A critical review of hot executive functioning in youth attention-deficit/hyperactivity disorder: Methodological limitations, conceptual considerations, and future directions / Morgan L. JUSKO ; Whitney D. FOSCO ; Erica D. MUSSER ; Joseph S. RAIKER in Development and Psychopathology, 36-2 (May 2024)  

Public ISBD [article]  inDevelopment and Psychopathology > 36-2 (May 2024) . - p.601-615 Titre : A critical review of hot executive functioning in youth attention-deficit/hyperactivity disorder: Methodological limitations, conceptual considerations, and future directions Type de document : Texte imprimé et/ou numérique Auteurs : Morgan L. JUSKO, Auteur ; Whitney D. FOSCO, Auteur ; Erica D. MUSSER, Auteur ; Joseph S. RAIKER, Auteur Article en page(s) : p.601-615 Langues : Anglais (eng) Mots-clés : attention-deficit/hyperactivity disorder  disruptive behavior problems  hot executive functioning  measurement  task design Index. décimale : PER Périodiques Résumé : Hot executive functioning (EF) - EF under emotionally or motivationally salient conditions - is a putative etiology of attention-deficit/hyperactivity disorder (ADHD), disruptive behavior problems (DBPs), and their related impairments. Despite two decades of research, the present study is the first review of the construct in youth ADHD, with a particular focus on the role of task design, age, and DBPs, as well as relevant conceptual and methodological considerations. While certain hot EF tasks have been investigated extensively (e.g., choice impulsivity), substantial inconsistency in measurement of the broader construct remains, severely limiting conclusions. Future research should a) consider the extent to which various hot EF tasks relate to one another, a higher order factor, and other related constructs; b) further investigate task design, particularly the elicitation of emotion or motivation and its anticipated effect on EF; and c) incorporate multiple levels of analysis to validate similarities and differences among tasks with regard to the affective experiences and cognitive demands they elicit. With improved measurement and conceptual clarity, hot EF has potential to advance the literature on etiological pathways to ADHD, DBPs and associated impairments and, more broadly, may represent a useful tool for understanding the influence of emotion and motivation on cognition. En ligne : https://dx.doi.org/10.1017/S0954579422001432 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=528 [article] A critical review of hot executive functioning in youth attention-deficit/hyperactivity disorder: Methodological limitations, conceptual considerations, and future directions [Texte imprimé et/ou numérique] / Morgan L. JUSKO, Auteur ; Whitney D. FOSCO, Auteur ; Erica D. MUSSER, Auteur ; Joseph S. RAIKER, Auteur . - p.601-615. Langues : Anglais (eng) in Development and Psychopathology > 36-2 (May 2024) . - p.601-615 Mots-clés : attention-deficit/hyperactivity disorder  disruptive behavior problems  hot executive functioning  measurement  task design Index. décimale : PER Périodiques Résumé : Hot executive functioning (EF) - EF under emotionally or motivationally salient conditions - is a putative etiology of attention-deficit/hyperactivity disorder (ADHD), disruptive behavior problems (DBPs), and their related impairments. Despite two decades of research, the present study is the first review of the construct in youth ADHD, with a particular focus on the role of task design, age, and DBPs, as well as relevant conceptual and methodological considerations. While certain hot EF tasks have been investigated extensively (e.g., choice impulsivity), substantial inconsistency in measurement of the broader construct remains, severely limiting conclusions. Future research should a) consider the extent to which various hot EF tasks relate to one another, a higher order factor, and other related constructs; b) further investigate task design, particularly the elicitation of emotion or motivation and its anticipated effect on EF; and c) incorporate multiple levels of analysis to validate similarities and differences among tasks with regard to the affective experiences and cognitive demands they elicit. With improved measurement and conceptual clarity, hot EF has potential to advance the literature on etiological pathways to ADHD, DBPs and associated impairments and, more broadly, may represent a useful tool for understanding the influence of emotion and motivation on cognition. En ligne : https://dx.doi.org/10.1017/S0954579422001432 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=528

