Annual Research Review: Neuroimmune network model of depression: a developmental perspective / Robin NUSSLOCK in Journal of Child Psychology and Psychiatry, 65-4 (April 2024)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 65-4 (April 2024) . - p.538-567 Titre : Annual Research Review: Neuroimmune network model of depression: a developmental perspective Type de document : Texte imprimé et/ou numérique Auteurs : Robin NUSSLOCK, Auteur ; Lauren B. ALLOY, Auteur ; Gene H. BRODY, Auteur ; Gregory E. MILLER, Auteur Article en page(s) : p.538-567 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Depression is a serious public health problem, and adolescence is an 'age of risk' for the onset of Major Depressive Disorder. Recently, we and others have proposed neuroimmune network models that highlight bidirectional communication between the brain and the immune system in both mental and physical health, including depression. These models draw on research indicating that the cellular actors (particularly monocytes) and signaling molecules (particularly cytokines) that orchestrate inflammation in the periphery can directly modulate the structure and function of the brain. In the brain, inflammatory activity heightens sensitivity to threats in the cortico-amygdala circuit, lowers sensitivity to rewards in the cortico-striatal circuit, and alters executive control and emotion regulation in the prefrontal cortex. When dysregulated, and particularly under conditions of chronic stress, inflammation can generate feelings of dysphoria, distress, and anhedonia. This is proposed to initiate unhealthy, self-medicating behaviors (e.g. substance use, poor diet) to manage the dysphoria, which further heighten inflammation. Over time, dysregulation in these brain circuits and the inflammatory response may compound each other to form a positive feedback loop, whereby dysregulation in one organ system exacerbates the other. We and others suggest that this neuroimmune dysregulation is a dynamic joint vulnerability for depression, particularly during adolescence. We have three goals for the present paper. First, we extend neuroimmune network models of mental and physical health to generate a developmental framework of risk for the onset of depression during adolescence. Second, we examine how a neuroimmune network perspective can help explain the high rates of comorbidity between depression and other psychiatric disorders across development, and multimorbidity between depression and stress-related medical illnesses. Finally, we consider how identifying neuroimmune pathways to depression can facilitate a 'next generation' of behavioral and biological interventions that target neuroimmune signaling to treat, and ideally prevent, depression in youth and adolescents. En ligne : https://doi.org/10.1111/jcpp.13961 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=523 [article] Annual Research Review: Neuroimmune network model of depression: a developmental perspective [Texte imprimé et/ou numérique] / Robin NUSSLOCK, Auteur ; Lauren B. ALLOY, Auteur ; Gene H. BRODY, Auteur ; Gregory E. MILLER, Auteur . - p.538-567. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 65-4 (April 2024) . - p.538-567 Index. décimale : PER Périodiques Résumé : Depression is a serious public health problem, and adolescence is an 'age of risk' for the onset of Major Depressive Disorder. Recently, we and others have proposed neuroimmune network models that highlight bidirectional communication between the brain and the immune system in both mental and physical health, including depression. These models draw on research indicating that the cellular actors (particularly monocytes) and signaling molecules (particularly cytokines) that orchestrate inflammation in the periphery can directly modulate the structure and function of the brain. In the brain, inflammatory activity heightens sensitivity to threats in the cortico-amygdala circuit, lowers sensitivity to rewards in the cortico-striatal circuit, and alters executive control and emotion regulation in the prefrontal cortex. When dysregulated, and particularly under conditions of chronic stress, inflammation can generate feelings of dysphoria, distress, and anhedonia. This is proposed to initiate unhealthy, self-medicating behaviors (e.g. substance use, poor diet) to manage the dysphoria, which further heighten inflammation. Over time, dysregulation in these brain circuits and the inflammatory response may compound each other to form a positive feedback loop, whereby dysregulation in one organ system exacerbates the other. We and others suggest that this neuroimmune dysregulation is a dynamic joint vulnerability for depression, particularly during adolescence. We have three goals for the present paper. First, we extend neuroimmune network models of mental and physical health to generate a developmental framework of risk for the onset of depression during adolescence. Second, we examine how a neuroimmune network perspective can help explain the high rates of comorbidity between depression and other psychiatric disorders across development, and multimorbidity between depression and stress-related medical illnesses. Finally, we consider how identifying neuroimmune pathways to depression can facilitate a 'next generation' of behavioral and biological interventions that target neuroimmune signaling to treat, and ideally prevent, depression in youth and adolescents. En ligne : https://doi.org/10.1111/jcpp.13961 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=523

