From alcohol initiation to tolerance to problems: Discordant twin modeling of a developmental process / Arielle R. DEUTSCH in Development and Psychopathology, 29-3 (August 2017)  

Public ISBD [article]  inDevelopment and Psychopathology > 29-3 (August 2017) . - p.845-861 Titre : From alcohol initiation to tolerance to problems: Discordant twin modeling of a developmental process Type de document : Texte imprimé et/ou numérique Auteurs : Arielle R. DEUTSCH, Auteur ; Wendy S. SLUTSKE, Auteur ; Michael T. LYNSKEY, Auteur ; Kathleen K. BUCHOLZ, Auteur ; Pamela A. F. MADDEN, Auteur ; Andrew C. HEATH, Auteur ; Nicholas G. MARTIN, Auteur Article en page(s) : p.845-861 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract The current study examined a stage-based alcohol use trajectory model to test for potential causal effects of earlier drinking milestones on later drinking milestones in a combined sample of two cohorts of Australian monozygotic and same-sex dizygotic twins (N = 7,398, age M = 30.46, SD = 2.61, 61% male, 56% monozygotic twins). Ages of drinking, drunkenness, regular drinking, tolerance, first nontolerance alcohol use disorder symptom, and alcohol use disorder symptom onsets were assessed retrospectively. Ages of milestone attainment (i.e., age-of-onset) and time between milestones (i.e., time-to-event) were examined via frailty models within a multilevel discordant twin design. For age-of-onset models, earlier ages of onset of antecedent drinking milestones increased hazards for earlier ages of onset for more proximal subsequent drinking milestones. For the time-to-event models, however, earlier ages of onset for the “starting” milestone decreased risk for a shorter time period between the starting and the “ending” milestone. Earlier age of onset of intermediate milestones between starting and ending drinking milestones had the opposite effect, increasing risk for a shorter time period between the starting and ending milestones. These results are consistent with a causal effect of an earlier age of drinking milestone onset on temporally proximal subsequent drinking milestones. En ligne : http://dx.doi.org/10.1017/s0954579416000523 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=311 [article] From alcohol initiation to tolerance to problems: Discordant twin modeling of a developmental process [Texte imprimé et/ou numérique] / Arielle R. DEUTSCH, Auteur ; Wendy S. SLUTSKE, Auteur ; Michael T. LYNSKEY, Auteur ; Kathleen K. BUCHOLZ, Auteur ; Pamela A. F. MADDEN, Auteur ; Andrew C. HEATH, Auteur ; Nicholas G. MARTIN, Auteur . - p.845-861. Langues : Anglais (eng) in Development and Psychopathology > 29-3 (August 2017) . - p.845-861 Index. décimale : PER Périodiques Résumé : Abstract The current study examined a stage-based alcohol use trajectory model to test for potential causal effects of earlier drinking milestones on later drinking milestones in a combined sample of two cohorts of Australian monozygotic and same-sex dizygotic twins (N = 7,398, age M = 30.46, SD = 2.61, 61% male, 56% monozygotic twins). Ages of drinking, drunkenness, regular drinking, tolerance, first nontolerance alcohol use disorder symptom, and alcohol use disorder symptom onsets were assessed retrospectively. Ages of milestone attainment (i.e., age-of-onset) and time between milestones (i.e., time-to-event) were examined via frailty models within a multilevel discordant twin design. For age-of-onset models, earlier ages of onset of antecedent drinking milestones increased hazards for earlier ages of onset for more proximal subsequent drinking milestones. For the time-to-event models, however, earlier ages of onset for the “starting” milestone decreased risk for a shorter time period between the starting and the “ending” milestone. Earlier age of onset of intermediate milestones between starting and ending drinking milestones had the opposite effect, increasing risk for a shorter time period between the starting and ending milestones. These results are consistent with a causal effect of an earlier age of drinking milestone onset on temporally proximal subsequent drinking milestones. En ligne : http://dx.doi.org/10.1017/s0954579416000523 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=311

