Context-dependent amygdala-prefrontal connectivity in youths with autism spectrum disorder / Isaac Ray CHRISTIAN in Research in Autism Spectrum Disorders, 91 (March 2022)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 91 (March 2022) . - 101913 Titre : Context-dependent amygdala-prefrontal connectivity in youths with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Isaac Ray CHRISTIAN, Auteur ; Michael T. LIUZZI, Auteur ; Qiongru YU, Auteur ; Maria KRYZA-LACOMBE, Auteur ; Christopher S. MONK, Auteur ; Johanna M. JARCHO, Auteur ; Jillian Lee WIGGINS, Auteur Année de publication : 2022 Article en page(s) : 101913 Langues : Anglais (eng) Mots-clés : Autism  Amygdala  Connectivity  Faces  Rest  Context Index. décimale : PER Périodiques Résumé : Background The amygdala-prefrontal cortex circuit is involved in processing socio-emotional cues and may partially mediate social impairment in autism spectrum disorder (ASD). Past task-based fMRI studies in ASD indicate a mix of hypo- and hyper-connectivity in response to socio-emotional stimuli whereas resting state studies report hypoconnectivity between these regions. However, it is still unknown whether ASD-related alterations in amygdala-prefrontal circuitry are present across socio-emotional tasks and resting state contexts within the same sample or instead, depend on context. Method ASD (n?=?47) and typically developing individuals (TD; n?=?72) underwent fMRI during an implicit emotional face processing task and during rest, and whole-brain amygdala connectivity was calculated to determine patterns that differed by context and diagnosis. Results Relative to TD, the ASD group demonstrated weaker left amygdala connectivity with the medial frontal gyrus and the left superior frontal gyrus during rest, but stronger connectivity during task. Furthermore, across both contexts, ASD vs. TD had stronger right amygdala connectivity with the left insula/superior temporal gyrus. Conclusion Findings suggest some alterations in amygdala connectivity of ASD may depend on context while others are pervasive across task and rest conditions. Understanding context-dependent brain alterations in ASD may help disambiguate the mechanisms subserving social impairment and provide targets for treatment. En ligne : https://doi.org/10.1016/j.rasd.2021.101913 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=458 [article] Context-dependent amygdala-prefrontal connectivity in youths with autism spectrum disorder [Texte imprimé et/ou numérique] / Isaac Ray CHRISTIAN, Auteur ; Michael T. LIUZZI, Auteur ; Qiongru YU, Auteur ; Maria KRYZA-LACOMBE, Auteur ; Christopher S. MONK, Auteur ; Johanna M. JARCHO, Auteur ; Jillian Lee WIGGINS, Auteur . - 2022 . - 101913. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 91 (March 2022) . - 101913 Mots-clés : Autism  Amygdala  Connectivity  Faces  Rest  Context Index. décimale : PER Périodiques Résumé : Background The amygdala-prefrontal cortex circuit is involved in processing socio-emotional cues and may partially mediate social impairment in autism spectrum disorder (ASD). Past task-based fMRI studies in ASD indicate a mix of hypo- and hyper-connectivity in response to socio-emotional stimuli whereas resting state studies report hypoconnectivity between these regions. However, it is still unknown whether ASD-related alterations in amygdala-prefrontal circuitry are present across socio-emotional tasks and resting state contexts within the same sample or instead, depend on context. Method ASD (n?=?47) and typically developing individuals (TD; n?=?72) underwent fMRI during an implicit emotional face processing task and during rest, and whole-brain amygdala connectivity was calculated to determine patterns that differed by context and diagnosis. Results Relative to TD, the ASD group demonstrated weaker left amygdala connectivity with the medial frontal gyrus and the left superior frontal gyrus during rest, but stronger connectivity during task. Furthermore, across both contexts, ASD vs. TD had stronger right amygdala connectivity with the left insula/superior temporal gyrus. Conclusion Findings suggest some alterations in amygdala connectivity of ASD may depend on context while others are pervasive across task and rest conditions. Understanding context-dependent brain alterations in ASD may help disambiguate the mechanisms subserving social impairment and provide targets for treatment. En ligne : https://doi.org/10.1016/j.rasd.2021.101913 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=458