A cascade model connecting life stress to risk behavior among rural African American emerging adults / Gene H. BRODY in Development and Psychopathology, 22-3 (August 2010)  

Public ISBD [article]  inDevelopment and Psychopathology > 22-3 (August 2010) . - p.667-678 Titre : A cascade model connecting life stress to risk behavior among rural African American emerging adults Type de document : Texte imprimé et/ou numérique Auteurs : Gene H. BRODY, Auteur ; Yi-Fu CHEN, Auteur ; Steven M. KOGAN, Auteur Année de publication : 2010 Article en page(s) : p.667-678 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : A three-wave cascade model linking life stress to increases in risk behavior was tested with 347 African American emerging adults living in the rural South. Data analyses using structural equation modeling and latent growth curve modeling demonstrated that life stress was linked to increases in risk behavior as African Americans transitioned out of secondary school. The cascade model indicated that life stress fostered increases in negative emotions. Negative emotions, in turn, were linked to increases in affiliations with deviant peers and romantic partners; this forecast increases in risk behavior. The findings supported a stress proliferation framework, in which primary stressors affect increases in secondary stressors that carry forward to influence changes in risk behaviors that can potentially compromise mental health. En ligne : http://dx.doi.org/10.1017/s0954579410000350 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=108 [article] A cascade model connecting life stress to risk behavior among rural African American emerging adults [Texte imprimé et/ou numérique] / Gene H. BRODY, Auteur ; Yi-Fu CHEN, Auteur ; Steven M. KOGAN, Auteur . - 2010 . - p.667-678. Langues : Anglais (eng) in Development and Psychopathology > 22-3 (August 2010) . - p.667-678 Index. décimale : PER Périodiques Résumé : A three-wave cascade model linking life stress to increases in risk behavior was tested with 347 African American emerging adults living in the rural South. Data analyses using structural equation modeling and latent growth curve modeling demonstrated that life stress was linked to increases in risk behavior as African Americans transitioned out of secondary school. The cascade model indicated that life stress fostered increases in negative emotions. Negative emotions, in turn, were linked to increases in affiliations with deviant peers and romantic partners; this forecast increases in risk behavior. The findings supported a stress proliferation framework, in which primary stressors affect increases in secondary stressors that carry forward to influence changes in risk behaviors that can potentially compromise mental health. En ligne : http://dx.doi.org/10.1017/s0954579410000350 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=108

Contextual risks and psychosocial outcomes among rural African American emerging adults: A latent profile analysis / Trenette Clark GOINGS in Development and Psychopathology, 34-1 (February 2022)  

