Behavioral Evaluation of Genetic Mouse Models of Autism / Mu YANG

Public ISBD in Autism Spectrum Disorders / David G. AMARAL Titre : Behavioral Evaluation of Genetic Mouse Models of Autism Type de document : Texte imprimé et/ou numérique Auteurs : Mu YANG, Auteur ; Maria Luisa SCATTONI, Auteur ; Kathryn K. CHADMAN, Auteur ; Jill L. SILVERMAN, Auteur ; Jacqueline N. CRAWLEY, Auteur Année de publication : 2011 Importance : p.906-934 Langues : Anglais (eng) Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=140 in Autism Spectrum Disorders / David G. AMARAL Behavioral Evaluation of Genetic Mouse Models of Autism [Texte imprimé et/ou numérique] / Mu YANG, Auteur ; Maria Luisa SCATTONI, Auteur ; Kathryn K. CHADMAN, Auteur ; Jill L. SILVERMAN, Auteur ; Jacqueline N. CRAWLEY, Auteur . - 2011 . - p.906-934. Langues : Anglais (eng) Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=140

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Inbred strain preference in the BTBR T(+) Itpr3(tf) /J mouse model of autism spectrum disorder: Does the stranger mouse matter in social approach? / K. RYAN in Autism Research, 12-8 (August 2019)  

