Finger tapping-related activation differences in treatment-naïve pediatric Tourette syndrome: a comparison of the preferred and nonpreferred hand / Veit ROESSNER in Journal of Child Psychology and Psychiatry, 54-3 (March 2013)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 54-3 (March 2013) . - p.273-279 Titre : Finger tapping-related activation differences in treatment-naïve pediatric Tourette syndrome: a comparison of the preferred and nonpreferred hand Type de document : Texte imprimé et/ou numérique Auteurs : Veit ROESSNER, Auteur ; Matthias WITTFOTH, Auteur ; Julia M. AUGUST, Auteur ; Aribert ROTHENBERGER, Auteur ; Jürgen BAUDEWIG, Auteur ; Peter DECHENT, Auteur Article en page(s) : p.273-279 Mots-clés : Finger tapping  motor network  tourette syndrome  primary sensorimotor cortex  children Index. décimale : PER Périodiques Résumé : Background: Disturbances of motor circuitry are commonly encountered in Tourette syndrome (TS). The aim of this study was to investigate simple motor performance differences between boys with TS and healthy controls. Methods: We attempted to provide insight into motor network alterations by studying a group of treatment-naïve patients suffering from ‘pure’ TS, i.e., without comorbid symptomatology at an early stage of disease. We used functional MRI to compare activation patterns during right (preferred) and left (nonpreferred) index finger tapping between 22 TS boys (12.6 ± 1.7 years) and 22 age-matched healthy control boys. Results: Boys with TS revealed altered motor network recruitment for right (dominant) and left (nondominant) index finger tapping. Brain activation patterns in response to index finger tapping of the nonpreferred left hand reflected the most prominent differences, including activation decrease in contralateral sensorimotor cortex while recruiting premotor and prefrontal regions along with the left inferior parietal lobule to a greater extent. Conclusions: This study demonstrates clear functional differences of simple index finger tapping in early-stage TS. We suggest that this reflects the requirement for additional brain networks to keep a normal performance level during the actual task and adaptive mechanisms due to continuous tic suppression and performance in TS. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02584.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=191 [article] Finger tapping-related activation differences in treatment-naïve pediatric Tourette syndrome: a comparison of the preferred and nonpreferred hand [Texte imprimé et/ou numérique] / Veit ROESSNER, Auteur ; Matthias WITTFOTH, Auteur ; Julia M. AUGUST, Auteur ; Aribert ROTHENBERGER, Auteur ; Jürgen BAUDEWIG, Auteur ; Peter DECHENT, Auteur . - p.273-279. in Journal of Child Psychology and Psychiatry > 54-3 (March 2013) . - p.273-279 Mots-clés : Finger tapping  motor network  tourette syndrome  primary sensorimotor cortex  children Index. décimale : PER Périodiques Résumé : Background: Disturbances of motor circuitry are commonly encountered in Tourette syndrome (TS). The aim of this study was to investigate simple motor performance differences between boys with TS and healthy controls. Methods: We attempted to provide insight into motor network alterations by studying a group of treatment-naïve patients suffering from ‘pure’ TS, i.e., without comorbid symptomatology at an early stage of disease. We used functional MRI to compare activation patterns during right (preferred) and left (nonpreferred) index finger tapping between 22 TS boys (12.6 ± 1.7 years) and 22 age-matched healthy control boys. Results: Boys with TS revealed altered motor network recruitment for right (dominant) and left (nondominant) index finger tapping. Brain activation patterns in response to index finger tapping of the nonpreferred left hand reflected the most prominent differences, including activation decrease in contralateral sensorimotor cortex while recruiting premotor and prefrontal regions along with the left inferior parietal lobule to a greater extent. Conclusions: This study demonstrates clear functional differences of simple index finger tapping in early-stage TS. We suggest that this reflects the requirement for additional brain networks to keep a normal performance level during the actual task and adaptive mechanisms due to continuous tic suppression and performance in TS. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02584.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=191

