15 recherche sur le mot-clé 'Tourette syndrome'

Altered perception-action binding modulates inhibitory control in Gilles de la Tourette syndrome / Vanessa PETRUO in Journal of Child Psychology and Psychiatry, 60-9 (September 2019)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 60-9 (September 2019) . - p.953-962 Titre : Altered perception-action binding modulates inhibitory control in Gilles de la Tourette syndrome Type de document : texte imprimé Auteurs : Vanessa PETRUO, Auteur ; Benjamin BODMER, Auteur ; Valerie C. BRANDT, Auteur ; Leoni BAUMUNG, Auteur ; Veit ROESSNER, Auteur ; A. MUNCHAU, Auteur ; Christian BESTE, Auteur Article en page(s) : p.953-962 Langues : Anglais (eng) Mots-clés : Tourette syndrome  cognitive control  event related potential  neurophysiology  response inhibition, inferior parietal cortex, theory of event coding Index. décimale : PER Périodiques Résumé : BACKGROUND: Gilles de la Tourette Syndrome (GTS) is a multifaceted neuropsychiatric developmental disorder with onset in childhood or adolescence and frequent remissions in early adulthood. A rather new emerging concept of this syndrome suggests that it is a disorder of purposeful actions, in which sensory processes and their relation to motor responses (actions) play a particularly important role. Thus, this syndrome might be conceived as a condition of altered 'perception-action binding'. In the current study, we test this novel concept in the context of inhibitory control. METHODS: We examined N = 35 adolescent GTS patients and N = 39 healthy controls in a Go/Nogo-task manipulating the complexity of sensory information triggering identical actions; i.e. to inhibit a motor response. This was combined with event-related potential recordings, EEG data decomposition and source localization. RESULTS: GTS patients showed worse performance compared to controls and larger performance differences when inhibitory control had to be exerted using unimodal visual compared to bimodal auditory-visual stimuli. This suggests increased binding between bimodal stimuli and responses leading to increased costs of switching between responses instructed by bimodal and those instructed by unimodal stimuli. The neurophysiological data showed that this was related to mechanisms mediating between stimulus evaluation and response selection; i.e. perception-action binding processes in the right inferior parietal cortex (BA40). CONCLUSIONS: Stimulus-action inhibition binding is stronger in GTS patients than healthy controls and affects inhibitory control corroborating the concept suggesting that GTS might be a condition of altered perception-action integration (binding); i.e. a disorder of purposeful actions. En ligne : http://dx.doi.org/10.1111/jcpp.12938 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=405 [article] Altered perception-action binding modulates inhibitory control in Gilles de la Tourette syndrome [texte imprimé] / Vanessa PETRUO, Auteur ; Benjamin BODMER, Auteur ; Valerie C. BRANDT, Auteur ; Leoni BAUMUNG, Auteur ; Veit ROESSNER, Auteur ; A. MUNCHAU, Auteur ; Christian BESTE, Auteur . - p.953-962. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 60-9 (September 2019) . - p.953-962 Mots-clés : Tourette syndrome  cognitive control  event related potential  neurophysiology  response inhibition, inferior parietal cortex, theory of event coding Index. décimale : PER Périodiques Résumé : BACKGROUND: Gilles de la Tourette Syndrome (GTS) is a multifaceted neuropsychiatric developmental disorder with onset in childhood or adolescence and frequent remissions in early adulthood. A rather new emerging concept of this syndrome suggests that it is a disorder of purposeful actions, in which sensory processes and their relation to motor responses (actions) play a particularly important role. Thus, this syndrome might be conceived as a condition of altered 'perception-action binding'. In the current study, we test this novel concept in the context of inhibitory control. METHODS: We examined N = 35 adolescent GTS patients and N = 39 healthy controls in a Go/Nogo-task manipulating the complexity of sensory information triggering identical actions; i.e. to inhibit a motor response. This was combined with event-related potential recordings, EEG data decomposition and source localization. RESULTS: GTS patients showed worse performance compared to controls and larger performance differences when inhibitory control had to be exerted using unimodal visual compared to bimodal auditory-visual stimuli. This suggests increased binding between bimodal stimuli and responses leading to increased costs of switching between responses instructed by bimodal and those instructed by unimodal stimuli. The neurophysiological data showed that this was related to mechanisms mediating between stimulus evaluation and response selection; i.e. perception-action binding processes in the right inferior parietal cortex (BA40). CONCLUSIONS: Stimulus-action inhibition binding is stronger in GTS patients than healthy controls and affects inhibitory control corroborating the concept suggesting that GTS might be a condition of altered perception-action integration (binding); i.e. a disorder of purposeful actions. En ligne : http://dx.doi.org/10.1111/jcpp.12938 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=405

