Non-Invasive Evaluation of the GABAergic/Glutamatergic System in Autistic Patients Observed by MEGA-Editing Proton MR Spectroscopy Using a Clinical 3 Tesla Instrument / Masafumi HARADA in Journal of Autism and Developmental Disorders, 41-4 (April 2011)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 41-4 (April 2011) . - p.447-454 Titre : Non-Invasive Evaluation of the GABAergic/Glutamatergic System in Autistic Patients Observed by MEGA-Editing Proton MR Spectroscopy Using a Clinical 3 Tesla Instrument Type de document : Texte imprimé et/ou numérique Auteurs : Masafumi HARADA, Auteur ; Masako M. TAKI, Auteur ; Ayumi NOSE, Auteur ; Hitoshi KUBO, Auteur ; Kenji MORI, Auteur ; Hiromu NISHITANI, Auteur ; Tsuyoshi MATSUDA, Auteur Année de publication : 2011 Article en page(s) : p.447-454 Langues : Anglais (eng) Mots-clés : GABA  Glutamate  Autism  MRS  MEGA-editing  NAA Index. décimale : PER Périodiques Résumé : Amino acids related to neurotransmitters and the GABAergic/glutamatergic system were measured using a 3 T-MRI instrument in 12 patients with autism and 10 normal controls. All measurements were performed in the frontal lobe (FL) and lenticular nuclei (LN) using a conventional sequence for n-acetyl aspartate (NAA) and glutamate (Glu), and the MEGA-editing method for GABA. The GABA level and [GABA]/[NAA] ratio were significantly lower (p < 0.01) in the FL, but not the LN, in patients with autism compared to normal controls. The [GABA]/[Glu] ratio in the FL was also significantly lower (p < 0.05) in the patients than in the normal controls, thus suggesting a possible abnormality in the regulation between GABA and Glu. En ligne : http://dx.doi.org/10.1007/s10803-010-1065-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=119 [article] Non-Invasive Evaluation of the GABAergic/Glutamatergic System in Autistic Patients Observed by MEGA-Editing Proton MR Spectroscopy Using a Clinical 3 Tesla Instrument [Texte imprimé et/ou numérique] / Masafumi HARADA, Auteur ; Masako M. TAKI, Auteur ; Ayumi NOSE, Auteur ; Hitoshi KUBO, Auteur ; Kenji MORI, Auteur ; Hiromu NISHITANI, Auteur ; Tsuyoshi MATSUDA, Auteur . - 2011 . - p.447-454. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 41-4 (April 2011) . - p.447-454 Mots-clés : GABA  Glutamate  Autism  MRS  MEGA-editing  NAA Index. décimale : PER Périodiques Résumé : Amino acids related to neurotransmitters and the GABAergic/glutamatergic system were measured using a 3 T-MRI instrument in 12 patients with autism and 10 normal controls. All measurements were performed in the frontal lobe (FL) and lenticular nuclei (LN) using a conventional sequence for n-acetyl aspartate (NAA) and glutamate (Glu), and the MEGA-editing method for GABA. The GABA level and [GABA]/[NAA] ratio were significantly lower (p < 0.01) in the FL, but not the LN, in patients with autism compared to normal controls. The [GABA]/[Glu] ratio in the FL was also significantly lower (p < 0.05) in the patients than in the normal controls, thus suggesting a possible abnormality in the regulation between GABA and Glu. En ligne : http://dx.doi.org/10.1007/s10803-010-1065-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=119

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