Biological embedding of neighborhood disadvantage and collective efficacy: Influences on chronic illness via accelerated cardiometabolic age / Man-Kit LEI in Development and Psychopathology, 30-5 (December 2018)  

Public ISBD [article]  inDevelopment and Psychopathology > 30-5 (December 2018) . - p.1797-1815 Titre : Biological embedding of neighborhood disadvantage and collective efficacy: Influences on chronic illness via accelerated cardiometabolic age Type de document : Texte imprimé et/ou numérique Auteurs : Man-Kit LEI, Auteur ; Steven R. H. BEACH, Auteur ; Ronald L. SIMONS, Auteur Article en page(s) : p.1797-1815 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The present study extends prior research on the link between neighborhood disadvantage and chronic illness by testing an integrated model in which neighborhood characteristics exert effects on health conditions through accelerated cardiometabolic aging. Hypotheses were tested using a sample of 408 African Americans from the Family and Community Health Study. Using four waves of data spanning young adulthood (ages 18–29), we first found durable effects of neighborhood disadvantage on accelerated cardiometabolic aging and chronic illness. Then, we used marginal structural modeling to adjust for potential neighborhood selection effects. As expected, accelerated cardiometabolic aging was the biopsychosocial mechanism that mediated much of the association between neighborhood disadvantage and chronic illness. This finding provides additional support for the view that neighborhood disadvantage can influence morbidity and mortality by creating social contexts that becomes biologically embedded. Perceived neighborhood collective efficacy served to buffer the relationship between neighborhood disadvantage and biological aging, identifying neighborhood-level resilience factor. Overall, our results indicate that neighborhood context serves as a fundamental cause of weathering and accelerated biological aging. Residing in a disadvantaged neighborhood increases biological wear and tear that ultimately leads to onset of chronic illness, but access to perceived collective efficacy buffers the impact of these neighborhood effects. From an intervention standpoint, identifying such an integrated model may help inform future health-promoting interventions. En ligne : http://dx.doi.org/10.1017/S0954579418000937 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=370 [article] Biological embedding of neighborhood disadvantage and collective efficacy: Influences on chronic illness via accelerated cardiometabolic age [Texte imprimé et/ou numérique] / Man-Kit LEI, Auteur ; Steven R. H. BEACH, Auteur ; Ronald L. SIMONS, Auteur . - p.1797-1815. Langues : Anglais (eng) in Development and Psychopathology > 30-5 (December 2018) . - p.1797-1815 Index. décimale : PER Périodiques Résumé : The present study extends prior research on the link between neighborhood disadvantage and chronic illness by testing an integrated model in which neighborhood characteristics exert effects on health conditions through accelerated cardiometabolic aging. Hypotheses were tested using a sample of 408 African Americans from the Family and Community Health Study. Using four waves of data spanning young adulthood (ages 18–29), we first found durable effects of neighborhood disadvantage on accelerated cardiometabolic aging and chronic illness. Then, we used marginal structural modeling to adjust for potential neighborhood selection effects. As expected, accelerated cardiometabolic aging was the biopsychosocial mechanism that mediated much of the association between neighborhood disadvantage and chronic illness. This finding provides additional support for the view that neighborhood disadvantage can influence morbidity and mortality by creating social contexts that becomes biologically embedded. Perceived neighborhood collective efficacy served to buffer the relationship between neighborhood disadvantage and biological aging, identifying neighborhood-level resilience factor. Overall, our results indicate that neighborhood context serves as a fundamental cause of weathering and accelerated biological aging. Residing in a disadvantaged neighborhood increases biological wear and tear that ultimately leads to onset of chronic illness, but access to perceived collective efficacy buffers the impact of these neighborhood effects. From an intervention standpoint, identifying such an integrated model may help inform future health-promoting interventions. En ligne : http://dx.doi.org/10.1017/S0954579418000937 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=370

Childhood adversity is linked to adult health among African Americans via adolescent weight gain and effects are genetically moderated / Steven R. H. BEACH in Development and Psychopathology, 33-3 (August 2021)  

