Association of cognitive function and liability to addiction with childhood herpesvirus infections: A prospective cohort study / Michael M. VANYUKOV in Development and Psychopathology, 30-1 (February 2018)  

Public ISBD [article]  inDevelopment and Psychopathology > 30-1 (February 2018) . - p.143-152 Titre : Association of cognitive function and liability to addiction with childhood herpesvirus infections: A prospective cohort study Type de document : texte imprimé Auteurs : Michael M. VANYUKOV, Auteur ; Vishwajit NIMGAONKAR, Auteur ; Levent KIRISCI, Auteur ; Galina P. KIRILLOVA, Auteur ; Maureen D. REYNOLDS, Auteur ; Konasale PRASAD, Auteur ; Ralph E. TARTER, Auteur ; Robert H. YOLKEN, Auteur Article en page(s) : p.143-152 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Liability to substance use disorder (SUD) is largely nonspecific to particular drugs and is related to behavior dysregulation, including reduced cognitive control. Recent data suggest that cognitive mechanisms may be influenced by exposure to neurotropic infections, such as human herpesviruses. In this study, serological evidence of exposure to human herpesvirus Herpes simplex virus Type 1 (HSV-1), cytomegalovirus (CMV), and Epstein–Barr virus (EBV) as well as Toxoplasma gondii was determined in childhood (age ~11 years) in 395 sons and 174 daughters of fathers with or without SUD. Its relationships with a cognitive characteristic (IQ) in childhood and with risk for SUD in adulthood were examined using correlation, regression, survival, and path analyses. Exposure to HSV-1, EBV, and T. gondii in males and females, and CMV in males, was associated with lower IQ. Independent of that relationship, EBV in females and possibly in males, and CMV and possibly HSV-1 in females were associated with elevated risk for SUD. Therefore, childhood neurotropic infections may influence cognitive development and risk for behavior disorders such as SUD. The results may point to new avenues for alleviating cognitive impairment and SUD risk. En ligne : https://doi.org/10.1017/S0954579417000529 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=335 [article] Association of cognitive function and liability to addiction with childhood herpesvirus infections: A prospective cohort study [texte imprimé] / Michael M. VANYUKOV, Auteur ; Vishwajit NIMGAONKAR, Auteur ; Levent KIRISCI, Auteur ; Galina P. KIRILLOVA, Auteur ; Maureen D. REYNOLDS, Auteur ; Konasale PRASAD, Auteur ; Ralph E. TARTER, Auteur ; Robert H. YOLKEN, Auteur . - p.143-152. Langues : Anglais (eng) in Development and Psychopathology > 30-1 (February 2018) . - p.143-152 Index. décimale : PER Périodiques Résumé : Liability to substance use disorder (SUD) is largely nonspecific to particular drugs and is related to behavior dysregulation, including reduced cognitive control. Recent data suggest that cognitive mechanisms may be influenced by exposure to neurotropic infections, such as human herpesviruses. In this study, serological evidence of exposure to human herpesvirus Herpes simplex virus Type 1 (HSV-1), cytomegalovirus (CMV), and Epstein–Barr virus (EBV) as well as Toxoplasma gondii was determined in childhood (age ~11 years) in 395 sons and 174 daughters of fathers with or without SUD. Its relationships with a cognitive characteristic (IQ) in childhood and with risk for SUD in adulthood were examined using correlation, regression, survival, and path analyses. Exposure to HSV-1, EBV, and T. gondii in males and females, and CMV in males, was associated with lower IQ. Independent of that relationship, EBV in females and possibly in males, and CMV and possibly HSV-1 in females were associated with elevated risk for SUD. Therefore, childhood neurotropic infections may influence cognitive development and risk for behavior disorders such as SUD. The results may point to new avenues for alleviating cognitive impairment and SUD risk. En ligne : https://doi.org/10.1017/S0954579417000529 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=335

Association of cognitive function and liability to addiction with childhood herpesvirus infections: A prospective cohort study—ERRATUM / Michael M. VANYUKOV in Development and Psychopathology, 30-1 (February 2018)  

