Differential susceptibility in longitudinal models of gene–environment interaction for adolescent depression / James J. LI in Development and Psychopathology, 25-4 (November 2013)  

Public ISBD [article]  inDevelopment and Psychopathology > 25-4 (November 2013) . - p.991-1003 Titre : Differential susceptibility in longitudinal models of gene–environment interaction for adolescent depression Type de document : Texte imprimé et/ou numérique Auteurs : James J. LI, Auteur ; Michele S. BERK, Auteur ; Steve S. LEE, Auteur Article en page(s) : p.991-1003 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Although family support reliably predicts the development of adolescent depression and suicidal behaviors, relatively little is known about the interplay of family support with potential genetic factors. We tested the association of the 44 base pair polymorphism in the serotonin transporter linked promoter region gene (5-HTTLPR), family support (i.e., cohesion, communication, and warmth), and their interaction with self-reported depression symptoms and risk for suicide in 1,030 Caucasian adolescents and young adults from the National Longitudinal Study of Adolescent Health. High-quality family support predicted fewer symptoms of depression and reduced risk for suicidality. There was also a significant interaction between 5-HTTLPR and family support for boys and a marginally significant interaction for girls. Among boys with poor family support, youth with at least one short allele had more symptoms of depression and a higher risk for suicide attempts relative to boys homozygous for the long allele. However, in the presence of high family support, boys with the short allele had the fewest depression symptoms (but not suicide attempts). Results suggest that the short allele may increase reactivity to both negative and positive family influences in the development of depression. We discuss the potential role of interactive exchanges between family support and offspring genotype in the development of adolescent depression and suicidal behaviors. En ligne : http://dx.doi.org/10.1017/S0954579413000321 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=219 [article] Differential susceptibility in longitudinal models of gene–environment interaction for adolescent depression [Texte imprimé et/ou numérique] / James J. LI, Auteur ; Michele S. BERK, Auteur ; Steve S. LEE, Auteur . - p.991-1003. Langues : Anglais (eng) in Development and Psychopathology > 25-4 (November 2013) . - p.991-1003 Index. décimale : PER Périodiques Résumé : Although family support reliably predicts the development of adolescent depression and suicidal behaviors, relatively little is known about the interplay of family support with potential genetic factors. We tested the association of the 44 base pair polymorphism in the serotonin transporter linked promoter region gene (5-HTTLPR), family support (i.e., cohesion, communication, and warmth), and their interaction with self-reported depression symptoms and risk for suicide in 1,030 Caucasian adolescents and young adults from the National Longitudinal Study of Adolescent Health. High-quality family support predicted fewer symptoms of depression and reduced risk for suicidality. There was also a significant interaction between 5-HTTLPR and family support for boys and a marginally significant interaction for girls. Among boys with poor family support, youth with at least one short allele had more symptoms of depression and a higher risk for suicide attempts relative to boys homozygous for the long allele. However, in the presence of high family support, boys with the short allele had the fewest depression symptoms (but not suicide attempts). Results suggest that the short allele may increase reactivity to both negative and positive family influences in the development of depression. We discuss the potential role of interactive exchanges between family support and offspring genotype in the development of adolescent depression and suicidal behaviors. En ligne : http://dx.doi.org/10.1017/S0954579413000321 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=219

EMPIRICAL ARTICLES: Are There Sex Differences in the Predictive Validity of DSM—IV ADHD Among Younger Children? / Benjamin B. LAHEY in Journal of Clinical Child & Adolescent Psychology, 36-2 (April-June 2007)  