Public ISBD [article]  inDevelopment and Psychopathology > 34-1 (February 2022) . - p.395-407 Titre : Contextual risks and psychosocial outcomes among rural African American emerging adults: A latent profile analysis Type de document : Texte imprimé et/ou numérique Auteurs : Trenette Clark GOINGS, Auteur ; Tianyi YU, Auteur ; Gene H. BRODY, Auteur Article en page(s) : p.395-407 Langues : Anglais (eng) Mots-clés : Black  child maltreatment  depression  discrimination  drug use Index. décimale : PER Périodiques Résumé : African American emerging adults face unique contextual risks that place them at heightened risk for poor psychosocial outcomes. The purpose of this study was to identify profiles of contextual risks among rural African American emerging adults and determine how risk profiles relate to psychosocial outcomes. Our representative sample included 667 fifth graders who live in the rural South and were followed from preadolescence into emerging adulthood. Contextual risks were assessed at ages 19?21 years via six indicators: perceived stress, daily stress, community disadvantage, parent?child conflict, racial discrimination, and childhood trauma. Four psychosocial variables were also assessed at ages 19?21 years: self-regulation, racial identity, parent support, and friend support. Psychosocial outcomes were assessed at age 25 years: education, substance use, future orientation, depressive symptoms, and externalizing behaviors. Latent profile analysis results indicated that the sample could be characterized by three patterns of contextual risk: low contextual risk, high contextual risk, and high contextual risk?childhood trauma. Risk profiles were associated with psychosocial outcomes, with the childhood trauma and high-risk profiles faring worse than the low-risk profile. Further, childhood trauma was particularly predictive of worse outcomes for emerging adults. Findings highlight the need for research and prevention programs that mitigate the effects of contextual risks on psychosocial outcomes for African American emerging adults in rural areas. En ligne : http://dx.doi.org/10.1017/s0954579420001339 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=474 [article] Contextual risks and psychosocial outcomes among rural African American emerging adults: A latent profile analysis [Texte imprimé et/ou numérique] / Trenette Clark GOINGS, Auteur ; Tianyi YU, Auteur ; Gene H. BRODY, Auteur . - p.395-407. Langues : Anglais (eng) in Development and Psychopathology > 34-1 (February 2022) . - p.395-407 Mots-clés : Black  child maltreatment  depression  discrimination  drug use Index. décimale : PER Périodiques Résumé : African American emerging adults face unique contextual risks that place them at heightened risk for poor psychosocial outcomes. The purpose of this study was to identify profiles of contextual risks among rural African American emerging adults and determine how risk profiles relate to psychosocial outcomes. Our representative sample included 667 fifth graders who live in the rural South and were followed from preadolescence into emerging adulthood. Contextual risks were assessed at ages 19?21 years via six indicators: perceived stress, daily stress, community disadvantage, parent?child conflict, racial discrimination, and childhood trauma. Four psychosocial variables were also assessed at ages 19?21 years: self-regulation, racial identity, parent support, and friend support. Psychosocial outcomes were assessed at age 25 years: education, substance use, future orientation, depressive symptoms, and externalizing behaviors. Latent profile analysis results indicated that the sample could be characterized by three patterns of contextual risk: low contextual risk, high contextual risk, and high contextual risk?childhood trauma. Risk profiles were associated with psychosocial outcomes, with the childhood trauma and high-risk profiles faring worse than the low-risk profile. Further, childhood trauma was particularly predictive of worse outcomes for emerging adults. Findings highlight the need for research and prevention programs that mitigate the effects of contextual risks on psychosocial outcomes for African American emerging adults in rural areas. En ligne : http://dx.doi.org/10.1017/s0954579420001339 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=474

A differential susceptibility analysis reveals the “who and how” about adolescents' responses to preventive interventions: Tests of first- and second-generation Gene × Intervention hypotheses / Gene H. BRODY in Development and Psychopathology, 27-1 (February 2015)  