An observational study of emotion regulation in children with Tourette syndrome / Julie HAGSTRØM in Journal of Child Psychology and Psychiatry, 62-6 (June 2021)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 62-6 (June 2021) . - p.790-797 Titre : An observational study of emotion regulation in children with Tourette syndrome Type de document : texte imprimé Auteurs : Julie HAGSTRØM, Auteur ; Katrine S. SPANG, Auteur ; Signe VANGKILDE, Auteur ; Katrine MAIGAARD, Auteur ; Liselotte SKOV, Auteur ; Anne Katrine PAGSBERG, Auteur ; Jens Richardt MØLLEGAARD JEPSEN, Auteur ; Kerstin J. PLESSEN, Auteur Article en page(s) : p.790-797 Langues : Anglais (eng) Mots-clés : Attention Deficit Disorder with Hyperactivity/epidemiology  Comorbidity  Emotional Regulation  Humans  Tic Disorders  Tourette Syndrome  Emotion regulation  attention-deficit/hyperactivity disorder  premonitory urges  tic severity Index. décimale : PER Périodiques Résumé : BACKGROUND: Explosive outbursts occur in 25%-70% of children with Tourette syndrome (TS) and may cause more distress than the tics themselves. Previous studies have indicated that a comorbid diagnosis of attention-deficit/hyperactivity disorder (ADHD) is associated with emotional dysregulation in TS; however, this relationship has almost exclusively been studied using parent-reported questionnaires. METHODS: We examined emotion regulation (ER) with an observational measure in 150 medication-naïve children aged 7-12 allocated to four groups: Forty-nine children with TS, 23 children with ADHD, 16 children with TS + ADHD, and 62 typically developing controls. We assessed participants' ER ability, as well as parent-child interactions in the context of a complex puzzle task, and coded the observed behavior with the Tangram Emotion Coding Manual (TEC-M). We examined group differences in ER, as well as associations between ER and severity of symptoms pertaining to TS and ADHD. RESULTS: Children with TS did not differ from controls in their ER ability. However, children with ADHD and TS + ADHD had more problems with ER than those with TS only and controls. Finally, parents of children with ADHD displayed more tension during the experimental task. ER ability was not associated with tic severity nor premonitory urges; however, better ER ability was associated with less severe symptoms of ADHD. CONCLUSIONS: This study is the first to evaluate ER with an observational, clinician-rated measure in a controlled social setting in children with TS. Our findings support earlier questionnaire-based studies by showing impaired ER in children with TS + ADHD, but not in children with TS without comorbidity. These findings inform our understanding of the phenomenology of emotional dysregulation in TS and the role of comorbid disorders. En ligne : http://dx.doi.org/10.1111/jcpp.13375 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456 [article] An observational study of emotion regulation in children with Tourette syndrome [texte imprimé] / Julie HAGSTRØM, Auteur ; Katrine S. SPANG, Auteur ; Signe VANGKILDE, Auteur ; Katrine MAIGAARD, Auteur ; Liselotte SKOV, Auteur ; Anne Katrine PAGSBERG, Auteur ; Jens Richardt MØLLEGAARD JEPSEN, Auteur ; Kerstin J. PLESSEN, Auteur . - p.790-797. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 62-6 (June 2021) . - p.790-797 Mots-clés : Attention Deficit Disorder with Hyperactivity/epidemiology  Comorbidity  Emotional Regulation  Humans  Tic Disorders  Tourette Syndrome  Emotion regulation  attention-deficit/hyperactivity disorder  premonitory urges  tic severity Index. décimale : PER Périodiques Résumé : BACKGROUND: Explosive outbursts occur in 25%-70% of children with Tourette syndrome (TS) and may cause more distress than the tics themselves. Previous studies have indicated that a comorbid diagnosis of attention-deficit/hyperactivity disorder (ADHD) is associated with emotional dysregulation in TS; however, this relationship has almost exclusively been studied using parent-reported questionnaires. METHODS: We examined emotion regulation (ER) with an observational measure in 150 medication-naïve children aged 7-12 allocated to four groups: Forty-nine children with TS, 23 children with ADHD, 16 children with TS + ADHD, and 62 typically developing controls. We assessed participants' ER ability, as well as parent-child interactions in the context of a complex puzzle task, and coded the observed behavior with the Tangram Emotion Coding Manual (TEC-M). We examined group differences in ER, as well as associations between ER and severity of symptoms pertaining to TS and ADHD. RESULTS: Children with TS did not differ from controls in their ER ability. However, children with ADHD and TS + ADHD had more problems with ER than those with TS only and controls. Finally, parents of children with ADHD displayed more tension during the experimental task. ER ability was not associated with tic severity nor premonitory urges; however, better ER ability was associated with less severe symptoms of ADHD. CONCLUSIONS: This study is the first to evaluate ER with an observational, clinician-rated measure in a controlled social setting in children with TS. Our findings support earlier questionnaire-based studies by showing impaired ER in children with TS + ADHD, but not in children with TS without comorbidity. These findings inform our understanding of the phenomenology of emotional dysregulation in TS and the role of comorbid disorders. En ligne : http://dx.doi.org/10.1111/jcpp.13375 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456