Public ISBD [article]  inJournal of Clinical Child & Adolescent Psychology > 36-2 (April-June 2007) . - p.113-126 Titre : EMPIRICAL ARTICLES: Are There Sex Differences in the Predictive Validity of DSM—IV ADHD Among Younger Children? Type de document : Texte imprimé et/ou numérique Auteurs : Benjamin B. LAHEY, Auteur ; William E. PELHAM, Auteur ; Andrea CHRONIS, Auteur ; Steve S. LEE, Auteur ; Cynthia M. HARTUNG, Auteur ; Jan LONEY, Auteur Année de publication : 2007 Article en page(s) : p.113-126 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : We assessed the predictive validity of attention-deficit/hyperactivity disorder (ADHD) in 20 girls and 98 boys who met the Diagnostic and Statistical Manual for Mental Disorders (4th ed., American Psychiatric Association, 1994) criteria for ADHD at 4 to 6 years of age compared to 24 female and 102 male comparison children. Over the next 8 years, both girls and boys who met criteria for ADHD in Year 1 exhibited more ADHD symptoms and impairment than same-sex comparison children. Effect sizes were consistently large, indicating that the diagnosis of ADHD at 4 to 6 years of age has predictive validity for both sexes. Both girls and boys with ADHD in Year 1 also exhibited higher levels of symptoms of conduct disorder, major depression, and anxiety disorders in early adolescence than same-sex comparison children, controlling levels of the same symptoms in Year 1. This indicates both substantial homotypic and heterotypic continuity for ADHD in both sexes, but significant interactions with time indicated that childhood ADHD predicts more steeply rising symptoms of anxiety and depression during early adolescence in girls than in boys. En ligne : http://dx.doi.org/10.1080/15374410701274066 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=144 [article] EMPIRICAL ARTICLES: Are There Sex Differences in the Predictive Validity of DSM—IV ADHD Among Younger Children? [Texte imprimé et/ou numérique] / Benjamin B. LAHEY, Auteur ; William E. PELHAM, Auteur ; Andrea CHRONIS, Auteur ; Steve S. LEE, Auteur ; Cynthia M. HARTUNG, Auteur ; Jan LONEY, Auteur . - 2007 . - p.113-126. Langues : Anglais (eng) in Journal of Clinical Child & Adolescent Psychology > 36-2 (April-June 2007) . - p.113-126 Index. décimale : PER Périodiques Résumé : We assessed the predictive validity of attention-deficit/hyperactivity disorder (ADHD) in 20 girls and 98 boys who met the Diagnostic and Statistical Manual for Mental Disorders (4th ed., American Psychiatric Association, 1994) criteria for ADHD at 4 to 6 years of age compared to 24 female and 102 male comparison children. Over the next 8 years, both girls and boys who met criteria for ADHD in Year 1 exhibited more ADHD symptoms and impairment than same-sex comparison children. Effect sizes were consistently large, indicating that the diagnosis of ADHD at 4 to 6 years of age has predictive validity for both sexes. Both girls and boys with ADHD in Year 1 also exhibited higher levels of symptoms of conduct disorder, major depression, and anxiety disorders in early adolescence than same-sex comparison children, controlling levels of the same symptoms in Year 1. This indicates both substantial homotypic and heterotypic continuity for ADHD in both sexes, but significant interactions with time indicated that childhood ADHD predicts more steeply rising symptoms of anxiety and depression during early adolescence in girls than in boys. En ligne : http://dx.doi.org/10.1080/15374410701274066 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=144

Few Girls With Childhood Attention-Deficit/Hyperactivity Disorder Show Positive Adjustment During Adolescence / Elizabeth B. OWENS in Journal of Clinical Child & Adolescent Psychology, 38-1 (January-February 2009)  

Public ISBD [article]  inJournal of Clinical Child & Adolescent Psychology > 38-1 (January-February 2009) . - p.132-143 Titre : Few Girls With Childhood Attention-Deficit/Hyperactivity Disorder Show Positive Adjustment During Adolescence Type de document : Texte imprimé et/ou numérique Auteurs : Elizabeth B. OWENS, Auteur ; Stephen P. HINSHAW, Auteur ; Benjamin B. LAHEY, Auteur ; Steve S. LEE, Auteur Année de publication : 2009 Article en page(s) : p.132-143 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Employing data from 140 prospectively followed girls with attention-deficit/hyperactivity disorder (ADHD) and 88 age- and ethnicity-matched comparison girls, we adopted a person-centered analytic approach to assess rates of adolescent positive adjustment (PA) across six domains: ADHD symptoms, externalizing symptoms, internalizing symptoms, social skills, peer acceptance, and school achievement. During adolescence, between 19.8% and 61.1% of the girls with childhood ADHD met criteria for PA when the six domains were considered independently. A total of 16.4% of the ADHD sample showed PA in at least five of six domains, versus 86.4% of the comparison girls. Results were similar when PA was examined excluding the ADHD symptom domain. Most girls did not “grow out of” the symptoms and impairments related to their ADHD. En ligne : http://dx.doi.org/10.1080/15374410802575313 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=682 [article] Few Girls With Childhood Attention-Deficit/Hyperactivity Disorder Show Positive Adjustment During Adolescence [Texte imprimé et/ou numérique] / Elizabeth B. OWENS, Auteur ; Stephen P. HINSHAW, Auteur ; Benjamin B. LAHEY, Auteur ; Steve S. LEE, Auteur . - 2009 . - p.132-143. Langues : Anglais (eng) in Journal of Clinical Child & Adolescent Psychology > 38-1 (January-February 2009) . - p.132-143 Index. décimale : PER Périodiques Résumé : Employing data from 140 prospectively followed girls with attention-deficit/hyperactivity disorder (ADHD) and 88 age- and ethnicity-matched comparison girls, we adopted a person-centered analytic approach to assess rates of adolescent positive adjustment (PA) across six domains: ADHD symptoms, externalizing symptoms, internalizing symptoms, social skills, peer acceptance, and school achievement. During adolescence, between 19.8% and 61.1% of the girls with childhood ADHD met criteria for PA when the six domains were considered independently. A total of 16.4% of the ADHD sample showed PA in at least five of six domains, versus 86.4% of the comparison girls. Results were similar when PA was examined excluding the ADHD symptom domain. Most girls did not “grow out of” the symptoms and impairments related to their ADHD. En ligne : http://dx.doi.org/10.1080/15374410802575313 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=682