Differences in neural response to extinction recall in young adults with or without history of behavioral inhibition / Tomer SHECHNER in Development and Psychopathology, 30-1 (February 2018)  

Public ISBD [article]  inDevelopment and Psychopathology > 30-1 (February 2018) . - p.179-189 Titre : Differences in neural response to extinction recall in young adults with or without history of behavioral inhibition Type de document : Texte imprimé et/ou numérique Auteurs : Tomer SHECHNER, Auteur ; Nathan A. FOX, Auteur ; Jamie A. MASH, Auteur ; Johanna M. JARCHO, Auteur ; Gang CHEN, Auteur ; Ellen LEIBENLUFT, Auteur ; Daniel S. PINE, Auteur ; Jennifer C. BRITTON, Auteur Article en page(s) : p.179-189 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Behavioral inhibition (BI) is a temperament identified in early childhood that is associated with risk for anxiety disorders, yet only about half of behaviorally inhibited children manifest anxiety later in life. We compared brain function and behavior during extinction recall in a sample of nonanxious young adults characterized in childhood with BI (n = 22) or with no BI (n = 28). Three weeks after undergoing fear conditioning and extinction, participants completed a functional magnetic resonance imaging extinction recall task assessing memory and threat differentiation for conditioned stimuli. While self-report and psychophysiological measures of differential conditioning and extinction were similar across groups, BI-related differences in brain function emerged during extinction recall. Childhood BI was associated with greater activation in subgenual anterior cingulate cortex in response to cues signaling safety. This pattern of results may reflect neural correlates that promote resilience against anxiety in a temperamentally at-risk population. En ligne : https://doi.org/10.1017/S0954579417000554 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=336 [article] Differences in neural response to extinction recall in young adults with or without history of behavioral inhibition [Texte imprimé et/ou numérique] / Tomer SHECHNER, Auteur ; Nathan A. FOX, Auteur ; Jamie A. MASH, Auteur ; Johanna M. JARCHO, Auteur ; Gang CHEN, Auteur ; Ellen LEIBENLUFT, Auteur ; Daniel S. PINE, Auteur ; Jennifer C. BRITTON, Auteur . - p.179-189. Langues : Anglais (eng) in Development and Psychopathology > 30-1 (February 2018) . - p.179-189 Index. décimale : PER Périodiques Résumé : Behavioral inhibition (BI) is a temperament identified in early childhood that is associated with risk for anxiety disorders, yet only about half of behaviorally inhibited children manifest anxiety later in life. We compared brain function and behavior during extinction recall in a sample of nonanxious young adults characterized in childhood with BI (n = 22) or with no BI (n = 28). Three weeks after undergoing fear conditioning and extinction, participants completed a functional magnetic resonance imaging extinction recall task assessing memory and threat differentiation for conditioned stimuli. While self-report and psychophysiological measures of differential conditioning and extinction were similar across groups, BI-related differences in brain function emerged during extinction recall. Childhood BI was associated with greater activation in subgenual anterior cingulate cortex in response to cues signaling safety. This pattern of results may reflect neural correlates that promote resilience against anxiety in a temperamentally at-risk population. En ligne : https://doi.org/10.1017/S0954579417000554 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=336

Irritability and rejection-elicited aggression in adolescents and young adults / Megan QUARMLEY in Journal of Child Psychology and Psychiatry, 64-9 (September 2023)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 64-9 (September 2023) . - p.1346-1358 Titre : Irritability and rejection-elicited aggression in adolescents and young adults Type de document : Texte imprimé et/ou numérique Auteurs : Megan QUARMLEY, Auteur ; Athena VAFIADIS, Auteur ; Johanna M. JARCHO, Auteur Article en page(s) : p.1346-1358 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background Violence exacts staggering personal and financial costs - a burden disproportionally born by adolescents and young adults. This may be partially due