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Further Commentary on Mitochondrial Dysfunction in Autism Spectrum Disorder: Assessment and Treatment Considerations / Stephen R. DAGER in Journal of Autism and Developmental Disorders, 42-4 (April 2012)
[article]
Titre : Further Commentary on Mitochondrial Dysfunction in Autism Spectrum Disorder: Assessment and Treatment Considerations Type de document : Texte imprimé et/ou numérique Auteurs : Stephen R. DAGER, Auteur ; Neva M. CORRIGAN, Auteur ; Annette ESTES, Auteur ; Dennis W.W. SHAW, Auteur Année de publication : 2012 Article en page(s) : p.643-646 Langues : Anglais (eng) Mots-clés : Autism Developmental disorders MRS MRI Mitochondrial disorders Brain lactate Index. décimale : PER Périodiques Résumé : The authors respond to a recent letter (Rossignol and Frye 2011 ) critical of their paper, “Proton magnetic resonance spectroscopy and MRI reveal no evidence for brain mitochondrial dysfunction in children with autism spectrum disorder” (Corrigan et al. 2011 ). Further considerations regarding the assessment of mitochondrial dysfunction in autism spectrum disorder, and related treatment considerations, are discussed. En ligne : http://dx.doi.org/10.1007/s10803-011-1352-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=154
in Journal of Autism and Developmental Disorders > 42-4 (April 2012) . - p.643-646[article] Further Commentary on Mitochondrial Dysfunction in Autism Spectrum Disorder: Assessment and Treatment Considerations [Texte imprimé et/ou numérique] / Stephen R. DAGER, Auteur ; Neva M. CORRIGAN, Auteur ; Annette ESTES, Auteur ; Dennis W.W. SHAW, Auteur . - 2012 . - p.643-646.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 42-4 (April 2012) . - p.643-646
Mots-clés : Autism Developmental disorders MRS MRI Mitochondrial disorders Brain lactate Index. décimale : PER Périodiques Résumé : The authors respond to a recent letter (Rossignol and Frye 2011 ) critical of their paper, “Proton magnetic resonance spectroscopy and MRI reveal no evidence for brain mitochondrial dysfunction in children with autism spectrum disorder” (Corrigan et al. 2011 ). Further considerations regarding the assessment of mitochondrial dysfunction in autism spectrum disorder, and related treatment considerations, are discussed. En ligne : http://dx.doi.org/10.1007/s10803-011-1352-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=154 Non-Invasive Evaluation of the GABAergic/Glutamatergic System in Autistic Patients Observed by MEGA-Editing Proton MR Spectroscopy Using a Clinical 3 Tesla Instrument / Masafumi HARADA in Journal of Autism and Developmental Disorders, 41-4 (April 2011)
[article]
Titre : Non-Invasive Evaluation of the GABAergic/Glutamatergic System in Autistic Patients Observed by MEGA-Editing Proton MR Spectroscopy Using a Clinical 3 Tesla Instrument Type de document : Texte imprimé et/ou numérique Auteurs : Masafumi HARADA, Auteur ; Masako M. TAKI, Auteur ; Ayumi NOSE, Auteur ; Hitoshi KUBO, Auteur ; Kenji MORI, Auteur ; Hiromu NISHITANI, Auteur ; Tsuyoshi MATSUDA, Auteur Année de publication : 2011 Article en page(s) : p.447-454 Langues : Anglais (eng) Mots-clés : GABA Glutamate Autism MRS MEGA-editing NAA Index. décimale : PER Périodiques Résumé : Amino acids related to neurotransmitters and the GABAergic/glutamatergic system were measured using a 3 T-MRI instrument in 12 patients with autism and 10 normal controls. All measurements were performed in the frontal lobe (FL) and lenticular nuclei (LN) using a conventional sequence for n-acetyl aspartate (NAA) and glutamate (Glu), and the MEGA-editing method for GABA. The GABA level and [GABA]/[NAA] ratio were significantly lower (p < 0.01) in the FL, but not the LN, in patients with autism compared to normal controls. The [GABA]/[Glu] ratio in the FL was also significantly lower (p < 0.05) in the patients than in the normal controls, thus suggesting a possible abnormality in the regulation between GABA and Glu. En ligne : http://dx.doi.org/10.1007/s10803-010-1065-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=119
in Journal of Autism and Developmental Disorders > 41-4 (April 2011) . - p.447-454[article] Non-Invasive Evaluation of the GABAergic/Glutamatergic System in Autistic Patients Observed by MEGA-Editing Proton MR Spectroscopy Using a Clinical 3 Tesla Instrument [Texte imprimé et/ou numérique] / Masafumi HARADA, Auteur ; Masako M. TAKI, Auteur ; Ayumi NOSE, Auteur ; Hitoshi KUBO, Auteur ; Kenji MORI, Auteur ; Hiromu NISHITANI, Auteur ; Tsuyoshi MATSUDA, Auteur . - 2011 . - p.447-454.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 41-4 (April 2011) . - p.447-454