Public ISBD [article]  inDevelopment and Psychopathology > 33-3 (August 2021) . - p.803-820 Titre : Childhood adversity is linked to adult health among African Americans via adolescent weight gain and effects are genetically moderated Type de document : Texte imprimé et/ou numérique Auteurs : Steven R. H. BEACH, Auteur ; Mei Ling ONG, Auteur ; Man-Kit LEI, Auteur ; Eric KLOPACK, Auteur ; Sierra E. CARTER, Auteur ; Ronald L. SIMONS, Auteur ; Frederick X. GIBBONS, Auteur ; Justin A. LAVNER, Auteur ; Robert A. PHILIBERT, Auteur ; Kaixiong YE, Auteur Article en page(s) : p.803-820 Langues : Anglais (eng) Mots-clés : African American  childhood adversity  genetic risk  health disparities  obesity Index. décimale : PER Périodiques Résumé : Identifying the mechanisms linking early experiences, genetic risk factors, and their interaction with later health consequences is central to the development of preventive interventions and identifying potential boundary conditions for their efficacy. In the current investigation of 412 African American adolescents followed across a 20-year period, we examined change in body mass index (BMI) across adolescence as one possible mechanism linking childhood adversity and adult health. We found associations of childhood adversity with objective indicators of young adult health, including a cardiometabolic risk index, a methylomic aging index, and a count of chronic health conditions. Childhood adversities were associated with objective indicators indirectly through their association with gains in BMI across adolescence and early adulthood. We also found evidence of an association of genetic risk with weight gain across adolescence and young adult health, as well as genetic moderation of childhood adversity's effect on gains in BMI, resulting in moderated mediation. These patterns indicated that genetic risk moderated the indirect pathways from childhood adversity to young adult health outcomes and childhood adversity moderated the indirect pathways from genetic risk to young adult health outcomes through effects on weight gain during adolescence and early adulthood. En ligne : http://dx.doi.org/10.1017/S0954579420000061 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457 [article] Childhood adversity is linked to adult health among African Americans via adolescent weight gain and effects are genetically moderated [Texte imprimé et/ou numérique] / Steven R. H. BEACH, Auteur ; Mei Ling ONG, Auteur ; Man-Kit LEI, Auteur ; Eric KLOPACK, Auteur ; Sierra E. CARTER, Auteur ; Ronald L. SIMONS, Auteur ; Frederick X. GIBBONS, Auteur ; Justin A. LAVNER, Auteur ; Robert A. PHILIBERT, Auteur ; Kaixiong YE, Auteur . - p.803-820. Langues : Anglais (eng) in Development and Psychopathology > 33-3 (August 2021) . - p.803-820 Mots-clés : African American  childhood adversity  genetic risk  health disparities  obesity Index. décimale : PER Périodiques Résumé : Identifying the mechanisms linking early experiences, genetic risk factors, and their interaction with later health consequences is central to the development of preventive interventions and identifying potential boundary conditions for their efficacy. In the current investigation of 412 African American adolescents followed across a 20-year period, we examined change in body mass index (BMI) across adolescence as one possible mechanism linking childhood adversity and adult health. We found associations of childhood adversity with objective indicators of young adult health, including a cardiometabolic risk index, a methylomic aging index, and a count of chronic health conditions. Childhood adversities were associated with objective indicators indirectly through their association with gains in BMI across adolescence and early adulthood. We also found evidence of an association of genetic risk with weight gain across adolescence and young adult health, as well as genetic moderation of childhood adversity's effect on gains in BMI, resulting in moderated mediation. These patterns indicated that genetic risk moderated the indirect pathways from childhood adversity to young adult health outcomes and childhood adversity moderated the indirect pathways from genetic risk to young adult health outcomes through effects on weight gain during adolescence and early adulthood. En ligne : http://dx.doi.org/10.1017/S0954579420000061 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457

Childhood adversity predicts black young adults? DNA methylation-based accelerated aging: A dual pathway model / Steven R. H. BEACH in Development and Psychopathology, 34-2 (May 2022)  

