Context-dependent amygdala-prefrontal connectivity in youths with autism spectrum disorder / Isaac Ray CHRISTIAN in Research in Autism Spectrum Disorders, 91 (March 2022)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 91 (March 2022) . - 101913 Titre : Context-dependent amygdala-prefrontal connectivity in youths with autism spectrum disorder Type de document : texte imprimé Auteurs : Isaac Ray CHRISTIAN, Auteur ; Michael T. LIUZZI, Auteur ; Qiongru YU, Auteur ; Maria KRYZA-LACOMBE, Auteur ; Christopher S. MONK, Auteur ; Johanna M. JARCHO, Auteur ; Jillian Lee WIGGINS, Auteur Année de publication : 2022 Article en page(s) : 101913 Langues : Anglais (eng) Mots-clés : Autism  Amygdala  Connectivity  Faces  Rest  Context Index. décimale : PER Périodiques Résumé : Background The amygdala-prefrontal cortex circuit is involved in processing socio-emotional cues and may partially mediate social impairment in autism spectrum disorder (ASD). Past task-based fMRI studies in ASD indicate a mix of hypo- and hyper-connectivity in response to socio-emotional stimuli whereas resting state studies report hypoconnectivity between these regions. However, it is still unknown whether ASD-related alterations in amygdala-prefrontal circuitry are present across socio-emotional tasks and resting state contexts within the same sample or instead, depend on context. Method ASD (n = 47) and typically developing individuals (TD; n = 72) underwent fMRI during an implicit emotional face processing task and during rest, and whole-brain amygdala connectivity was calculated to determine patterns that differed by context and diagnosis. Results Relative to TD, the ASD group demonstrated weaker left amygdala connectivity with the medial frontal gyrus and the left superior frontal gyrus during rest, but stronger connectivity during task. Furthermore, across both contexts, ASD vs. TD had stronger right amygdala connectivity with the left insula/superior temporal gyrus. Conclusion Findings suggest some alterations in amygdala connectivity of ASD may depend on context while others are pervasive across task and rest conditions. Understanding context-dependent brain alterations in ASD may help disambiguate the mechanisms subserving social impairment and provide targets for treatment. En ligne : https://doi.org/10.1016/j.rasd.2021.101913 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=458 [article] Context-dependent amygdala-prefrontal connectivity in youths with autism spectrum disorder [texte imprimé] / Isaac Ray CHRISTIAN, Auteur ; Michael T. LIUZZI, Auteur ; Qiongru YU, Auteur ; Maria KRYZA-LACOMBE, Auteur ; Christopher S. MONK, Auteur ; Johanna M. JARCHO, Auteur ; Jillian Lee WIGGINS, Auteur . - 2022 . - 101913. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 91 (March 2022) . - 101913 Mots-clés : Autism  Amygdala  Connectivity  Faces  Rest  Context Index. décimale : PER Périodiques Résumé : Background The amygdala-prefrontal cortex circuit is involved in processing socio-emotional cues and may partially mediate social impairment in autism spectrum disorder (ASD). Past task-based fMRI studies in ASD indicate a mix of hypo- and hyper-connectivity in response to socio-emotional stimuli whereas resting state studies report hypoconnectivity between these regions. However, it is still unknown whether ASD-related alterations in amygdala-prefrontal circuitry are present across socio-emotional tasks and resting state contexts within the same sample or instead, depend on context. Method ASD (n = 47) and typically developing individuals (TD; n = 72) underwent fMRI during an implicit emotional face processing task and during rest, and whole-brain amygdala connectivity was calculated to determine patterns that differed by context and diagnosis. Results Relative to TD, the ASD group demonstrated weaker left amygdala connectivity with the medial frontal gyrus and the left superior frontal gyrus during rest, but stronger connectivity during task. Furthermore, across both contexts, ASD vs. TD had stronger right amygdala connectivity with the left insula/superior temporal gyrus. Conclusion Findings suggest some alterations in amygdala connectivity of ASD may depend on context while others are pervasive across task and rest conditions. Understanding context-dependent brain alterations in ASD may help disambiguate the mechanisms subserving social impairment and provide targets for treatment. En ligne : https://doi.org/10.1016/j.rasd.2021.101913 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=458

Identifying early pathways of risk and resilience: The codevelopment of internalizing and externalizing symptoms and the role of harsh parenting / Jillian Lee WIGGINS in Development and Psychopathology, 27-4 (Part 1) (November 2015)  

