CRISPR/Cas9-mediated heterozygous knockout of the autism gene CHD8 and characterization of its transcriptional networks in neurodevelopment / Ping WANG in Molecular Autism, (October 2015)  

Public ISBD [article]  inMolecular Autism > (October 2015) . - p.1-18 Titre : CRISPR/Cas9-mediated heterozygous knockout of the autism gene CHD8 and characterization of its transcriptional networks in neurodevelopment Type de document : texte imprimé Auteurs : Ping WANG, Auteur ; Mingyan LIN, Auteur ; Erika PEDROSA, Auteur ; Anastasia HRABOVSKY, Auteur ; Zheng ZHANG, Auteur ; Wenjun GUO, Auteur ; Herbert M. LACHMAN, Auteur ; Deyou ZHENG, Auteur Article en page(s) : p.1-18 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Disruptive mutation in the CHD8 gene is one of the top genetic risk factors in autism spectrum disorders (ASDs). Previous analyses of genome-wide CHD8 occupancy and reduced expression of CHD8 by shRNA knockdown in committed neural cells showed that CHD8 regulates multiple cell processes critical for neural functions, and its targets are enriched with ASD-associated genes. En ligne : http://dx.doi.org/10.1186/s13229-015-0048-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277 [article] CRISPR/Cas9-mediated heterozygous knockout of the autism gene CHD8 and characterization of its transcriptional networks in neurodevelopment [texte imprimé] / Ping WANG, Auteur ; Mingyan LIN, Auteur ; Erika PEDROSA, Auteur ; Anastasia HRABOVSKY, Auteur ; Zheng ZHANG, Auteur ; Wenjun GUO, Auteur ; Herbert M. LACHMAN, Auteur ; Deyou ZHENG, Auteur . - p.1-18. Langues : Anglais (eng) in Molecular Autism > (October 2015) . - p.1-18 Index. décimale : PER Périodiques Résumé : Disruptive mutation in the CHD8 gene is one of the top genetic risk factors in autism spectrum disorders (ASDs). Previous analyses of genome-wide CHD8 occupancy and reduced expression of CHD8 by shRNA knockdown in committed neural cells showed that CHD8 regulates multiple cell processes critical for neural functions, and its targets are enriched with ASD-associated genes. En ligne : http://dx.doi.org/10.1186/s13229-015-0048-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277

Executive Function in High-Functioning Autism Spectrum Disorder: A Meta-analysis of fMRI Studies / Zheng ZHANG in Journal of Autism and Developmental Disorders, 50-11 (November 2020)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 50-11 (November 2020) . - p.4022-4038 Titre : Executive Function in High-Functioning Autism Spectrum Disorder: A Meta-analysis of fMRI Studies Type de document : texte imprimé Auteurs : Zheng ZHANG, Auteur ; Peng PENG, Auteur ; Delong ZHANG, Auteur Article en page(s) : p.4022-4038 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Development  Executive function  Fronto-parietal areas  Meta-analysis  Unity and diversity Index. décimale : PER Périodiques Résumé : Abnormalities in executive function (EF) are clinical markers for autism spectrum disorder (ASD). However, the neural mechanisms underlying abnormal EF in ASD remain unclear. This meta-analysis investigated the construct, abnormalities, and age-related changes of EF in ASD. Thirty-three fMRI studies of inhibition, updating, and switching in individuals with high-functioning ASD were included (n = 1114; age range 7-57 years). The results revealed that the EF construct in ASD could be unitary (i.e., common EF) in children/adolescents, but unitary and diverse (i.e., common EF and inhibition) in adults. Abnormalities in this EF construct were found across development in individuals with ASD in comparison with typically developing individuals. Implications and recommendations are discussed for EF theory and for practice in ASD. En ligne : http://dx.doi.org/10.1007/s10803-020-04461-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=432 [article] Executive Function in High-Functioning Autism Spectrum Disorder: A Meta-analysis of fMRI Studies [texte imprimé] / Zheng ZHANG, Auteur ; Peng PENG, Auteur ; Delong ZHANG, Auteur . - p.4022-4038. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 50-11 (November 2020) . - p.4022-4038 Mots-clés : Autism spectrum disorder  Development  Executive function  Fronto-parietal areas  Meta-analysis  Unity and diversity Index. décimale : PER Périodiques Résumé : Abnormalities in executive function (EF) are clinical markers for autism spectrum disorder (ASD). However, the neural mechanisms underlying abnormal EF in ASD remain unclear. This meta-analysis investigated the construct, abnormalities, and age-related changes of EF in ASD. Thirty-three fMRI studies of inhibition, updating, and switching in individuals with high-functioning ASD were included (n = 1114; age range 7-57 years). The results revealed that the EF construct in ASD could be unitary (i.e., common EF) in children/adolescents, but unitary and diverse (i.e., common EF and inhibition) in adults. Abnormalities in this EF construct were found across development in individuals with ASD in comparison with typically developing individuals. Implications and recommendations are discussed for EF theory and for practice in ASD. En ligne : http://dx.doi.org/10.1007/s10803-020-04461-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=432

