Co-development of early adolescent alcohol use and depressive feelings: The role of the mu-opioid receptor A118G polymorphism / Marloes KLEINJAN in Development and Psychopathology, 27-3 (August 2015)  

Public ISBD [article]  inDevelopment and Psychopathology > 27-3 (August 2015) . - p.915-925 Titre : Co-development of early adolescent alcohol use and depressive feelings: The role of the mu-opioid receptor A118G polymorphism Type de document : Texte imprimé et/ou numérique Auteurs : Marloes KLEINJAN, Auteur ; Mayke ROZING, Auteur ; Rutger C. M. E. ENGELS, Auteur ; Maaike VERHAGEN, Auteur Article en page(s) : p.915-925 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Alcohol use and depressive feelings are often related among early adolescents. However, the nature and underlying mechanisms of this association are not yet clear. The aim of this study was to investigate the co-development of alcohol use and depressive feelings over time and to examine the effects of the mu-opioid receptor (OPRM1) A118G genotype on such co-development. Data from a five-wave longitudinal, genetically informed survey study, with intervals of 4 months among a group of 739 normative early adolescents (12–13 years of age at baseline), were analyzed using a dual latent growth curve approach. OPRM1 status was evaluated from saliva-derived DNA samples. The results indicated a positive association between alcohol use and depressive feelings both at the initial levels and over time, indicating co-development in early adolescence. Compared to OPRM1 118G carriers, homozygous 118A carriers showed a greater increase in frequency of alcohol use and higher levels of depressive feelings over time. Evidence for co-development was only found within the group of homozygous 118A carriers, whereas in OPRM1 118G carriers the development of alcohol use and depressive feelings over time were not significantly associated. These results highlight the potential of OPRM1 as a common etiological factor for the development of alcohol use and depressive feelings in early adolescence. En ligne : http://dx.doi.org/10.1017/S0954579414000911 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=263 [article] Co-development of early adolescent alcohol use and depressive feelings: The role of the mu-opioid receptor A118G polymorphism [Texte imprimé et/ou numérique] / Marloes KLEINJAN, Auteur ; Mayke ROZING, Auteur ; Rutger C. M. E. ENGELS, Auteur ; Maaike VERHAGEN, Auteur . - p.915-925. Langues : Anglais (eng) in Development and Psychopathology > 27-3 (August 2015) . - p.915-925 Index. décimale : PER Périodiques Résumé : Alcohol use and depressive feelings are often related among early adolescents. However, the nature and underlying mechanisms of this association are not yet clear. The aim of this study was to investigate the co-development of alcohol use and depressive feelings over time and to examine the effects of the mu-opioid receptor (OPRM1) A118G genotype on such co-development. Data from a five-wave longitudinal, genetically informed survey study, with intervals of 4 months among a group of 739 normative early adolescents (12–13 years of age at baseline), were analyzed using a dual latent growth curve approach. OPRM1 status was evaluated from saliva-derived DNA samples. The results indicated a positive association between alcohol use and depressive feelings both at the initial levels and over time, indicating co-development in early adolescence. Compared to OPRM1 118G carriers, homozygous 118A carriers showed a greater increase in frequency of alcohol use and higher levels of depressive feelings over time. Evidence for co-development was only found within the group of homozygous 118A carriers, whereas in OPRM1 118G carriers the development of alcohol use and depressive feelings over time were not significantly associated. These results highlight the potential of OPRM1 as a common etiological factor for the development of alcohol use and depressive feelings in early adolescence. En ligne : http://dx.doi.org/10.1017/S0954579414000911 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=263

