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Détail de l'auteur
Auteur Michele S. BERK |
Documents disponibles écrits par cet auteur (2)
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Differential susceptibility in longitudinal models of gene–environment interaction for adolescent depression / James J. LI in Development and Psychopathology, 25-4 (November 2013)
[article]
Titre : Differential susceptibility in longitudinal models of gene–environment interaction for adolescent depression Type de document : Texte imprimé et/ou numérique Auteurs : James J. LI, Auteur ; Michele S. BERK, Auteur ; Steve S. LEE, Auteur Article en page(s) : p.991-1003 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Although family support reliably predicts the development of adolescent depression and suicidal behaviors, relatively little is known about the interplay of family support with potential genetic factors. We tested the association of the 44 base pair polymorphism in the serotonin transporter linked promoter region gene (5-HTTLPR), family support (i.e., cohesion, communication, and warmth), and their interaction with self-reported depression symptoms and risk for suicide in 1,030 Caucasian adolescents and young adults from the National Longitudinal Study of Adolescent Health. High-quality family support predicted fewer symptoms of depression and reduced risk for suicidality. There was also a significant interaction between 5-HTTLPR and family support for boys and a marginally significant interaction for girls. Among boys with poor family support, youth with at least one short allele had more symptoms of depression and a higher risk for suicide attempts relative to boys homozygous for the long allele. However, in the presence of high family support, boys with the short allele had the fewest depression symptoms (but not suicide attempts). Results suggest that the short allele may increase reactivity to both negative and positive family influences in the development of depression. We discuss the potential role of interactive exchanges between family support and offspring genotype in the development of adolescent depression and suicidal behaviors. En ligne : http://dx.doi.org/10.1017/S0954579413000321 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=219
in Development and Psychopathology > 25-4 (November 2013) . - p.991-1003[article] Differential susceptibility in longitudinal models of gene–environment interaction for adolescent depression [Texte imprimé et/ou numérique] / James J. LI, Auteur ; Michele S. BERK, Auteur ; Steve S. LEE, Auteur . - p.991-1003.
Langues : Anglais (eng)
in Development and Psychopathology > 25-4 (November 2013) . - p.991-1003
Index. décimale : PER Périodiques Résumé : Although family support reliably predicts the development of adolescent depression and suicidal behaviors, relatively little is known about the interplay of family support with potential genetic factors. We tested the association of the 44 base pair polymorphism in the serotonin transporter linked promoter region gene (5-HTTLPR), family support (i.e., cohesion, communication, and warmth), and their interaction with self-reported depression symptoms and risk for suicide in 1,030 Caucasian adolescents and young adults from the National Longitudinal Study of Adolescent Health. High-quality family support predicted fewer symptoms of depression and reduced risk for suicidality. There was also a significant interaction between 5-HTTLPR and family support for boys and a marginally significant interaction for girls. Among boys with poor family support, youth with at least one short allele had more symptoms of depression and a higher risk for suicide attempts relative to boys homozygous for the long allele. However, in the presence of high family support, boys with the short allele had the fewest depression symptoms (but not suicide attempts). Results suggest that the short allele may increase reactivity to both negative and positive family influences in the development of depression. We discuss the potential role of interactive exchanges between family support and offspring genotype in the development of adolescent depression and suicidal behaviors. En ligne : http://dx.doi.org/10.1017/S0954579413000321 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=219 Predictors and moderators of recurring self-harm in adolescents participating in a comparative treatment trial of psychological interventions / Molly ADRIAN in Journal of Child Psychology and Psychiatry, 60-10 (October 2019)
[article]