Genetic and environmental influences on extreme personality dispositions in adolescent female twins / Michele L. PERGADIA in Journal of Child Psychology and Psychiatry, 47-9 (September 2006)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 47-9 (September 2006) . - p.902–909 Titre : Genetic and environmental influences on extreme personality dispositions in adolescent female twins Type de document : Texte imprimé et/ou numérique Auteurs : Michele L. PERGADIA, Auteur ; Pamela A.F. MADDEN, Auteur ; Christina N. LESSOV, Auteur ; Alexandre A. TODOROV, Auteur ; Kathleen K. BUCHOLZ, Auteur ; Nicholas G. MARTIN, Auteur ; Andrew C. HEATH, Auteur Année de publication : 2006 Article en page(s) : p.902–909 Langues : Anglais (eng) Mots-clés : Personality genetic-analyses twin-studies internalizing externalizing Index. décimale : PER Périodiques Résumé : Background: The objective was to determine whether the pattern of environmental and genetic influences on deviant personality scores differs from that observed for the normative range of personality, comparing results in adolescent and adult female twins. Methods: A sample of 2,796 female adolescent twins ascertained from birth records provided Junior Eysenck Personality Questionnaire data. The average age of the sample was 17.0 years (S.D. 2.3). Genetic analyses of continuous and extreme personality scores were conducted. Results were compared for 3,178 adult female twins. Results: Genetic analysis of continuous traits in adolescent female twins were similar to findings in adult female twins, with genetic influences accounting for between 37% and 44% of the variance in Extraversion (Ex), Neuroticism (N), and Social Non-Conformity (SNC), with significant evidence of shared environmental influences (19%) found only for SNC in the adult female twins. Analyses of extreme personality characteristics, defined categorically, in the adolescent data and replicated in the adult female data, yielded estimates for high N and high SNC that deviated substantially (p < .05) from those obtained in the continuous trait analyses, and provided suggestive evidence that shared family environment may play a more important role in determining personality deviance than has been previously found when personality is viewed continuously. However, multiple-threshold models that assumed the same genetic and environmental determinants of both normative range variation and extreme scores gave acceptable fits for each personality dimension. Conclusions: The hypothesis of differences in genetic or environmental factors responsible for N and SNC among female twins with scores in the extreme versus normative ranges was partially supported, but not for Ex. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2005.01568.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=776 [article] Genetic and environmental influences on extreme personality dispositions in adolescent female twins [Texte imprimé et/ou numérique] / Michele L. PERGADIA, Auteur ; Pamela A.F. MADDEN, Auteur ; Christina N. LESSOV, Auteur ; Alexandre A. TODOROV, Auteur ; Kathleen K. BUCHOLZ, Auteur ; Nicholas G. MARTIN, Auteur ; Andrew C. HEATH, Auteur . - 2006 . - p.902–909. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 47-9 (September 2006) . - p.902–909 Mots-clés : Personality genetic-analyses twin-studies internalizing externalizing Index. décimale : PER Périodiques Résumé : Background: The objective was to determine whether the pattern of environmental and genetic influences on deviant personality scores differs from that observed for the normative range of personality, comparing results in adolescent and adult female twins. Methods: A sample of 2,796 female adolescent twins ascertained from birth records provided Junior Eysenck Personality Questionnaire data. The average age of the sample was 17.0 years (S.D. 2.3). Genetic analyses of continuous and extreme personality scores were conducted. Results were compared for 3,178 adult female twins. Results: Genetic analysis of continuous traits in adolescent female twins were similar to findings in adult female twins, with genetic influences accounting for between 37% and 44% of the variance in Extraversion (Ex), Neuroticism (N), and Social Non-Conformity (SNC), with significant evidence of shared environmental influences (19%) found only for SNC in the adult female twins. Analyses of extreme personality characteristics, defined categorically, in the adolescent data and replicated in the adult female data, yielded estimates for high N and high SNC that deviated substantially (p < .05) from those obtained in the continuous trait analyses, and provided suggestive evidence that shared family environment may play a more important role in determining personality deviance than has been previously found when personality is viewed continuously. However, multiple-threshold models that assumed the same genetic and environmental determinants of both normative range variation and extreme scores gave acceptable fits for each personality dimension. Conclusions: The hypothesis of differences in genetic or environmental factors responsible for N and SNC among female twins with scores in the extreme versus normative ranges was partially supported, but not for Ex. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2005.01568.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=776

The role of parental genotype in the intergenerational transmission of externalizing behavior: Evidence for genetic nurturance / Sally I. Chun KUO in Development and Psychopathology, 34-5 (December 2022)  