Mots-clés : GABA Glutamate Autism MRS MEGA-editing NAA Index. décimale : PER Périodiques Résumé : Amino acids related to neurotransmitters and the GABAergic/glutamatergic system were measured using a 3 T-MRI instrument in 12 patients with autism and 10 normal controls. All measurements were performed in the frontal lobe (FL) and lenticular nuclei (LN) using a conventional sequence for n-acetyl aspartate (NAA) and glutamate (Glu), and the MEGA-editing method for GABA. The GABA level and [GABA]/[NAA] ratio were significantly lower (p < 0.01) in the FL, but not the LN, in patients with autism compared to normal controls. The [GABA]/[Glu] ratio in the FL was also significantly lower (p < 0.05) in the patients than in the normal controls, thus suggesting a possible abnormality in the regulation between GABA and Glu. En ligne : http://dx.doi.org/10.1007/s10803-010-1065-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=119 Proton Magnetic Resonance Spectroscopy and MRI Reveal No Evidence for Brain Mitochondrial Dysfunction in Children with Autism Spectrum Disorder / Neva M. CORRIGAN in Journal of Autism and Developmental Disorders, 42-1 (January 2012)
[article]
Titre : Proton Magnetic Resonance Spectroscopy and MRI Reveal No Evidence for Brain Mitochondrial Dysfunction in Children with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Neva M. CORRIGAN, Auteur ; Dennis W.W. SHAW, Auteur ; Todd RICHARDS, Auteur ; Annette ESTES, Auteur ; Seth D. FRIEDMAN, Auteur ; Helen PETROPOULOS, Auteur ; Alan ARTRU, Auteur ; Stephen R. DAGER, Auteur Année de publication : 2012 Article en page(s) : p.105-115 Langues : Anglais (eng) Mots-clés : Autism Developmental disorders MRS MRI Mitochondrial disorders Brain metabolism Lactate Index. décimale : PER Périodiques Résumé : Brain mitochondrial dysfunction has been proposed as an etiologic factor in autism spectrum disorder (ASD). Proton magnetic resonance spectroscopic imaging ( 1 HMRS) and MRI were used to assess for evidence of brain mitochondrial dysfunction in longitudinal samples of children with ASD or developmental delay (DD), and cross-sectionally in typically developing (TD) children at 3–4, 6–7 and 9–10 years-of-age. A total of 239 studies from 130 unique participants (54ASD, 22DD, 54TD) were acquired. 1 HMRS and MRI revealed no evidence for brain mitochondrial dysfunction in the children with ASD. Findings do not support a substantive role for brain mitochondrial abnormalities in the etiology or symptom expression of ASD, nor the widespread use of hyperbaric oxygen treatment that has been advocated on the basis of this proposed relationship. En ligne : http://dx.doi.org/10.1007/s10803-011-1216-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=151
in Journal of Autism and Developmental Disorders > 42-1 (January 2012) . - p.105-115[article] Proton Magnetic Resonance Spectroscopy and MRI Reveal No Evidence for Brain Mitochondrial Dysfunction in Children with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Neva M. CORRIGAN, Auteur ; Dennis W.W. SHAW, Auteur ; Todd RICHARDS, Auteur ; Annette ESTES, Auteur ; Seth D. FRIEDMAN, Auteur ; Helen PETROPOULOS, Auteur ; Alan ARTRU, Auteur ; Stephen R. DAGER, Auteur . - 2012 . - p.105-115.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 42-1 (January 2012) . - p.105-115
Mots-clés : Autism Developmental disorders MRS MRI Mitochondrial disorders Brain metabolism Lactate Index. décimale : PER Périodiques Résumé : Brain mitochondrial dysfunction has been proposed as an etiologic factor in autism spectrum disorder (ASD). Proton magnetic resonance spectroscopic imaging ( 1 HMRS) and MRI were used to assess for evidence of brain mitochondrial dysfunction in longitudinal samples of children with ASD or developmental delay (DD), and cross-sectionally in typically developing (TD) children at 3–4, 6–7 and 9–10 years-of-age. A total of 239 studies from 130 unique participants (54ASD, 22DD, 54TD) were acquired. 1 HMRS and MRI revealed no evidence for brain mitochondrial dysfunction in the children with ASD. Findings do not support a substantive role for brain mitochondrial abnormalities in the etiology or symptom expression of ASD, nor the widespread use of hyperbaric oxygen treatment that has been advocated on the basis of this proposed relationship. En ligne : http://dx.doi.org/10.1007/s10803-011-1216-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=151 Reduced GABA and altered somatosensory function in children with autism spectrum disorder / Nicolaas A. J. PUTS in Autism Research, 10-4 (April 2017)
[article]