Public ISBD [article]  inDevelopment and Psychopathology > 30-1 (February 2018) . - p.371-372 Titre : Association of cognitive function and liability to addiction with childhood herpesvirus infections: A prospective cohort study—ERRATUM Type de document : texte imprimé Auteurs : Michael M. VANYUKOV, Auteur ; Vishwajit NIMGAONKAR, Auteur ; Levent KIRISCI, Auteur ; Galina P. KIRILLOVA, Auteur ; Maureen D. REYNOLDS, Auteur ; Konasale PRASAD, Auteur ; Ralph E. TARTER, Auteur ; Robert H. YOLKEN, Auteur Article en page(s) : p.371-372 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : https://doi.org/10.1017/S0954579417000906 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=336 [article] Association of cognitive function and liability to addiction with childhood herpesvirus infections: A prospective cohort study—ERRATUM [texte imprimé] / Michael M. VANYUKOV, Auteur ; Vishwajit NIMGAONKAR, Auteur ; Levent KIRISCI, Auteur ; Galina P. KIRILLOVA, Auteur ; Maureen D. REYNOLDS, Auteur ; Konasale PRASAD, Auteur ; Ralph E. TARTER, Auteur ; Robert H. YOLKEN, Auteur . - p.371-372. Langues : Anglais (eng) in Development and Psychopathology > 30-1 (February 2018) . - p.371-372 Index. décimale : PER Périodiques En ligne : https://doi.org/10.1017/S0954579417000906 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=336

Brain-derived neurotrophic factor and autism: maternal and infant peripheral blood levels in the Early Markers for Autism (EMA) study / Lisa A. CROEN in Autism Research, 1-2 (April 2008)  

Public ISBD [article]  inAutism Research > 1-2 (April 2008) . - p.130-137 Titre : Brain-derived neurotrophic factor and autism: maternal and infant peripheral blood levels in the Early Markers for Autism (EMA) study Type de document : texte imprimé Auteurs : Lisa A. CROEN, Auteur ; David J. HANSEN, Auteur ; Martin KHARRAZI, Auteur ; Bruce FIREMAN, Auteur ; Cathleen K. YOSHIDA, Auteur ; Robert YOLKEN, Auteur ; Daniel BRAUNSCHWEIG, Auteur ; Paula GOINES, Auteur ; Judy VAN DE WATER, Auteur ; Judith K. GRETHER, Auteur Année de publication : 2008 Article en page(s) : p.130-137 Langues : Anglais (eng) Mots-clés : biologic-markers neurotrophin autism BDNF prenatal Index. décimale : PER Périodiques Résumé : To investigate levels of brain-derived neurotrophic factor (BDNF) in mid-pregnancy and neonatal blood specimens as early biologic markers for autism, we conducted a population-based case-control study nested within the cohort of infants born from July 2000 to September 2001 to women who participated in the prenatal screening program in Orange County, CA. Cases (n=84) were all children receiving services for autism at the Regional Center of Orange County. Two comparison groups from the same study population were included: children with mental retardation or developmental delay (n=49) receiving services at the same regional center, and children not receiving services for developmental disabilities, randomly sampled from the California birth certificate files (n=159), and frequency matched to autism cases on sex, birth year, and birth month. BDNF concentrations were measured in archived mid-pregnancy and neonatal blood specimens drawn during routine prenatal and newborn screening using a highly sensitive bead-based assay (Luminex, Biosource Human BDNF Antibody Bead Kit, Invitrogen-Biosource, Carlsbad, CA). The concentration of BDNF in maternal mid-pregnancy and neonatal specimens was similar across all three study groups. These data do not support previous findings of an association between BDNF and autism and suggest that the concentration of BDNF during critical periods of early neurodevelopment is not likely to be a useful biomarker for autism susceptibility. En ligne : http://dx.doi.org/10.1002/aur.14 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=930 [article] Brain-derived neurotrophic factor and autism: maternal and infant peripheral blood levels in the Early Markers for Autism (EMA) study [texte imprimé] / Lisa A. CROEN, Auteur ; David J. HANSEN, Auteur ; Martin KHARRAZI, Auteur ; Bruce FIREMAN, Auteur ; Cathleen K. YOSHIDA, Auteur ; Robert YOLKEN, Auteur ; Daniel BRAUNSCHWEIG, Auteur ; Paula GOINES, Auteur ; Judy VAN DE WATER, Auteur ; Judith K. GRETHER, Auteur . - 2008 . - p.130-137. Langues : Anglais (eng) in Autism Research > 1-2 (April 2008) . - p.130-137 Mots-clés : biologic-markers neurotrophin autism BDNF prenatal Index. décimale : PER Périodiques Résumé : To investigate levels of brain-derived neurotrophic factor (BDNF) in mid-pregnancy and neonatal blood specimens as early biologic markers for autism, we conducted a population-based case-control study nested within the cohort of infants born from July 2000 to September 2001 to women who participated in the prenatal screening program in Orange County, CA. Cases (n=84) were all children receiving services for autism at the Regional Center of Orange County. Two comparison groups from the same study population were included: children with mental retardation or developmental delay (n=49) receiving services at the same regional center, and children not receiving services for developmental disabilities, randomly sampled from the California birth certificate files (n=159), and frequency matched to autism cases on sex, birth year, and birth month. BDNF concentrations were measured in archived mid-pregnancy and neonatal blood specimens drawn during routine prenatal and newborn screening using a highly sensitive bead-based assay (Luminex, Biosource Human BDNF Antibody Bead Kit, Invitrogen-Biosource, Carlsbad, CA). The concentration of BDNF in maternal mid-pregnancy and neonatal specimens was similar across all three study groups. These data do not support previous findings of an association between BDNF and autism and suggest that the concentration of BDNF during critical periods of early neurodevelopment is not likely to be a useful biomarker for autism susceptibility. En ligne : http://dx.doi.org/10.1002/aur.14 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=930

