Neonatal Brainstem Function and 4-Month Arousal-Modulated Attention Are Jointly Associated With Autism / Ira L. COHEN in Autism Research, 6-1 (February 2013)  

Public ISBD [article]  inAutism Research > 6-1 (February 2013) . - p.11-22 Titre : Neonatal Brainstem Function and 4-Month Arousal-Modulated Attention Are Jointly Associated With Autism Type de document : Texte imprimé et/ou numérique Auteurs : Ira L. COHEN, Auteur ; Judith M. GARDNER, Auteur ; Bernard Z. KARMEL, Auteur ; Ha T. T. PHAN, Auteur ; Phyllis KITTLER, Auteur ; Tina Rovito GOMEZ, Auteur ; Maripaz G. GONZALEZ, Auteur ; Elizabeth M. LENNON, Auteur ; Santosh PARAB, Auteur ; Anthony BARONE, Auteur Année de publication : 2013 Article en page(s) : p.11-22 Langues : Anglais (eng) Mots-clés : auditory brainstem response  infancy  attention  arousal  repetitive and ritualistic behaviors  autism spectrum disorder Index. décimale : PER Périodiques Résumé : The authors evaluated the contribution of initially abnormal neonatal auditory brainstem responses (ABRs) and 4-month arousal-modulated attention visual preference to later autism spectrum disorder (ASD) behaviors in neonatal intensive care unit (NICU) graduates. A longitudinal study design was used to compare NICU graduates with normal ABRs (n?=?28) to those with initially abnormal ABRs (n?=?46) that later resolved. At 4 months postterm age, visual preference (measured after feeding) for a random check pattern flashing at 1, 3, or 8?Hz and gestational age (GA) served as additional predictors. Outcome measures were PDD Behavior Inventory (PDDBI) scores at 3.4 years (standard deviation?=?1.2), and developmental quotients (DQ) obtained around the same age with the Griffiths Mental Development Scales (GMDS). Preferences for higher rates of stimulation at 4 months were highly correlated with PDDBI scores (all P-values??0.01) and the GMDS Hearing and Speech DQ, but only in those with initially abnormal ABRs. Effects were strongest for a PDDBI social competence measure most associated with a diagnosis of autism. For those with abnormal ABRs, increases in preference for higher rates of stimulation as infants were linked to nonlinear increases in severity of ASD at 3 years and to an ASD diagnosis. Abnormal ABRs were associated with later reports of repetitive and ritualistic behaviors irrespective of 4-month preference for stimulation. The joint occurrence of initially abnormal neonatal ABRs and preference for more stimulation at 4 months, both indices of early brainstem dysfunction, may be a marker for the development of autism in this cohort. En ligne : http://dx.doi.org/10.1002/aur.1259 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=192 [article] Neonatal Brainstem Function and 4-Month Arousal-Modulated Attention Are Jointly Associated With Autism [Texte imprimé et/ou numérique] / Ira L. COHEN, Auteur ; Judith M. GARDNER, Auteur ; Bernard Z. KARMEL, Auteur ; Ha T. T. PHAN, Auteur ; Phyllis KITTLER, Auteur ; Tina Rovito GOMEZ, Auteur ; Maripaz G. GONZALEZ, Auteur ; Elizabeth M. LENNON, Auteur ; Santosh PARAB, Auteur ; Anthony BARONE, Auteur . - 2013 . - p.11-22. Langues : Anglais (eng) in Autism Research > 6-1 (February 2013) . - p.11-22 Mots-clés : auditory brainstem response  infancy  attention  arousal  repetitive and ritualistic behaviors  autism spectrum disorder Index. décimale : PER Périodiques Résumé : The authors evaluated the contribution of initially abnormal neonatal auditory brainstem responses (ABRs) and 4-month arousal-modulated attention visual preference to later autism spectrum disorder (ASD) behaviors in neonatal intensive care unit (NICU) graduates. A longitudinal study design was used to compare NICU graduates with normal ABRs (n?=?28) to those with initially abnormal ABRs (n?=?46) that later resolved. At 4 months postterm age, visual preference (measured after feeding) for a random check pattern flashing at 1, 3, or 8?Hz and gestational age (GA) served as additional predictors. Outcome measures were PDD Behavior Inventory (PDDBI) scores at 3.4 years (standard deviation?