Public ISBD [article]  inAutism Research > 12-8 (August 2019) . - p.1184-1191 Titre : Inbred strain preference in the BTBR T(+) Itpr3(tf) /J mouse model of autism spectrum disorder: Does the stranger mouse matter in social approach? Type de document : Texte imprimé et/ou numérique Auteurs : K. RYAN, Auteur ; L. THOMPSON, Auteur ; P. A. MENDOZA, Auteur ; Kathryn K. CHADMAN, Auteur Article en page(s) : p.1184-1191 Langues : Anglais (eng) Mots-clés : Asd  Btbr  C57bl/6j  female  male  mice  social behavior  social preference Index. décimale : PER Périodiques Résumé : BTBR T(+) Itpr3(tf) /J (BTBR) mice have been used as a model of autism spectrum disorder (ASD) due to their low levels of sociability and high levels of repetitive grooming. These experiments explored social behavior in the BTBR and C57BL/6J mice using variations of the three-chambered social approach test. In the first test, the subject mice had a choice between a stranger mouse of the same strain or from a strain with a different level of sociability. The BTBR male mice demonstrated a strong preference for the more social C57BL/6J stranger mouse, as did the C57BL/6J male mice, although more moderately with sniff time only. The C57BL/6J female mice showed a moderate preference, sniff time only, for the BTBR stranger mouse, whereas the BTBR female mice did not show a preference. The second experiment examined whether the subject mouse preferred a stranger mouse or bedding from the stranger mouse home cage. Male BTBR mice always preferred bedding, whereas the C57BL/6J male mice did not show a preference. Both BTBR and C57BL/6J female mice preferred bedding when the stranger mouse was a different strain but not when the stranger mouse was the same strain. Therefore, the stranger mouse strain seems to influence the preference of the female mice more than the male mice. The mice preferred spending time in the chamber with the social smell but not the actual stranger mouse although not always significantly. This suggests that contact with a stranger mouse is more stressful or anxiety provoking than the smell. Autism Res 2019, 12: 1184-1191. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: BTBR T(+) Itpr3(tf) /J (BTBR) mice have been used as a model of autism spectrum disorder (ASD) due to their low levels of sociability and high levels of repetitive grooming. These experiments explored social behavior in the BTBR and C57BL/6J mice using variations of the three-chambered social approach test. These experiments examined how the sociability level of the stranger mouse affected the subject mouse's preference and if social odor was preferable to a social situation in the BTBR mice. The BTBR male mice demonstrated a strong preference for the more social C57BL/6J stranger mouse, as did the C57BL/6J male mice. The C57BL/6J female mice showed a moderate preference for the BTBR stranger mouse, whereas the BTBR female mice did not show a preference for either stranger mouse. The second modification let the subject mouse have a choice between a stranger mouse or bedding. Male BTBR mice preferred bedding, regardless of the strain of the stranger mouse, whereas the C57BL/6J male mice did not show a preference. Both BTBR and C57BL/6J female mice preferred bedding when the stranger mouse was a different strain but showed no preference when the stranger mouse was from the same strain. The stranger mouse strain seems to influence the female mice more. Male BTBR mice preferred spending time in the chamber with the social smell but not the actual mouse, suggesting that actual contact with a stranger mouse is more stressful or anxiety provoking. En ligne : http://dx.doi.org/10.1002/aur.2158 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=405 [article] Inbred strain preference in the BTBR T(+) Itpr3(tf) /J mouse model of autism spectrum disorder: Does the stranger mouse matter in social approach? [Texte imprimé et/ou numérique] / K. RYAN, Auteur ; L. THOMPSON, Auteur ; P. A. MENDOZA, Auteur ; Kathryn K. CHADMAN, Auteur . - p.1184-1191. Langues : Anglais (eng) in Autism Research > 12-8 (August 2019) . - p.1184-1191 Mots-clés : Asd  Btbr  C57bl/6j  female  male  mice  social behavior  social preference Index. décimale : PER Périodiques Résumé : BTBR T(+) Itpr3(tf) /J (BTBR) mice have been used as a model of autism spectrum disorder (ASD) due to their low levels of sociability and high levels of repetitive grooming. These experiments explored social behavior in the BTBR and C57BL/6J mice using variations of the three-chambered social approach test. In the first test, the subject mice had a choice between a stranger mouse of the same strain or from a strain with a different level of sociability. The BTBR male mice demonstrated a strong preference for the more social C57BL/6J stranger mouse, as did the C57BL/6J male mice, although more moderately with sniff time only. The C57BL/6J female mice showed a moderate preference, sniff time only, for the BTBR stranger mouse, whereas the BTBR female mice did not show a preference. The second experiment examined whether the subject mouse preferred a stranger mouse or bedding from the stranger mouse home cage. Male BTBR mice always preferred bedding, whereas the C57BL/6J male mice did not show a preference. Both BTBR and C57BL/6J female mice preferred bedding when the stranger mouse was a different strain but not when the stranger mouse was the same strain. Therefore, the stranger mouse strain seems to influence the preference of the female mice more than the male mice. The mice preferred spending time in the chamber with the social smell but not the actual stranger mouse although not always significantly. This suggests that contact with a stranger mouse is more stressful or anxiety provoking than the smell. Autism Res 2019, 12: 1184-1191. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: BTBR T(+) Itpr3(tf) /J (BTBR) mice have been used as a model of autism spectrum disorder (ASD) due to their low levels of sociability and high levels of repetitive grooming. These experiments explored social behavior in the BTBR and C57BL/6J mice using variations of the three-chambered social approach test. These experiments examined how the sociability level of the stranger mouse affected the subject mouse's preference and if social odor was preferable to a social situation in the BTBR mice. The BTBR male mice demonstrated a strong preference for the more social C57BL/6J stranger mouse, as did the C57BL/6J male mice. The C57BL/6J female mice showed a moderate preference for the BTBR stranger mouse, whereas the BTBR female mice did not show a preference for either stranger mouse. The second modification let the subject mouse have a choice between a stranger mouse or bedding. Male BTBR mice preferred bedding, regardless of the strain of the stranger mouse, whereas the C57BL/6J male mice did not show a preference. Both BTBR and C57BL/6J female mice preferred bedding when the stranger mouse was a different strain but showed no preference when the stranger mouse was from the same strain. The stranger mouse strain seems to influence the female mice more. Male BTBR mice preferred spending time in the chamber with the social smell but not the actual mouse, suggesting that actual contact with a stranger mouse is more stressful or anxiety provoking. En ligne : http://dx.doi.org/10.1002/aur.2158 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=405

Minimal aberrant behavioral phenotypes of neuroligin-3 R451C knockin mice / Kathryn K. CHADMAN in Autism Research, 1-3 (June 2008)  

