Associating Neural Alterations and Genotype in Autism and Fragile X Syndrome: Incorporating Perceptual Phenotypes in Causal Modeling / Armando BERTONE in Journal of Autism and Developmental Disorders, 40-12 (December 2010)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 40-12 (December 2010) . - p.1541-1548 Titre : Associating Neural Alterations and Genotype in Autism and Fragile X Syndrome: Incorporating Perceptual Phenotypes in Causal Modeling Type de document : Texte imprimé et/ou numérique Auteurs : Armando BERTONE, Auteur ; Julie HANCK, Auteur ; Cary KOGAN, Auteur ; Avi CHAUDHURI, Auteur ; Kim CORNISH, Auteur Année de publication : 2010 Article en page(s) : p.1541-1548 Langues : Anglais (eng) Mots-clés : Autism  Fragile X syndrome  Vision  Neural networks  Causal model  Genetics Index. décimale : PER Périodiques Résumé : We have previously described (see companion paper, this issue) the utility of using perceptual signatures for defining and dissociating condition-specific neural functioning underlying early visual processes in autism and FXS. These perceptually-driven hypotheses are based on differential performance evidenced only at the earliest stages of visual information processing, mediated by local neural network functioning. In this paper, we first review how most large-scale neural models are unable to address atypical low-level perceptual functioning in autism, and then suggest how condition-specific, local neural endophenotypes (described in our companion paper) can be incorporated into causal models to infer target candidate gene or gene clusters that are implicated in autism’s pathogenesis. The usefulness of such a translational research approach is discussed. En ligne : http://dx.doi.org/10.1007/s10803-010-1110-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=114 [article] Associating Neural Alterations and Genotype in Autism and Fragile X Syndrome: Incorporating Perceptual Phenotypes in Causal Modeling [Texte imprimé et/ou numérique] / Armando BERTONE, Auteur ; Julie HANCK, Auteur ; Cary KOGAN, Auteur ; Avi CHAUDHURI, Auteur ; Kim CORNISH, Auteur . - 2010 . - p.1541-1548. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 40-12 (December 2010) . - p.1541-1548 Mots-clés : Autism  Fragile X syndrome  Vision  Neural networks  Causal model  Genetics Index. décimale : PER Périodiques Résumé : We have previously described (see companion paper, this issue) the utility of using perceptual signatures for defining and dissociating condition-specific neural functioning underlying early visual processes in autism and FXS. These perceptually-driven hypotheses are based on differential performance evidenced only at the earliest stages of visual information processing, mediated by local neural network functioning. In this paper, we first review how most large-scale neural models are unable to address atypical low-level perceptual functioning in autism, and then suggest how condition-specific, local neural endophenotypes (described in our companion paper) can be incorporated into causal models to infer target candidate gene or gene clusters that are implicated in autism’s pathogenesis. The usefulness of such a translational research approach is discussed. En ligne : http://dx.doi.org/10.1007/s10803-010-1110-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=114

Using Perceptual Signatures to Define and Dissociate Condition-Specific Neural Etiology: Autism and Fragile X Syndrome as Model Conditions / Armando BERTONE in Journal of Autism and Developmental Disorders, 40-12 (December 2010)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 40-12 (December 2010) . - p.1531-1540 Titre : Using Perceptual Signatures to Define and Dissociate Condition-Specific Neural Etiology: Autism and Fragile X Syndrome as Model Conditions Type de document : Texte imprimé et/ou numérique Auteurs : Armando BERTONE, Auteur ; Julie HANCK, Auteur ; Cary KOGAN, Auteur ; Avi CHAUDHURI, Auteur ; Kim CORNISH, Auteur Année de publication : 2010 Article en page(s) : p.1531-1540 Langues : Anglais (eng) Mots-clés : Autism  Fragile X syndrome  Vision  Perception  Perceptual signatures  Neural networks Index. décimale : PER Périodiques Résumé : The functional link between genetic alteration and behavioral end-state is rarely straightforward and never linear. Cases where neurodevlopmental conditions defined by a distinct genetic etiology share behavioral phenotypes are exemplary, as is the case for autism and Fragile X Syndrome (FXS). In this paper and its companion paper, we propose a method for assessing the functional link between genotype and neural alteration across these target conditions by comparing their perceptual signatures. In the present paper, we discuss how such signatures can be used to (1) define and differentiate various aspects of neural functioning in autism and FXS, and subsequently, (2) to infer candidate causal (genetic) mechanisms based on such signatures (see companion paper, this issue). En ligne : http://dx.doi.org/10.1007/s10803-010-1109-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=114 [article] Using Perceptual Signatures to Define and Dissociate Condition-Specific Neural Etiology: Autism and Fragile X Syndrome as Model Conditions [Texte imprimé et/ou numérique] / Armando BERTONE, Auteur ; Julie HANCK, Auteur ; Cary KOGAN, Auteur ; Avi CHAUDHURI, Auteur ; Kim CORNISH, Auteur . - 2010 . - p.1531-1540. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 40-12 (December 2010) . - p.1531-1540 Mots-clés : Autism  Fragile X syndrome  Vision  Perception  Perceptual signatures  Neural networks Index. décimale : PER Périodiques Résumé : The functional link between genetic alteration and behavioral end-state is rarely straightforward and never linear. Cases where neurodevlopmental conditions defined by a distinct genetic etiology share behavioral phenotypes are exemplary, as is the case for autism and Fragile X Syndrome (FXS). In this paper and its companion paper, we propose a method for assessing the functional link between genotype and neural alteration across these target conditions by comparing their perceptual signatures. In the present paper, we discuss how such signatures can be used to (1) define and differentiate various aspects of neural functioning in autism and FXS, and subsequently, (2) to infer candidate causal (genetic) mechanisms based on such signatures (see companion paper, this issue). En ligne : http://dx.doi.org/10.1007/s10803-010-1109-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=114

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