Public ISBD [article]  inDevelopment and Psychopathology > 34-2 (May 2022) . - 689-703 Titre : Childhood adversity predicts black young adults? DNA methylation-based accelerated aging: A dual pathway model Type de document : Texte imprimé et/ou numérique Auteurs : Steven R. H. BEACH, Auteur ; Frederick X. GIBBONS, Auteur ; Sierra E. CARTER, Auteur ; Mei Ling ONG, Auteur ; Justin A. LAVNER, Auteur ; Man-Kit LEI, Auteur ; Ronald L. SIMONS, Auteur ; Meg GERRARD, Auteur ; Robert A. PHILIBERT, Auteur Article en page(s) : 689-703 Langues : Anglais (eng) Mots-clés : discrimination  DNAm-aging  FKBP5  Life History Index. décimale : PER Périodiques Résumé : We expand upon prior work (Gibbons et al., ) relating childhood stressor effects, particularly harsh childhood environments, to risky behavior and ultimately physical health by adding longer-term outcomes ? deoxyribonucleic acid (DNA) methylation-based measures of accelerated aging (DNAm-aging). Further, following work on the effects of early exposure to danger (McLaughlin et al., ), we also identify an additional pathway from harsh childhood environments to DNAm-aging that we label the danger/FKBP5 pathway, which includes early exposure to dangerous community conditions that are thought to impact glucocorticoid regulation and pro-inflammatory mechanisms. Because different DNAm-aging indices provide different windows on accelerated aging, we contrast effects on early indices of DNAm-aging based on chronological age with later indices that focused on predicting biological outcomes. We utilize data from Family and Community Health Study participants (N = 449) from age 10 to 29. We find that harshness influences parenting, which, in turn, influences accelerated DNAm-aging through the risky cognitions and substance use (i.e., behavioral) pathway outlined by Gibbons et al. (). Harshness is also associated with increased exposure to threat/danger, which, in turn, leads to accelerated DNAm-aging through effects on FKBP5 activity and enhanced pro-inflammatory tendencies (i.e., the danger/FKBP5 pathway). En ligne : http://dx.doi.org/10.1017/s0954579421001541 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=474 [article] Childhood adversity predicts black young adults? DNA methylation-based accelerated aging: A dual pathway model [Texte imprimé et/ou numérique] / Steven R. H. BEACH, Auteur ; Frederick X. GIBBONS, Auteur ; Sierra E. CARTER, Auteur ; Mei Ling ONG, Auteur ; Justin A. LAVNER, Auteur ; Man-Kit LEI, Auteur ; Ronald L. SIMONS, Auteur ; Meg GERRARD, Auteur ; Robert A. PHILIBERT, Auteur . - 689-703. Langues : Anglais (eng) in Development and Psychopathology > 34-2 (May 2022) . - 689-703 Mots-clés : discrimination  DNAm-aging  FKBP5  Life History Index. décimale : PER Périodiques Résumé : We expand upon prior work (Gibbons et al., ) relating childhood stressor effects, particularly harsh childhood environments, to risky behavior and ultimately physical health by adding longer-term outcomes ? deoxyribonucleic acid (DNA) methylation-based measures of accelerated aging (DNAm-aging). Further, following work on the effects of early exposure to danger (McLaughlin et al., ), we also identify an additional pathway from harsh childhood environments to DNAm-aging that we label the danger/FKBP5 pathway, which includes early exposure to dangerous community conditions that are thought to impact glucocorticoid regulation and pro-inflammatory mechanisms. Because different DNAm-aging indices provide different windows on accelerated aging, we contrast effects on early indices of DNAm-aging based on chronological age with later indices that focused on predicting biological outcomes. We utilize data from Family and Community Health Study participants (N = 449) from age 10 to 29. We find that harshness influences parenting, which, in turn, influences accelerated DNAm-aging through the risky cognitions and substance use (i.e., behavioral) pathway outlined by Gibbons et al. (). Harshness is also associated with increased exposure to threat/danger, which, in turn, leads to accelerated DNAm-aging through effects on FKBP5 activity and enhanced pro-inflammatory tendencies (i.e., the danger/FKBP5 pathway). En ligne : http://dx.doi.org/10.1017/s0954579421001541 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=474

A differential susceptibility analysis reveals the “who and how” about adolescents' responses to preventive interventions: Tests of first- and second-generation Gene × Intervention hypotheses / Gene H. BRODY in Development and Psychopathology, 27-1 (February 2015)  

