[article] 
inJournal of Child Psychology and Psychiatry > 53-6 (June 2012) . - p.706–715

Titre :	Shared genetic influences on ADHD symptoms and very low-frequency EEG activity: a twin study
Type de document :	Texte imprimé et/ou numérique
Auteurs :	Charlotte TYE, Auteur ; Frühling V. RIJSDIJK, Auteur ; Corina U. GREVEN, Auteur ; Jonna KUNTSI, Auteur ; Philip ASHERSON, Auteur ; Gráinne MCLOUGHLIN, Auteur
Année de publication :	2012
Article en page(s) :	p.706–715
Langues :	Anglais (eng)
Mots-clés :	ADHD  EEG  very low-frequency activity  endophenotype  genetics  heritability
Index. décimale :	PER Périodiques
Résumé :	Background:  Attention deficit hyperactivity disorder (ADHD) is a common and highly heritable neurodevelopmental disorder with a complex aetiology. The identification of candidate intermediate phenotypes that are both heritable and genetically linked to ADHD may facilitate the detection of susceptibility genes and elucidate aetiological pathways. Very low-frequency (VLF; <0.5 Hz) electroencephalographic (EEG) activity represents a promising indicator of risk for ADHD, but it currently remains unclear as to whether it is heritable or genetically linked to the disorder. Methods:  Direct-current (DC)-EEG was recorded during a cognitive activation condition in 30 monozygotic and dizygotic adolescent twin pairs concordant or discordant for high ADHD symptom scores, and 37 monozygotic and dizygotic matched-control twin pairs with low ADHD symptom scores. Structural equation modelling was used to quantify the genetic and environmental contributions to the phenotypic covariance between ADHD and VLF activity. Results:  Attention deficit hyperactivity disorder was significantly associated with reduced VLF power during cognitive activation, which suggests reduced synchronization of widespread neuronal activity. Very low-frequency power demonstrated modest heritability (0.31), and the genetic correlation (−0.80) indicated a substantial degree of overlap in genetic influences on ADHD and VLF activity. Conclusions:  Altered VLF activity is a potential candidate intermediate phenotype of ADHD, which warrants further investigation of underlying neurobiological and genetic mechanisms.
En ligne :	http://dx.doi.org/10.1111/j.1469-7610.2011.02501.x
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=157

[article] Shared genetic influences on ADHD symptoms and very low-frequency EEG activity: a twin study [Texte imprimé et/ou numérique] / Charlotte TYE, Auteur ; Frühling V. RIJSDIJK, Auteur ; Corina U. GREVEN, Auteur ; Jonna KUNTSI, Auteur ; Philip ASHERSON, Auteur ; Gráinne MCLOUGHLIN, Auteur . - 2012 . - p.706–715.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 53-6 (June 2012) . - p.706–715

Mots-clés :	ADHD  EEG  very low-frequency activity  endophenotype  genetics  heritability
Index. décimale :	PER Périodiques
Résumé :	Background:  Attention deficit hyperactivity disorder (ADHD) is a common and highly heritable neurodevelopmental disorder with a complex aetiology. The identification of candidate intermediate phenotypes that are both heritable and genetically linked to ADHD may facilitate the detection of susceptibility genes and elucidate aetiological pathways. Very low-frequency (VLF; <0.5 Hz) electroencephalographic (EEG) activity represents a promising indicator of risk for ADHD, but it currently remains unclear as to whether it is heritable or genetically linked to the disorder. Methods:  Direct-current (DC)-EEG was recorded during a cognitive activation condition in 30 monozygotic and dizygotic adolescent twin pairs concordant or discordant for high ADHD symptom scores, and 37 monozygotic and dizygotic matched-control twin pairs with low ADHD symptom scores. Structural equation modelling was used to quantify the genetic and environmental contributions to the phenotypic covariance between ADHD and VLF activity. Results:  Attention deficit hyperactivity disorder was significantly associated with reduced VLF power during cognitive activation, which suggests reduced synchronization of widespread neuronal activity. Very low-frequency power demonstrated modest heritability (0.31), and the genetic correlation (−0.80) indicated a substantial degree of overlap in genetic influences on ADHD and VLF activity. Conclusions:  Altered VLF activity is a potential candidate intermediate phenotype of ADHD, which warrants further investigation of underlying neurobiological and genetic mechanisms.
En ligne :	http://dx.doi.org/10.1111/j.1469-7610.2011.02501.x
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=157