Antenatal Ultrasound and Risk of Autism Spectrum Disorders / Judith K. GRETHER in Journal of Autism and Developmental Disorders, 40-2 (February 2010)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 40-2 (February 2010) . - p.238-245 Titre : Antenatal Ultrasound and Risk of Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Judith K. GRETHER, Auteur ; Cathleen K. YOSHIDA, Auteur ; Sherian XU LI, Auteur ; Lisa A. CROEN, Auteur Année de publication : 2010 Article en page(s) : p.238-245 Langues : Anglais (eng) Mots-clés : Antenatal-ultrasound Obstetrical-ultrasound Autism Index. décimale : PER Périodiques Résumé : We evaluated antenatal ultrasound (U/S) exposure as a risk factor for autism spectrum disorders (ASD), comparing affected singleton children and control children born 1995–1999 and enrolled in the Kaiser Permanente health care system. Among children with ASD (n = 362) and controls (n = 393), 13% had no antenatal exposure to U/S examinations; case–control differences in number of exposures during the entire gestation or by trimester were small and not statistically significant. In analyses adjusted for covariates, cases were generally similar to controls with regard to the number of U/S scans throughout gestation and during each trimester. This study indicates that antenatal U/S is unlikely to increase the risk of ASD, although studies examining ASD subgroups remain to be conducted. En ligne : http://dx.doi.org/10.1007/s10803-009-0859-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=965 [article] Antenatal Ultrasound and Risk of Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Judith K. GRETHER, Auteur ; Cathleen K. YOSHIDA, Auteur ; Sherian XU LI, Auteur ; Lisa A. CROEN, Auteur . - 2010 . - p.238-245. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 40-2 (February 2010) . - p.238-245 Mots-clés : Antenatal-ultrasound Obstetrical-ultrasound Autism Index. décimale : PER Périodiques Résumé : We evaluated antenatal ultrasound (U/S) exposure as a risk factor for autism spectrum disorders (ASD), comparing affected singleton children and control children born 1995–1999 and enrolled in the Kaiser Permanente health care system. Among children with ASD (n = 362) and controls (n = 393), 13% had no antenatal exposure to U/S examinations; case–control differences in number of exposures during the entire gestation or by trimester were small and not statistically significant. In analyses adjusted for covariates, cases were generally similar to controls with regard to the number of U/S scans throughout gestation and during each trimester. This study indicates that antenatal U/S is unlikely to increase the risk of ASD, although studies examining ASD subgroups remain to be conducted. En ligne : http://dx.doi.org/10.1007/s10803-009-0859-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=965

Barriers to Healthcare for Latinx Autistic Children and Adolescents / Luke P. GROSVENOR ; Ryan J. Cohen ; Nancy P. Gordon ; Maria L. MASSOLO ; Hilda J. CERROS ; Cathleen K. YOSHIDA ; Jennifer L. AMES ; Lisa A. CROEN in Journal of Autism and Developmental Disorders, 55-2 (February 2025)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 55-2 (February 2025) . - p.605-619 Titre : Barriers to Healthcare for Latinx Autistic Children and Adolescents : Journal of Autism and Developmental Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Luke P. GROSVENOR, Auteur ; Ryan J. Cohen, Auteur ; Nancy P. Gordon, Auteur ; Maria L. MASSOLO, Auteur ; Hilda J. CERROS, Auteur ; Cathleen K. YOSHIDA, Auteur ; Jennifer L. AMES, Auteur ; Lisa A. CROEN, Auteur Article en page(s) : p.605-619 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Purpose: To understand the ways in which autistic Latinx children experience disparities in diagnosis, healthcare, and receipt of specialty services. Methods: 417 individuals who identified as Latinx caregivers of autistic children who were members of the same integrated healthcare system in Northern California were surveyed. Responses were analyzed using the child?s insurance coverage (Government or Commercial) and caregiver?s primary language (Spanish or English). Results: Compared to the commercially-insured, government-insured participants accessed several services at a higher rate and were less likely to cite the high cost of co-pays as a barrier. Conclusion: There were no significant differences in service access by language status, but Spanish speakers were more likely to cite health literacy as a barrier to receiving care. En ligne : https://doi.org/10.1007/s10803-023-06229-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=548 [article] Barriers to Healthcare for Latinx Autistic Children and Adolescents : Journal of Autism and Developmental Disorders [Texte imprimé et/ou numérique] / Luke P. GROSVENOR, Auteur ; Ryan J. Cohen, Auteur ; Nancy P. Gordon, Auteur ; Maria L. MASSOLO, Auteur ; Hilda J. CERROS, Auteur ; Cathleen K. YOSHIDA, Auteur ; Jennifer L. AMES, Auteur ; Lisa A. CROEN, Auteur . - p.605-619. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 55-2 (February 2025) . - p.605-619 Index. décimale : PER Périodiques Résumé : Purpose: To understand the ways in which autistic Latinx children experience disparities in diagnosis, healthcare, and receipt of specialty services. Methods: 417 individuals who identified as Latinx caregivers of autistic children who were members of the same integrated healthcare system in Northern California were surveyed. Responses were analyzed using the child?s insurance coverage (Government or Commercial) and caregiver?s primary language (Spanish or English). Results: Compared to the commercially-insured, government-insured participants accessed several services at a higher rate and were less likely to cite the high cost of co-pays as a barrier. Conclusion: There were no significant differences in service access by language status, but Spanish speakers were more likely to cite health literacy as a barrier to receiving care. En ligne : https://doi.org/10.1007/s10803-023-06229-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=548