Editorial: Are we too high on medicinal cannabis in child psychiatry? Examining the evidence in Tourette syndrome / Loren S. HARDEMAN in Journal of Child Psychology and Psychiatry, 66-12 (December 2025)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 66-12 (December 2025) . - p.1781-1783 Titre : Editorial: Are we too high on medicinal cannabis in child psychiatry? Examining the evidence in Tourette syndrome Type de document : texte imprimé Auteurs : Loren S. HARDEMAN, Auteur ; Luis C. FARHAT, Auteur ; Julian KOENIG, Auteur ; Michael H. BLOCH, Auteur Article en page(s) : p.1781-1783 Langues : Anglais (eng) Mots-clés : Tourette syndrome  pharmacotherapy  neurodevelopmental disorders Index. décimale : PER Périodiques Résumé : There has been renewed interest in elucidating the role of the endocannabinoid system on both brain development and psychological phenomena across the lifespan. In parallel to these efforts, the use of cannabis-related drugs for the treatment of psychiatric disorders in the community has increased considerably over the past several years. In an excellent research review article in JCPP, Tansey et al. provide a comprehensive overview of what the field of developmental psychopathology has learned about the endocannabinoid system. The purpose of this Editorial is to build upon the discussion around the current state of evidence for medicinal cannabis for psychiatric disorders, using Tourette syndrome and chronic tic disorders as an illustrative example. En ligne : https://doi.org/10.1111/jcpp.70075 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=572 [article] Editorial: Are we too high on medicinal cannabis in child psychiatry? Examining the evidence in Tourette syndrome [texte imprimé] / Loren S. HARDEMAN, Auteur ; Luis C. FARHAT, Auteur ; Julian KOENIG, Auteur ; Michael H. BLOCH, Auteur . - p.1781-1783. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 66-12 (December 2025) . - p.1781-1783 Mots-clés : Tourette syndrome  pharmacotherapy  neurodevelopmental disorders Index. décimale : PER Périodiques Résumé : There has been renewed interest in elucidating the role of the endocannabinoid system on both brain development and psychological phenomena across the lifespan. In parallel to these efforts, the use of cannabis-related drugs for the treatment of psychiatric disorders in the community has increased considerably over the past several years. In an excellent research review article in JCPP, Tansey et al. provide a comprehensive overview of what the field of developmental psychopathology has learned about the endocannabinoid system. The purpose of this Editorial is to build upon the discussion around the current state of evidence for medicinal cannabis for psychiatric disorders, using Tourette syndrome and chronic tic disorders as an illustrative example. En ligne : https://doi.org/10.1111/jcpp.70075 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=572

