Antisocial peer affiliation and externalizing disorders: Evidence for Gene × Environment × Development interaction / Diana R. SAMEK in Development and Psychopathology, 29-1 (February 2017)  

Public ISBD [article]  inDevelopment and Psychopathology > 29-1 (February 2017) . - p.155-172 Titre : Antisocial peer affiliation and externalizing disorders: Evidence for Gene × Environment × Development interaction Type de document : Texte imprimé et/ou numérique Auteurs : Diana R. SAMEK, Auteur ; Brian M. HICKS, Auteur ; Margaret A. KEYES, Auteur ; William G. IACONO, Auteur ; Matt MCGUE, Auteur Article en page(s) : p.155-172 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : AbstractGene × Environment interaction contributes to externalizing disorders in childhood and adolescence, but little is known about whether such effects are long lasting or present in adulthood. We examined gene–environment interplay in the concurrent and prospective associations between antisocial peer affiliation and externalizing disorders (antisocial behavior and substance use disorders) at ages 17, 20, 24, and 29. The sample included 1,382 same-sex twin pairs participating in the Minnesota Twin Family Study. We detected a Gene × Environment interaction at age 17, such that additive genetic influences on antisocial behavior and substance use disorders were greater in the context of greater antisocial peer affiliation. This Gene × Environment interaction was not present for antisocial behavior symptoms after age 17, but it was for substance use disorder symptoms through age 29 (though effect sizes were largest at age 17). The results suggest adolescence is a critical period for the development of externalizing disorders wherein exposure to greater environmental adversity is associated with a greater expression of genetic risk. This form of Gene × Environment interaction may persist through young adulthood for substance use disorders, but it appears to be limited to adolescence for antisocial behavior. En ligne : http://dx.doi.org/10.1017/s0954579416000109 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298 [article] Antisocial peer affiliation and externalizing disorders: Evidence for Gene × Environment × Development interaction [Texte imprimé et/ou numérique] / Diana R. SAMEK, Auteur ; Brian M. HICKS, Auteur ; Margaret A. KEYES, Auteur ; William G. IACONO, Auteur ; Matt MCGUE, Auteur . - p.155-172. Langues : Anglais (eng) in Development and Psychopathology > 29-1 (February 2017) . - p.155-172 Index. décimale : PER Périodiques Résumé : AbstractGene × Environment interaction contributes to externalizing disorders in childhood and adolescence, but little is known about whether such effects are long lasting or present in adulthood. We examined gene–environment interplay in the concurrent and prospective associations between antisocial peer affiliation and externalizing disorders (antisocial behavior and substance use disorders) at ages 17, 20, 24, and 29. The sample included 1,382 same-sex twin pairs participating in the Minnesota Twin Family Study. We detected a Gene × Environment interaction at age 17, such that additive genetic influences on antisocial behavior and substance use disorders were greater in the context of greater antisocial peer affiliation. This Gene × Environment interaction was not present for antisocial behavior symptoms after age 17, but it was for substance use disorder symptoms through age 29 (though effect sizes were largest at age 17). The results suggest adolescence is a critical period for the development of externalizing disorders wherein exposure to greater environmental adversity is associated with a greater expression of genetic risk. This form of Gene × Environment interaction may persist through young adulthood for substance use disorders, but it appears to be limited to adolescence for antisocial behavior. En ligne : http://dx.doi.org/10.1017/s0954579416000109 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298

Gene–environment correlation in the development of adolescent substance abuse: Selection effects of child personality and mediation via contextual risk factors / Brian M. HICKS in Development and Psychopathology, 25-1 (February 2013)  