Delay discounting of reward in ADHD: application in young children / Vanessa B. WILSON in Journal of Child Psychology and Psychiatry, 52-3 (March 2011)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 52-3 (March 2011) . - p.256-264 Titre : Delay discounting of reward in ADHD: application in young children Type de document : Texte imprimé et/ou numérique Auteurs : Vanessa B. WILSON, Auteur ; Suzanne H. MITCHELL, Auteur ; Erica D. MUSSER, Auteur ; Colleen F. SCHMITT, Auteur ; Joel T. NIGG, Auteur Année de publication : 2011 Article en page(s) : p.256-264 Langues : Anglais (eng) Mots-clés : Impulsivity  delay discounting  ADHD Index. décimale : PER Périodiques Résumé : Background:  A key underlying process that may contribute to attention-deficit/hyperactivity disorder (ADHD) involves alterations in reward evaluation, including assessing the relative value of immediate over delayed rewards. This study examines whether children with ADHD discount the value of delayed rewards to a greater degree than typically developing children using a delay discounting task. Methods:  Children aged 7–9 years diagnosed with ADHD and controls completed a task in which they chose between a hypothetical $10 available after a delay (7, 30, 90 and 180 days) versus various amounts available immediately. Results:  ADHD participants discounted more steeply than controls. However, this effect did not survive covarying of IQ. Conclusions:  ADHD is associated with a steeper delay gradient when contemplating hypothetical later rewards, but not independently of IQ. The interplay of cognitive processing and IQ with reward evaluation in ADHD requires further exploration. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02347.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=118 [article] Delay discounting of reward in ADHD: application in young children [Texte imprimé et/ou numérique] / Vanessa B. WILSON, Auteur ; Suzanne H. MITCHELL, Auteur ; Erica D. MUSSER, Auteur ; Colleen F. SCHMITT, Auteur ; Joel T. NIGG, Auteur . - 2011 . - p.256-264. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 52-3 (March 2011) . - p.256-264 Mots-clés : Impulsivity  delay discounting  ADHD Index. décimale : PER Périodiques Résumé : Background:  A key underlying process that may contribute to attention-deficit/hyperactivity disorder (ADHD) involves alterations in reward evaluation, including assessing the relative value of immediate over delayed rewards. This study examines whether children with ADHD discount the value of delayed rewards to a greater degree than typically developing children using a delay discounting task. Methods:  Children aged 7–9 years diagnosed with ADHD and controls completed a task in which they chose between a hypothetical $10 available after a delay (7, 30, 90 and 180 days) versus various amounts available immediately. Results:  ADHD participants discounted more steeply than controls. However, this effect did not survive covarying of IQ. Conclusions:  ADHD is associated with a steeper delay gradient when contemplating hypothetical later rewards, but not independently of IQ. The interplay of cognitive processing and IQ with reward evaluation in ADHD requires further exploration. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02347.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=118

Maternal prepregnancy body mass index and offspring attention-deficit/hyperactivity disorder: a quasi-experimental sibling-comparison, population-based design / Erica D. MUSSER in Journal of Child Psychology and Psychiatry, 58-3 (March 2017)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 58-3 (March 2017) . - p.240-247 Titre : Maternal prepregnancy body mass index and offspring attention-deficit/hyperactivity disorder: a quasi-experimental sibling-comparison, population-based design Type de document : Texte imprimé et/ou numérique Auteurs : Erica D. MUSSER, Auteur ; Michael T. WILLOUGHBY, Auteur ; Suzanne WRIGHT, Auteur ; Elinor L. SULLIVAN, Auteur ; Diane D. STADLER, Auteur ; Brent F. OLSON, Auteur ; Robert D. STEINER, Auteur ; Joel T. NIGG, Auteur Article en page(s) : p.240-247 Langues : Anglais (eng) Mots-clés : Attention-deficit/hyperactivity disorder  maternal BMI  quasi-experimental design Index. décimale : PER Périodiques Résumé : Background High maternal prepregnancy body mass index (BMI) has been associated with increased risk of offspring attention-deficit/hyperactivity disorder (ADHD). However, whether this effect is attributable to maternal or familial level confounds has been little examined. Methods The present study sought to examine these associations, utilizing data from the medical records of a health care system which treats 350,000 patients annually and a sibling-comparison design in a sample of 4,682 children born to 3,645 mothers. Results When examining the overall maternal effect, a linear association was observed between maternal prepregnancy BMI and child ADHD [b = 0.04, 95% confidence interval (95% CI) = 0.02–0.06, p = .0003], such that a one-unit (i.e. 1 kg/m2) increase in prepregnancy BMI was associated with a 4% increase in the odds of ADHD (exp b = 1.04). However, when the model was reparameterized to take full advantage of the sibling design to allow for the examination of both maternal and child-specific effects, the child-specific prepregnancy BMI effect was not reliably different from zero (b = ?0.08, 95% CI = ?0.23 to 0.06, p = .24). In contrast, at the maternal-level, average prepregnancy BMI was a reliably non-zero predictor of child ADHD (b = 0.04, 95% CI = 0.02–0.06, p < .0001) with each one-unit increase in maternal prepregnancy BMI associated with a 4.2% increase in the odds of ADHD (exp b = 1.04, 95% CI = 1.02–1.06). Conclusions The association between maternal prepregnancy BMI and offspring ADHD may be better accounted for by familial or maternal confounds rather than a direct causal effect of BMI. En ligne : http://dx.doi.org/10.1111/jcpp.12662 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303 [article] Maternal prepregnancy body mass index and offspring attention-deficit/hyperactivity disorder: a quasi-experimental sibling-comparison, population-based design [Texte imprimé et/ou numérique] / Erica D. MUSSER, Auteur ; Michael T. WILLOUGHBY, Auteur ; Suzanne WRIGHT, Auteur ; Elinor L. SULLIVAN, Auteur ; Diane D. STADLER, Auteur ; Brent F. OLSON, Auteur ; Robert D. STEINER, Auteur ; Joel T. NIGG, Auteur . - p.240-247. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 58-3 (March 2017) . - p.240-247 Mots-clés : Attention-deficit/hyperactivity disorder  maternal BMI  quasi-experimental design Index. décimale : PER Périodiques Résumé : Background High maternal prepregnancy body mass index (BMI) has been associated with increased risk of offspring attention-deficit/hyperactivity disorder (ADHD). However, whether this effect is attributable to maternal or familial level confounds has been little examined. Methods The present study sought to examine these associations, utilizing data from the medical records of a health care system which treats 350,000 patients annually and a sibling-comparison design in a sample of 4,682 children born to 3,645 mothers. Results When examining the overall maternal effect, a linear association was observed between maternal prepregnancy BMI and child ADHD [b = 0.04, 95% confidence interval (95% CI) = 0.02–0.06, p = .0003], such that a one-unit (i.e. 1 kg/m2) increase in prepregnancy BMI was associated with a 4% increase in the odds of ADHD (exp b = 1.04). However, when the model was reparameterized to take full advantage of the sibling design to allow for the examination of both maternal and child-specific effects, the child-specific prepregnancy BMI effect was not reliably different from zero (b = ?0.08, 95% CI = ?0.23 to 0.06, p = .24). In contrast, at the maternal-level, average prepregnancy BMI was a reliably non-zero predictor of child ADHD (b = 0.04, 95% CI = 0.02–0.06, p < .0001) with each one-unit increase in maternal prepregnancy BMI associated with a 4.2% increase in the odds of ADHD (exp b = 1.04, 95% CI = 1.02–1.06). Conclusions The association between maternal prepregnancy BMI and offspring ADHD may be better accounted for by familial or maternal confounds rather than a direct causal effect of BMI. En ligne : http://dx.doi.org/10.1111/jcpp.12662 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303