Finger tapping-related activation differences in treatment-naïve pediatric Tourette syndrome: a comparison of the preferred and nonpreferred hand / Veit ROESSNER in Journal of Child Psychology and Psychiatry, 54-3 (March 2013)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 54-3 (March 2013) . - p.273-279 Titre : Finger tapping-related activation differences in treatment-naïve pediatric Tourette syndrome: a comparison of the preferred and nonpreferred hand Type de document : texte imprimé Auteurs : Veit ROESSNER, Auteur ; Matthias WITTFOTH, Auteur ; Julia M. AUGUST, Auteur ; Aribert ROTHENBERGER, Auteur ; Jürgen BAUDEWIG, Auteur ; Peter DECHENT, Auteur Article en page(s) : p.273-279 Mots-clés : Finger tapping  motor network  tourette syndrome  primary sensorimotor cortex  children Index. décimale : PER Périodiques Résumé : Background: Disturbances of motor circuitry are commonly encountered in Tourette syndrome (TS). The aim of this study was to investigate simple motor performance differences between boys with TS and healthy controls. Methods: We attempted to provide insight into motor network alterations by studying a group of treatment-naïve patients suffering from ‘pure’ TS, i.e., without comorbid symptomatology at an early stage of disease. We used functional MRI to compare activation patterns during right (preferred) and left (nonpreferred) index finger tapping between 22 TS boys (12.6 ± 1.7 years) and 22 age-matched healthy control boys. Results: Boys with TS revealed altered motor network recruitment for right (dominant) and left (nondominant) index finger tapping. Brain activation patterns in response to index finger tapping of the nonpreferred left hand reflected the most prominent differences, including activation decrease in contralateral sensorimotor cortex while recruiting premotor and prefrontal regions along with the left inferior parietal lobule to a greater extent. Conclusions: This study demonstrates clear functional differences of simple index finger tapping in early-stage TS. We suggest that this reflects the requirement for additional brain networks to keep a normal performance level during the actual task and adaptive mechanisms due to continuous tic suppression and performance in TS. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02584.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=191 [article] Finger tapping-related activation differences in treatment-naïve pediatric Tourette syndrome: a comparison of the preferred and nonpreferred hand [texte imprimé] / Veit ROESSNER, Auteur ; Matthias WITTFOTH, Auteur ; Julia M. AUGUST, Auteur ; Aribert ROTHENBERGER, Auteur ; Jürgen BAUDEWIG, Auteur ; Peter DECHENT, Auteur . - p.273-279. in Journal of Child Psychology and Psychiatry > 54-3 (March 2013) . - p.273-279 Mots-clés : Finger tapping  motor network  tourette syndrome  primary sensorimotor cortex  children Index. décimale : PER Périodiques Résumé : Background: Disturbances of motor circuitry are commonly encountered in Tourette syndrome (TS). The aim of this study was to investigate simple motor performance differences between boys with TS and healthy controls. Methods: We attempted to provide insight into motor network alterations by studying a group of treatment-naïve patients suffering from ‘pure’ TS, i.e., without comorbid symptomatology at an early stage of disease. We used functional MRI to compare activation patterns during right (preferred) and left (nonpreferred) index finger tapping between 22 TS boys (12.6 ± 1.7 years) and 22 age-matched healthy control boys. Results: Boys with TS revealed altered motor network recruitment for right (dominant) and left (nondominant) index finger tapping. Brain activation patterns in response to index finger tapping of the nonpreferred left hand reflected the most prominent differences, including activation decrease in contralateral sensorimotor cortex while recruiting premotor and prefrontal regions along with the left inferior parietal lobule to a greater extent. Conclusions: This study demonstrates clear functional differences of simple index finger tapping in early-stage TS. We suggest that this reflects the requirement for additional brain networks to keep a normal performance level during the actual task and adaptive mechanisms due to continuous tic suppression and performance in TS. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02584.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=191