to an increased sensitivity to social rejection during this critical phase of development. Irritability, a transdiagnostic symptom, is often elicited by social interactions. Yet, little is known about age differences in social rejection-elicited aggression and irritability. Progress toward testing such relations has been hindered by a lack of ecologically-valid tasks that enable the measurement of in-the-moment social rejection-elicited aggression. Methods In this paper, we describe an initial study of young adults (n=55) that demonstrates the efficacy of a novel Virtual School and Aggression Paradigm (VS-AP). Next, we replicate these results in a second study of adolescents and young adults (ages 11-25?years; n=173) and examine relations between social rejection-elicited aggression, irritability, and age. Results We found that aggressive behavior in the VS-AP differed for accepting, rejecting, and unpredictable peer types (Study 1: F(2, 108)=20.57, p<.001, ?2=.28; Study 2: F(2, 344)=152.13, p<.001, ?2=.47), demonstrating that the VS-AP successfully models social rejection-elicited aggression. In Study 2, age was negatively correlated with aggressive behavior (r=?.29, p<.001) and irritability (r=?.28, p<.001), while irritability was positively correlated with aggressive behavior (r=.28, p<.001). Age moderated the relation between social rejection-elicited aggression and irritability. Specifically, irritability was more predictive of aggression in young adults than in adolescents (F(3, 167)=7.07, p<.001). Conclusions Data suggest mechanisms promoting rejection-elicited aggression may differ across development and vary for those with and without high levels of irritability. The VS-AP is a promising tool for probing neurocognitive, developmental, and clinically relevant mechanisms underlying social rejection-elicited aggression. En ligne : https://doi.org/10.1111/jcpp.13804 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=512 [article] Irritability and rejection-elicited aggression in adolescents and young adults [Texte imprimé et/ou numérique] / Megan QUARMLEY, Auteur ; Athena VAFIADIS, Auteur ; Johanna M. JARCHO, Auteur . - p.1346-1358. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 64-9 (September 2023) . - p.1346-1358 Index. décimale : PER Périodiques Résumé : Background Violence exacts staggering personal and financial costs - a burden disproportionally born by adolescents and young adults. This may be partially due to an increased sensitivity to social rejection during this critical phase of development. Irritability, a transdiagnostic symptom, is often elicited by social interactions. Yet, little is known about age differences in social rejection-elicited aggression and irritability. Progress toward testing such relations has been hindered by a lack of ecologically-valid tasks that enable the measurement of in-the-moment social rejection-elicited aggression. Methods In this paper, we describe an initial study of young adults (n=55) that demonstrates the efficacy of a novel Virtual School and Aggression Paradigm (VS-AP). Next, we replicate these results in a second study of adolescents and young adults (ages 11-25?years; n=173) and examine relations between social rejection-elicited aggression, irritability, and age. Results We found that aggressive behavior in the VS-AP differed for accepting, rejecting, and unpredictable peer types (Study 1: F(2, 108)=20.57, p<.001, ?2=.28; Study 2: F(2, 344)=152.13, p<.001, ?2=.47), demonstrating that the VS-AP successfully models social rejection-elicited aggression. In Study 2, age was negatively correlated with aggressive behavior (r=?.29, p<.001) and irritability (r=?.28, p<.001), while irritability was positively correlated with aggressive behavior (r=.28, p<.001). Age moderated the relation between social rejection-elicited aggression and irritability. Specifically, irritability was more predictive of aggression in young adults than in adolescents (F(3, 167)=7.07, p<.001). Conclusions Data suggest mechanisms promoting rejection-elicited aggression may differ across development and vary for those with and without high levels of irritability. The VS-AP is a promising tool for probing neurocognitive, developmental, and clinically relevant mechanisms underlying social rejection-elicited aggression. En ligne : https://doi.org/10.1111/jcpp.13804 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=512

