' Continuous Performance Test (CPT) at the 24-month assessment point. Outcome measures included standard CPT outcomes (e.g., errors of commission, mean hit reaction time (RT)) and RT indicators derived from an Ex-Gaussian distributional model (i.e., mu, sigma, and tau). Results: Analyses revealed significant effects of medication across all neuropsychological outcome measures. Results on the Ex-Gaussian outcome measures revealed that stimulant medication slows RT and reduces RT variability. Conclusions: This demonstrates the importance of including analytic strategies that can accurately model the actual distributional pattern, including the positive skew. Further, the results of the study relate to several theoretical models of ADHD. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2005.01469.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=730 [article] Assessing medication effects in the MTA study using neuropsychological outcomes [Texte imprimé et/ou numérique] / Jeffery N. EPSTEIN, Auteur ; Peter S. JENSEN, Auteur ; John S. MARCH, Auteur ; Jeffrey H. NEWCORN, Auteur ; William E. PELHAM, Auteur ; Joanne B. SEVERE, Auteur ; James M. SWANSON, Auteur ; Karen WELLS, Auteur ; Benedetto VITIELLO, Auteur ; Betsy HOZA, Auteur ; Stephen P. HINSHAW, Auteur ; Kimberly HOAGWOOD, Auteur ; C. Keith CONNERS, Auteur ; Aaron S. HERVEY, Auteur ; Simon T. TONEV, Auteur ; L. Eugene ARNOLD, Auteur ; Howard B. ABIKOFF, Auteur ; Glen ELLIOTT, Auteur ; Laurence L. GREENHILL, Auteur ; Lily HECHTMAN, Auteur ; Timothy WIGAL, Auteur . - 2006 . - p.446–456. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 47-5 (May 2006) . - p.446–456 Mots-clés : ADHD/ADD go/no-go-test stimulants reaction-time distributions neuropsychology pharmacology Index. décimale : PER Périodiques Résumé : Background: While studies have increasingly investigated deficits in reaction time (RT) and RT variability in children with attention deficit/hyperactivity disorder (ADHD), few studies have examined the effects of stimulant medication on these important neuropsychological outcome measures. Methods: 316 children who participated in the Multimodal Treatment Study of Children with ADHD (MTA) completed the Conners' Continuous Performance Test (CPT) at the 24-month assessment point. Outcome measures included standard CPT outcomes (e.g., errors of commission, mean hit reaction time (RT)) and RT indicators derived from an Ex-Gaussian distributional model (i.e., mu, sigma, and tau). Results: Analyses revealed significant effects of medication across all neuropsychological outcome measures. Results on the Ex-Gaussian outcome measures revealed that stimulant medication slows RT and reduces RT variability. Conclusions: This demonstrates the importance of including analytic strategies that can accurately model the actual distributional pattern, including the positive skew. Further, the results of the study relate to several theoretical models of ADHD. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2005.01469.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=730

Cas 15.1 : Ne respecte pas les règles / Juan D. PEDRAZA

Public ISBD in DSM-5®. Cas cliniques / John W. BARNHILL Titre : Cas 15.1 : Ne respecte pas les règles Type de document : Texte imprimé et/ou numérique Auteurs : Juan D. PEDRAZA, Auteur ; Jeffrey H. NEWCORN, Auteur Année de publication : 2016 Importance : p.206-209 Langues : Français (fre) Index. décimale : SCI-A SCI-A - Classifications Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=470 in DSM-5®. Cas cliniques / John W. BARNHILL Cas 15.1 : Ne respecte pas les règles [Texte imprimé et/ou numérique] / Juan D. PEDRAZA, Auteur ; Jeffrey H. NEWCORN, Auteur . - 2016 . - p.206-209. Langues : Français (fre) Index. décimale : SCI-A SCI-A - Classifications Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=470

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Childhood Maltreatment and Conduct Disorder: Independent Predictors of Adolescent Substance Use Disorders in Youth with Attention Deficit/Hyperactivity Disorder / Virginia A. DE SANCTIS in Journal of Clinical Child & Adolescent Psychology, 37-4 (October-December 2008)  

