Dépouillements

Ubiquitin-proteasome dependent degradation of GABAAα1 in autism spectrum disorder / Amanda CRIDER in Molecular Autism, (September 2014)  

Public ISBD [article]  inMolecular Autism > (September 2014) . - p.1-10 Titre : Ubiquitin-proteasome dependent degradation of GABAAα1 in autism spectrum disorder Type de document : texte imprimé Auteurs : Amanda CRIDER, Auteur ; Chirayu D. PANDYA, Auteur ; Diya PETER, Auteur ; Anthony O. AHMED, Auteur ; Anilkumar PILLAI, Auteur Article en page(s) : p.1-10 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Although the neurobiological basis of autism spectrum disorder (ASD) is not fully understood, recent studies have indicated the potential role of GABAA receptors in the pathophysiology of ASD. GABAA receptors play a crucial role in various neurodevelopmental processes and adult neuroplasticity. However, the mechanism(s) of regulation of GABAA receptors in ASD remains poorly understood. En ligne : http://dx.doi.org/10.1186/2040-2392-5-45 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=276 [article] Ubiquitin-proteasome dependent degradation of GABAAα1 in autism spectrum disorder [texte imprimé] / Amanda CRIDER, Auteur ; Chirayu D. PANDYA, Auteur ; Diya PETER, Auteur ; Anthony O. AHMED, Auteur ; Anilkumar PILLAI, Auteur . - p.1-10. Langues : Anglais (eng) in Molecular Autism > (September 2014) . - p.1-10 Index. décimale : PER Périodiques Résumé : Although the neurobiological basis of autism spectrum disorder (ASD) is not fully understood, recent studies have indicated the potential role of GABAA receptors in the pathophysiology of ASD. GABAA receptors play a crucial role in various neurodevelopmental processes and adult neuroplasticity. However, the mechanism(s) of regulation of GABAA receptors in ASD remains poorly understood. En ligne : http://dx.doi.org/10.1186/2040-2392-5-45 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=276

Dysregulation of estrogen receptor beta (ERβ), aromatase (CYP19A1), and ER co-activators in the middle frontal gyrus of autism spectrum disorder subjects / Amanda CRIDER in Molecular Autism, (September 2014)  

Public ISBD [article]  inMolecular Autism > (September 2014) . - p.1-10 Titre : Dysregulation of estrogen receptor beta (ERβ), aromatase (CYP19A1), and ER co-activators in the middle frontal gyrus of autism spectrum disorder subjects Type de document : texte imprimé Auteurs : Amanda CRIDER, Auteur ; Roshni THAKKAR, Auteur ; Anthony O. AHMED, Auteur ; Anilkumar PILLAI, Auteur Article en page(s) : p.1-10 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) are much more common in males than in females. Molecular alterations within the estrogen receptor (ER) signaling pathway may contribute to the sex difference in ASD, but the extent of such abnormalities in the brain is not known. En ligne : http://dx.doi.org/10.1186/2040-2392-5-46 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=276 [article] Dysregulation of estrogen receptor beta (ERβ), aromatase (CYP19A1), and ER co-activators in the middle frontal gyrus of autism spectrum disorder subjects [texte imprimé] / Amanda CRIDER, Auteur ; Roshni THAKKAR, Auteur ; Anthony O. AHMED, Auteur ; Anilkumar PILLAI, Auteur . - p.1-10. Langues : Anglais (eng) in Molecular Autism > (September 2014) . - p.1-10 Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) are much more common in males than in females. Molecular alterations within the estrogen receptor (ER) signaling pathway may contribute to the sex difference in ASD, but the extent of such abnormalities in the brain is not known. En ligne : http://dx.doi.org/10.1186/2040-2392-5-46 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=276

Saccadic eye movement abnormalities in autism spectrum disorder indicate dysfunctions in cerebellum and brainstem / Lauren M. SCHMITT in Molecular Autism, (September 2014)  