Public ISBD [article]  inAutism Research > 1-3 (June 2008) . - p.147-158 Titre : Minimal aberrant behavioral phenotypes of neuroligin-3 R451C knockin mice Type de document : Texte imprimé et/ou numérique Auteurs : Kathryn K. CHADMAN, Auteur ; Nathaniel HEINTZ, Auteur ; Shiaoching GONG, Auteur ; Maria Luisa SCATTONI, Auteur ; Sarah E. BOLTUCK, Auteur ; Shruti U. GANDHY, Auteur ; Jacqueline N. CRAWLEY, Auteur Année de publication : 2008 Article en page(s) : p.147-158 Langues : Anglais (eng) Mots-clés : autism mouse-model neuroligin behavior-phenotyping social-behavior Index. décimale : PER Périodiques Résumé : Neuroligin-3 is a member of the class of cell adhesion proteins that mediate synapse development and have been implicated in autism. Mice with the human R451C mutation (NL3), identical to the point mutation found in two brothers with autism spectrum disorders, were generated and phenotyped in multiple behavioral assays with face validity to the diagnostic symptoms of autism. No differences between NL3 and their wildtype (WT) littermate controls were detected on measures of juvenile reciprocal social interaction, adult social approach, cognitive abilities, and resistance to change in a spatial habit, findings which were replicated in several cohorts of males and females. Physical and procedural abilities were similar across genotypes on measures of general health, sensory abilities, sensorimotor gating, motor functions, and anxiety-related traits. Minor developmental differences were detected between NL3 and WT, including slightly different rates of somatic growth, slower righting reflexes at postnatal days 2-6, faster homing reflexes in females, and less vocalizations on postnatal day 8 in males. Significant differences in NL3 adults included somewhat longer latencies to fall from the rotarod, less vertical activity in the open field, and less acoustic startle to high decibel tones. The humanized R451C mutation in mice did not result in apparent autism-like phenotypes, but produced detectable functional consequences that may be interpreted in terms of physical development and/or reduced sensitivity to stimuli. En ligne : http://dx.doi.org/10.1002/aur.22 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=931 [article] Minimal aberrant behavioral phenotypes of neuroligin-3 R451C knockin mice [Texte imprimé et/ou numérique] / Kathryn K. CHADMAN, Auteur ; Nathaniel HEINTZ, Auteur ; Shiaoching GONG, Auteur ; Maria Luisa SCATTONI, Auteur ; Sarah E. BOLTUCK, Auteur ; Shruti U. GANDHY, Auteur ; Jacqueline N. CRAWLEY, Auteur . - 2008 . - p.147-158. Langues : Anglais (eng) in Autism Research > 1-3 (June 2008) . - p.147-158 Mots-clés : autism mouse-model neuroligin behavior-phenotyping social-behavior Index. décimale : PER Périodiques Résumé : Neuroligin-3 is a member of the class of cell adhesion proteins that mediate synapse development and have been implicated in autism. Mice with the human R451C mutation (NL3), identical to the point mutation found in two brothers with autism spectrum disorders, were generated and phenotyped in multiple behavioral assays with face validity to the diagnostic symptoms of autism. No differences between NL3 and their wildtype (WT) littermate controls were detected on measures of juvenile reciprocal social interaction, adult social approach, cognitive abilities, and resistance to change in a spatial habit, findings which were replicated in several cohorts of males and females. Physical and procedural abilities were similar across genotypes on measures of general health, sensory abilities, sensorimotor gating, motor functions, and anxiety-related traits. Minor developmental differences were detected between NL3 and WT, including slightly different rates of somatic growth, slower righting reflexes at postnatal days 2-6, faster homing reflexes in females, and less vocalizations on postnatal day 8 in males. Significant differences in NL3 adults included somewhat longer latencies to fall from the rotarod, less vertical activity in the open field, and less acoustic startle to high decibel tones. The humanized R451C mutation in mice did not result in apparent autism-like phenotypes, but produced detectable functional consequences that may be interpreted in terms of physical development and/or reduced sensitivity to stimuli. En ligne : http://dx.doi.org/10.1002/aur.22 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=931

Pharmacological inhibition of the primary endocannabinoid producing enzyme, DGL-?, induces autism spectrum disorder-like and co-morbid phenotypes in adult C57BL/J mice / W. FYKE in Autism Research, 14-7 (July 2021)  