Public ISBD [article]  inDevelopment and Psychopathology > 27-1 (February 2015) . - p.37-49 Titre : A differential susceptibility analysis reveals the “who and how” about adolescents' responses to preventive interventions: Tests of first- and second-generation Gene × Intervention hypotheses Type de document : Texte imprimé et/ou numérique Auteurs : Gene H. BRODY, Auteur ; Tianyi YU, Auteur ; Steven R. H. BEACH, Auteur Article en page(s) : p.37-49 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : This study was designed to investigate a genetic moderation effect of dopamine receptor 4 gene (DRD4) alleles that have seven or more repeats (long alleles) on an intervention to deter drug use among rural African American adolescents in high-risk families. Adolescents (N = 291, M age = 17) were assigned randomly to the Adults in the Making (AIM) program or to a control condition and were followed for 27.5 months. Adolescents provided data on drug use and vulnerability cognitions three times after pretest. Pretest assessments of caregiver depressive symptoms, disruption in the home, and support toward the adolescent were used to construct a family risk index. Adolescents living in high-risk families who carried at least one DRD4 long allele and were assigned to the control condition evinced greater escalations in drug use than did (a) adolescents who lived in high-risk families, carried the DRD4 long allele, and were assigned to AIM, or (b) adolescents assigned to either condition who carried no DRD4 long alleles. AIM-induced reductions in vulnerability cognitions were responsible for the Family Risk × AIM × DRD4 status drug use prevention effects. These findings support differential susceptibility predictions and imply that prevention effects on genetically susceptible individuals may be underestimated. En ligne : http://dx.doi.org/10.1017/S095457941400128X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=257 [article] A differential susceptibility analysis reveals the “who and how” about adolescents' responses to preventive interventions: Tests of first- and second-generation Gene × Intervention hypotheses [Texte imprimé et/ou numérique] / Gene H. BRODY, Auteur ; Tianyi YU, Auteur ; Steven R. H. BEACH, Auteur . - p.37-49. Langues : Anglais (eng) in Development and Psychopathology > 27-1 (February 2015) . - p.37-49 Index. décimale : PER Périodiques Résumé : This study was designed to investigate a genetic moderation effect of dopamine receptor 4 gene (DRD4) alleles that have seven or more repeats (long alleles) on an intervention to deter drug use among rural African American adolescents in high-risk families. Adolescents (N = 291, M age = 17) were assigned randomly to the Adults in the Making (AIM) program or to a control condition and were followed for 27.5 months. Adolescents provided data on drug use and vulnerability cognitions three times after pretest. Pretest assessments of caregiver depressive symptoms, disruption in the home, and support toward the adolescent were used to construct a family risk index. Adolescents living in high-risk families who carried at least one DRD4 long allele and were assigned to the control condition evinced greater escalations in drug use than did (a) adolescents who lived in high-risk families, carried the DRD4 long allele, and were assigned to AIM, or (b) adolescents assigned to either condition who carried no DRD4 long alleles. AIM-induced reductions in vulnerability cognitions were responsible for the Family Risk × AIM × DRD4 status drug use prevention effects. These findings support differential susceptibility predictions and imply that prevention effects on genetically susceptible individuals may be underestimated. En ligne : http://dx.doi.org/10.1017/S095457941400128X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=257