Perceptual metrics of individuals with autism provide evidence for disinhibition / Vinay TANNAN in Autism Research, 1-4 (August 2008)  

Public ISBD [article]  inAutism Research > 1-4 (August 2008) . - p.223-230 Titre : Perceptual metrics of individuals with autism provide evidence for disinhibition Type de document : texte imprimé Auteurs : Vinay TANNAN, Auteur ; Grace T. BARANEK, Auteur ; Jameson K. HOLDEN, Auteur ; Zheng ZHANG, Auteur ; Mark A. TOMMERDAHL, Auteur Année de publication : 2008 Article en page(s) : p.223-230 Langues : Anglais (eng) Mots-clés : autism inhibition adaptation habituation amplitude discrimination sensory-discrimination Index. décimale : PER Périodiques Résumé : Adults with autism exhibit inhibitory deficits that are often manifested in behavioral modifications, such as repetitive behaviors, and/or sensory hyper-responsiveness. If such behaviors are the result of a generalized deficiency in inhibitory neurotransmission, then it stands to reason that deficits involving localized cortical-cortical interactions - such as in sensory discrimination tasks - could be detected and quantified. This study exemplifies a newly developed method for quantifying sensory testing metrics. Our novel sensory discrimination tests may provide (a) an effective means for biobehavioral assessment of deficits specific to autism and (b) an efficient and sensitive measure of change following treatment. The sensory discriminative capacity of ten subjects with autism and ten controls was compared both before and after short duration adapting stimuli. Specifically, vibrotactile amplitude discriminative capacity was obtained both in the presence and absence of 1 sec adapting stimuli that were delivered 1 sec prior to the comparison stimuli. Although adaptation had a pronounced effect on the amplitude discriminative capacity of the control subjects, little or no impact was observed on the sensory discriminative capacity of the subjects with autism. This lack of impact of the adapting stimuli on the responses of the subjects with autism was interpreted to be consistent with the reduced GABAergic-mediated inhibition described in previous reports. One significant aspect of this study is that the methods could prove to be a useful and efficient way to detect specific neural deficits and monitor the efficacy of pharmacological or behavioral treatments in autism. En ligne : http://dx.doi.org/10.1002/aur.34 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=932 [article] Perceptual metrics of individuals with autism provide evidence for disinhibition [texte imprimé] / Vinay TANNAN, Auteur ; Grace T. BARANEK, Auteur ; Jameson K. HOLDEN, Auteur ; Zheng ZHANG, Auteur ; Mark A. TOMMERDAHL, Auteur . - 2008 . - p.223-230. Langues : Anglais (eng) in Autism Research > 1-4 (August 2008) . - p.223-230 Mots-clés : autism inhibition adaptation habituation amplitude discrimination sensory-discrimination Index. décimale : PER Périodiques Résumé : Adults with autism exhibit inhibitory deficits that are often manifested in behavioral modifications, such as repetitive behaviors, and/or sensory hyper-responsiveness. If such behaviors are the result of a generalized deficiency in inhibitory neurotransmission, then it stands to reason that deficits involving localized cortical-cortical interactions - such as in sensory discrimination tasks - could be detected and quantified. This study exemplifies a newly developed method for quantifying sensory testing metrics. Our novel sensory discrimination tests may provide (a) an effective means for biobehavioral assessment of deficits specific to autism and (b) an efficient and sensitive measure of change following treatment. The sensory discriminative capacity of ten subjects with autism and ten controls was compared both before and after short duration adapting stimuli. Specifically, vibrotactile amplitude discriminative capacity was obtained both in the presence and absence of 1 sec adapting stimuli that were delivered 1 sec prior to the comparison stimuli. Although adaptation had a pronounced effect on the amplitude discriminative capacity of the control subjects, little or no impact was observed on the sensory discriminative capacity of the subjects with autism. This lack of impact of the adapting stimuli on the responses of the subjects with autism was interpreted to be consistent with the reduced GABAergic-mediated inhibition described in previous reports. One significant aspect of this study is that the methods could prove to be a useful and efficient way to detect specific neural deficits and monitor the efficacy of pharmacological or behavioral treatments in autism. En ligne : http://dx.doi.org/10.1002/aur.34 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=932

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