Brief Report: Initial Trial of Alpha7-Nicotinic Receptor Stimulation in Two Adult Patients with Autism Spectrum Disorder / Ann OLINCY in Journal of Autism and Developmental Disorders, 46-12 (December 2016)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 46-12 (December 2016) . - p.3812-3817 Titre : Brief Report: Initial Trial of Alpha7-Nicotinic Receptor Stimulation in Two Adult Patients with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Ann OLINCY, Auteur ; Audrey BLAKELEY-SMITH, Auteur ; Lynn JOHNSON, Auteur ; William R. KEM, Auteur ; Robert FREEDMAN, Auteur Article en page(s) : p.3812-3817 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Attention  Sensory gating  Receptors nicotinic Index. décimale : PER Périodiques Résumé : Abnormalities in CHRNA7, the alpha7-nicotinic receptor gene, have been reported in autism spectrum disorder. These genetic abnormalities potentially decrease the receptor’s expression and diminish its functional role. This double-blind, placebo-controlled crossover study in two adult patients investigated whether an investigational receptor-specific partial agonist drug would increase the inhibitory functions of the gene and thereby increase patients’ attention. An electrophysiological biomarker, P50 inhibition, verified the intended neurobiological effect of the agonist, and neuropsychological testing verified a primary cognitive effect. Both patients perceived increased attention in their self-ratings. Alpha7-nicotinic receptor agonists, currently the target of drug development in schizophrenia and Alzheimer Disease, may also have positive clinical effects in autism spectrum disorder. En ligne : http://dx.doi.org/10.1007/s10803-016-2890-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=297 [article] Brief Report: Initial Trial of Alpha7-Nicotinic Receptor Stimulation in Two Adult Patients with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Ann OLINCY, Auteur ; Audrey BLAKELEY-SMITH, Auteur ; Lynn JOHNSON, Auteur ; William R. KEM, Auteur ; Robert FREEDMAN, Auteur . - p.3812-3817. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 46-12 (December 2016) . - p.3812-3817 Mots-clés : Autism spectrum disorder  Attention  Sensory gating  Receptors nicotinic Index. décimale : PER Périodiques Résumé : Abnormalities in CHRNA7, the alpha7-nicotinic receptor gene, have been reported in autism spectrum disorder. These genetic abnormalities potentially decrease the receptor’s expression and diminish its functional role. This double-blind, placebo-controlled crossover study in two adult patients investigated whether an investigational receptor-specific partial agonist drug would increase the inhibitory functions of the gene and thereby increase patients’ attention. An electrophysiological biomarker, P50 inhibition, verified the intended neurobiological effect of the agonist, and neuropsychological testing verified a primary cognitive effect. Both patients perceived increased attention in their self-ratings. Alpha7-nicotinic receptor agonists, currently the target of drug development in schizophrenia and Alzheimer Disease, may also have positive clinical effects in autism spectrum disorder. En ligne : http://dx.doi.org/10.1007/s10803-016-2890-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=297

Research Review: Cholinergic mechanisms, early brain development, and risk for schizophrenia / Randal G. ROSS in Journal of Child Psychology and Psychiatry, 51-5 (May 2010)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 51-5 (May 2010) . - p.535-549 Titre : Research Review: Cholinergic mechanisms, early brain development, and risk for schizophrenia Type de document : Texte imprimé et/ou numérique Auteurs : Randal G. ROSS, Auteur ; Catherine ADAMS, Auteur ; Karen E. STEVENS, Auteur ; William R. PROCTOR, Auteur ; Sherry LEONARD, Auteur ; Michael A. KISLEY, Auteur ; Sharon K. HUNTER, Auteur ; Robert FREEDMAN, Auteur Année de publication : 2010 Article en page(s) : p.535-549 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The onset of diagnostic symptomology for neuropsychiatric diseases is often the end result of a decades-long process of aberrant brain development. Identification of novel treatment strategies aimed at normalizing early brain development and preventing mental illness should be a major therapeutic goal. However, there are few models for how this goal might be achieved. This review uses the development of a psychophysiological correlate of attentional deficits in schizophrenia to propose a developmental model with translational primary prevention implications. Review of genetic and neurobiological studies suggests that an early interaction between α7 nicotinic receptor density and choline availability may contribute to the development of schizophrenia-associated attentional deficits. Therapeutic implications, including perinatal dietary choline supplementation, are discussed. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02187.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=101 [article] Research Review: Cholinergic mechanisms, early brain development, and risk for schizophrenia [Texte imprimé et/ou numérique] / Randal G. ROSS, Auteur ; Catherine ADAMS, Auteur ; Karen E. STEVENS, Auteur ; William R. PROCTOR, Auteur ; Sherry LEONARD, Auteur ; Michael A. KISLEY, Auteur ; Sharon K. HUNTER, Auteur ; Robert FREEDMAN, Auteur . - 2010 . - p.535-549. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 51-5 (May 2010) . - p.535-549 Index. décimale : PER Périodiques Résumé : The onset of diagnostic symptomology for neuropsychiatric diseases is often the end result of a decades-long process of aberrant brain development. Identification of novel treatment strategies aimed at normalizing early brain development and preventing mental illness should be a major therapeutic goal. However, there are few models for how this goal might be achieved. This review uses the development of a psychophysiological correlate of attentional deficits in schizophrenia to propose a developmental model with translational primary prevention implications. Review of genetic and neurobiological studies suggests that an early interaction between α7 nicotinic receptor density and choline availability may contribute to the development of schizophrenia-associated attentional deficits. Therapeutic implications, including perinatal dietary choline supplementation, are discussed. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02187.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=101

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