Public ISBD [article]  inMolecular Autism > (September 2014) . - p.1-13 Titre : Saccadic eye movement abnormalities in autism spectrum disorder indicate dysfunctions in cerebellum and brainstem Type de document : texte imprimé Auteurs : Lauren M. SCHMITT, Auteur ; Edwin H. Jr COOK, Auteur ; John A. SWEENEY, Auteur ; Matthew W. MOSCONI, Auteur Article en page(s) : p.1-13 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Individuals with autism spectrum disorder (ASD) show atypical scan paths during social interaction and when viewing faces, and recent evidence suggests that they also show abnormal saccadic eye movement dynamics and accuracy when viewing less complex and non-social stimuli. Eye movements are a uniquely promising target for studies of ASD as their spatial and temporal characteristics can be measured precisely and the brain circuits supporting them are well-defined. Control of saccade metrics is supported by discrete circuits within the cerebellum and brainstem - two brain regions implicated in magnetic resonance (MR) morphometry and histopathological studies of ASD. The functional integrity of these distinct brain systems can be examined by evaluating different parameters of visually-guided saccades. En ligne : http://dx.doi.org/10.1186/2040-2392-5-47 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=276 [article] Saccadic eye movement abnormalities in autism spectrum disorder indicate dysfunctions in cerebellum and brainstem [texte imprimé] / Lauren M. SCHMITT, Auteur ; Edwin H. Jr COOK, Auteur ; John A. SWEENEY, Auteur ; Matthew W. MOSCONI, Auteur . - p.1-13. Langues : Anglais (eng) in Molecular Autism > (September 2014) . - p.1-13 Index. décimale : PER Périodiques Résumé : Individuals with autism spectrum disorder (ASD) show atypical scan paths during social interaction and when viewing faces, and recent evidence suggests that they also show abnormal saccadic eye movement dynamics and accuracy when viewing less complex and non-social stimuli. Eye movements are a uniquely promising target for studies of ASD as their spatial and temporal characteristics can be measured precisely and the brain circuits supporting them are well-defined. Control of saccade metrics is supported by discrete circuits within the cerebellum and brainstem - two brain regions implicated in magnetic resonance (MR) morphometry and histopathological studies of ASD. The functional integrity of these distinct brain systems can be examined by evaluating different parameters of visually-guided saccades. En ligne : http://dx.doi.org/10.1186/2040-2392-5-47 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=276

Genetic variation in the oxytocin receptor (OXTR) gene is associated with Asperger Syndrome / Agnese DI NAPOLI in Molecular Autism, (September 2014)  

Public ISBD [article]  inMolecular Autism > (September 2014) . - p.1-7 Titre : Genetic variation in the oxytocin receptor (OXTR) gene is associated with Asperger Syndrome Type de document : texte imprimé Auteurs : Agnese DI NAPOLI, Auteur ; Varun WARRIER, Auteur ; Simon BARON-COHEN, Auteur ; Bhismadev CHAKRABARTI, Auteur Article en page(s) : p.1-7 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Autism Spectrum Conditions (ASC) are a group of neurodevelopmental conditions characterized by impairments in communication and social interaction, alongside unusually repetitive behaviors and narrow interests. ASC are highly heritable and have complex patterns of inheritance where multiple genes are involved, alongside environmental and epigenetic factors. Asperger Syndrome (AS) is a subgroup of these conditions, where there is no history of language or cognitive delay. Animal models suggest a role for oxytocin (OXT) and oxytocin receptor (OXTR) genes in social-emotional behaviors, and several studies indicate that the oxytocin/oxytocin receptor system is altered in individuals with ASC. Previous studies have reported associations between genetic variations in the OXTR gene and ASC. En ligne : http://dx.doi.org/10.1186/2040-2392-5-48 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=276 [article] Genetic variation in the oxytocin receptor (OXTR) gene is associated with Asperger Syndrome [texte imprimé] / Agnese DI NAPOLI, Auteur ; Varun WARRIER, Auteur ; Simon BARON-COHEN, Auteur ; Bhismadev CHAKRABARTI, Auteur . - p.1-7. Langues : Anglais (eng) in Molecular Autism > (September 2014) . - p.1-7 Index. décimale : PER Périodiques Résumé : Autism Spectrum Conditions (ASC) are a group of neurodevelopmental conditions characterized by impairments in communication and social interaction, alongside unusually repetitive behaviors and narrow interests. ASC are highly heritable and have complex patterns of inheritance where multiple genes are involved, alongside environmental and epigenetic factors. Asperger Syndrome (AS) is a subgroup of these conditions, where there is no history of language or cognitive delay. Animal models suggest a role for oxytocin (OXT) and oxytocin receptor (OXTR) genes in social-emotional behaviors, and several studies indicate that the oxytocin/oxytocin receptor system is altered in individuals with ASC. Previous studies have reported associations between genetic variations in the OXTR gene and ASC. En ligne : http://dx.doi.org/10.1186/2040-2392-5-48 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=276