=?1.2), and developmental quotients (DQ) obtained around the same age with the Griffiths Mental Development Scales (GMDS). Preferences for higher rates of stimulation at 4 months were highly correlated with PDDBI scores (all P-values??0.01) and the GMDS Hearing and Speech DQ, but only in those with initially abnormal ABRs. Effects were strongest for a PDDBI social competence measure most associated with a diagnosis of autism. For those with abnormal ABRs, increases in preference for higher rates of stimulation as infants were linked to nonlinear increases in severity of ASD at 3 years and to an ASD diagnosis. Abnormal ABRs were associated with later reports of repetitive and ritualistic behaviors irrespective of 4-month preference for stimulation. The joint occurrence of initially abnormal neonatal ABRs and preference for more stimulation at 4 months, both indices of early brainstem dysfunction, may be a marker for the development of autism in this cohort. En ligne : http://dx.doi.org/10.1002/aur.1259 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=192

Parent PDD Behavior Inventory Profiles of Young Children Classified According to Autism Diagnostic Observation Schedule-Generic and Autism Diagnostic Interview-Revised Criteria / Ira L. COHEN in Journal of Autism and Developmental Disorders, 40-2 (February 2010)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 40-2 (February 2010) . - p.246-254 Titre : Parent PDD Behavior Inventory Profiles of Young Children Classified According to Autism Diagnostic Observation Schedule-Generic and Autism Diagnostic Interview-Revised Criteria Type de document : Texte imprimé et/ou numérique Auteurs : Ira L. COHEN, Auteur ; Tina Rovito GOMEZ, Auteur ; Maripaz G. GONZALEZ, Auteur ; Elizabeth M. LENNON, Auteur ; Bernard Z. KARMEL, Auteur ; Judith M. GARDNER, Auteur Année de publication : 2010 Article en page(s) : p.246-254 Langues : Anglais (eng) Mots-clés : Autism Assessment Diagnosis Rating-scales Index. décimale : PER Périodiques Résumé : Quantitative variations in score profiles from the parent version of the PDD Behavior Inventory (PDDBI) were examined in young Autism and PDD-NOS groups defined by ADOS-G and ADI-R criteria, relative to a not spectrum (NS) group of similar age. Both the Autism and the PDD-NOS group profiles markedly differed from the NS group. The most sensitive measures of group differences were those domain and composite scores that assessed social communication competence, as well as the overall Autism Composite score. Sensitivity, specificity and positive and negative predictability measures were quite good for these measures. It was concluded that the PDDBI is useful in assisting in the differential diagnosis of autism spectrum disorder. En ligne : http://dx.doi.org/10.1007/s10803-009-0863-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=965 [article] Parent PDD Behavior Inventory Profiles of Young Children Classified According to Autism Diagnostic Observation Schedule-Generic and Autism Diagnostic Interview-Revised Criteria [Texte imprimé et/ou numérique] / Ira L. COHEN, Auteur ; Tina Rovito GOMEZ, Auteur ; Maripaz G. GONZALEZ, Auteur ; Elizabeth M. LENNON, Auteur ; Bernard Z. KARMEL, Auteur ; Judith M. GARDNER, Auteur . - 2010 . - p.246-254. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 40-2 (February 2010) . - p.246-254 Mots-clés : Autism Assessment Diagnosis Rating-scales Index. décimale : PER Périodiques Résumé : Quantitative variations in score profiles from the parent version of the PDD Behavior Inventory (PDDBI) were examined in young Autism and PDD-NOS groups defined by ADOS-G and ADI-R criteria, relative to a not spectrum (NS) group of similar age. Both the Autism and the PDD-NOS group profiles markedly differed from the NS group. The most sensitive measures of group differences were those domain and composite scores that assessed social communication competence, as well as the overall Autism Composite score. Sensitivity, specificity and positive and negative predictability measures were quite good for these measures. It was concluded that the PDDBI is useful in assisting in the differential diagnosis of autism spectrum disorder. En ligne : http://dx.doi.org/10.1007/s10803-009-0863-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=965

Rating scale measures are associated with Noldus EthoVision-XT video tracking of behaviors of children on the autism spectrum / Ira L. COHEN in Molecular Autism, (February 2014)  