Public ISBD [article]  inAutism Research > 14-7 (July 2021) . - p.1375-1389 Titre : Pharmacological inhibition of the primary endocannabinoid producing enzyme, DGL-?, induces autism spectrum disorder-like and co-morbid phenotypes in adult C57BL/J mice Type de document : Texte imprimé et/ou numérique Auteurs : W. FYKE, Auteur ; J. M. ALARCON, Auteur ; M. VELINOV, Auteur ; Kathryn K. CHADMAN, Auteur Article en page(s) : p.1375-1389 Langues : Anglais (eng) Mots-clés : Animals  Anxiety  Autism Spectrum Disorder  Disease Models, Animal  Endocannabinoids  Male  Mice  Mice, Inbred C57BL  Phenotype  Dgl-?  autism spectrum disorders  mouse models  neurodevelopmental disorders Index. décimale : PER Périodiques Résumé : Accumulating evidence links dysfunction in the endocannabinoid system (ECS) with the pathology of neurodevelopmental disorders, particularly autism spectrum disorder (ASD). Variants in ECS genes CNR1 and DAGLA are associated with neurological phenotypes in humans. The endocannabinoids (eCBs), 2-AG and AEA, which act at the primary cannabinoid receptor (CB1), mediate behaviors relevant to neurodevelopmental disorders. The overlap between these eCBs is poorly understood. Most ECS studies have focused on stress responses, anxiety, and epilepsy, however, its role in social behavior and communication has only recently come under investigation. This represents a critical gap in our understanding of the ECS and its relationship to ASD. Furthermore, the increasing prevalence of ASD and a lack of therapeutics emphasize a crucial need for novel therapeutic targets. To this aim, we used an inhibitor of the eCB producing enzyme DGL-?, DO34, and the CB1 inverse agonist, rimonabant, to evaluate the role of the primary eCB, 2-AG, in ASD. Adult male C57BL/6J mice were used in a series of behavioral paradigms which assessed social behavior, social communication, repetitive behaviors, anxiety and locomotor activity. DO34 and rimonabant increased anxiety-like behavior, while only DO34 induced hyperactivity, social deficits, and repetitive self-grooming behavior. These data indicate that reduced 2-AG bioavailability, or CB1 inhibition, each induce unique respective behavioral phenotypes relevant to neurodevelopmental disorders, particularly ASD. This suggests fundamental differences in CB1 signaling via 2-AG and the CB1 receptor itself, particularly for social behaviors, and that 2-AG signaling may represent a target for the development of novel therapeutics. LAY SUMMARY: Endocannabinoids play a critical role in the developing nervous system. Alterations in the endocannabinoid system are linked to neurodevelopmental disorders. Studies suggest these variants may play a critical role in the core symptoms of autism spectrum disorder. In this study, pharmacological inhibition of the primary endocannabinoid producing enzyme, DGL-?, induced a constellation of deficits in behavioral domains associated with autism. En ligne : http://dx.doi.org/10.1002/aur.2520 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449 [article] Pharmacological inhibition of the primary endocannabinoid producing enzyme, DGL-?, induces autism spectrum disorder-like and co-morbid phenotypes in adult C57BL/J mice [Texte imprimé et/ou numérique] / W. FYKE, Auteur ; J. M. ALARCON, Auteur ; M. VELINOV, Auteur ; Kathryn K. CHADMAN, Auteur . - p.1375-1389. Langues : Anglais (eng) in Autism Research > 14-7 (July 2021) . - p.1375-1389 Mots-clés : Animals  Anxiety  Autism Spectrum Disorder  Disease Models, Animal  Endocannabinoids  Male  Mice  Mice, Inbred C57BL  Phenotype  Dgl-?  autism spectrum disorders  mouse models  neurodevelopmental disorders Index. décimale : PER Périodiques Résumé : Accumulating evidence links dysfunction in the endocannabinoid system (ECS) with the pathology of neurodevelopmental disorders, particularly autism spectrum disorder (ASD). Variants in ECS genes CNR1 and DAGLA are associated with neurological phenotypes in humans. The endocannabinoids (eCBs), 2-AG and AEA, which act at the primary cannabinoid receptor (CB1), mediate behaviors relevant to neurodevelopmental disorders. The overlap between these eCBs is poorly understood. Most ECS studies have focused on stress responses, anxiety, and epilepsy, however, its role in social behavior and communication has only recently come under investigation. This represents a critical gap in our understanding of the ECS and its relationship to ASD. Furthermore, the increasing prevalence of ASD and a lack of therapeutics emphasize a crucial need for novel therapeutic targets. To this aim, we used an inhibitor of the eCB producing enzyme DGL-?, DO34, and the CB1 inverse agonist, rimonabant, to evaluate the role of the primary eCB, 2-AG, in ASD. Adult male C57BL/6J mice were used in a series of behavioral paradigms which assessed social behavior, social communication, repetitive behaviors, anxiety and locomotor activity. DO34 and rimonabant increased anxiety-like behavior, while only DO34 induced hyperactivity, social deficits, and repetitive self-grooming behavior. These data indicate that reduced 2-AG bioavailability, or CB1 inhibition, each induce unique respective behavioral phenotypes relevant to neurodevelopmental disorders, particularly ASD. This suggests fundamental differences in CB1 signaling via 2-AG and the CB1 receptor itself, particularly for social behaviors, and that 2-AG signaling may represent a target for the development of novel therapeutics. LAY SUMMARY: Endocannabinoids play a critical role in the developing nervous system. Alterations in the endocannabinoid system are linked to neurodevelopmental disorders. Studies suggest these variants may play a critical role in the core symptoms of autism spectrum disorder. In this study, pharmacological inhibition of the primary endocannabinoid producing enzyme, DGL-?, induced a constellation of deficits in behavioral domains associated with autism. En ligne : http://dx.doi.org/10.1002/aur.2520 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449