Titre : Reduced GABA and altered somatosensory function in children with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Nicolaas A. J. PUTS, Auteur ; Ericka L. WODKA, Auteur ; Ashley D. HARRIS, Auteur ; Deana CROCETTI, Auteur ; Mark TOMMERDAHL, Auteur ; Stewart H. MOSTOFSKY, Auteur ; Richard A. E. EDDEN, Auteur Article en page(s) : p.608-619 Langues : Anglais (eng) Mots-clés : autism somatosensory GABA magnetic resonance spectroscopy tactile MRS touch Index. décimale : PER Périodiques Résumé : Background: Abnormal responses to tactile stimuli are a common feature of autism spectrum disorder (ASD). Several lines of evidence suggest that GABAergic function, which has a crucial role in tactile processing, is altered in ASD. In this study, we determine whether in vivo GABA levels are altered in children with ASD, and whether alterations in GABA levels are associated with abnormal tactile function in these children. Methods: GABA-edited magnetic resonance spectroscopy was acquired in 37 children with Autism and 35 typically developing children (TDC) from voxels over primary sensorimotor and occipital cortices. Children performed tactile tasks previously shown to be altered in ASD, linked to inhibitory mechanisms. Detection threshold was measured with- and without the presence of a slowly increasing sub-threshold stimulus. Amplitude discrimination was measured with- and without the presence of an adapting stimulus, and frequency discrimination was measured. Results: Sensorimotor GABA levels were significantly reduced in children with autism compared to healthy controls. Occipital GABA levels were normal. Sensorimotor GABA levels correlated with dynamic detection threshold as well as with the effect of sub-threshold stimulation. Sensorimotor GABA levels also correlated with amplitude discrimination after adaptation (an effect absent in autism) and frequency discrimination in controls, but not in children with autism. Conclusions: GABA levels correlate with behavioral measures of inhibition. Children with autism have reduced GABA, associated with abnormalities in tactile performance. We show here that altered in vivo GABA levels might predict abnormal tactile information processing in ASD and that the GABA system may be a future target for therapies. En ligne : http://dx.doi.org/10.1002/aur.1691 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307
in Autism Research > 10-4 (April 2017) . - p.608-619[article] Reduced GABA and altered somatosensory function in children with autism spectrum disorder [Texte imprimé et/ou numérique] / Nicolaas A. J. PUTS, Auteur ; Ericka L. WODKA, Auteur ; Ashley D. HARRIS, Auteur ; Deana CROCETTI, Auteur ; Mark TOMMERDAHL, Auteur ; Stewart H. MOSTOFSKY, Auteur ; Richard A. E. EDDEN, Auteur . - p.608-619.
Langues : Anglais (eng)
in Autism Research > 10-4 (April 2017) . - p.608-619
Mots-clés : autism somatosensory GABA magnetic resonance spectroscopy tactile MRS touch Index. décimale : PER Périodiques Résumé : Background: Abnormal responses to tactile stimuli are a common feature of autism spectrum disorder (ASD). Several lines of evidence suggest that GABAergic function, which has a crucial role in tactile processing, is altered in ASD. In this study, we determine whether in vivo GABA levels are altered in children with ASD, and whether alterations in GABA levels are associated with abnormal tactile function in these children. Methods: GABA-edited magnetic resonance spectroscopy was acquired in 37 children with Autism and 35 typically developing children (TDC) from voxels over primary sensorimotor and occipital cortices. Children performed tactile tasks previously shown to be altered in ASD, linked to inhibitory mechanisms. Detection threshold was measured with- and without the presence of a slowly increasing sub-threshold stimulus. Amplitude discrimination was measured with- and without the presence of an adapting stimulus, and frequency discrimination was measured. Results: Sensorimotor GABA levels were significantly reduced in children with autism compared to healthy controls. Occipital GABA levels were normal. Sensorimotor GABA levels correlated with dynamic detection threshold as well as with the effect of sub-threshold stimulation. Sensorimotor GABA levels also correlated with amplitude discrimination after adaptation (an effect absent in autism) and frequency discrimination in controls, but not in children with autism. Conclusions: GABA levels correlate with behavioral measures of inhibition. Children with autism have reduced GABA, associated with abnormalities in tactile performance. We show here that altered in vivo GABA levels might predict abnormal tactile information processing in ASD and that the GABA system may be a future target for therapies. En ligne : http://dx.doi.org/10.1002/aur.1691 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307