Public ISBD [article]  inMolecular Autism > (February 2014) Titre : Rating scale measures are associated with Noldus EthoVision-XT video tracking of behaviors of children on the autism spectrum Type de document : Texte imprimé et/ou numérique Auteurs : Ira L. COHEN, Auteur ; Judith M. GARDNER, Auteur ; Bernard Z. KARMEL, Auteur ; Soh-Yule KIM, Auteur Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Children with Autism Spectrum Disorder (ASD) show unusual social behaviors and repetitive behaviors. Some of these behaviors, e.g., time spent in an area or turning rate/direction, can be automatically tracked. Automated tracking has several advantages over subjective ratings including reliability, amount of information provided, and consistency across laboratories, and is potentially of importance for diagnosis, animal models and objective assessment of treatment efficacy. However, its validity for ASD has not been examined. In this exploratory study, we examined associations between rating scale data with automated tracking of children's movements using the Noldus EthoVision XT system; i.e., tracking not involving a human observer. Based on our observations and previous research, we predicted that time spent in the periphery of the room would be associated with autism severity and that rate and direction of turning would be associated with stereotypies. Children with and without ASD were observed in a free-play situation for 3 min before and 3 min after Autism Diagnostic Observation Scale - Generic (ADOS-G) testing. The Noldus system provided measures of the rate and direction of turning, and time spent near the periphery or the parent. Ratings of the severity of maladaptive social behaviors, stereotypies, autism severity, and arousal problems were positively correlated with increases in percent time spent in the periphery in the total sample and in the ASD subset. Adaptive social communication skills decreased with increases in the percentage of time spent in the periphery and increases in the latency to approach the parent in the ASD group. The rate and direction of turning was linked with stereotypies only in the group without ASD (the faster the rate of a turn to the left, the worse the rating). In the ASD group, there was a shift from a neutral turning bias prior to the ADOS assessment to a strong left turn bias after the ADOS assessment. In the entire sample, this left turn bias was associated with measures of autism severity.CONCLUSION:Results suggest that automated tracking yields valid and unbiased information for assessing children with autism. Turning bias is an interesting and unexplored measure related to autism. En ligne : http://dx.doi.org/10.1186/2040-2392-5-15 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=227 [article] Rating scale measures are associated with Noldus EthoVision-XT video tracking of behaviors of children on the autism spectrum [Texte imprimé et/ou numérique] / Ira L. COHEN, Auteur ; Judith M. GARDNER, Auteur ; Bernard Z. KARMEL, Auteur ; Soh-Yule KIM, Auteur. Langues : Anglais (eng) in Molecular Autism > (February 2014) Index. décimale : PER Périodiques Résumé : Children with Autism Spectrum Disorder (ASD) show unusual social behaviors and repetitive behaviors. Some of these behaviors, e.g., time spent in an area or turning rate/direction, can be automatically tracked. Automated tracking has several advantages over subjective ratings including reliability, amount of information provided, and consistency across laboratories, and is potentially of importance for diagnosis, animal models and objective assessment of treatment efficacy. However, its validity for ASD has not been examined. In this exploratory study, we examined associations between rating scale data with automated tracking of children's movements using the Noldus EthoVision XT system; i.e., tracking not involving a human observer. Based on our observations and previous research, we predicted that time spent in the periphery of the room would be associated with autism severity and that rate and direction of turning would be associated with stereotypies. Children with and without ASD were observed in a free-play situation for 3 min before and 3 min after Autism Diagnostic Observation Scale - Generic (ADOS-G) testing. The Noldus system provided measures of the rate and direction of turning, and time spent near the periphery or the parent. Ratings of the severity of maladaptive social behaviors, stereotypies, autism severity, and arousal problems were positively correlated with increases in percent time spent in the periphery in the total sample and in the ASD subset. Adaptive social communication skills decreased with increases in the percentage of time spent in the periphery and increases in the