Differential susceptibility to prevention: GABAergic, dopaminergic, and multilocus effects / Gene H. BRODY in Journal of Child Psychology and Psychiatry, 54-8 (August 2013)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 54-8 (August 2013) . - p.863-871 Titre : Differential susceptibility to prevention: GABAergic, dopaminergic, and multilocus effects Type de document : Texte imprimé et/ou numérique Auteurs : Gene H. BRODY, Auteur ; Yi-Fu CHEN, Auteur ; Steven R. H. BEACH, Auteur Article en page(s) : p.863-871 Langues : Anglais (eng) Mots-clés : Alcohol use  African American  genetics  prevention  risk Index. décimale : PER Périodiques Résumé : Background: Randomized prevention trials provide a unique opportunity to test hypotheses about the interaction of genetic predispositions with contextual processes to create variations in phenotypes over time. Methods: Using two longitudinal, randomized prevention trials, molecular genetic and alcohol use outcome data were gathered from more than 900 youths to determine whether prevention program participation would, across 2 years, moderate genetic risk for increased alcohol use conferred by the dopaminergic and GABAergic systems. Results: We found that (a) variance in dopaminergic (DRD2, DRD4, ANKK1) and GABAergic (GABRG1, GABRA2) genes forecast increases in alcohol use across 2 years, and (b) youths at genetic risk who were assigned to the control condition displayed greater increases in alcohol use across 2 years than did youths at genetic risk who were assigned to the prevention condition or youths without genetic risk who were assigned to either condition. Conclusions: This study is unique in combining data from two large prevention trials to test hypotheses regarding genetic main effects and gene × prevention interactions. Focusing on gene systems purported to confer risk for alcohol use and abuse, the study demonstrated that participation in efficacious prevention programs can moderate genetic risk. The results also support the differential susceptibility hypothesis that some youths, for genetic reasons, are more susceptible than others to both positive and negative contextual influences. En ligne : http://dx.doi.org/10.1111/jcpp.12042 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=210 [article] Differential susceptibility to prevention: GABAergic, dopaminergic, and multilocus effects [Texte imprimé et/ou numérique] / Gene H. BRODY, Auteur ; Yi-Fu CHEN, Auteur ; Steven R. H. BEACH, Auteur . - p.863-871. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 54-8 (August 2013) . - p.863-871 Mots-clés : Alcohol use  African American  genetics  prevention  risk Index. décimale : PER Périodiques Résumé : Background: Randomized prevention trials provide a unique opportunity to test hypotheses about the interaction of genetic predispositions with contextual processes to create variations in phenotypes over time. Methods: Using two longitudinal, randomized prevention trials, molecular genetic and alcohol use outcome data were gathered from more than 900 youths to determine whether prevention program participation would, across 2 years, moderate genetic risk for increased alcohol use conferred by the dopaminergic and GABAergic systems. Results: We found that (a) variance in dopaminergic (DRD2, DRD4, ANKK1) and GABAergic (GABRG1, GABRA2) genes forecast increases in alcohol use across 2 years, and (b) youths at genetic risk who were assigned to the control condition displayed greater increases in alcohol use across 2 years than did youths at genetic risk who were assigned to the prevention condition or youths without genetic risk who were assigned to either condition. Conclusions: This study is unique in combining data from two large prevention trials to test hypotheses regarding genetic main effects and gene × prevention interactions. Focusing on gene systems purported to confer risk for alcohol use and abuse, the study demonstrated that participation in efficacious prevention programs can moderate genetic risk. The results also support the differential susceptibility hypothesis that some youths, for genetic reasons, are more susceptible than others to both positive and negative contextual influences. En ligne : http://dx.doi.org/10.1111/jcpp.12042 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=210

Exploring genetic moderators and epigenetic mediators of contextual and family effects: From Gene × Environment to epigenetics / Steven R. H. BEACH in Development and Psychopathology, 28-4 pt2 (November 2016)  

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A family-centered prevention ameliorates the associations of low self-control during childhood with employment income and poverty status in young African American adults / Gene H. BRODY in Journal of Child Psychology and Psychiatry, 61-4 (April 2020)  

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Family-centered prevention ameliorates the longitudinal association between risky family processes and epigenetic aging / Gene H. BRODY in Journal of Child Psychology and Psychiatry, 57-5 (May 2016)  

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Is serotonin transporter genotype associated with epigenetic susceptibility or vulnerability? Examination of the impact of socioeconomic status risk on African American youth / Steven R. H. BEACH in Development and Psychopathology, 26-2 (May 2014)  

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Life stress, the dopamine receptor gene, and emerging adult drug use trajectories: A longitudinal, multilevel, mediated moderation analysis / Gene H. BRODY in Development and Psychopathology, 24-3 (August 2012)  

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Neighborhood × Serotonin Transporter Linked Polymorphic Region (5-HTTLPR) interactions for substance use from ages 10 to 24 years using a harmonized data set of African American children / Michael WINDLE in Development and Psychopathology, 28-2 (May 2016)  

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Perceived discrimination, serotonin transporter linked polymorphic region status, and the development of conduct problems / Gene H. BRODY in Development and Psychopathology, 23-2 (May 2011)  

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Preventive parenting intervention during childhood and young black adults' unhealthful behaviors: a randomized controlled trial / Gene H. BRODY in Journal of Child Psychology and Psychiatry, 60-1 (January 2019)  

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Resilience to adversity and the early origins of disease / Gene H. BRODY in Development and Psychopathology, 28-4 pt2 (November 2016)  

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Smoking in young adulthood among African Americans: Interconnected effects of supportive parenting in early adolescence, proinflammatory epitype, and young adult stress / Steven R. H. BEACH in Development and Psychopathology, 29-3 (August 2017)  

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