Methylomic analysis of salivary DNA in childhood ADHD identifies altered DNA methylation in VIPR2 / Beth WILMOT in Journal of Child Psychology and Psychiatry, 57-2 (February 2016)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 57-2 (February 2016) . - p.152-160 Titre : Methylomic analysis of salivary DNA in childhood ADHD identifies altered DNA methylation in VIPR2 Type de document : Texte imprimé et/ou numérique Auteurs : Beth WILMOT, Auteur ; Rebecca FRY, Auteur ; Lisa SMEESTER, Auteur ; Erica D. MUSSER, Auteur ; Jonathan MILL, Auteur ; Joel T. NIGG, Auteur Article en page(s) : p.152-160 Langues : Anglais (eng) Mots-clés : ADHD  methylation  epigenetic Index. décimale : PER Périodiques Résumé : Background Peripheral epigenetic marks hold promise for understanding psychiatric illness and may represent fingerprints of gene–environment interactions. We conducted an initial examination of CpG methylation variation in children with or without attention-deficit/hyperactivity disorder (ADHD). Methods Children age 7–12 were recruited, screened, evaluated and assigned to ADHD or non-ADHD groups by defined research criteria. Two independent age-matched samples were examined, a discovery set (n = 92, all boys, half control, half ADHD) and a confirmation set (n = 20, half ADHD, all boys). 5-methylcytosine levels were quantified in salivary DNA using the Illumina 450 K HumanMethylation array. Genes for which multiple probes were nominally significant and had a beta difference of at least 2% were evaluated for biological relevance and prioritized for confirmation and sequence validation. Gene pathways were explored and described. Results Two genes met the criteria for confirmation testing, VIPR2 and MYT1L; both had multiple probes meeting cutoffs and strong biological relevance. Probes on VIPR2 passed FDR correction in the confirmation set and were confirmed through bisulfite sequencing. Enrichment analysis suggested involvement of gene sets or pathways related to inflammatory processes and modulation of monoamine and cholinergic neurotransmission. Conclusions Although it is unknown to what extent CpG methylation seen in peripheral tissue reflect transcriptomic changes in the brain, these initial results indicate that peripheral DNA methylation markers in ADHD may be promising and suggest targeted hypotheses for future study in larger samples. En ligne : http://dx.doi.org/10.1111/jcpp.12457 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=280 [article] Methylomic analysis of salivary DNA in childhood ADHD identifies altered DNA methylation in VIPR2 [Texte imprimé et/ou numérique] / Beth WILMOT, Auteur ; Rebecca FRY, Auteur ; Lisa SMEESTER, Auteur ; Erica D. MUSSER, Auteur ; Jonathan MILL, Auteur ; Joel T. NIGG, Auteur . - p.152-160. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 57-2 (February 2016) . - p.152-160 Mots-clés : ADHD  methylation  epigenetic Index. décimale : PER Périodiques Résumé : Background Peripheral epigenetic marks hold promise for understanding psychiatric illness and may represent fingerprints of gene–environment interactions. We conducted an initial examination of CpG methylation variation in children with or without attention-deficit/hyperactivity disorder (ADHD). Methods Children age 7–12 were recruited, screened, evaluated and assigned to ADHD or non-ADHD groups by defined research criteria. Two independent age-matched samples were examined, a discovery set (n = 92, all boys, half control, half ADHD) and a confirmation set (n = 20, half ADHD, all boys). 5-methylcytosine levels were quantified in salivary DNA using the Illumina 450 K HumanMethylation array. Genes for which multiple probes were nominally significant and had a beta difference of at least 2% were evaluated for biological relevance and prioritized for confirmation and sequence validation. Gene pathways were explored and described. Results Two genes met the criteria for confirmation testing, VIPR2 and MYT1L; both had multiple probes meeting cutoffs and strong biological relevance. Probes on VIPR2 passed FDR correction in the confirmation set and were confirmed through bisulfite sequencing. Enrichment analysis suggested involvement of gene sets or pathways related to inflammatory processes and modulation of monoamine and cholinergic neurotransmission. Conclusions Although it is unknown to what extent CpG methylation seen in peripheral tissue reflect transcriptomic changes in the brain, these initial results indicate that peripheral DNA methylation markers in ADHD may be promising and suggest targeted hypotheses for future study in larger samples. En ligne : http://dx.doi.org/10.1111/jcpp.12457 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=280