Titre : Predictors and moderators of recurring self-harm in adolescents participating in a comparative treatment trial of psychological interventions Type de document : Texte imprimé et/ou numérique Auteurs : Molly ADRIAN, Auteur ; E. MCCAULEY, Auteur ; Michele S. BERK, Auteur ; J. R. ASARNOW, Auteur ; K. KORSLUND, Auteur ; C. AVINA, Auteur ; R. GALLOP, Auteur ; Marsha M. LINEHAN, Auteur Article en page(s) : p.1123-1132 Langues : Anglais (eng) Mots-clés : Moderators dialectical behavior therapy predictors treatment response Index. décimale : PER Périodiques Résumé : BACKGROUND: In primary analyses, dialectical behavior therapy (DBT) was associated with greater reduction in self-harm during treatment than individual/group supportive therapy (IGST). The objective of this paper was to examine predictors and moderators of treatment outcomes for suicidal adolescents who participated in a randomized controlled trial evaluating DBT and IGST. METHODS: Adolescents (N = 173) were included in the intent-to-treat sample and randomized to receive 6 months of DBT or IGST. Potential baseline predictors and moderators were identified within four categories: demographics, severity markers, parental psychopathology, and psychosocial variables. Primary outcomes were suicide attempts (SA) and nonsuicidal self-injury evaluated at baseline, midtreatment (3 months), and end of treatment (6 months) via the Suicide Attempt and Self-Injury Interview (Psychological Assessment, 18, 2006, 303). For each moderator or predictor, a generalized linear mixed model was conducted to examine main and interactive effects of treatment and the candidate variable on outcomes. RESULTS: Adolescents with higher family conflict, more extensive self-harm histories, and more externalizing problems produced on average more reduction on SH frequency from baseline to post-treatment. Adolescents meeting BPD diagnosis were more likely to have high SH frequency at post-treatment. Analyses indicated significant moderation effects for emotion dysregulation on NSSI and SH. DBT was associated with better rates of improvement compared to IGST for adolescents with higher baseline emotion dysregulation and those whose parents reported greater psychopathology and emotion dysregulation. A significant moderation effect for ethnicity on SA over the treatment period was observed, where DBT produced better rate of improvement compared to IGST for Hispanic/Latino individuals. CONCLUSIONS: These findings may help to inform salient treatment targets and guide treatment planning. Adolescents that have high levels of family conflict, externalizing problems, and increased level of severity markers demonstrated the most change in self-harm behaviors over the course of treatment and benefitted from both treatment interventions. Those with higher levels of emotion dysregulation and parent psychopathology may benefit more from the DBT. En ligne : http://dx.doi.org/10.1111/jcpp.13099 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=406
in Journal of Child Psychology and Psychiatry > 60-10 (October 2019) . - p.1123-1132[article] Predictors and moderators of recurring self-harm in adolescents participating in a comparative treatment trial of psychological interventions [Texte imprimé et/ou numérique] / Molly ADRIAN, Auteur ; E. MCCAULEY, Auteur ; Michele S. BERK, Auteur ; J. R. ASARNOW, Auteur ; K. KORSLUND, Auteur ; C. AVINA, Auteur ; R. GALLOP, Auteur ; Marsha M. LINEHAN, Auteur . - p.1123-1132.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 60-10 (October 2019) . - p.1123-1132
Mots-clés : Moderators dialectical behavior therapy predictors treatment response Index. décimale : PER Périodiques Résumé : BACKGROUND: In primary analyses, dialectical behavior therapy (DBT) was associated with greater reduction in self-harm during treatment than individual/group supportive therapy (IGST). The objective of this paper was to examine predictors and moderators of treatment outcomes for suicidal adolescents who participated in a randomized controlled trial evaluating DBT and IGST. METHODS: Adolescents (N = 173) were included in the intent-to-treat sample and randomized to receive 6 months of DBT or IGST. Potential baseline predictors and moderators were identified within four categories: demographics, severity markers, parental psychopathology, and psychosocial variables. Primary outcomes were suicide attempts (SA) and nonsuicidal self-injury evaluated at baseline, midtreatment (3 months), and end of treatment (6 months) via the Suicide Attempt and Self-Injury Interview (Psychological Assessment, 18, 2006, 303). For each moderator or predictor, a generalized linear mixed model was conducted to examine main and interactive effects of treatment and the candidate variable on outcomes. RESULTS: Adolescents with higher family conflict, more extensive self-harm histories, and more externalizing problems produced on average more reduction on SH frequency from baseline to post-treatment. Adolescents meeting BPD diagnosis were more likely to have high SH frequency at post-treatment. Analyses indicated significant moderation effects for emotion dysregulation on NSSI and SH. DBT was associated with better rates of improvement compared to IGST for adolescents with higher baseline emotion dysregulation and those whose parents reported greater psychopathology and emotion dysregulation. A significant moderation effect for ethnicity on SA over the treatment period was observed, where DBT produced better rate of improvement compared to IGST for Hispanic/Latino individuals. CONCLUSIONS: These findings may help to inform salient treatment targets and guide treatment planning. Adolescents that have high levels of family conflict, externalizing problems, and increased level of severity markers demonstrated the most change in self-harm behaviors over the course of treatment and benefitted from both treatment interventions. Those with higher levels of emotion dysregulation and parent psychopathology may benefit more from the DBT. En ligne : http://dx.doi.org/10.1111/jcpp.13099 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=406