Maternal antibodies to gliadin and autism spectrum disorders in offspring-A population-based case-control study in Sweden / Renee M. GARDNER in Autism Research, 14-9 (September 2021)  

Public ISBD [article]  inAutism Research > 14-9 (September 2021) . - p.2002-2016 Titre : Maternal antibodies to gliadin and autism spectrum disorders in offspring-A population-based case-control study in Sweden Type de document : texte imprimé Auteurs : Renee M. GARDNER, Auteur ; Ida SAMUELSSON, Auteur ; Emily G. SEVERANCE, Auteur ; Hugo SJÖQVIST, Auteur ; Robert H. YOLKEN, Auteur ; Christina DALMAN, Auteur ; HÃ¥kan KARLSSON, Auteur Article en page(s) : p.2002-2016 Langues : Anglais (eng) Mots-clés : Attention Deficit Disorder with Hyperactivity  Autism Spectrum Disorder/epidemiology  Case-Control Studies  Female  Gliadin  Humans  Pregnancy  Sweden/epidemiology  attention deficit hyperactivity disorder  autism spectrum disorder  gliadin  gluten-sensitivity  intellectual disability Index. décimale : PER Périodiques Résumé : While individuals diagnosed with autism spectrum disorders (ASD) have higher levels of antibodies directed towards gliadin, a component of wheat gluten, no study has examined anti-gliadin antibodies (AGA) in etiologically relevant periods before diagnosis. The objective of this study was to investigate if maternal levels of AGA, during pregnancy and at the time of birth, are associated with ASD in offspring. We analyzed AGA in archived neonatal dried blood spots (NDBS) for 921 ASD cases and 1090 controls, and in paired maternal sera collected earlier in pregnancy for a subset of 547 cases and 428 controls. We examined associations with ASD diagnoses as a group and considering common comorbidities (intellectual disability [ID] and attention-deficit/hyperactivity disorder). We compared 206 cases to their unaffected siblings to examine the potential for confounding by shared familial factors. Odds of ASD tended to be lower among those with the highest levels (≥90th percentile) of AGA compared to those with low levels (<80th percentile; OR 0.78, 95% CI 0.56-1.09, measured in NDBS). This pattern was more apparent for ASD with comorbid ID when measured in NDBS (0.51, 0.30-0.87), with a similar trend in maternal sera (0.55, 0.24-1.29). High levels of AGA were similarly associated with lower odds of ASD in the sibling comparison. In summary, we found little association between maternal antibodies raised against components of gluten and risk of ASD in general. Exposure to high levels of AGA in the pre- and perinatal periods may be protective in terms of risk for ASD with ID. LAY SUMMARY: There is a debate among both scientists and community members as to whether an immune reaction to gluten exposure could be considered a cause of autism. We examined antibodies that are directed against gliadin, a part of gluten, in samples collected from pregnant mothers and their newborn babies. We did not see any major differences in the antibody level among those children diagnosed with ASD or their mothers compared to children who were not diagnosed with ASD. High levels of the antibodies were in fact associated with a somewhat lower risk of ASD with co-occurring intellectual disabilities, though we cannot tell from this study why that might be the case. En ligne : http://dx.doi.org/10.1002/aur.2567 