Brain-derived neurotrophic factor and autism: maternal and infant peripheral blood levels in the Early Markers for Autism (EMA) study / Lisa A. CROEN in Autism Research, 1-2 (April 2008)  

Public ISBD [article]  inAutism Research > 1-2 (April 2008) . - p.130-137 Titre : Brain-derived neurotrophic factor and autism: maternal and infant peripheral blood levels in the Early Markers for Autism (EMA) study Type de document : Texte imprimé et/ou numérique Auteurs : Lisa A. CROEN, Auteur ; David J. HANSEN, Auteur ; Martin KHARRAZI, Auteur ; Bruce FIREMAN, Auteur ; Cathleen K. YOSHIDA, Auteur ; Robert YOLKEN, Auteur ; Daniel BRAUNSCHWEIG, Auteur ; Paula GOINES, Auteur ; Judy VAN DE WATER, Auteur ; Judith K. GRETHER, Auteur Année de publication : 2008 Article en page(s) : p.130-137 Langues : Anglais (eng) Mots-clés : biologic-markers neurotrophin autism BDNF prenatal Index. décimale : PER Périodiques Résumé : To investigate levels of brain-derived neurotrophic factor (BDNF) in mid-pregnancy and neonatal blood specimens as early biologic markers for autism, we conducted a population-based case-control study nested within the cohort of infants born from July 2000 to September 2001 to women who participated in the prenatal screening program in Orange County, CA. Cases (n=84) were all children receiving services for autism at the Regional Center of Orange County. Two comparison groups from the same study population were included: children with mental retardation or developmental delay (n=49) receiving services at the same regional center, and children not receiving services for developmental disabilities, randomly sampled from the California birth certificate files (n=159), and frequency matched to autism cases on sex, birth year, and birth month. BDNF concentrations were measured in archived mid-pregnancy and neonatal blood specimens drawn during routine prenatal and newborn screening using a highly sensitive bead-based assay (Luminex, Biosource Human BDNF Antibody Bead Kit, Invitrogen-Biosource, Carlsbad, CA). The concentration of BDNF in maternal mid-pregnancy and neonatal specimens was similar across all three study groups. These data do not support previous findings of an association between BDNF and autism and suggest that the concentration of BDNF during critical periods of early neurodevelopment is not likely to be a useful biomarker for autism susceptibility. En ligne : http://dx.doi.org/10.1002/aur.14 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=930 [article] Brain-derived neurotrophic factor and autism: maternal and infant peripheral blood levels in the Early Markers for Autism (EMA) study [Texte imprimé et/ou numérique] / Lisa A. CROEN, Auteur ; David J. HANSEN, Auteur ; Martin KHARRAZI, Auteur ; Bruce FIREMAN, Auteur ; Cathleen K. YOSHIDA, Auteur ; Robert YOLKEN, Auteur ; Daniel BRAUNSCHWEIG, Auteur ; Paula GOINES, Auteur ; Judy VAN DE WATER, Auteur ; Judith K. GRETHER, Auteur . - 2008 . - p.130-137. Langues : Anglais (eng) in Autism Research > 1-2 (April 2008) . - p.130-137 Mots-clés : biologic-markers neurotrophin autism BDNF prenatal Index. décimale : PER Périodiques Résumé : To investigate levels of brain-derived neurotrophic factor (BDNF) in mid-pregnancy and neonatal blood specimens as early biologic markers for autism, we conducted a population-based case-control study nested within the cohort of infants born from July 2000 to September 2001 to women who participated in the prenatal screening program in Orange County, CA. Cases (n=84) were all children receiving services for autism at the Regional Center of Orange County. Two comparison groups from the same study population were included: children with mental retardation or developmental delay (n=49) receiving services at the same regional center, and children not receiving services for developmental disabilities, randomly sampled from the California birth certificate files (n=159), and frequency matched to autism cases on sex, birth year, and birth month. BDNF concentrations were measured in archived mid-pregnancy and neonatal blood specimens drawn during routine prenatal and newborn screening using a highly sensitive bead-based assay (Luminex, Biosource Human BDNF Antibody Bead Kit, Invitrogen-Biosource, Carlsbad, CA). The concentration of BDNF in maternal mid-pregnancy and neonatal specimens was similar across all three study groups. These data do not support previous findings of an association between BDNF and autism and suggest that the concentration of BDNF during critical periods of early neurodevelopment is not likely to be a useful biomarker for autism susceptibility. En ligne : http://dx.doi.org/10.1002/aur.14 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=930