Public ISBD [article]  inDevelopment and Psychopathology > 34-5 (December 2022) . - p.1865-1875 Titre : The role of parental genotype in the intergenerational transmission of externalizing behavior: Evidence for genetic nurturance Type de document : Texte imprimé et/ou numérique Auteurs : Sally I. Chun KUO, Auteur ; Holly E. POORE, Auteur ; Peter B. BARR, Auteur ; Isabella S. CHIRICO, Auteur ; Fazil ALIEV, Auteur ; Kathleen K. BUCHOLZ, Auteur ; Grace CHAN, Auteur ; Chella KAMARAJAN, Auteur ; John R. KRAMER, Auteur ; Vivia V. MCCUTCHEON, Auteur ; Martin H. PLAWECKI, Auteur ; Danielle M. DICK, Auteur Article en page(s) : p.1865-1875 Langues : Anglais (eng) Mots-clés : adolescent externalizing  gene-environment correlation  genetic nurture  parenting  polygenic score Index. décimale : PER Périodiques Résumé : The purpose of this study was to examine possible pathways by which genetic risk associated with externalizing is transmitted in families. We used molecular data to disentangle the genetic and environmental pathways contributing to adolescent externalizing behavior in a sample of 1,111 adolescents (50% female; 719 European and 392 African ancestry) and their parents from the Collaborative Study on the Genetics of Alcoholism. We found evidence for genetic nurture such that parental externalizing polygenic scores were associated with adolescent externalizing behavior, over and above the effect of adolescents’ own externalizing polygenic scores. Mediation analysis indicated that parental externalizing psychopathology partly explained the effect of parental genotype on children’s externalizing behavior. We also found evidence for evocative gene-environment correlation, whereby adolescent externalizing polygenic scores were associated with lower parent “child communication, less parent “child closeness, and lower parental knowledge, controlling for parental genotype. These effects were observed among participants of European ancestry but not African ancestry, likely due to the limited predictive power of polygenic scores across ancestral background. These results demonstrate that in addition to genetic transmission, genes influence offspring behavior through the influence of parental genotypes on their children’s environmental experiences, and the role of children’s genotypes in shaping parent “child relationships. En ligne : http://dx.doi.org/10.1017/S0954579422000700 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=492 [article] The role of parental genotype in the intergenerational transmission of externalizing behavior: Evidence for genetic nurturance [Texte imprimé et/ou numérique] / Sally I. Chun KUO, Auteur ; Holly E. POORE, Auteur ; Peter B. BARR, Auteur ; Isabella S. CHIRICO, Auteur ; Fazil ALIEV, Auteur ; Kathleen K. BUCHOLZ, Auteur ; Grace CHAN, Auteur ; Chella KAMARAJAN, Auteur ; John R. KRAMER, Auteur ; Vivia V. MCCUTCHEON, Auteur ; Martin H. PLAWECKI, Auteur ; Danielle M. DICK, Auteur . - p.1865-1875. Langues : Anglais (eng) in Development and Psychopathology > 34-5 (December 2022) . - p.1865-1875 Mots-clés : adolescent externalizing  gene-environment correlation  genetic nurture  parenting  polygenic score Index. décimale : PER Périodiques Résumé : The purpose of this study was to examine possible pathways by which genetic risk associated with externalizing is transmitted in families. We used molecular data to disentangle the genetic and environmental pathways contributing to adolescent externalizing behavior in a sample of 1,111 adolescents (50% female; 719 European and 392 African ancestry) and their parents from the Collaborative Study on the Genetics of Alcoholism. We found evidence for genetic nurture such that parental externalizing polygenic scores were associated with adolescent externalizing behavior, over and above the effect of adolescents’ own externalizing polygenic scores. Mediation analysis indicated that parental externalizing psychopathology partly explained the effect of parental genotype on children’s externalizing behavior. We also found evidence for evocative gene-environment correlation, whereby adolescent externalizing polygenic scores were associated with lower parent “child communication, less parent “child closeness, and lower parental knowledge, controlling for parental genotype. These effects were observed among participants of European ancestry but not African ancestry, likely due to the limited predictive power of polygenic scores across ancestral background. These results demonstrate that in addition to genetic transmission, genes influence offspring behavior through the influence of parental genotypes on their children’s environmental experiences, and the role of children’s genotypes in shaping parent “child relationships. En ligne : http://dx.doi.org/10.1017/S0954579422000700 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=492

Using a developmental perspective to examine the moderating effects of marriage on heavy episodic drinking in a young adult sample enriched for risk / Seung Bin CHO in Development and Psychopathology, 33-3 (August 2021)  