Public ISBD [article]  inDevelopment and Psychopathology > 27-4 (Part 1) (November 2015) . - p.1295-1312 Titre : Identifying early pathways of risk and resilience: The codevelopment of internalizing and externalizing symptoms and the role of harsh parenting Type de document : texte imprimé Auteurs : Jillian Lee WIGGINS, Auteur ; Colter MITCHELL, Auteur ; Luke W. HYDE, Auteur ; Christopher S. MONK, Auteur Année de publication : 2015 Article en page(s) : p.1295-1312 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Psychological disorders co-occur often in children, but little has been done to document the types of conjoint pathways internalizing and externalizing symptoms may take from the crucial early period of toddlerhood or how harsh parenting may overlap with early symptom codevelopment. To examine symptom codevelopment trajectories, we identified latent classes of individuals based on internalizing and externalizing symptoms across ages 3–9 and found three symptom codevelopment classes: normative symptoms (low), severe-decreasing symptoms (initially high but rapidly declining), and severe symptoms (high) trajectories. Next, joint models examined how parenting trajectories overlapped with internalizing and externalizing symptom trajectories. These trajectory classes demonstrated that, normatively, harsh parenting increased after toddlerhood, but the severe symptoms class was characterized by a higher level and a steeper increase in harsh parenting and the severe-decreasing class by high, stable harsh parenting. In addition, a transactional model examined the bidirectional relationships among internalizing and externalizing symptoms and harsh parenting because they may cascade over time in this early period. Harsh parenting uniquely contributed to externalizing symptoms, controlling for internalizing symptoms, but not vice versa. In addition, internalizing symptoms appeared to be a mechanism by which externalizing symptoms increase. Results highlight the importance of accounting for both internalizing and externalizing symptoms from an early age to understand risk for developing psychopathology and the role harsh parenting plays in influencing these trajectories. En ligne : http://dx.doi.org/10.1017/S0954579414001412 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=268 [article] Identifying early pathways of risk and resilience: The codevelopment of internalizing and externalizing symptoms and the role of harsh parenting [texte imprimé] / Jillian Lee WIGGINS, Auteur ; Colter MITCHELL, Auteur ; Luke W. HYDE, Auteur ; Christopher S. MONK, Auteur . - 2015 . - p.1295-1312. Langues : Anglais (eng) in Development and Psychopathology > 27-4 (Part 1) (November 2015) . - p.1295-1312 Index. décimale : PER Périodiques Résumé : Psychological disorders co-occur often in children, but little has been done to document the types of conjoint pathways internalizing and externalizing symptoms may take from the crucial early period of toddlerhood or how harsh parenting may overlap with early symptom codevelopment. To examine symptom codevelopment trajectories, we identified latent classes of individuals based on internalizing and externalizing symptoms across ages 3–9 and found three symptom codevelopment classes: normative symptoms (low), severe-decreasing symptoms (initially high but rapidly declining), and severe symptoms (high) trajectories. Next, joint models examined how parenting trajectories overlapped with internalizing and externalizing symptom trajectories. These trajectory classes demonstrated that, normatively, harsh parenting increased after toddlerhood, but the severe symptoms class was characterized by a higher level and a steeper increase in harsh parenting and the severe-decreasing class by high, stable harsh parenting. In addition, a transactional model examined the bidirectional relationships among internalizing and externalizing symptoms and harsh parenting because they may cascade over time in this early period. Harsh parenting uniquely contributed to externalizing symptoms, controlling for internalizing symptoms, but not vice versa. In addition, internalizing symptoms appeared to be a mechanism by which externalizing symptoms increase. Results highlight the importance of accounting for both internalizing and externalizing symptoms from an early age to understand risk for developing psychopathology and the role harsh parenting plays in influencing these trajectories. En ligne : http://dx.doi.org/10.1017/S0954579414001412 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=268