latency to approach the parent in the ASD group. The rate and direction of turning was linked with stereotypies only in the group without ASD (the faster the rate of a turn to the left, the worse the rating). In the ASD group, there was a shift from a neutral turning bias prior to the ADOS assessment to a strong left turn bias after the ADOS assessment. In the entire sample, this left turn bias was associated with measures of autism severity.CONCLUSION:Results suggest that automated tracking yields valid and unbiased information for assessing children with autism. Turning bias is an interesting and unexplored measure related to autism. En ligne : http://dx.doi.org/10.1186/2040-2392-5-15 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=227

Using the PDD Behavior Inventory as a Level 2 Screener: A Classification and Regression Trees Analysis / Ira L. COHEN in Journal of Autism and Developmental Disorders, 46-9 (September 2016)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 46-9 (September 2016) . - p.3006-3022 Titre : Using the PDD Behavior Inventory as a Level 2 Screener: A Classification and Regression Trees Analysis Type de document : Texte imprimé et/ou numérique Auteurs : Ira L. COHEN, Auteur ; Xudong LIU, Auteur ; Melissa HUDSON, Auteur ; Jennifer GILLIS, Auteur ; Rachel N. S. CAVALARI, Auteur ; Raymond G. ROMANCZYK, Auteur ; Bernard Z. KARMEL, Auteur ; Judith M. GARDNER, Auteur Article en page(s) : p.3006-3022 Langues : Anglais (eng) Mots-clés : Level 2 screeners  Autism Spectrum Disorder  Decision trees  Data mining  Machine learning  Seizures  Monoamine Oxidase A  Genotype  Phenotype  Subgroups Index. décimale : PER Périodiques Résumé : In order to improve discrimination accuracy between Autism Spectrum Disorder (ASD) and similar neurodevelopmental disorders, a data mining procedure, Classification and Regression Trees (CART), was used on a large multi-site sample of PDD Behavior Inventory (PDDBI) forms on children with and without ASD. Discrimination accuracy exceeded 80 %, generalized to an independent validation set, and generalized across age groups and sites, and agreed well with ADOS classifications. Parent PDDBIs yielded better results than teacher PDDBIs but, when CART predictions agreed across informants, sensitivity increased. Results also revealed three subtypes of ASD: minimally verbal, verbal, and atypical; and two, relatively common subtypes of non-ASD children: social pragmatic problems and good social skills. These subgroups corresponded to differences in behavior profiles and associated bio-medical findings. En ligne : http://dx.doi.org/10.1007/s10803-016-2843-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=292 [article] Using the PDD Behavior Inventory as a Level 2 Screener: A Classification and Regression Trees Analysis [Texte imprimé et/ou numérique] / Ira L. COHEN, Auteur ; Xudong LIU, Auteur ; Melissa HUDSON, Auteur ; Jennifer GILLIS, Auteur ; Rachel N. S. CAVALARI, Auteur ; Raymond G. ROMANCZYK, Auteur ; Bernard Z. KARMEL, Auteur ; Judith M. GARDNER, Auteur . - p.3006-3022. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 46-9 (September 2016) . - p.3006-3022 Mots-clés : Level 2 screeners  Autism Spectrum Disorder  Decision trees  Data mining  Machine learning  Seizures  Monoamine Oxidase A  Genotype  Phenotype  Subgroups Index. décimale : PER Périodiques Résumé : In order to improve discrimination accuracy between Autism Spectrum Disorder (ASD) and similar neurodevelopmental disorders, a data mining procedure, Classification and Regression Trees (CART), was used on a large multi-site sample of PDD Behavior Inventory (PDDBI) forms on children with and without ASD. Discrimination accuracy exceeded 80 %, generalized to an independent validation set, and generalized across age groups and sites, and agreed well with ADOS classifications. Parent PDDBIs yielded better results than teacher PDDBIs but, when CART predictions agreed across informants, sensitivity increased. Results also revealed three subtypes of ASD: minimally verbal, verbal, and atypical; and two, relatively common subtypes of non-ASD children: social pragmatic problems and good social skills. These subgroups corresponded to differences in behavior profiles and associated bio-medical findings. En ligne : http://dx.doi.org/10.1007/s10803-016-2843-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=292

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