The BTBR T+tf/J (BTBR) Mouse Model of Autism / Kathryn K. CHADMAN in Autism - Open Access, 2-S ([01/12/2012])  

Public ISBD [article]  inAutism - Open Access > 2-S [01/12/2012] . - 7 p. Titre : The BTBR T+tf/J (BTBR) Mouse Model of Autism Type de document : Texte imprimé et/ou numérique Auteurs : Kathryn K. CHADMAN, Auteur ; Sara R. GUARIGLIA, Auteur Article en page(s) : 7 p. Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Mouse models of neuropsychiatric disorders are validated according to three different criteria: face validity, construct validity and predictive validity. Autism Spectrum Disorders (ASDs) are diagnosed behaviorally, therefore, mouse models of ASDs rely primarily on face validity. The three diagnostic criteria for ASDs are impairments in social interaction, communication and repetitive behavior, and/or restricted interests. The BTBR T+tf/J (BTBR) mice are an inbred strain used as model of ASDs. All three types of behavioral criteria have been evaluated in the BTBR mice. An advantage of using an inbred strain, such as BTBR is that, the mice are considered genetically identical and offer good controls for experimentation. The BTBR mice have demonstrated face validity for the three core behaviors that define ASDs. Low levels of social behavior, altered communication and spontaneous grooming comprise the behavioral phenotype of the BTBR mice. For construct validity, the BTBR mice have some physiological characteristics similar to humans with ASDs. Several drug and behavioral treatments for ASDs have been examined in the BTBR mice; however this area of research is still being developed. This review will offer a description of the behavior and physiology of the BTBR mice as a model for ASDs. En ligne : https://dx.doi.org/10.4172/2165-7890.S1-009 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=409 [article] The BTBR T+tf/J (BTBR) Mouse Model of Autism [Texte imprimé et/ou numérique] / Kathryn K. CHADMAN, Auteur ; Sara R. GUARIGLIA, Auteur . - 7 p. Langues : Anglais (eng) in Autism - Open Access > 2-S [01/12/2012] . - 7 p. Index. décimale : PER Périodiques Résumé : Mouse models of neuropsychiatric disorders are validated according to three different criteria: face validity, construct validity and predictive validity. Autism Spectrum Disorders (ASDs) are diagnosed behaviorally, therefore, mouse models of ASDs rely primarily on face validity. The three diagnostic criteria for ASDs are impairments in social interaction, communication and repetitive behavior, and/or restricted interests. The BTBR T+tf/J (BTBR) mice are an inbred strain used as model of ASDs. All three types of behavioral criteria have been evaluated in the BTBR mice. An advantage of using an inbred strain, such as BTBR is that, the mice are considered genetically identical and offer good controls for experimentation. The BTBR mice have demonstrated face validity for the three core behaviors that define ASDs. Low levels of social behavior, altered communication and spontaneous grooming comprise the behavioral phenotype of the BTBR mice. For construct validity, the BTBR mice have some physiological characteristics similar to humans with ASDs. Several drug and behavioral treatments for ASDs have been examined in the BTBR mice; however this area of research is still being developed. This review will offer a description of the behavior and physiology of the BTBR mice as a model for ASDs. En ligne : https://dx.doi.org/10.4172/2165-7890.S1-009 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=409

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