Context-dependent amygdala-prefrontal connectivity in youths with autism spectrum disorder / Isaac Ray CHRISTIAN in Research in Autism Spectrum Disorders, 91 (March 2022)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 91 (March 2022) . - 101913 Titre : Context-dependent amygdala-prefrontal connectivity in youths with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Isaac Ray CHRISTIAN, Auteur ; Michael T. LIUZZI, Auteur ; Qiongru YU, Auteur ; Maria KRYZA-LACOMBE, Auteur ; Christopher S. MONK, Auteur ; Johanna M. JARCHO, Auteur ; Jillian Lee WIGGINS, Auteur Année de publication : 2022 Article en page(s) : 101913 Langues : Anglais (eng) Mots-clés : Autism  Amygdala  Connectivity  Faces  Rest  Context Index. décimale : PER Périodiques Résumé : Background The amygdala-prefrontal cortex circuit is involved in processing socio-emotional cues and may partially mediate social impairment in autism spectrum disorder (ASD). Past task-based fMRI studies in ASD indicate a mix of hypo- and hyper-connectivity in response to socio-emotional stimuli whereas resting state studies report hypoconnectivity between these regions. However, it is still unknown whether ASD-related alterations in amygdala-prefrontal circuitry are present across socio-emotional tasks and resting state contexts within the same sample or instead, depend on context. Method ASD (n?=?47) and typically developing individuals (TD; n?=?72) underwent fMRI during an implicit emotional face processing task and during rest, and whole-brain amygdala connectivity was calculated to determine patterns that differed by context and diagnosis. Results Relative to TD, the ASD group demonstrated weaker left amygdala connectivity with the medial frontal gyrus and the left superior frontal gyrus during rest, but stronger connectivity during task. Furthermore, across both contexts, ASD vs. TD had stronger right amygdala connectivity with the left insula/superior temporal gyrus. Conclusion Findings suggest some alterations in amygdala connectivity of ASD may depend on context while others are pervasive across task and rest conditions. Understanding context-dependent brain alterations in ASD may help disambiguate the mechanisms subserving social impairment and provide targets for treatment. En ligne : https://doi.org/10.1016/j.rasd.2021.101913 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=458 [article] Context-dependent amygdala-prefrontal connectivity in youths with autism spectrum disorder [Texte imprimé et/ou numérique] / Isaac Ray CHRISTIAN, Auteur ; Michael T. LIUZZI, Auteur ; Qiongru YU, Auteur ; Maria KRYZA-LACOMBE, Auteur ; Christopher S. MONK, Auteur ; Johanna M. JARCHO, Auteur ; Jillian Lee WIGGINS, Auteur . - 2022 . - 101913. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 91 (March 2022) . - 101913 Mots-clés : Autism  Amygdala  Connectivity  Faces  Rest  Context Index. décimale : PER Périodiques Résumé : Background The amygdala-prefrontal cortex circuit is involved in processing socio-emotional cues and may partially mediate social impairment in autism spectrum disorder (ASD). Past task-based fMRI studies in ASD indicate a mix of hypo- and hyper-connectivity in response to socio-emotional stimuli whereas resting state studies report hypoconnectivity between these regions. However, it is still unknown whether ASD-related alterations in amygdala-prefrontal circuitry are present across socio-emotional tasks and resting state contexts within the same sample or instead, depend on context. Method ASD (n?=?47) and typically developing individuals (TD; n?=?72) underwent fMRI during an implicit emotional face processing task and during rest, and whole-brain amygdala connectivity was calculated to determine patterns that differed by context and diagnosis. Results Relative to TD, the ASD group demonstrated weaker left amygdala connectivity with the medial frontal gyrus and the left superior frontal gyrus during rest, but stronger connectivity during task. Furthermore, across both contexts, ASD vs. TD had stronger right amygdala connectivity with the left insula/superior temporal gyrus. Conclusion Findings suggest some alterations in amygdala connectivity of ASD may depend on context while others are pervasive across task and rest conditions. Understanding context-dependent brain alterations in ASD may help disambiguate the mechanisms subserving social impairment and provide targets for treatment. En ligne : https://doi.org/10.1016/j.rasd.2021.101913 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=458

Identifying early pathways of risk and resilience: The codevelopment of internalizing and externalizing symptoms and the role of harsh parenting / Jillian Lee WIGGINS in Development and Psychopathology, 27-4 (Part 1) (November 2015)  