Increased mid-gestational IFN-gamma, IL-4, and IL-5 in women giving birth to a child with autism: a case-control study / Paula GOINES in Molecular Autism, (August 2011)  

Public ISBD [article]  inMolecular Autism > (August 2011) . - 41 p. Titre : Increased mid-gestational IFN-gamma, IL-4, and IL-5 in women giving birth to a child with autism: a case-control study Type de document : Texte imprimé et/ou numérique Auteurs : Paula GOINES, Auteur ; Lisa A. CROEN, Auteur ; Daniel BRAUNSCHWEIG, Auteur ; Cathleen K. YOSHIDA, Auteur ; Judith K. GRETHER, Auteur ; David J. HANSEN, Auteur ; Martin KHARRAZI, Auteur ; Paul ASHWOOD, Auteur ; Judy VAN DE WATER, Auteur Année de publication : 2011 Article en page(s) : 41 p. Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background Immune anomalies have been documented in individuals with autism spectrum disorders (ASDs) and their family members. It is unknown whether the maternal immune profile during pregnancy is associated with the risk of bearing a child with ASD or other neurodevelopmental disorders. Methods Using Luminex technology, levels of 17 cytokines and chemokines were measured in banked serum collected from women at 15 to 19 weeks of gestation who gave birth to a child ultimately diagnosed with (1) ASD (n = 84), (2) a developmental delay (DD) but not autism (n = 49) or (3) no known developmental disability (general population (GP); n = 159). ASD and DD risk associated with maternal cytokine and chemokine levels was estimated by using multivariable logistic regression analysis. Results Elevated concentrations of IFN-gamma, IL-4 and IL-5 in midgestation maternal serum were significantly associated with a 50% increased risk of ASD, regardless of ASD onset type and the presence of intellectual disability. By contrast, elevated concentrations of IL-2, IL-4 and IL-6 were significantly associated with an increased risk of DD without autism. Conclusion The profile of elevated serum IFN-gamma, IL-4 and IL-5 was more common in women who gave birth to a child subsequently diagnosed with ASD. An alternative profile of increased IL-2, IL-4 and IL-6 was more common for women who gave birth to a child subsequently diagnosed with DD without autism. Further investigation is needed to characterize the relationship between these divergent maternal immunological phenotypes and to evaluate their effect on neurodevelopment. En ligne : http://dx.doi.org/10.1186/2040-2392-2-13 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=141 [article] Increased mid-gestational IFN-gamma, IL-4, and IL-5 in women giving birth to a child with autism: a case-control study [Texte imprimé et/ou numérique] / Paula GOINES, Auteur ; Lisa A. CROEN, Auteur ; Daniel BRAUNSCHWEIG, Auteur ; Cathleen K. YOSHIDA, Auteur ; Judith K. GRETHER, Auteur ; David J. HANSEN, Auteur ; Martin KHARRAZI, Auteur ; Paul ASHWOOD, Auteur ; Judy VAN DE WATER, Auteur . - 2011 . - 41 p. Langues : Anglais (eng) in Molecular Autism > (August 2011) . - 41 p. Index. décimale : PER Périodiques Résumé : Background Immune anomalies have been documented in individuals with autism spectrum disorders (ASDs) and their family members. It is unknown whether the maternal immune profile during pregnancy is associated with the risk of bearing a child with ASD or other neurodevelopmental disorders. Methods Using Luminex technology, levels of 17 cytokines and chemokines were measured in banked serum collected from women at 15 to 19 weeks of gestation who gave birth to a child ultimately diagnosed with (1) ASD (n = 84), (2) a developmental delay (DD) but not autism (n = 49) or (3) no known developmental disability (general population (GP); n = 159). ASD and DD risk associated with maternal cytokine and chemokine levels was estimated by using multivariable logistic regression analysis. Results Elevated concentrations of IFN-gamma, IL-4 and IL-5 in midgestation maternal serum were significantly associated with a 50% increased risk of ASD, regardless of ASD onset type and the presence of intellectual disability. By contrast, elevated concentrations of IL-2, IL-4 and IL-6 were significantly associated with an increased risk of DD without autism. Conclusion The profile of elevated serum IFN-gamma, IL-4 and IL-5 was more common in women who gave birth to a child subsequently diagnosed with ASD. An alternative profile of increased IL-2, IL-4 and IL-6 was more common for women who gave birth to a child subsequently diagnosed with DD without autism. Further investigation is needed to characterize the relationship between these divergent maternal immunological phenotypes and to evaluate their effect on neurodevelopment. En ligne : http://dx.doi.org/10.1186/2040-2392-2-13 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=141