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 [article] Maternal antibodies to gliadin and autism spectrum disorders in offspring-A population-based case-control study in Sweden [texte imprimé] / Renee M. GARDNER, Auteur ; Ida SAMUELSSON, Auteur ; Emily G. SEVERANCE, Auteur ; Hugo SJÖQVIST, Auteur ; Robert H. YOLKEN, Auteur ; Christina DALMAN, Auteur ; HÃ¥kan KARLSSON, Auteur . - p.2002-2016. Langues : Anglais (eng) in Autism Research > 14-9 (September 2021) . - p.2002-2016 Mots-clés : Attention Deficit Disorder with Hyperactivity  Autism Spectrum Disorder/epidemiology  Case-Control Studies  Female  Gliadin  Humans  Pregnancy  Sweden/epidemiology  attention deficit hyperactivity disorder  autism spectrum disorder  gliadin  gluten-sensitivity  intellectual disability Index. décimale : PER Périodiques Résumé : While individuals diagnosed with autism spectrum disorders (ASD) have higher levels of antibodies directed towards gliadin, a component of wheat gluten, no study has examined anti-gliadin antibodies (AGA) in etiologically relevant periods before diagnosis. The objective of this study was to investigate if maternal levels of AGA, during pregnancy and at the time of birth, are associated with ASD in offspring. We analyzed AGA in archived neonatal dried blood spots (NDBS) for 921 ASD cases and 1090 controls, and in paired maternal sera collected earlier in pregnancy for a subset of 547 cases and 428 controls. We examined associations with ASD diagnoses as a group and considering common comorbidities (intellectual disability [ID] and attention-deficit/hyperactivity disorder). We compared 206 cases to their unaffected siblings to examine the potential for confounding by shared familial factors. Odds of ASD tended to be lower among those with the highest levels (≥90th percentile) of AGA compared to those with low levels (<80th percentile; OR 0.78, 95% CI 0.56-1.09, measured in NDBS). This pattern was more apparent for ASD with comorbid ID when measured in NDBS (0.51, 0.30-0.87), with a similar trend in maternal sera (0.55, 0.24-1.29). High levels of AGA were similarly associated with lower odds of ASD in the sibling comparison. In summary, we found little association between maternal antibodies raised against components of gluten and risk of ASD in general. Exposure to high levels of AGA in the pre- and perinatal periods may be protective in terms of risk for ASD with ID. LAY SUMMARY: There is a debate among both scientists and community members as to whether an immune reaction to gluten exposure could be considered a cause of autism. We examined antibodies that are directed against gliadin, a part of gluten, in samples collected from pregnant mothers and their newborn babies. We did not see any major differences in the antibody level among those children diagnosed with ASD or their mothers compared to children who were not diagnosed with ASD. High levels of the antibodies were in fact associated with a somewhat lower risk of ASD with co-occurring intellectual disabilities, though we cannot tell from this study why that might be the case. En ligne : http://dx.doi.org/10.1002/aur.2567 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450

Neonatally measured immunoglobulins and risk of autism / Judith K. GRETHER in Autism Research, 3-6 (December 2010)  