Interaction of dopamine transporter (DAT1) genotype and maltreatment for ADHD: a latent class analysis / James J. LI in Journal of Child Psychology and Psychiatry, 53-9 (September 2012)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 53-9 (September 2012) . - p.997-1005 Titre : Interaction of dopamine transporter (DAT1) genotype and maltreatment for ADHD: a latent class analysis Type de document : Texte imprimé et/ou numérique Auteurs : James J. LI, Auteur ; Steve S. LEE, Auteur Année de publication : 2012 Article en page(s) : p.997-1005 Langues : Anglais (eng) Mots-clés : ADHD  latent class analysis  gene-environment interaction  DAT1  maltreatment Index. décimale : PER Périodiques Résumé : Background:  Although the association of the dopamine transporter (DAT1) gene and attention-deficit/hyperactivity disorder (ADHD) has been widely studied, far less is known about its potential interaction with environmental risk factors. Given that maltreatment is a replicated risk factor for ADHD, we explored the interaction between DAT1 and maltreatment with ADHD symptoms defined dimensionally and using latent class analysis (LCA). Method:  We tested the association of the 40 base-pair variable number of tandem repeats polymorphism in DAT1, maltreatment, and their interaction in 2,488 boys and girls from the National Longitudinal Study of Adolescent Health. Results:  In boys, ADHD symptoms were optimally defined by four classes (Combined, Hyperactive/Impulsive, Inattentive, and Normal), whereas in girls, ADHD symptoms were defined by three classes (Combined, Combined-Mild, Normal). A significant DAT1 × maltreatment interaction revealed that maltreated girls homozygous for the 10-repeat allele had more symptoms of ADHD, and were also 2.5 times more likely to be classified in the Combined ADHD group than in the Normal Group. Conclusions:  The underlying structure of ADHD symptoms differed between boys and girls and DAT1 interacted with maltreatment to predict ADHD symptoms and ADHD status derived from LCA. Interactive exchanges between maltreatment and DAT1 for ADHD symptoms, and their implications for intervention, are discussed. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02563.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=179 [article] Interaction of dopamine transporter (DAT1) genotype and maltreatment for ADHD: a latent class analysis [Texte imprimé et/ou numérique] / James J. LI, Auteur ; Steve S. LEE, Auteur . - 2012 . - p.997-1005. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 53-9 (September 2012) . - p.997-1005 Mots-clés : ADHD  latent class analysis  gene-environment interaction  DAT1  maltreatment Index. décimale : PER Périodiques Résumé : Background:  Although the association of the dopamine transporter (DAT1) gene and attention-deficit/hyperactivity disorder (ADHD) has been widely studied, far less is known about its potential interaction with environmental risk factors. Given that maltreatment is a replicated risk factor for ADHD, we explored the interaction between DAT1 and maltreatment with ADHD symptoms defined dimensionally and using latent class analysis (LCA). Method:  We tested the association of the 40 base-pair variable number of tandem repeats polymorphism in DAT1, maltreatment, and their interaction in 2,488 boys and girls from the National Longitudinal Study of Adolescent Health. Results:  In boys, ADHD symptoms were optimally defined by four classes (Combined, Hyperactive/Impulsive, Inattentive, and Normal), whereas in girls, ADHD symptoms were defined by three classes (Combined, Combined-Mild, Normal). A significant DAT1 × maltreatment interaction revealed that maltreated girls homozygous for the 10-repeat allele had more symptoms of ADHD, and were also 2.5 times more likely to be classified in the Combined ADHD group than in the Normal Group. Conclusions:  The underlying structure of ADHD symptoms differed between boys and girls and DAT1 interacted with maltreatment to predict ADHD symptoms and ADHD status derived from LCA. Interactive exchanges between maltreatment and DAT1 for ADHD symptoms, and their implications for intervention, are discussed. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02563.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=179