Shared familial transmission of autism spectrum and attention-deficit/hyperactivity disorders / Erica D. MUSSER in Journal of Child Psychology and Psychiatry, 55-7 (July 2014)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 55-7 (July 2014) . - p.819-827 Titre : Shared familial transmission of autism spectrum and attention-deficit/hyperactivity disorders Type de document : Texte imprimé et/ou numérique Auteurs : Erica D. MUSSER, Auteur ; Elizabeth HAWKEY, Auteur ; Svetlana S. KACHAN-LIU, Auteur ; Paul LEES, Auteur ; Jean-Baptiste ROULLET, Auteur ; Katrina GODDARD, Auteur ; Robert D. STEINER, Auteur ; Joel T. NIGG, Auteur Article en page(s) : p.819-827 Langues : Anglais (eng) Mots-clés : Attention-deficit/hyperactivity disorder  autism spectrum disorder  shared familial transmission Index. décimale : PER Périodiques Résumé : Background To determine whether familial transmission is shared between autism spectrum disorders and attention-deficit/hyperactivity disorder, we assessed the prevalence, rates of comorbidity, and familial transmission of both disorders in a large population-based sample of children during a recent 7 year period. Methods Study participants included all children born to parents with the Kaiser Permanente Northwest (KPNW) Health Plan between 1 January 1998 and 31 December 2004 (n = 35,073). Children and mothers with physician-identified autism spectrum disorders (ASD) and/or attention-deficit/hyperactivity disorder (ADHD) were identified via electronic medical records maintained for all KPNW members. Results Among children aged 6–12 years, prevalence was 2.0% for ADHD and 0.8% for ASD; within those groups, 0.2% of the full sample (19% of the ASD sample and 9.6% of the ADHD sample) had co-occurring ASD and ADHD, when all children were included. When mothers had a diagnosis of ADHD, first born offspring were at 6-fold risk of ADHD alone (OR = 5.02, p .0001) and at 2.5-fold risk of ASD alone (OR = 2.52, p .01). Results were not accounted for by maternal age, child gestational age, child gender, and child race. Conclusions Autism spectrum disorders shares familial transmission with ADHD. ADHD and ASD have a partially overlapping diathesis. En ligne : http://dx.doi.org/10.1111/jcpp.12201 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=235 [article] Shared familial transmission of autism spectrum and attention-deficit/hyperactivity disorders [Texte imprimé et/ou numérique] / Erica D. MUSSER, Auteur ; Elizabeth HAWKEY, Auteur ; Svetlana S. KACHAN-LIU, Auteur ; Paul LEES, Auteur ; Jean-Baptiste ROULLET, Auteur ; Katrina GODDARD, Auteur ; Robert D. STEINER, Auteur ; Joel T. NIGG, Auteur . - p.819-827. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 55-7 (July 2014) . - p.819-827 Mots-clés : Attention-deficit/hyperactivity disorder  autism spectrum disorder  shared familial transmission Index. décimale : PER Périodiques Résumé : Background To determine whether familial transmission is shared between autism spectrum disorders and attention-deficit/hyperactivity disorder, we assessed the prevalence, rates of comorbidity, and familial transmission of both disorders in a large population-based sample of children during a recent 7 year period. Methods Study participants included all children born to parents with the Kaiser Permanente Northwest (KPNW) Health Plan between 1 January 1998 and 31 December 2004 (n = 35,073). Children and mothers with physician-identified autism spectrum disorders (ASD) and/or attention-deficit/hyperactivity disorder (ADHD) were identified via electronic medical records maintained for all KPNW members. Results Among children aged 6–12 years, prevalence was 2.0% for ADHD and 0.8% for ASD; within those groups, 0.2% of the full sample (19% of the ASD sample and 9.6% of the ADHD sample) had co-occurring ASD and ADHD, when all children were included. When mothers had a diagnosis of ADHD, first born offspring were at 6-fold risk of ADHD alone (OR = 5.02, p .0001) and at 2.5-fold risk of ASD alone (OR = 2.52, p .01). Results were not accounted for by maternal age, child gestational age, child gender, and child race. Conclusions Autism spectrum disorders shares familial transmission with ADHD. ADHD and ASD have a partially overlapping diathesis. En ligne : http://dx.doi.org/10.1111/jcpp.12201 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=235

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