Loneliness in adolescence: gene × environment interactions involving the serotonin transporter gene / Eeske VAN ROEKEL in Journal of Child Psychology and Psychiatry, 51-7 (July 2010)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 51-7 (July 2010) . - p.747-754 Titre : Loneliness in adolescence: gene × environment interactions involving the serotonin transporter gene Type de document : Texte imprimé et/ou numérique Auteurs : Eeske VAN ROEKEL, Auteur ; Rutger C.M.E. ENGELS, Auteur ; Ron H. J. SCHOLTE, Auteur ; Luc GOOSSENS, Auteur ; Maaike VERHAGEN, Auteur Année de publication : 2010 Article en page(s) : p.747-754 Langues : Anglais (eng) Mots-clés : Loneliness serotonin-transporter 5-HTTLPR parental-support gene–environment-interaction adolescence Index. décimale : PER Périodiques Résumé : Background: Loneliness is assumed to peak in early adolescence and to decrease throughout middle and late adolescence, but longitudinal confirmation of this tendency is lacking. Behavioral genetic studies with twin designs have found a significant genetic component for loneliness in children and adults, but no molecular genetic studies have been conducted to reveal the functional polymorphisms involved. Methods: Associations among the serotonin transporter gene (5-HTTLPR), sex, parental support, and loneliness were examined in a longitudinal study spanning five annual waves (N = 306). Results: Using latent growth curve modeling (LGCM), loneliness was found to be highest in early adolescence and slowly declined throughout adolescence. The 5-HTTLPR genotype was related to the development of loneliness, in that short allele carriers remained stable in loneliness over time, whereas adolescents with the long-long genotype decreased in loneliness. Interactions were found between maternal support and 5-HTTLPR genotype, showing that adolescents who perceived little support from their mothers and carried a short allele were at increased risk for developing loneliness. Conclusions: Our study is the first to chart adolescent loneliness longitudinally and to examine the genetic underpinnings of loneliness. Our results contribute to a further understanding of the environmental and genetic basis of loneliness. Replication of our results is needed in both population-based and clinical samples. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02225.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=101 [article] Loneliness in adolescence: gene × environment interactions involving the serotonin transporter gene [Texte imprimé et/ou numérique] / Eeske VAN ROEKEL, Auteur ; Rutger C.M.E. ENGELS, Auteur ; Ron H. J. SCHOLTE, Auteur ; Luc GOOSSENS, Auteur ; Maaike VERHAGEN, Auteur . - 2010 . - p.747-754. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 51-7 (July 2010) . - p.747-754 Mots-clés : Loneliness serotonin-transporter 5-HTTLPR parental-support gene–environment-interaction adolescence Index. décimale : PER Périodiques Résumé : Background: Loneliness is assumed to peak in early adolescence and to decrease throughout middle and late adolescence, but longitudinal confirmation of this tendency is lacking. Behavioral genetic studies with twin designs have found a significant genetic component for loneliness in children and adults, but no molecular genetic studies have been conducted to reveal the functional polymorphisms involved. Methods: Associations among the serotonin transporter gene (5-HTTLPR), sex, parental support, and loneliness were examined in a longitudinal study spanning five annual waves (N = 306). Results: Using latent growth curve modeling (LGCM), loneliness was found to be highest in early adolescence and slowly declined throughout adolescence. The 5-HTTLPR genotype was related to the development of loneliness, in that short allele carriers remained stable in loneliness over time, whereas adolescents with the long-long genotype decreased in loneliness. Interactions were found between maternal support and 5-HTTLPR genotype, showing that adolescents who perceived little support from their mothers and carried a short allele were at increased risk for developing loneliness. Conclusions: Our study is the first to chart adolescent loneliness longitudinally and to examine the genetic underpinnings of loneliness. Our results contribute to a further understanding of the environmental and genetic basis of loneliness. Replication of our results is needed in both population-based and clinical samples. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02225.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=101

The dopamine D2 receptor gene, perceived parental support, and adolescent loneliness: longitudinal evidence for gene–environment interactions / Eeske VAN ROEKEL in Journal of Child Psychology and Psychiatry, 52-10 (October 2011)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 52-10 (October 2011) . - p.1044-1051 Titre : The dopamine D2 receptor gene, perceived parental support, and adolescent loneliness: longitudinal evidence for gene–environment interactions Type de document : Texte imprimé et/ou numérique Auteurs : Eeske VAN ROEKEL, Auteur ; Luc GOOSSENS, Auteur ; Ron H. J. SCHOLTE, Auteur ; Rutger C.M.E. ENGELS, Auteur ; Maaike VERHAGEN, Auteur Année de publication : 2011 Article en page(s) : p.1044-1051 Langues : Anglais (eng) Mots-clés : loneliness  dopamine D2 receptor gene  DRD2  parental support  gene–environment interaction  adolescence Index. décimale : PER Périodiques Résumé : Background:  Loneliness is a common problem in adolescence. Earlier research focused on genes within the serotonin and oxytocin systems, but no studies have examined the role of dopamine-related genes in loneliness. In the present study, we focused on the dopamine D2 receptor gene (DRD2). Methods:  Associations among the DRD2, sex, parental support, and loneliness were examined in a longitudinal study spanning five annual waves (N = 307). Results:  Using Latent Growth Curve Modeling, DRD2 genotype was not directly related to loneliness. Interactions were found between parental support and DRD2 genotype, showing that adolescents with the A2A2 genotype who perceived little support from their parents had the highest baseline levels of loneliness. Adolescents with an A1 allele were not susceptible to the rewarding effect of parental support. Conclusions:  The present study is the first to examine the role of the DRD2 genotype in loneliness. Our results contribute to a further understanding of the environmental and genetic basis of loneliness in adolescence. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02424.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=142 [article] The dopamine D2 receptor gene, perceived parental support, and adolescent loneliness: longitudinal evidence for gene–environment interactions [Texte imprimé et/ou numérique] / Eeske VAN ROEKEL, Auteur ; Luc GOOSSENS, Auteur ; Ron H. J. SCHOLTE, Auteur ; Rutger C.M.E. ENGELS, Auteur ; Maaike VERHAGEN, Auteur . - 2011 . - p.1044-1051. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 52-10 (October 2011) . - p.1044-1051 Mots-clés : loneliness  dopamine D2 receptor gene  DRD2  parental support  gene–environment interaction  adolescence Index. décimale : PER Périodiques Résumé : Background:  Loneliness is a common problem in adolescence. Earlier research focused on genes within the serotonin and oxytocin systems, but no studies have examined the role of dopamine-related genes in loneliness. In the present study, we focused on the dopamine D2 receptor gene (DRD2). Methods:  Associations among the DRD2, sex, parental support, and loneliness were examined in a longitudinal study spanning five annual waves (N = 307). Results:  Using Latent Growth Curve Modeling, DRD2 genotype was not directly related to loneliness. Interactions were found between parental support and DRD2 genotype, showing that adolescents with the A2A2 genotype who perceived little support from their parents had the highest baseline levels of loneliness. Adolescents with an A1 allele were not susceptible to the rewarding effect of parental support. Conclusions:  The present study is the first to examine the role of the DRD2 genotype in loneliness. Our results contribute to a further understanding of the environmental and genetic basis of loneliness in adolescence. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02424.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=142

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