Neural activation to emotional faces in adolescents with autism spectrum disorders / Shih-Jen WENG in Journal of Child Psychology and Psychiatry, 52-3 (March 2011)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 52-3 (March 2011) . - p.296-305 Titre : Neural activation to emotional faces in adolescents with autism spectrum disorders Type de document : texte imprimé Auteurs : Shih-Jen WENG, Auteur ; Melisa CARRASCO, Auteur ; Johnna R. SWARTZ, Auteur ; Jillian Lee WIGGINS, Auteur ; Nikhil KURAPATI, Auteur ; Israel LIBERZON, Auteur ; Susan RISI, Auteur ; Catherine LORD, Auteur ; Christopher S. MONK, Auteur Année de publication : 2011 Article en page(s) : p.296-305 Langues : Anglais (eng) Mots-clés : Autism  adolescents  fMRI  faces  emotion Index. décimale : PER Périodiques Résumé : Background:  Autism spectrum disorders (ASD) involve a core deficit in social functioning and impairments in the ability to recognize face emotions. In an emotional faces task designed to constrain group differences in attention, the present study used functional MRI to characterize activation in the amygdala, ventral prefrontal cortex (vPFC), and striatum, three structures involved in socio-emotional processing in adolescents with ASD. Methods:  Twenty-two adolescents with ASD and 20 healthy adolescents viewed facial expressions (happy, fearful, sad and neutral) that were briefly presented (250 ms) during functional MRI acquisition. To monitor attention, subjects pressed a button to identify the gender of each face. Results:  The ASD group showed greater activation to the faces relative to the control group in the amygdala, vPFC and striatum. Follow-up analyses indicated that the ASD relative to control group showed greater activation in the amygdala, vPFC and striatum (p < .05 small volume corrected), particularly to sad faces. Moreover, in the ASD group, there was a negative correlation between developmental variables (age and pubertal status) and mean activation from the whole bilateral amygdala; younger adolescents showed greater activation than older adolescents. There were no group differences in accuracy or reaction time in the gender identification task. Conclusions:  When group differences in attention to facial expressions were limited, adolescents with ASD showed greater activation in structures involved in socio-emotional processing. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02317.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=118 [article] Neural activation to emotional faces in adolescents with autism spectrum disorders [texte imprimé] / Shih-Jen WENG, Auteur ; Melisa CARRASCO, Auteur ; Johnna R. SWARTZ, Auteur ; Jillian Lee WIGGINS, Auteur ; Nikhil KURAPATI, Auteur ; Israel LIBERZON, Auteur ; Susan RISI, Auteur ; Catherine LORD, Auteur ; Christopher S. MONK, Auteur . - 2011 . - p.296-305. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 52-3 (March 2011) . - p.296-305 Mots-clés : Autism  adolescents  fMRI  faces  emotion Index. décimale : PER Périodiques Résumé : Background:  Autism spectrum disorders (ASD) involve a core deficit in social functioning and impairments in the ability to recognize face emotions. In an emotional faces task designed to constrain group differences in attention, the present study used functional MRI to characterize activation in the amygdala, ventral prefrontal cortex (vPFC), and striatum, three structures involved in socio-emotional processing in adolescents with ASD. Methods:  Twenty-two adolescents with ASD and 20 healthy adolescents viewed facial expressions (happy, fearful, sad and neutral) that were briefly presented (250 ms) during functional MRI acquisition. To monitor attention, subjects pressed a button to identify the gender of each face. Results:  The ASD group showed greater activation to the faces relative to the control group in the amygdala, vPFC and striatum. Follow-up analyses indicated that the ASD relative to control group showed greater activation in the amygdala, vPFC and striatum (p < .05 small volume corrected), particularly to sad faces. Moreover, in the ASD group, there was a negative correlation between developmental variables (age and pubertal status) and mean activation from the whole bilateral amygdala; younger adolescents showed greater activation than older adolescents. There were no group differences in accuracy or reaction time in the gender identification task. Conclusions:  When group differences in attention to facial expressions were limited, adolescents with ASD showed greater activation in structures involved in socio-emotional processing. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02317.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=118

Risk and resilience profiles and their transition pathways in the ABCD Study / Sabrena TUY ; Lea Rose DOUGHERTY ; Jillian Lee WIGGINS in Development and Psychopathology, 37-4 (October 2025)  