Public ISBD [article]  inDevelopment and Psychopathology > 25-1 (February 2013) . - p.119-132 Titre : Gene–environment correlation in the development of adolescent substance abuse: Selection effects of child personality and mediation via contextual risk factors Type de document : Texte imprimé et/ou numérique Auteurs : Brian M. HICKS, Auteur ; Wendy JOHNSON, Auteur ; C. Emily DURBIN, Auteur ; Daniel M. BLONIGEN, Auteur ; William G. IACONO, Auteur ; Matt MCGUE, Auteur Article en page(s) : p.119-132 Index. décimale : PER Périodiques Résumé : We used a longitudinal twin design to examine selection effects of personality traits at age 11 on high-risk environmental contexts at age 14 and the extent to which these contexts mediated risk for substance abuse at age 17. Socialization at age 11 (willingness to follow rules and endorse conventional values) predicted exposure to contextual risk at age 14. Contextual risk partially mediated the effect of socialization on substance abuse, though socialization also had a direct effect. In contrast, boldness at age 11 (social engagement and assurance, thrill seeking, and stress resilience) also predicted substance abuse directly but was unrelated to contextual risk. There was substantial overlap in the genetic and shared environmental influences on socialization and contextual risk, and genetic risk in socialization contributed to substance abuse indirectly via increased exposure to contextual risk. This suggests that active gene–environment correlations related to individual differences in socialization contributed to an early, high-risk developmental trajectory for adolescent substance abuse. In contrast, boldness appeared to index an independent and direct genetic risk factor for adolescent substance abuse. En ligne : http://dx.doi.org/10.1017/S0954579412000946 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=190 [article] Gene–environment correlation in the development of adolescent substance abuse: Selection effects of child personality and mediation via contextual risk factors [Texte imprimé et/ou numérique] / Brian M. HICKS, Auteur ; Wendy JOHNSON, Auteur ; C. Emily DURBIN, Auteur ; Daniel M. BLONIGEN, Auteur ; William G. IACONO, Auteur ; Matt MCGUE, Auteur . - p.119-132. in Development and Psychopathology > 25-1 (February 2013) . - p.119-132 Index. décimale : PER Périodiques Résumé : We used a longitudinal twin design to examine selection effects of personality traits at age 11 on high-risk environmental contexts at age 14 and the extent to which these contexts mediated risk for substance abuse at age 17. Socialization at age 11 (willingness to follow rules and endorse conventional values) predicted exposure to contextual risk at age 14. Contextual risk partially mediated the effect of socialization on substance abuse, though socialization also had a direct effect. In contrast, boldness at age 11 (social engagement and assurance, thrill seeking, and stress resilience) also predicted substance abuse directly but was unrelated to contextual risk. There was substantial overlap in the genetic and shared environmental influences on socialization and contextual risk, and genetic risk in socialization contributed to substance abuse indirectly via increased exposure to contextual risk. This suggests that active gene–environment correlations related to individual differences in socialization contributed to an early, high-risk developmental trajectory for adolescent substance abuse. In contrast, boldness appeared to index an independent and direct genetic risk factor for adolescent substance abuse. En ligne : http://dx.doi.org/10.1017/S0954579412000946 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=190

Gene–environment interplay in internalizing disorders: consistent findings across six environmental risk factors / Brian M. HICKS in Journal of Child Psychology and Psychiatry, 50-10 (October 2009)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 50-10 (October 2009) . - p.1309-1317 Titre : Gene–environment interplay in internalizing disorders: consistent findings across six environmental risk factors Type de document : Texte imprimé et/ou numérique Auteurs : Brian M. HICKS, Auteur ; William G. IACONO, Auteur ; Matt MCGUE, Auteur ; Ana C. DIRAGO, Auteur Année de publication : 2009 Article en page(s) : p.1309-1317 Langues : Anglais (eng) Mots-clés : Behavioral-genetics internalizing-disorder adolescence environmental-influences adversity Index. décimale : PER Périodiques Résumé : Background: Behavior genetic methods can help to elucidate gene-environment (G-E) interplay in the development of internalizing (INT) disorders (i.e., major depression and anxiety disorders). To date, however, no study has conducted a comprehensive analysis examining multiple environmental risk factors with the purpose of delineating general mechanisms of G-E influence in the development of INT disorders. Methods: The sample consisted of 1315 male and female twin pairs participating in the age 17 assessment of the Minnesota Twin Family Study. Quantitative G-E interplay models were used to examine how genetic and environmental risk for INT disorders changes as a function of environmental context. Multiple measures and informants were employed to construct composite measures of INT disorders and six environmental risk factors including: stressful life events, mother–child and father–child relationship problems, antisocial and prosocial peer affiliation, and academic achievement and engagement. Results: Significant moderation effects were detected between each environmental risk factor and INT such that in the context of greater environmental adversity, nonshared environmental factors became more important in the etiology of INT symptoms. Conclusion: Our results are consistent with the interpretation that environmental stressors have a causative effect on the emergence of INT disorders. The consistency of our results suggests a general mechanism of environmental influence on INT disorders regardless of the specific form of environmental risk. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02100.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=838 [article] Gene–environment interplay in internalizing disorders: consistent findings across six environmental risk factors [Texte imprimé et/ou numérique] / Brian M. HICKS, Auteur ; William G. IACONO, Auteur ; Matt MCGUE, Auteur ; Ana C. DIRAGO, Auteur . - 2009 . - p.1309-1317. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 50-10 (October 2009) . - p.1309-1317 Mots-clés : Behavioral-genetics internalizing-disorder adolescence environmental-influences adversity Index. décimale : PER Périodiques Résumé : Background: Behavior genetic methods can help to elucidate gene-environment (G-E) interplay in the development of internalizing (INT) disorders (i.e., major depression and anxiety disorders). To date, however, no study has conducted a comprehensive analysis examining multiple environmental risk factors with the purpose of delineating general mechanisms of G-E influence in the development of INT disorders. Methods: The sample consisted of 1315 male and female twin pairs participating in the age 17 assessment of the Minnesota Twin Family Study. Quantitative G-E interplay models were used to examine how genetic and environmental risk for INT disorders changes as a function of environmental context. Multiple measures and informants were employed to construct composite measures of INT disorders and six environmental risk factors including: stressful life events, mother–child and father–child relationship problems, antisocial and prosocial peer affiliation, and academic achievement and engagement. Results: Significant moderation effects were detected between each environmental risk factor and INT such that in the context of greater environmental adversity, nonshared environmental factors became more important in the etiology of INT symptoms. Conclusion: Our results are consistent with the interpretation that environmental stressors have a causative effect on the emergence of INT disorders. The consistency of our results suggests a general mechanism of environmental influence on INT disorders regardless of the specific form of environmental risk. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02100.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=838