Lasting associations between early-childhood temperament and late-adolescent reward-circuitry response to peer feedback / Amanda E. GUYER in Development and Psychopathology, 26-1 (February 2014)  

Public ISBD [article]  inDevelopment and Psychopathology > 26-1 (February 2014) . - p.229-243 Titre : Lasting associations between early-childhood temperament and late-adolescent reward-circuitry response to peer feedback Type de document : Texte imprimé et/ou numérique Auteurs : Amanda E. GUYER, Auteur ; Brenda BENSON, Auteur ; Victoria R. CHOATE, Auteur ; Yair BAR-HAIM, Auteur ; Koraly PEREZ-EDGAR, Auteur ; Johanna M. JARCHO, Auteur ; Daniel S. PINE, Auteur ; Monique ERNST, Auteur ; Nathan A. FOX, Auteur ; Eric E. NELSON, Auteur Article en page(s) : p.229-243 Langues : Français (fre) Index. décimale : PER Périodiques Résumé : Behavioral inhibition, a temperament identifiable in infancy, is associated with heightened withdrawal from social encounters. Prior studies raise particular interest in the striatum, which responds uniquely to monetary gains in behaviorally inhibited children followed into adolescence. Although behavioral manifestations of inhibition are expressed primarily in the social domain, it remains unclear whether observed striatal alterations to monetary incentives also extend to social contexts. In the current study, imaging data were acquired from 39 participants (17 males, 22 females; ages 16–18 years) characterized since infancy on measures of behavioral inhibition. A social evaluation task was used to assess neural response to anticipation and receipt of positive and negative feedback from novel peers, classified by participants as being of high or low interest. As with monetary rewards, striatal response patterns differed during both anticipation and receipt of social reward between behaviorally inhibited and noninhibited adolescents. The current results, when combined with prior findings, suggest that early-life temperament predicts altered striatal response in both social and nonsocial contexts and provide support for continuity between temperament measured in early childhood and neural response to social signals measured in late adolescence and early adulthood. En ligne : http://dx.doi.org/10.1017/S0954579413000941 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=224 [article] Lasting associations between early-childhood temperament and late-adolescent reward-circuitry response to peer feedback [Texte imprimé et/ou numérique] / Amanda E. GUYER, Auteur ; Brenda BENSON, Auteur ; Victoria R. CHOATE, Auteur ; Yair BAR-HAIM, Auteur ; Koraly PEREZ-EDGAR, Auteur ; Johanna M. JARCHO, Auteur ; Daniel S. PINE, Auteur ; Monique ERNST, Auteur ; Nathan A. FOX, Auteur ; Eric E. NELSON, Auteur . - p.229-243. Langues : Français (fre) in Development and Psychopathology > 26-1 (February 2014) . - p.229-243 Index. décimale : PER Périodiques Résumé : Behavioral inhibition, a temperament identifiable in infancy, is associated with heightened withdrawal from social encounters. Prior studies raise particular interest in the striatum, which responds uniquely to monetary gains in behaviorally inhibited children followed into adolescence. Although behavioral manifestations of inhibition are expressed primarily in the social domain, it remains unclear whether observed striatal alterations to monetary incentives also extend to social contexts. In the current study, imaging data were acquired from 39 participants (17 males, 22 females; ages 16–18 years) characterized since infancy on measures of behavioral inhibition. A social evaluation task was used to assess neural response to anticipation and receipt of positive and negative feedback from novel peers, classified by participants as being of high or low interest. As with monetary rewards, striatal response patterns differed during both anticipation and receipt of social reward between behaviorally inhibited and noninhibited adolescents. The current results, when combined with prior findings, suggest that early-life temperament predicts altered striatal response in both social and nonsocial contexts and provide support for continuity between temperament measured in early childhood and neural response to social signals measured in late adolescence and early adulthood. En ligne : http://dx.doi.org/10.1017/S0954579413000941 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=224

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