Prenatal and Neonatal Thyroid Stimulating Hormone Levels and Autism Spectrum Disorders / Vincent M. YAU in Journal of Autism and Developmental Disorders, 45-3 (March 2015)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 45-3 (March 2015) . - p.719-730 Titre : Prenatal and Neonatal Thyroid Stimulating Hormone Levels and Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Vincent M. YAU, Auteur ; Marta LUTSKY, Auteur ; Cathleen K. YOSHIDA, Auteur ; Bill LASLEY, Auteur ; Martin KHARRAZI, Auteur ; Gayle WINDHAM, Auteur ; Nancy GEE, Auteur ; Lisa A. CROEN, Auteur Article en page(s) : p.719-730 Langues : Anglais (eng) Mots-clés : Thyroid  Thyroid stimulating hormone  Autism  Pregnancy  Developmental delay Index. décimale : PER Périodiques Résumé : Thyroid hormones are critical for normal brain development. This study examined autism spectrum disorders (ASD) and thyroid stimulating hormone (TSH) levels measured in mid-pregnancy maternal serum and infant blood after birth. Three groups of children born in Orange County, CA in 2000–2001were identified: ASD (n = 78), developmental delay (n = 45), and general population controls (GP) (n = 149). Samples were retrieved from prenatal and newborn screening specimen archives. Adjusted logistic regression models showed inverse associations between ASD and log transformed TSH levels in maternal serum samples (ASD vs. GP: OR [95 % CI] 0.33 [0.12–0.91], Early Onset ASD vs. GP: 0.31 [0.10–0.98]). Results for thyroid levels in newborn blood samples were similar though not significant (ASD vs. GP: 0.61 [0.18–2.04]). En ligne : http://dx.doi.org/10.1007/s10803-014-2227-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=258 [article] Prenatal and Neonatal Thyroid Stimulating Hormone Levels and Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Vincent M. YAU, Auteur ; Marta LUTSKY, Auteur ; Cathleen K. YOSHIDA, Auteur ; Bill LASLEY, Auteur ; Martin KHARRAZI, Auteur ; Gayle WINDHAM, Auteur ; Nancy GEE, Auteur ; Lisa A. CROEN, Auteur . - p.719-730. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 45-3 (March 2015) . - p.719-730 Mots-clés : Thyroid  Thyroid stimulating hormone  Autism  Pregnancy  Developmental delay Index. décimale : PER Périodiques Résumé : Thyroid hormones are critical for normal brain development. This study examined autism spectrum disorders (ASD) and thyroid stimulating hormone (TSH) levels measured in mid-pregnancy maternal serum and infant blood after birth. Three groups of children born in Orange County, CA in 2000–2001were identified: ASD (n = 78), developmental delay (n = 45), and general population controls (GP) (n = 149). Samples were retrieved from prenatal and newborn screening specimen archives. Adjusted logistic regression models showed inverse associations between ASD and log transformed TSH levels in maternal serum samples (ASD vs. GP: OR [95 % CI] 0.33 [0.12–0.91], Early Onset ASD vs. GP: 0.31 [0.10–0.98]). Results for thyroid levels in newborn blood samples were similar though not significant (ASD vs. GP: 0.61 [0.18–2.04]). En ligne : http://dx.doi.org/10.1007/s10803-014-2227-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=258

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