Brief Report: Abnormal Association Between the Thalamus and Brain Size in Asperger’s Disorder / Antonio Y. HARDAN in Journal of Autism and Developmental Disorders, 38-2 (February 2008)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 38-2 (February 2008) . - p.390-394 Titre : Brief Report: Abnormal Association Between the Thalamus and Brain Size in Asperger’s Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Antonio Y. HARDAN, Auteur ; Nadine M. MELHEM, Auteur ; Nancy J. MINSHEW, Auteur ; Ragy R. GIRGIS, Auteur ; Jason ADAMS, Auteur ; Andrew R. GILBERT, Auteur ; Matcheri S. KESHAVAN, Auteur Année de publication : 2008 Article en page(s) : p.390-394 Langues : Anglais (eng) Mots-clés : Asperger’s-disorder Thalamus MRI Brain-size Autism Volume Index. décimale : PER Périodiques Résumé : The objective of this study was to examine the relationship between thalamic volume and brain size in individuals with Asperger’s disorder (ASP). Volumetric measurements of the thalamus were performed on MRI scans obtained from 12 individuals with ASP (age range: 10–35 years) and 12 healthy controls (age range: 9–33 years). A positive correlation was found between total brain volume and thalamic size in controls, but not in ASP subjects. This occurred in the absence of differences in mean thalamic volumes between the study groups. Findings from this investigation point to an abnormal relationship between the thalamus and its projection areas in ASP and are consistent with similar studies in autism, supporting that these disorders are qualitatively similar and possibly quantitatively different. En ligne : http://dx.doi.org/10.1007/s10803-007-0385-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=319 [article] Brief Report: Abnormal Association Between the Thalamus and Brain Size in Asperger’s Disorder [Texte imprimé et/ou numérique] / Antonio Y. HARDAN, Auteur ; Nadine M. MELHEM, Auteur ; Nancy J. MINSHEW, Auteur ; Ragy R. GIRGIS, Auteur ; Jason ADAMS, Auteur ; Andrew R. GILBERT, Auteur ; Matcheri S. KESHAVAN, Auteur . - 2008 . - p.390-394. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 38-2 (February 2008) . - p.390-394 Mots-clés : Asperger’s-disorder Thalamus MRI Brain-size Autism Volume Index. décimale : PER Périodiques Résumé : The objective of this study was to examine the relationship between thalamic volume and brain size in individuals with Asperger’s disorder (ASP). Volumetric measurements of the thalamus were performed on MRI scans obtained from 12 individuals with ASP (age range: 10–35 years) and 12 healthy controls (age range: 9–33 years). A positive correlation was found between total brain volume and thalamic size in controls, but not in ASP subjects. This occurred in the absence of differences in mean thalamic volumes between the study groups. Findings from this investigation point to an abnormal relationship between the thalamus and its projection areas in ASP and are consistent with similar studies in autism, supporting that these disorders are qualitatively similar and possibly quantitatively different. En ligne : http://dx.doi.org/10.1007/s10803-007-0385-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=319

Commentary: The course of depression after childhood parental death – a reflection on Berg et al. (2016) / Nadine M. MELHEM in Journal of Child Psychology and Psychiatry, 57-12 (December 2016)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 57-12 (December 2016) . - p.1467-1469 Titre : Commentary: The course of depression after childhood parental death – a reflection on Berg et al. (2016) Type de document : Texte imprimé et/ou numérique Auteurs : Nadine M. MELHEM, Auteur ; David A. BRENT, Auteur Article en page(s) : p.1467-1469 Langues : Anglais (eng) Mots-clés : Depression  death Index. décimale : PER Périodiques Résumé : Berg et al.'s study highlights the long-lasting impact of childhood parental death on depression in adulthood in the absence of early preventive and intervention efforts. Given the long-term effects of childhood parental death, it seems that the most propitious time to intervene is early on after the death. Several prevention and intervention approaches have been shown to reduce the incidence of depression and to ameliorate its course and thus could be potential approaches to intervene with parentally bereaved children. Future longitudinal studies focused on children and adolescents are also needed to examine the biological pathways that set the stage for increased vulnerability across the life span following childhood parental death and adversity in order to inform novel targets for interventions. En ligne : http://dx.doi.org/10.1111/jcpp.12626 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298 [article] Commentary: The course of depression after childhood parental death – a reflection on Berg et al. (2016) [Texte imprimé et/ou numérique] / Nadine M. MELHEM, Auteur ; David A. BRENT, Auteur . - p.1467-1469. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 57-12 (December 2016) . - p.1467-1469 Mots-clés : Depression  death Index. décimale : PER Périodiques Résumé : Berg et al.'s study highlights the long-lasting impact of childhood parental death on depression in adulthood in the absence of early preventive and intervention efforts. Given the long-term effects of childhood parental death, it seems that the most propitious time to intervene is early on after the death. Several prevention and intervention approaches have been shown to reduce the incidence of depression and to ameliorate its course and thus could be potential approaches to intervene with parentally bereaved children. Future longitudinal studies focused on children and adolescents are also needed to examine the biological pathways that set the stage for increased vulnerability across the life span following childhood parental death and adversity in order to inform novel targets for interventions. En ligne : http://dx.doi.org/10.1111/jcpp.12626 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298

Common genetic variants, acting additively, are a major source of risk for autism / Lambertus KLEI in Molecular Autism, (October 2012)  

Public ISBD [article]  inMolecular Autism > (October 2012) . - 13 p. Titre : Common genetic variants, acting additively, are a major source of risk for autism Type de document : Texte imprimé et/ou numérique Auteurs : Lambertus KLEI, Auteur ; Stephan J. SANDERS, Auteur ; Michael T. MURTHA, Auteur ; Vanessa HUS, Auteur ; Jennifer K. LOWE, Auteur ; A. J. WILLSEY, Auteur ; Daniel MORENO DE LUCA, Auteur ; Timothy W. YU, Auteur ; Eric FOMBONNE, Auteur ; Daniel H. GESCHWIND, Auteur ; Dorothy E. GRICE, Auteur ; David H. LEDBETTER, Auteur ; Catherine LORD, Auteur ; Shrikant M. MANE, Auteur ; Christa L. MARTIN, Auteur ; Donna M. MARTIN, Auteur ; Eric M. MORROW, Auteur ; Christopher A. WALSH, Auteur ; Nadine M. MELHEM, Auteur ; Pauline CHASTE, Auteur ; James S. SUTCLIFFE, Auteur ; Matthew W. STATE, Auteur ; Edwin H. Jr COOK, Auteur ; Kathryn ROEDER, Auteur ; Bernie DEVLIN, Auteur Année de publication : 2012 Article en page(s) : 13 p. Langues : Anglais (eng) Mots-clés : Narrow-sense heritability  Multiplex  Simplex  Quantitative genetics Index. décimale : PER Périodiques Résumé : Background Autism spectrum disorders (ASD) are early onset neurodevelopmental syndromes typified by impairments in reciprocal social interaction and communication, accompanied by restricted and repetitive behaviors. While rare and especially de novo genetic variation are known to affect liability, whether common genetic polymorphism plays a substantial role is an open question and the relative contribution of genes and environment is contentious. It is probable that the relative contributions of rare and common variation, as well as environment, differs between ASD families having only a single affected individual (simplex) versus multiplex families who have two or more affected individuals. Methods By using quantitative genetics techniques and the contrast of ASD subjects to controls, we estimate what portion of liability can be explained by additive genetic effects, known as narrow-sense heritability. We evaluate relatives of ASD subjects using the same methods to evaluate the assumptions of the additive model and partition families by simplex/multiplex status to determine how heritability changes with status. Results By analyzing common variation throughout the genome, we show that common genetic polymorphism exerts substantial additive genetic effects on ASD liability and that simplex/multiplex family status has an impact on the identified composition of that risk. As a fraction of the total variation in liability, the estimated narrow-sense heritability exceeds 60% for ASD individuals from multiplex families and is approximately 40% for simplex families. By analyzing parents, unaffected siblings and alleles not transmitted from parents to their affected children, we conclude that the data for simplex ASD families follow the expectation for additive models closely. The data from multiplex families deviate somewhat from an additive model, possibly due to parental assortative mating. Conclusions Our results, when viewed in the