Genetic and environmental influences on the codevelopment among borderline personality disorder traits, major depression symptoms, and substance use disorder symptoms from adolescence to young adulthood / Marina A. BORNOVALOVA in Development and Psychopathology, 30-1 (February 2018)  

Public ISBD [article]  inDevelopment and Psychopathology > 30-1 (February 2018) . - p.49-65 Titre : Genetic and environmental influences on the codevelopment among borderline personality disorder traits, major depression symptoms, and substance use disorder symptoms from adolescence to young adulthood Type de document : Texte imprimé et/ou numérique Auteurs : Marina A. BORNOVALOVA, Auteur ; Brad VERHULST, Auteur ; Troy WEBBER, Auteur ; Matt MCGUE, Auteur ; William G. IACONO, Auteur ; Brian M. HICKS, Auteur Article en page(s) : p.49-65 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Although borderline personality disorder (BPD) traits decline from adolescence to adulthood, comorbid psychopathology such as symptoms of major depressive disorder (MDD), alcohol use disorder (AUD), and drug use disorders (DUDs) likely disrupt this normative decline. Using a longitudinal sample of female twins (N = 1,763), we examined if levels of BPD traits were correlated with changes in MDD, AUD, and DUD symptoms from ages 14 to 24. A parallel process biometric latent growth model examined the contributions of genetic and environmental factors to the relationships between developmental components of these phenotypes. Higher BPD trait levels predicted a greater rate of increase in AUD and DUD symptoms, and higher AUD and DUD symptoms predicted a slower rate of decline of BPD traits from ages 14 to 24. Common genetic influences accounted for the associations between BPD traits and each disorder, as well as the interrelationships of AUD and DUD symptoms. Both genetic and nonshared environmental influences accounted for the correlated levels between BPD traits and MDD symptoms, but solely environmental influences accounted for the correlated changes between the two over time. Results indicate that higher levels of BPD traits may contribute to an earlier onset and faster escalation of AUD and DUD symptoms, and substance use problems slow the normative decline in BPD traits. Overall, our data suggests that primarily genetic influences contribute to the comorbidity between BPD features and substance use disorder symptoms. We discuss our data in the context of two major theories of developmental psychopathology and comorbidity. En ligne : https://doi.org/10.1017/S0954579417000463 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=335 [article] Genetic and environmental influences on the codevelopment among borderline personality disorder traits, major depression symptoms, and substance use disorder symptoms from adolescence to young adulthood [Texte imprimé et/ou numérique] / Marina A. BORNOVALOVA, Auteur ; Brad VERHULST, Auteur ; Troy WEBBER, Auteur ; Matt MCGUE, Auteur ; William G. IACONO, Auteur ; Brian M. HICKS, Auteur . - p.49-65. Langues : Anglais (eng) in Development and Psychopathology > 30-1 (February 2018) . - p.49-65 Index. décimale : PER Périodiques Résumé : Although borderline personality disorder (BPD) traits decline from adolescence to adulthood, comorbid psychopathology such as symptoms of major depressive disorder (MDD), alcohol use disorder (AUD), and drug use disorders (DUDs) likely disrupt this normative decline. Using a longitudinal sample of female twins (N = 1,763), we examined if levels of BPD traits were correlated with changes in MDD, AUD, and DUD symptoms from ages 14 to 24. A parallel process biometric latent growth model examined the contributions of genetic and environmental factors to the relationships between developmental components of these phenotypes. Higher BPD trait levels predicted a greater rate of increase in AUD and DUD symptoms, and higher AUD and DUD symptoms predicted a slower rate of decline of BPD traits from ages 14 to 24. Common genetic influences accounted for the associations between BPD traits and each disorder, as well as the interrelationships of AUD and DUD symptoms. Both genetic and nonshared environmental influences accounted for the correlated levels between BPD traits and MDD symptoms, but solely environmental influences accounted for the correlated changes between the two over time. Results indicate that higher levels of BPD traits may contribute to an earlier onset and faster escalation of AUD and DUD symptoms, and substance use problems slow the normative decline in BPD traits. Overall, our data suggests that primarily genetic influences contribute to the comorbidity between BPD features and substance use disorder symptoms. We discuss our data in the context of two major theories of developmental psychopathology and comorbidity. En ligne : https://doi.org/10.1017/S0954579417000463 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=335