Latent trajectories of adolescent antisocial behavior: Serotonin transporter linked polymorphic region (5-HTTLPR) genotype influences sensitivity to perceived parental support / Irene TUNG in Development and Psychopathology, 29-1 (February 2017)  

Public ISBD [article]  inDevelopment and Psychopathology > 29-1 (February 2017) . - p.185-201 Titre : Latent trajectories of adolescent antisocial behavior: Serotonin transporter linked polymorphic region (5-HTTLPR) genotype influences sensitivity to perceived parental support Type de document : Texte imprimé et/ou numérique Auteurs : Irene TUNG, Auteur ; Steve S. LEE, Auteur Article en page(s) : p.185-201 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : AbstractAlthough prevailing theories of antisocial behavior (ASB) emphasize distinct developmental trajectories, few studies have explored gene–environment interplay underlying membership in empirically derived trajectories. To improve knowledge about the development of overt (e.g., aggression) and covert (e.g., delinquency) ASB, we tested the association of the 44-base pair promoter polymorphism in the serotonin transporter linked polymorphic region gene (5-HTTLPR), perceived parental support (e.g., closeness and warmth), and their interaction with ASB trajectories derived using latent class growth analysis in 2,558 adolescents followed prospectively into adulthood from the National Longitudinal Study of Adolescent Health. Three distinct trajectories emerged for overt (low desisting, adolescent peak, and late onset) and covert ASB (high stable, low stable, and nonoffending). Controlling for sex, parental support inversely predicted membership in the adolescent-peak overt ASB trajectory (vs. low desisting), but was unrelated to class membership for covert ASB. Furthermore, the 5-HTTLPR genotype significantly moderated the association of parental support on overt ASB trajectory membership. It is interesting that the pattern of Gene × Environment interaction differed by trajectory class: whereas short allele carriers were more sensitive to parental support in predicting the late-onset trajectory, the long/long genotype functioned as a potential “plasticity genotype” for the adolescent-peak trajectory group. We discuss these preliminary findings in the context of the differential susceptibility hypothesis and discuss the need for future studies to integrate gene–environment interplay and prospective longitudinal designs. En ligne : http://dx.doi.org/10.1017/s0954579416000031 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298 [article] Latent trajectories of adolescent antisocial behavior: Serotonin transporter linked polymorphic region (5-HTTLPR) genotype influences sensitivity to perceived parental support [Texte imprimé et/ou numérique] / Irene TUNG, Auteur ; Steve S. LEE, Auteur . - p.185-201. Langues : Anglais (eng) in Development and Psychopathology > 29-1 (February 2017) . - p.185-201 Index. décimale : PER Périodiques Résumé : AbstractAlthough prevailing theories of antisocial behavior (ASB) emphasize distinct developmental trajectories, few studies have explored gene–environment interplay underlying membership in empirically derived trajectories. To improve knowledge about the development of overt (e.g., aggression) and covert (e.g., delinquency) ASB, we tested the association of the 44-base pair promoter polymorphism in the serotonin transporter linked polymorphic region gene (5-HTTLPR), perceived parental support (e.g., closeness and warmth), and their interaction with ASB trajectories derived using latent class growth analysis in 2,558 adolescents followed prospectively into adulthood from the National Longitudinal Study of Adolescent Health. Three distinct trajectories emerged for overt (low desisting, adolescent peak, and late onset) and covert ASB (high stable, low stable, and nonoffending). Controlling for sex, parental support inversely predicted membership in the adolescent-peak overt ASB trajectory (vs. low desisting), but was unrelated to class membership for covert ASB. Furthermore, the 5-HTTLPR genotype significantly moderated the association of parental support on overt ASB trajectory membership. It is interesting that the pattern of Gene × Environment interaction differed by trajectory class: whereas short allele carriers were more sensitive to parental support in predicting the late-onset trajectory, the long/long genotype functioned as a potential “plasticity genotype” for the adolescent-peak trajectory group. We discuss these preliminary findings in the context of the differential susceptibility hypothesis and discuss the need for future studies to integrate gene–environment interplay and prospective longitudinal designs. En ligne : http://dx.doi.org/10.1017/s0954579416000031 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298

Predictive validity of ICD-10 hyperkinetic disorder relative to DSM-IV attention-deficit/hyperactivity disorder among younger children / Benjamin B. LAHEY in Journal of Child Psychology and Psychiatry, 47-5 (May 2006)  

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