Public ISBD [article]  inDevelopment and Psychopathology > 33-3 (August 2021) . - p.1097-1106 Titre : Using a developmental perspective to examine the moderating effects of marriage on heavy episodic drinking in a young adult sample enriched for risk Type de document : Texte imprimé et/ou numérique Auteurs : Seung Bin CHO, Auteur ; Rebecca L. SMITH, Auteur ; Kathleen K. BUCHOLZ, Auteur ; Grace F. C. CHAN, Auteur ; Howard J. EDENBERG, Auteur ; Victor HESSELBROCK, Auteur ; John KRAMER, Auteur ; Vivia V. MCCUTCHEON, Auteur ; John NURNBERGER, Auteur ; Marc SCHUCKIT, Auteur ; Yong ZANG, Auteur ; Danielle M. DICK, Auteur ; Jessica E. SALVATORE, Auteur Article en page(s) : p.1097-1106 Langues : Anglais (eng) Mots-clés : alcohol  development  genetics  marital status  young adults Index. décimale : PER Périodiques Résumé : Many studies demonstrate that marriage protects against risky alcohol use and moderates genetic influences on alcohol outcomes; however, previous work has not considered these effects from a developmental perspective or in high-risk individuals. These represent important gaps, as it cannot be assumed that marriage has uniform effects across development or in high-risk samples. We took a longitudinal developmental approach to examine whether marital status was associated with heavy episodic drinking (HED), and whether marital status moderated polygenic influences on HED. Our sample included 937 individuals (53.25% female) from the Collaborative Study on the Genetics of Alcoholism who reported their HED and marital status biennially between the ages of 21 and 25. Polygenic risk scores (PRS) were derived from a genome-wide association study of alcohol consumption. Marital status was not associated with HED; however, we observed pathogenic gene-by-environment effects that changed across young adulthood. Among those who married young (age 21), individuals with higher PRS reported more HED; however, these effects decayed over time. The same pattern was found in supplementary analyses using parental history of alcohol use disorder as the index of genetic liability. Our findings indicate that early marriage may exacerbate risk for those with higher polygenic load. En ligne : http://dx.doi.org/10.1017/S0954579420000371 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457 [article] Using a developmental perspective to examine the moderating effects of marriage on heavy episodic drinking in a young adult sample enriched for risk [Texte imprimé et/ou numérique] / Seung Bin CHO, Auteur ; Rebecca L. SMITH, Auteur ; Kathleen K. BUCHOLZ, Auteur ; Grace F. C. CHAN, Auteur ; Howard J. EDENBERG, Auteur ; Victor HESSELBROCK, Auteur ; John KRAMER, Auteur ; Vivia V. MCCUTCHEON, Auteur ; John NURNBERGER, Auteur ; Marc SCHUCKIT, Auteur ; Yong ZANG, Auteur ; Danielle M. DICK, Auteur ; Jessica E. SALVATORE, Auteur . - p.1097-1106. Langues : Anglais (eng) in Development and Psychopathology > 33-3 (August 2021) . - p.1097-1106 Mots-clés : alcohol  development  genetics  marital status  young adults Index. décimale : PER Périodiques Résumé : Many studies demonstrate that marriage protects against risky alcohol use and moderates genetic influences on alcohol outcomes; however, previous work has not considered these effects from a developmental perspective or in high-risk individuals. These represent important gaps, as it cannot be assumed that marriage has uniform effects across development or in high-risk samples. We took a longitudinal developmental approach to examine whether marital status was associated with heavy episodic drinking (HED), and whether marital status moderated polygenic influences on HED. Our sample included 937 individuals (53.25% female) from the Collaborative Study on the Genetics of Alcoholism who reported their HED and marital status biennially between the ages of 21 and 25. Polygenic risk scores (PRS) were derived from a genome-wide association study of alcohol consumption. Marital status was not associated with HED; however, we observed pathogenic gene-by-environment effects that changed across young adulthood. Among those who married young (age 21), individuals with higher PRS reported more HED; however, these effects decayed over time. The same pattern was found in supplementary analyses using parental history of alcohol use disorder as the index of genetic liability. Our findings indicate that early marriage may exacerbate risk for those with higher polygenic load. En ligne : http://dx.doi.org/10.1017/S0954579420000371 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457

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