Public ISBD [article]  inJournal of Clinical Child & Adolescent Psychology > 37-4 (October-December 2008) . - p.785-793 Titre : Childhood Maltreatment and Conduct Disorder: Independent Predictors of Adolescent Substance Use Disorders in Youth with Attention Deficit/Hyperactivity Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Virginia A. DE SANCTIS, Auteur ; Jeffrey H. NEWCORN, Auteur ; David J. MARKS, Auteur ; Jeffrey M. HALPERIN, Auteur ; Joey W. TRAMPUSH, Auteur ; Carlin J. MILLER, Auteur ; Seth C. HARTY, Auteur Année de publication : 2008 Article en page(s) : p.785-793 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Children with attention deficit/hyperactivity disorder (ADHD) are at heightened risk for maltreatment and later substance use disorders (SUDs). We investigated the relationship of childhood maltreatment and other risk factors to SUDs among adolescents diagnosed with ADHD in childhood. Eighty adolescents diagnosed with ADHD when they were 7 to 11 years old were screened for histories of childhood maltreatment, and SUD diagnoses were formulated in accordance with the 4th edition of the Diagnostic and Statistical Manual of Mental Disorders. Lifetime history of problematic substance use was obtained for each parent at baseline. Childhood maltreatment predicted SUD outcome over and above that accounted for by childhood conduct disorder and problematic parental substance use, two potent predictors of adolescent SUDs. En ligne : http://dx.doi.org/10.1080/15374410802359650 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=646 [article] Childhood Maltreatment and Conduct Disorder: Independent Predictors of Adolescent Substance Use Disorders in Youth with Attention Deficit/Hyperactivity Disorder [Texte imprimé et/ou numérique] / Virginia A. DE SANCTIS, Auteur ; Jeffrey H. NEWCORN, Auteur ; David J. MARKS, Auteur ; Jeffrey M. HALPERIN, Auteur ; Joey W. TRAMPUSH, Auteur ; Carlin J. MILLER, Auteur ; Seth C. HARTY, Auteur . - 2008 . - p.785-793. Langues : Anglais (eng) in Journal of Clinical Child & Adolescent Psychology > 37-4 (October-December 2008) . - p.785-793 Index. décimale : PER Périodiques Résumé : Children with attention deficit/hyperactivity disorder (ADHD) are at heightened risk for maltreatment and later substance use disorders (SUDs). We investigated the relationship of childhood maltreatment and other risk factors to SUDs among adolescents diagnosed with ADHD in childhood. Eighty adolescents diagnosed with ADHD when they were 7 to 11 years old were screened for histories of childhood maltreatment, and SUD diagnoses were formulated in accordance with the 4th edition of the Diagnostic and Statistical Manual of Mental Disorders. Lifetime history of problematic substance use was obtained for each parent at baseline. Childhood maltreatment predicted SUD outcome over and above that accounted for by childhood conduct disorder and problematic parental substance use, two potent predictors of adolescent SUDs. En ligne : http://dx.doi.org/10.1080/15374410802359650 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=646