Public ISBD [article]  inAutism Research > 3-6 (December 2010) . - p.323-332 Titre : Neonatally measured immunoglobulins and risk of autism Type de document : texte imprimé Auteurs : Judith K. GRETHER, Auteur ; Lisa A. CROEN, Auteur ; Meredith C. ANDERSON, Auteur ; Karin B. NELSON, Auteur ; Robert YOLKEN, Auteur Année de publication : 2010 Article en page(s) : p.323-332 Langues : Anglais (eng) Mots-clés : autism  ASD  maternal immune function  immunoglobulins and pregnancy Index. décimale : PER Périodiques Résumé : Previous studies indicate that prenatal exposure to infections is a possible pathway through which autism spectrum disorders (ASD) could be initiated. We investigated whether immunoglobulin levels in archived specimens obtained from newborns subsequently diagnosed with ASD are different from levels in newborn specimens from controls. Children with ASD born in six California counties in 1994 were ascertained through records of the California Department of Developmental Services (DDS) and Kaiser Permanente; controls were randomly selected using birth certificates. Archived newborn blood specimens were obtained from the California Genetic Disease Screening Program (GDSP) for N = 213 cases and N = 265 controls and assayed to determine levels of total IgG, antigen-specific IgG to selected common pathogens, total IgM, total IgA, and C-reactive protein (CRP). We did not find measurable levels of total IgM or IgA in any neonate and measurable CRP was present in only a few. No antigen-specific IgG antibodies were elevated in cases compared to controls and total IgG levels were lower. In adjusted models, a 10-unit increase in total IgG yielded an OR = 0.72 (95% CI 0.56, 0.91); a significantly decreasing trend in risk of ASD was observed across increasing exposure quartiles of total IgG (P = 0.01). The finding of lower IgG in cases may indicate maternal immune dysfunction during gestation and/or impaired transplacental transfer of immunoglobulins. Further investigation of IgG levels in newborns and the mechanisms by which they might be associated with ASD are warranted. En ligne : http://dx.doi.org/10.1002/aur.160 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=115 [article] Neonatally measured immunoglobulins and risk of autism [texte imprimé] / Judith K. GRETHER, Auteur ; Lisa A. CROEN, Auteur ; Meredith C. ANDERSON, Auteur ; Karin B. NELSON, Auteur ; Robert YOLKEN, Auteur . - 2010 . - p.323-332. Langues : Anglais (eng) in Autism Research > 3-6 (December 2010) . - p.323-332 Mots-clés : autism  ASD  maternal immune function  immunoglobulins and pregnancy Index. décimale : PER Périodiques Résumé : Previous studies indicate that prenatal exposure to infections is a possible pathway through which autism spectrum disorders (ASD) could be initiated. We investigated whether immunoglobulin levels in archived specimens obtained from newborns subsequently diagnosed with ASD are different from levels in newborn specimens from controls. Children with ASD born in six California counties in 1994 were ascertained through records of the California Department of Developmental Services (DDS) and Kaiser Permanente; controls were randomly selected using birth certificates. Archived newborn blood specimens were obtained from the California Genetic Disease Screening Program (GDSP) for N = 213 cases and N = 265 controls and assayed to determine levels of total IgG, antigen-specific IgG to selected common pathogens, total IgM, total IgA, and C-reactive protein (CRP). We did not find measurable levels of total IgM or IgA in any neonate and measurable CRP was present in only a few. No antigen-specific IgG antibodies were elevated in cases compared to controls and total IgG levels were lower. In adjusted models, a 10-unit increase in total IgG yielded an OR = 0.72 (95% CI 0.56, 0.91); a significantly decreasing trend in risk of ASD was observed across increasing exposure quartiles of total IgG (P = 0.01). The finding of lower IgG in cases may indicate maternal immune dysfunction during gestation and/or impaired transplacental transfer of immunoglobulins. Further investigation of IgG levels in newborns and the mechanisms by which they might be associated with ASD are warranted. En ligne : http://dx.doi.org/10.1002/aur.160 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=115

Otitis media, antibiotics, and risk of autism spectrum disorder / Theresa WIMBERLEY in Autism Research, 11-10 (October 2018)  

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A profile and review of findings from the Early Markers for Autism study: unique contributions from a population-based case-control study in California / Kristen LYALL in Molecular Autism, 12 (2021)  

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