Increased putamen and callosal motor subregion in treatment-naïve boys with Tourette syndrome indicates changes in the bihemispheric motor network / Veit ROESSNER in Journal of Child Psychology and Psychiatry, 52-3 (March 2011)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 52-3 (March 2011) . - p.306-314 Titre : Increased putamen and callosal motor subregion in treatment-naïve boys with Tourette syndrome indicates changes in the bihemispheric motor network Type de document : Texte imprimé et/ou numérique Auteurs : Veit ROESSNER, Auteur ; Sebastian OVERLACK, Auteur ; Carsten SCHMIDT-SAMOA, Auteur ; Jürgen BAUDEWIG, Auteur ; Peter DECHENT, Auteur ; Aribert ROTHENBERGER, Auteur ; Gunther HELMS, Auteur Année de publication : 2011 Article en page(s) : p.306-314 Langues : Anglais (eng) Mots-clés : Tic disorders  Tourette syndrome  corpus callosum  basal ganglia  magnetic resonance imaging  child Index. décimale : PER Périodiques Résumé : Background:  Despite an increasing number of studies, findings of structural brain alterations in patients with Tourette syndrome are still inconsistent. Several confounders (comorbid conditions, medication, gender, age, IQ) might explain these discrepancies. In the present study, these confounders were excluded to identify differences in basal ganglia and corpus callosum size that can be ascribed more probably to Tourette syndrome per se. Methods:  High-resolution T1-weighted structural magnetic resonance images of 49 boys with Tourette syndrome were compared with those of 42 healthy boys. The groups were matched for IQ and age (9 to 15 years). Boys with comorbid conditions and previous treatment were excluded. Volumes of gray and white matter, cerebrospinal fluid as well as the size of the basal ganglia, the thalamus, the corpus callosum and its subregions were estimated. Results:  The left and right putamen and subregion 3 of the corpus callosum were larger in boys with Tourette syndrome than in healthy controls. No differences were found in volumes of caudate nucleus, globus pallidus or thalamus of each hemisphere or in total callosal size and its other subregions. Conclusions:  Bilateral enlargement of the putamen may reflect dopaminergic dysfunction or neuroimmunologic alterations (PANDAS) underlying Tourette syndrome. The larger callosal motor subregion 3 might be a consequence of daily tic activity. Previous divergent volumetric findings might be ascribed to confounding variables like comorbid conditions or medication, or to different imaging methods. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02324.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=118 [article] Increased putamen and callosal motor subregion in treatment-naïve boys with Tourette syndrome indicates changes in the bihemispheric motor network [Texte imprimé et/ou numérique] / Veit ROESSNER, Auteur ; Sebastian OVERLACK, Auteur ; Carsten SCHMIDT-SAMOA, Auteur ; Jürgen BAUDEWIG, Auteur ; Peter DECHENT, Auteur ; Aribert ROTHENBERGER, Auteur ; Gunther HELMS, Auteur . - 2011 . - p.306-314. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 52-3 (March 2011) . - p.306-314 Mots-clés : Tic disorders  Tourette syndrome  corpus callosum  basal ganglia  magnetic resonance imaging  child Index. décimale : PER Périodiques Résumé : Background:  Despite an increasing number of studies, findings of structural brain alterations in patients with Tourette syndrome are still inconsistent. Several confounders (comorbid conditions, medication, gender, age, IQ) might explain these discrepancies. In the present study, these confounders were excluded to identify differences in basal ganglia and corpus callosum size that can be ascribed more probably to Tourette syndrome per se. Methods:  High-resolution T1-weighted structural magnetic resonance images of 49 boys with Tourette syndrome were compared with those of 42 healthy boys. The groups were matched for IQ and age (9 to 15 years). Boys with comorbid conditions and previous treatment were excluded. Volumes of gray and white matter, cerebrospinal fluid as well as the size of the basal ganglia, the thalamus, the corpus callosum and its subregions were estimated. Results:  The left and right putamen and subregion 3 of the corpus callosum were larger in boys with Tourette syndrome than in healthy controls. No differences were found in volumes of caudate nucleus, globus pallidus or thalamus of each hemisphere or in total callosal size and its other subregions. Conclusions:  Bilateral enlargement of the putamen may reflect dopaminergic dysfunction or neuroimmunologic alterations (PANDAS) underlying Tourette syndrome. The larger callosal motor subregion 3 might be a consequence of daily tic activity. Previous divergent volumetric findings might be ascribed to confounding variables like comorbid conditions or medication, or to different imaging methods. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02324.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=118

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