Differential impact of methylphenidate and atomoxetine on sustained attention in youth with attention-deficit/hyperactivity disorder / Anne-Claude V. BÉDARD in Journal of Child Psychology and Psychiatry, 56-1 (January 2015)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 56-1 (January 2015) . - p.40-48 Titre : Differential impact of methylphenidate and atomoxetine on sustained attention in youth with attention-deficit/hyperactivity disorder Type de document : Texte imprimé et/ou numérique Auteurs : Anne-Claude V. BÉDARD, Auteur ; Mark A. STEIN, Auteur ; Jeffrey M. HALPERIN, Auteur ; Beth KRONE, Auteur ; Estrella RAJWAN, Auteur ; Jeffrey H. NEWCORN, Auteur Article en page(s) : p.40-48 Langues : Anglais (eng) Mots-clés : Attention-deficit/hyperactivity disorder  atomoxetine  methylphenidate  attention  vigilance Index. décimale : PER Périodiques Résumé : Background This study examined the effects of atomoxetine (ATX) and OROS methylphenidate (MPH) on laboratory measures of inhibitory control and attention in youth with attention-deficit/hyperactivity disorder (ADHD). It was hypothesized that performance would be improved by both treatments, but response profiles would differ because the medications work via different mechanisms. Methods One hundred and two youth (77 male; mean age = 10.5 ± 2.7 years) with ADHD received ATX (1.4 ± 0.5 mg/kg) and MPH (52.4 ± 16.6 mg) in a randomized, double-blind, crossover design. Medication was titrated in 4–6-week blocks separated by a 2-week placebo washout. Inhibitory control and attention measures were obtained at baseline, following washout, and at the end of each treatment using Conners' Continuous Performance Test II (CPT-II), which provided age-adjusted T-scores for reaction time (RT), reaction time variability (RT variability), and errors. Repeated-measures analyses of variance were performed, with Time (premedication, postmedication) and Treatment type (ATX, MPH) entered as within-subject factors. Data from the two treatment blocks were checked for order effects and combined if order effects were not present. Clinical trial registration: Clinicaltrials.gov: NCT00183391. Results Main effects for Time on RT (p = .03), RTSD (p = .001), and omission errors (p = .01) were significant. A significant Drug × Time interaction indicated that MPH improved RT, RTSD, and omission errors more than ATX (p < .05). Changes in performance with treatment did not correlate with changes in ADHD symptoms. Conclusions MPH has greater effects than ATX on CPT measures of sustained attention in youth with ADHD. However, the dissociation of cognitive and behavioral change with treatment indicates that CPT measures cannot be considered proxies for symptomatic improvement. Further research on the dissociation of cognitive and behavioral endpoints for ADHD is indicated. En ligne : http://dx.doi.org/10.1111/jcpp.12272 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=259 [article] Differential impact of methylphenidate and atomoxetine on sustained attention in youth with attention-deficit/hyperactivity disorder [Texte imprimé et/ou numérique] / Anne-Claude V. BÉDARD, Auteur ; Mark A. STEIN, Auteur ; Jeffrey M. HALPERIN, Auteur ; Beth KRONE, Auteur ; Estrella RAJWAN, Auteur ; Jeffrey H. NEWCORN, Auteur . - p.40-48. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 56-1 (January 2015) . - p.40-48 Mots-clés : Attention-deficit/hyperactivity disorder  atomoxetine  methylphenidate  attention  vigilance Index. décimale : PER Périodiques Résumé : Background This study examined the effects of atomoxetine (ATX) and OROS methylphenidate (MPH) on laboratory measures of inhibitory control and attention in youth with attention-deficit/hyperactivity disorder (ADHD). It was hypothesized that performance would be improved by both treatments, but response profiles would differ because the medications work via different mechanisms. Methods One hundred and two youth (77 male; mean age = 10.5 ± 2.7 years) with ADHD received ATX (1.4 ± 0.5 mg/kg) and MPH (52.4 ± 16.6 mg) in a randomized, double-blind, crossover design. Medication was titrated in 4–6-week blocks separated by a 2-week placebo washout. Inhibitory control and attention measures were obtained at baseline, following washout, and at the end of each treatment using Conners' Continuous Performance Test II (CPT-II), which provided age-adjusted T-scores for reaction time (RT), reaction time variability (RT variability), and errors. Repeated-measures analyses of variance were performed, with Time (premedication, postmedication) and Treatment type (ATX, MPH) entered as within-subject factors. Data from the two treatment blocks were checked for order effects and combined if order effects were not present. Clinical trial registration: Clinicaltrials.gov: NCT00183391. Results Main effects for Time on RT (p = .03), RTSD (p = .001), and omission errors (p = .01) were significant. A significant Drug × Time interaction indicated that MPH improved RT, RTSD, and omission errors more than ATX (p < .05). Changes in performance with treatment did not correlate with changes in ADHD symptoms. Conclusions MPH has greater effects than ATX on CPT measures of sustained attention in youth with ADHD. However, the dissociation of cognitive and behavioral change with treatment indicates that CPT measures cannot be considered proxies for symptomatic improvement. Further research on the dissociation of cognitive and behavioral endpoints for ADHD is indicated. En ligne : http://dx.doi.org/10.1111/jcpp.12272 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=259

Extended-release guanfacine hydrochloride in 6–17-year olds with ADHD: a randomised-withdrawal maintenance of efficacy study / Jeffrey H. NEWCORN in Journal of Child Psychology and Psychiatry, 57-6 (June 2016)  

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Neuropsychological outcome in adolescents/young adults with childhood ADHD: profiles of persisters, remitters and controls / Jeffrey M. HALPERIN in Journal of Child Psychology and Psychiatry, 49-9 (September 2008)  

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Practitioner Review: Continuity of mental health care from childhood to adulthood for youths with ADHD  -  who, how and when? / Nicoletta ADAMO in Journal of Child Psychology and Psychiatry, 65-11 (November 2024)  

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Prenatal exposure to a natural disaster and early development of psychiatric disorders during the preschool years: stress in pregnancy study / Yoko NOMURA in Journal of Child Psychology and Psychiatry, 64-7 (July 2023)  

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Response to uncertainty in developmental origins of health and disease research: commentary on Nomura et al. (2022) / Jeffrey H. NEWCORN ; Yasmin L. HURD in Journal of Child Psychology and Psychiatry, 65-7 (July 2024)  

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Roles of perinatal problems on adolescent antisocial behaviors among children born after 33 completed weeks: a prospective investigation / Yoko NOMURA in Journal of Child Psychology and Psychiatry, 49-10 (October 2008)  

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Young adult outcomes in the follow-up of the multimodal treatment study of attention-deficit/hyperactivity disorder: symptom persistence, source discrepancy, and height suppression / James M. SWANSON in Journal of Child Psychology and Psychiatry, 58-6 (June 2017)  

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