Public ISBD [article]  inDevelopment and Psychopathology > 27-4 (Part 1) (November 2015) . - p.1295-1312 Titre : Identifying early pathways of risk and resilience: The codevelopment of internalizing and externalizing symptoms and the role of harsh parenting Type de document : Texte imprimé et/ou numérique Auteurs : Jillian Lee WIGGINS, Auteur ; Colter MITCHELL, Auteur ; Luke W. HYDE, Auteur ; Christopher S. MONK, Auteur Année de publication : 2015 Article en page(s) : p.1295-1312 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Psychological disorders co-occur often in children, but little has been done to document the types of conjoint pathways internalizing and externalizing symptoms may take from the crucial early period of toddlerhood or how harsh parenting may overlap with early symptom codevelopment. To examine symptom codevelopment trajectories, we identified latent classes of individuals based on internalizing and externalizing symptoms across ages 3–9 and found three symptom codevelopment classes: normative symptoms (low), severe-decreasing symptoms (initially high but rapidly declining), and severe symptoms (high) trajectories. Next, joint models examined how parenting trajectories overlapped with internalizing and externalizing symptom trajectories. These trajectory classes demonstrated that, normatively, harsh parenting increased after toddlerhood, but the severe symptoms class was characterized by a higher level and a steeper increase in harsh parenting and the severe-decreasing class by high, stable harsh parenting. In addition, a transactional model examined the bidirectional relationships among internalizing and externalizing symptoms and harsh parenting because they may cascade over time in this early period. Harsh parenting uniquely contributed to externalizing symptoms, controlling for internalizing symptoms, but not vice versa. In addition, internalizing symptoms appeared to be a mechanism by which externalizing symptoms increase. Results highlight the importance of accounting for both internalizing and externalizing symptoms from an early age to understand risk for developing psychopathology and the role harsh parenting plays in influencing these trajectories. En ligne : http://dx.doi.org/10.1017/S0954579414001412 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=268 [article] Identifying early pathways of risk and resilience: The codevelopment of internalizing and externalizing symptoms and the role of harsh parenting [Texte imprimé et/ou numérique] / Jillian Lee WIGGINS, Auteur ; Colter MITCHELL, Auteur ; Luke W. HYDE, Auteur ; Christopher S. MONK, Auteur . - 2015 . - p.1295-1312. Langues : Anglais (eng) in Development and Psychopathology > 27-4 (Part 1) (November 2015) . - p.1295-1312 Index. décimale : PER Périodiques Résumé : Psychological disorders co-occur often in children, but little has been done to document the types of conjoint pathways internalizing and externalizing symptoms may take from the crucial early period of toddlerhood or how harsh parenting may overlap with early symptom codevelopment. To examine symptom codevelopment trajectories, we identified latent classes of individuals based on internalizing and externalizing symptoms across ages 3–9 and found three symptom codevelopment classes: normative symptoms (low), severe-decreasing symptoms (initially high but rapidly declining), and severe symptoms (high) trajectories. Next, joint models examined how parenting trajectories overlapped with internalizing and externalizing symptom trajectories. These trajectory classes demonstrated that, normatively, harsh parenting increased after toddlerhood, but the severe symptoms class was characterized by a higher level and a steeper increase in harsh parenting and the severe-decreasing class by high, stable harsh parenting. In addition, a transactional model examined the bidirectional relationships among internalizing and externalizing symptoms and harsh parenting because they may cascade over time in this early period. Harsh parenting uniquely contributed to externalizing symptoms, controlling for internalizing symptoms, but not vice versa. In addition, internalizing symptoms appeared to be a mechanism by which externalizing symptoms increase. Results highlight the importance of accounting for both internalizing and externalizing symptoms from an early age to understand risk for developing psychopathology and the role harsh parenting plays in influencing these trajectories. En ligne : http://dx.doi.org/10.1017/S0954579414001412 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=268