Identifying childhood characteristics that underlie premorbid risk for substance use disorders: Socialization and boldness / Brian M. HICKS in Development and Psychopathology, 26-1 (February 2014)  

Public ISBD [article]  inDevelopment and Psychopathology > 26-1 (February 2014) . - p.141-157 Titre : Identifying childhood characteristics that underlie premorbid risk for substance use disorders: Socialization and boldness Type de document : Texte imprimé et/ou numérique Auteurs : Brian M. HICKS, Auteur ; William G. IACONO, Auteur ; Matt MCGUE, Auteur Article en page(s) : p.141-157 Langues : Français (fre) Index. décimale : PER Périodiques Résumé : We utilized a longitudinal twin study (N = 2,510) to identify the child characteristics present prior to initiation of substance use that best predicted later substance use disorders. Two independent traits accounted for the majority of premorbid risk: socialization (conformity to rules and conventional values) and boldness (sociability and social assurance, stress resilience, and thrill seeking). Low socialization was associated with disruptive behavior disorders, parental externalizing disorders, and environmental adversity and exhibited moderate genetic (0.45) and shared environmental influences (0.30). Boldness was highly heritable (0.71) and associated with less internalizing distress and environmental adversity. In combination, these traits exhibited robust associations with adolescent and young adult substance use disorders (R = .48 and .50, respectively) and incremental prediction over disruptive behavior disorders, parental externalizing disorders, and environmental adversity. The results were replicated in an independent sample. Socialization and boldness offer a novel conceptualization of underlying risk for substance use disorders that has the potential to improve prediction and theory with implications for basic research, prevention, and intervention. En ligne : http://dx.doi.org/10.1017/S0954579413000862 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=224 [article] Identifying childhood characteristics that underlie premorbid risk for substance use disorders: Socialization and boldness [Texte imprimé et/ou numérique] / Brian M. HICKS, Auteur ; William G. IACONO, Auteur ; Matt MCGUE, Auteur . - p.141-157. Langues : Français (fre) in Development and Psychopathology > 26-1 (February 2014) . - p.141-157 Index. décimale : PER Périodiques Résumé : We utilized a longitudinal twin study (N = 2,510) to identify the child characteristics present prior to initiation of substance use that best predicted later substance use disorders. Two independent traits accounted for the majority of premorbid risk: socialization (conformity to rules and conventional values) and boldness (sociability and social assurance, stress resilience, and thrill seeking). Low socialization was associated with disruptive behavior disorders, parental externalizing disorders, and environmental adversity and exhibited moderate genetic (0.45) and shared environmental influences (0.30). Boldness was highly heritable (0.71) and associated with less internalizing distress and environmental adversity. In combination, these traits exhibited robust associations with adolescent and young adult substance use disorders (R = .48 and .50, respectively) and incremental prediction over disruptive behavior disorders, parental externalizing disorders, and environmental adversity. The results were replicated in an independent sample. Socialization and boldness offer a novel conceptualization of underlying risk for substance use disorders that has the potential to improve prediction and theory with implications for basic research, prevention, and intervention. En ligne : http://dx.doi.org/10.1017/S0954579413000862 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=224

Stability, change, and heritability of borderline personality disorder traits from adolescence to adulthood: A longitudinal twin study / Marina A. BORNOVALOVA in Development and Psychopathology, 21-4 (November 2009)  

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