context of results from genome-wide association studies, demonstrate that a myriad of common variants of very small effect impacts ASD liability. En ligne : http://dx.doi.org/10.1186/2040-2392-3-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=202 [article] Common genetic variants, acting additively, are a major source of risk for autism [Texte imprimé et/ou numérique] / Lambertus KLEI, Auteur ; Stephan J. SANDERS, Auteur ; Michael T. MURTHA, Auteur ; Vanessa HUS, Auteur ; Jennifer K. LOWE, Auteur ; A. J. WILLSEY, Auteur ; Daniel MORENO DE LUCA, Auteur ; Timothy W. YU, Auteur ; Eric FOMBONNE, Auteur ; Daniel H. GESCHWIND, Auteur ; Dorothy E. GRICE, Auteur ; David H. LEDBETTER, Auteur ; Catherine LORD, Auteur ; Shrikant M. MANE, Auteur ; Christa L. MARTIN, Auteur ; Donna M. MARTIN, Auteur ; Eric M. MORROW, Auteur ; Christopher A. WALSH, Auteur ; Nadine M. MELHEM, Auteur ; Pauline CHASTE, Auteur ; James S. SUTCLIFFE, Auteur ; Matthew W. STATE, Auteur ; Edwin H. Jr COOK, Auteur ; Kathryn ROEDER, Auteur ; Bernie DEVLIN, Auteur . - 2012 . - 13 p. Langues : Anglais (eng) in Molecular Autism > (October 2012) . - 13 p. Mots-clés : Narrow-sense heritability  Multiplex  Simplex  Quantitative genetics Index. décimale : PER Périodiques Résumé : Background Autism spectrum disorders (ASD) are early onset neurodevelopmental syndromes typified by impairments in reciprocal social interaction and communication, accompanied by restricted and repetitive behaviors. While rare and especially de novo genetic variation are known to affect liability, whether common genetic polymorphism plays a substantial role is an open question and the relative contribution of genes and environment is contentious. It is probable that the relative contributions of rare and common variation, as well as environment, differs between ASD families having only a single affected individual (simplex) versus multiplex families who have two or more affected individuals. Methods By using quantitative genetics techniques and the contrast of ASD subjects to controls, we estimate what portion of liability can be explained by additive genetic effects, known as narrow-sense heritability. We evaluate relatives of ASD subjects using the same methods to evaluate the assumptions of the additive model and partition families by simplex/multiplex status to determine how heritability changes with status. Results By analyzing common variation throughout the genome, we show that common genetic polymorphism exerts substantial additive genetic effects on ASD liability and that simplex/multiplex family status has an impact on the identified composition of that risk. As a fraction of the total variation in liability, the estimated narrow-sense heritability exceeds 60% for ASD individuals from multiplex families and is approximately 40% for simplex families. By analyzing parents, unaffected siblings and alleles not transmitted from parents to their affected children, we conclude that the data for simplex ASD families follow the expectation for additive models closely. The data from multiplex families deviate somewhat from an additive model, possibly due to parental assortative mating. Conclusions Our results, when viewed in the context of results from genome-wide association studies, demonstrate that a myriad of common variants of very small effect impacts ASD liability. En ligne : http://dx.doi.org/10.1186/2040-2392-3-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=202

Criterion validity of the Mood and Feelings Questionnaire for depressive episodes in clinic and non-clinic subjects / William BURLESON DAVISS in Journal of Child Psychology and Psychiatry, 47-9 (September 2006)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 47-9 (September 2006) . - p.927–934 Titre : Criterion validity of the Mood and Feelings Questionnaire for depressive episodes in clinic and non-clinic subjects Type de document : Texte imprimé et/ou numérique Auteurs : William BURLESON DAVISS, Auteur ; David A. BRENT, Auteur ; Boris BIRMAHER, Auteur ; Nadine M. MELHEM, Auteur ; David A. AXELSON, Auteur ; Shana M. MICHAELS, Auteur Année de publication : 2006 Article en page(s) : p.927–934 Langues : Anglais (eng) Mots-clés : Pediatric-depression assessment validity reliability Index. décimale : PER Périodiques Résumé : Background: Previous measures of pediatric depression have shown inconsistent validity in groups with differing demographics, comorbid diagnoses, and clinic or non-clinic origins. The current study re-examines the criterion validity of child- and parent-versions of the Mood and Feelings Questionnaire (MFQ-C, MFQ-P) in a heterogeneous sample of children and adolescents from clinic and non-clinic sources. Methods: Among 470 consecutive youth completing semi-structured interviews at a university-based child psychiatry center, total scores from the 33-item MFQ-C and 34-item MFQ-P were examined across subjects with and without mood disorders using analysis of variance, and receiver operating characteristics analysis. Results: Mean scores of the MFQ-C and MFQ-P, respectively, differed significantly (p < .0005) across youth having major depressive episodes (MDE) (33 and 32, n = 77), mood disorders not meeting criteria for current MDE (24 and 28, n = 75), and no mood disorders (12 and 10, n = 318). In the overall sample, areas under the curve (AUC) for discriminating MDE and any mood disorder, respectively, were .85 and .83 on the MFQ-C, .86 and .90 on the MFQ-P, and .89 and .90 on the MFQ-C and MFQ-P averaged together, suggesting moderate to high criterion validity. Similar findings were noted in subgroups divided by age, sex, race, comorbid psychopathology, and clinic or non-clinic origins. AUCs of these MFQ scores compared favorably with those of the Beck's Depressive Inventory, the Child Behavior Checklist's Anxious/Depressed scale and the Children's Depressive Rating Scale–Revised by the same raters. A score of 29 on the MFQ-C (positive screen rate 21%, sensitivity 68%, specificity 88%) or 27 on the MFQ-P (positive screen rate 23%, sensitivity 61%, specificity 85%) optimally discriminated youth with MDE from the rest of the sample. Conclusions: The MFQ-C and MFQ-P, especially used in combination, validly identify MDE or other mood disorders in youth diverse in demographic and clinical characteristics. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2006.01646.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=779 [article] Criterion validity of the Mood and Feelings Questionnaire for depressive episodes in clinic and non-clinic subjects [Texte imprimé et/ou numérique] / William BURLESON DAVISS, Auteur ; David A. BRENT, Auteur ; Boris BIRMAHER, Auteur ; Nadine M. MELHEM, Auteur ; David A. AXELSON, Auteur ; Shana M. MICHAELS, Auteur . - 2006 . - p.927–934. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 47-9 (September 2006) . - p.927–934 Mots-clés : Pediatric-depression assessment validity reliability Index. décimale : PER Périodiques Résumé : Background: Previous measures of pediatric depression have shown inconsistent validity in groups with differing demographics, comorbid diagnoses, and clinic or non-clinic origins. The current study re-examines the criterion validity of child- and parent-versions of the Mood and Feelings Questionnaire (MFQ-C, MFQ-P) in a heterogeneous sample of children and adolescents from clinic and non-clinic sources. Methods: Among 470 consecutive youth completing semi-structured interviews at a university-based child psychiatry center, total scores from the 33-item MFQ-C and 34-item MFQ-P were examined across subjects with and without mood disorders using analysis of variance, and receiver operating characteristics analysis. Results: Mean scores of the MFQ-C and MFQ-P, respectively, differed significantly (p < .0005) across youth having major depressive episodes (MDE) (33 and 32, n = 77), mood disorders not meeting criteria for current MDE (24 and 28, n = 75), and no mood disorders (12 and 10, n = 318). In the overall sample, areas under the curve (AUC) for discriminating MDE and any mood disorder, respectively, were .85 and .83 on the MFQ-C, .86 and .90 on the MFQ-P, and .89 and .90 on the MFQ-C and MFQ-P averaged together, suggesting moderate to high criterion validity. Similar findings were noted in subgroups divided by age, sex, race, comorbid psychopathology, and clinic or non-clinic origins. AUCs of these MFQ scores compared favorably with those of the Beck's Depressive Inventory, the Child Behavior Checklist's Anxious/Depressed scale and the Children's Depressive Rating Scale–Revised by the same raters. A score of 29 on the MFQ-C (positive screen rate 21%, sensitivity 68%, specificity 88%) or 27 on the MFQ-P (positive screen rate 23%, sensitivity 61%, specificity 85%) optimally discriminated youth with MDE from the rest of the sample. Conclusions: The MFQ-C and MFQ-P, especially used in combination, validly identify MDE or other mood disorders in youth diverse in demographic and clinical characteristics. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2006.01646.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=779

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