Neural activation to emotional faces in adolescents with autism spectrum disorders / Shih-Jen WENG in Journal of Child Psychology and Psychiatry, 52-3 (March 2011)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 52-3 (March 2011) . - p.296-305 Titre : Neural activation to emotional faces in adolescents with autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Shih-Jen WENG, Auteur ; Melisa CARRASCO, Auteur ; Johnna R. SWARTZ, Auteur ; Jillian Lee WIGGINS, Auteur ; Nikhil KURAPATI, Auteur ; Israel LIBERZON, Auteur ; Susan RISI, Auteur ; Catherine LORD, Auteur ; Christopher S. MONK, Auteur Année de publication : 2011 Article en page(s) : p.296-305 Langues : Anglais (eng) Mots-clés : Autism  adolescents  fMRI  faces  emotion Index. décimale : PER Périodiques Résumé : Background:  Autism spectrum disorders (ASD) involve a core deficit in social functioning and impairments in the ability to recognize face emotions. In an emotional faces task designed to constrain group differences in attention, the present study used functional MRI to characterize activation in the amygdala, ventral prefrontal cortex (vPFC), and striatum, three structures involved in socio-emotional processing in adolescents with ASD. Methods:  Twenty-two adolescents with ASD and 20 healthy adolescents viewed facial expressions (happy, fearful, sad and neutral) that were briefly presented (250 ms) during functional MRI acquisition. To monitor attention, subjects pressed a button to identify the gender of each face. Results:  The ASD group showed greater activation to the faces relative to the control group in the amygdala, vPFC and striatum. Follow-up analyses indicated that the ASD relative to control group showed greater activation in the amygdala, vPFC and striatum (p < .05 small volume corrected), particularly to sad faces. Moreover, in the ASD group, there was a negative correlation between developmental variables (age and pubertal status) and mean activation from the whole bilateral amygdala; younger adolescents showed greater activation than older adolescents. There were no group differences in accuracy or reaction time in the gender identification task. Conclusions:  When group differences in attention to facial expressions were limited, adolescents with ASD showed greater activation in structures involved in socio-emotional processing. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02317.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=118 [article] Neural activation to emotional faces in adolescents with autism spectrum disorders [Texte imprimé et/ou numérique] / Shih-Jen WENG, Auteur ; Melisa CARRASCO, Auteur ; Johnna R. SWARTZ, Auteur ; Jillian Lee WIGGINS, Auteur ; Nikhil KURAPATI, Auteur ; Israel LIBERZON, Auteur ; Susan RISI, Auteur ; Catherine LORD, Auteur ; Christopher S. MONK, Auteur . - 2011 . - p.296-305. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 52-3 (March 2011) . - p.296-305 Mots-clés : Autism  adolescents  fMRI  faces  emotion Index. décimale : PER Périodiques Résumé : Background:  Autism spectrum disorders (ASD) involve a core deficit in social functioning and impairments in the ability to recognize face emotions. In an emotional faces task designed to constrain group differences in attention, the present study used functional MRI to characterize activation in the amygdala, ventral prefrontal cortex (vPFC), and striatum, three structures involved in socio-emotional processing in adolescents with ASD. Methods:  Twenty-two adolescents with ASD and 20 healthy adolescents viewed facial expressions (happy, fearful, sad and neutral) that were briefly presented (250 ms) during functional MRI acquisition. To monitor attention, subjects pressed a button to identify the gender of each face. Results:  The ASD group showed greater activation to the faces relative to the control group in the amygdala, vPFC and striatum. Follow-up analyses indicated that the ASD relative to control group showed greater activation in the amygdala, vPFC and striatum (p < .05 small volume corrected), particularly to sad faces. Moreover, in the ASD group, there was a negative correlation between developmental variables (age and pubertal status) and mean activation from the whole bilateral amygdala; younger adolescents showed greater activation than older adolescents. There were no group differences in accuracy or reaction time in the gender identification task. Conclusions:  When group differences in attention to facial expressions were limited, adolescents with ASD showed greater activation in structures involved in socio-emotional processing. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02317.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=118

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