Public ISBD [article]  inDevelopment and Psychopathology > 37-4 (October 2025) . - p.2055-2064 Titre : Risk and resilience profiles and their transition pathways in the ABCD Study Type de document : texte imprimé Auteurs : Sabrena TUY, Auteur ; Lea Rose DOUGHERTY, Auteur ; Jillian Lee WIGGINS, Auteur Article en page(s) : p.2055-2064 Langues : Anglais (eng) Mots-clés : Developmental psychopathology  person-centered approach  risk and resilience Index. décimale : PER Périodiques Résumé : The transition from childhood to adolescence presents elevated risks for the onset of psychopathology in youth. Given the multilayered nature of development, the present study leverages the longitudinal, population-based Adolescent Brain Cognitive Development Study to derive ecologically informed risk/resilience profiles based on multilevel influences (e.g., neighborhood and family socioeconomic resources, parenting, school characteristics) and their transition pathways and examine their associations with psychopathology. Latent profile analysis characterized risk/resilience profiles at each time point (i.e., baseline, Year-1, Year-2); latent transition analysis estimated the most likely transition pathway for each individual. Analysis of covariance was used to examine associations between profile membership at baseline (i.e., ages 9-11) and psychopathology, both concurrently and at Year-2 follow-up. Further, we examined the associations between profile transition pathways and Year-2 psychopathology. Four distinct profiles emerged across time - High-SES High-Protective, High-SES Low-Protective, Low-SES High-Family-Risk, and Low-SES High-Protective. Despite reasonably high stability, significant transition over time among profiles was detected. Profile membership at baseline significantly correlated with concurrent psychopathology and predicted psychopathology 2 years later. Additionally, profile transition pathways significantly predicted Year-2 psychopathology, exemplifying equifinality and multifinality. Characterizing and tracing shifts in ecologically informed risk/resilience influences, our findings have the potential to inform more precise intervention efforts in youth. En ligne : https://dx.doi.org/10.1017/S0954579424001603 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=567 [article] Risk and resilience profiles and their transition pathways in the ABCD Study [texte imprimé] / Sabrena TUY, Auteur ; Lea Rose DOUGHERTY, Auteur ; Jillian Lee WIGGINS, Auteur . - p.2055-2064. Langues : Anglais (eng) in Development and Psychopathology > 37-4 (October 2025) . - p.2055-2064 Mots-clés : Developmental psychopathology  person-centered approach  risk and resilience Index. décimale : PER Périodiques Résumé : The transition from childhood to adolescence presents elevated risks for the onset of psychopathology in youth. Given the multilayered nature of development, the present study leverages the longitudinal, population-based Adolescent Brain Cognitive Development Study to derive ecologically informed risk/resilience profiles based on multilevel influences (e.g., neighborhood and family socioeconomic resources, parenting, school characteristics) and their transition pathways and examine their associations with psychopathology. Latent profile analysis characterized risk/resilience profiles at each time point (i.e., baseline, Year-1, Year-2); latent transition analysis estimated the most likely transition pathway for each individual. Analysis of covariance was used to examine associations between profile membership at baseline (i.e., ages 9-11) and psychopathology, both concurrently and at Year-2 follow-up. Further, we examined the associations between profile transition pathways and Year-2 psychopathology. Four distinct profiles emerged across time - High-SES High-Protective, High-SES Low-Protective, Low-SES High-Family-Risk, and Low-SES High-Protective. Despite reasonably high stability, significant transition over time among profiles was detected. Profile membership at baseline significantly correlated with concurrent psychopathology and predicted psychopathology 2 years later. Additionally, profile transition pathways significantly predicted Year-2 psychopathology, exemplifying equifinality and multifinality. Characterizing and tracing shifts in ecologically informed risk/resilience influences, our findings have the potential to inform more precise intervention efforts in youth. En ligne : https://dx.doi.org/10.1017/S0954579424001603 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=567

Risk and resilience profiles and their transition pathways in the ABCD Study - CORRIGENDUM / Sabrena TUY ; Lea Rose DOUGHERTY ; Jillian Lee WIGGINS in Development and Psychopathology, 37-4 (October 2025)  

Public ISBD [article]  inDevelopment and Psychopathology > 37-4 (October 2025) . - p.2249-2249 Titre : Risk and resilience profiles and their transition pathways in the ABCD Study - CORRIGENDUM Type de document : texte imprimé Auteurs : Sabrena TUY, Auteur ; Lea Rose DOUGHERTY, Auteur ; Jillian Lee WIGGINS, Auteur Article en page(s) : p.2249-2249 Langues : Anglais (eng) Mots-clés : Developmental psychopathology  corrigendum  person-centered approach  risk and resilience Index. décimale : PER Périodiques En ligne : https://dx.doi.org/10.1017/S0954579425000094 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=567 [article] Risk and resilience profiles and their transition pathways in the ABCD Study - CORRIGENDUM [texte imprimé] / Sabrena TUY, Auteur ; Lea Rose DOUGHERTY, Auteur ; Jillian Lee WIGGINS, Auteur . - p.2249-2249. Langues : Anglais (eng) in Development and Psychopathology > 37-4 (October 2025) . - p.2249-2249 Mots-clés : Developmental psychopathology  corrigendum  person-centered approach  risk and resilience Index. décimale : PER Périodiques En ligne : https://dx.doi.org/10.1017/S0954579425000094 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=567

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