Increased putamen and callosal motor subregion in treatment-naïve boys with Tourette syndrome indicates changes in the bihemispheric motor network / Veit ROESSNER in Journal of Child Psychology and Psychiatry, 52-3 (March 2011)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 52-3 (March 2011) . - p.306-314 Titre : Increased putamen and callosal motor subregion in treatment-naïve boys with Tourette syndrome indicates changes in the bihemispheric motor network Type de document : texte imprimé Auteurs : Veit ROESSNER, Auteur ; Sebastian OVERLACK, Auteur ; Carsten SCHMIDT-SAMOA, Auteur ; Jürgen BAUDEWIG, Auteur ; Peter DECHENT, Auteur ; Aribert ROTHENBERGER, Auteur ; Gunther HELMS, Auteur Année de publication : 2011 Article en page(s) : p.306-314 Langues : Anglais (eng) Mots-clés : Tic disorders  Tourette syndrome  corpus callosum  basal ganglia  magnetic resonance imaging  child Index. décimale : PER Périodiques Résumé : Background:  Despite an increasing number of studies, findings of structural brain alterations in patients with Tourette syndrome are still inconsistent. Several confounders (comorbid conditions, medication, gender, age, IQ) might explain these discrepancies. In the present study, these confounders were excluded to identify differences in basal ganglia and corpus callosum size that can be ascribed more probably to Tourette syndrome per se. Methods:  High-resolution T1-weighted structural magnetic resonance images of 49 boys with Tourette syndrome were compared with those of 42 healthy boys. The groups were matched for IQ and age (9 to 15 years). Boys with comorbid conditions and previous treatment were excluded. Volumes of gray and white matter, cerebrospinal fluid as well as the size of the basal ganglia, the thalamus, the corpus callosum and its subregions were estimated. Results:  The left and right putamen and subregion 3 of the corpus callosum were larger in boys with Tourette syndrome than in healthy controls. No differences were found in volumes of caudate nucleus, globus pallidus or thalamus of each hemisphere or in total callosal size and its other subregions. Conclusions:  Bilateral enlargement of the putamen may reflect dopaminergic dysfunction or neuroimmunologic alterations (PANDAS) underlying Tourette syndrome. The larger callosal motor subregion 3 might be a consequence of daily tic activity. Previous divergent volumetric findings might be ascribed to confounding variables like comorbid conditions or medication, or to different imaging methods. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02324.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=118 [article] Increased putamen and callosal motor subregion in treatment-naïve boys with Tourette syndrome indicates changes in the bihemispheric motor network [texte imprimé] / Veit ROESSNER, Auteur ; Sebastian OVERLACK, Auteur ; Carsten SCHMIDT-SAMOA, Auteur ; Jürgen BAUDEWIG, Auteur ; Peter DECHENT, Auteur ; Aribert ROTHENBERGER, Auteur ; Gunther HELMS, Auteur . - 2011 . - p.306-314. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 52-3 (March 2011) . - p.306-314 Mots-clés : Tic disorders  Tourette syndrome  corpus callosum  basal ganglia  magnetic resonance imaging  child Index. décimale : PER Périodiques Résumé : Background:  Despite an increasing number of studies, findings of structural brain alterations in patients with Tourette syndrome are still inconsistent. Several confounders (comorbid conditions, medication, gender, age, IQ) might explain these discrepancies. In the present study, these confounders were excluded to identify differences in basal ganglia and corpus callosum size that can be ascribed more probably to Tourette syndrome per se. Methods:  High-resolution T1-weighted structural magnetic resonance images of 49 boys with Tourette syndrome were compared with those of 42 healthy boys. The groups were matched for IQ and age (9 to 15 years). Boys with comorbid conditions and previous treatment were excluded. Volumes of gray and white matter, cerebrospinal fluid as well as the size of the basal ganglia, the thalamus, the corpus callosum and its subregions were estimated. Results:  The left and right putamen and subregion 3 of the corpus callosum were larger in boys with Tourette syndrome than in healthy controls. No differences were found in volumes of caudate nucleus, globus pallidus or thalamus of each hemisphere or in total callosal size and its other subregions. Conclusions:  Bilateral enlargement of the putamen may reflect dopaminergic dysfunction or neuroimmunologic alterations (PANDAS) underlying Tourette syndrome. The larger callosal motor subregion 3 might be a consequence of daily tic activity. Previous divergent volumetric findings might be ascribed to confounding variables like comorbid conditions or medication, or to different imaging methods. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02324.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=118

Inhibitory Deficits in Tourette Syndrome: A Function of Comorbidity and Symptom Severity / Sally OZONOFF in Journal of Child Psychology and Psychiatry, 39-8 (November 1998)

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Parental age and assisted reproductive technology in autism spectrum disorders, attention deficit hyperactivity disorder, and Tourette syndrome in a Japanese population / Takafumi SHIMADA in Research in Autism Spectrum Disorders, 6-1 (January-March 2012)  

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Practitioner Review: Treatments for Tourette syndrome in children and young people – a systematic review / Craig WHITTINGTON in Journal of Child Psychology and Psychiatry, 57-9 (September 2016)  

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A proprietary herbal medicine (5-Ling Granule) for Tourette syndrome: a randomized controlled trial / Yi ZHENG in Journal of Child Psychology and Psychiatry, 57-1 (January 2016)  

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A review of co-occurrence of autism spectrum disorder and Tourette syndrome / Efrosini KALYVA in Research in Autism Spectrum Disorders, 24 (April 2016)  

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