Public ISBD [article]  inDevelopment and Psychopathology > 27-1 (February 2015) . - p.37-49 Titre : A differential susceptibility analysis reveals the “who and how” about adolescents' responses to preventive interventions: Tests of first- and second-generation Gene × Intervention hypotheses Type de document : Texte imprimé et/ou numérique Auteurs : Gene H. BRODY, Auteur ; Tianyi YU, Auteur ; Steven R. H. BEACH, Auteur Article en page(s) : p.37-49 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : This study was designed to investigate a genetic moderation effect of dopamine receptor 4 gene (DRD4) alleles that have seven or more repeats (long alleles) on an intervention to deter drug use among rural African American adolescents in high-risk families. Adolescents (N = 291, M age = 17) were assigned randomly to the Adults in the Making (AIM) program or to a control condition and were followed for 27.5 months. Adolescents provided data on drug use and vulnerability cognitions three times after pretest. Pretest assessments of caregiver depressive symptoms, disruption in the home, and support toward the adolescent were used to construct a family risk index. Adolescents living in high-risk families who carried at least one DRD4 long allele and were assigned to the control condition evinced greater escalations in drug use than did (a) adolescents who lived in high-risk families, carried the DRD4 long allele, and were assigned to AIM, or (b) adolescents assigned to either condition who carried no DRD4 long alleles. AIM-induced reductions in vulnerability cognitions were responsible for the Family Risk × AIM × DRD4 status drug use prevention effects. These findings support differential susceptibility predictions and imply that prevention effects on genetically susceptible individuals may be underestimated. En ligne : http://dx.doi.org/10.1017/S095457941400128X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=257 [article] A differential susceptibility analysis reveals the “who and how” about adolescents' responses to preventive interventions: Tests of first- and second-generation Gene × Intervention hypotheses [Texte imprimé et/ou numérique] / Gene H. BRODY, Auteur ; Tianyi YU, Auteur ; Steven R. H. BEACH, Auteur . - p.37-49. Langues : Anglais (eng) in Development and Psychopathology > 27-1 (February 2015) . - p.37-49 Index. décimale : PER Périodiques Résumé : This study was designed to investigate a genetic moderation effect of dopamine receptor 4 gene (DRD4) alleles that have seven or more repeats (long alleles) on an intervention to deter drug use among rural African American adolescents in high-risk families. Adolescents (N = 291, M age = 17) were assigned randomly to the Adults in the Making (AIM) program or to a control condition and were followed for 27.5 months. Adolescents provided data on drug use and vulnerability cognitions three times after pretest. Pretest assessments of caregiver depressive symptoms, disruption in the home, and support toward the adolescent were used to construct a family risk index. Adolescents living in high-risk families who carried at least one DRD4 long allele and were assigned to the control condition evinced greater escalations in drug use than did (a) adolescents who lived in high-risk families, carried the DRD4 long allele, and were assigned to AIM, or (b) adolescents assigned to either condition who carried no DRD4 long alleles. AIM-induced reductions in vulnerability cognitions were responsible for the Family Risk × AIM × DRD4 status drug use prevention effects. These findings support differential susceptibility predictions and imply that prevention effects on genetically susceptible individuals may be underestimated. En ligne : http://dx.doi.org/10.1017/S095457941400128X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=257

Differential susceptibility to prevention: GABAergic, dopaminergic, and multilocus effects / Gene H. BRODY in Journal of Child Psychology and Psychiatry, 54-8 (August 2013)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 54-8 (August 2013) . - p.863-871 Titre : Differential susceptibility to prevention: GABAergic, dopaminergic, and multilocus effects Type de document : Texte imprimé et/ou numérique Auteurs : Gene H. BRODY, Auteur ; Yi-Fu CHEN, Auteur ; Steven R. H. BEACH, Auteur Article en page(s) : p.863-871 Langues : Anglais (eng) Mots-clés : Alcohol use  African American  genetics  prevention  risk Index. décimale : PER Périodiques Résumé : Background: Randomized prevention trials provide a unique opportunity to test hypotheses about the interaction of genetic predispositions with contextual processes to create variations in phenotypes over time. Methods: Using two longitudinal, randomized prevention trials, molecular genetic and alcohol use outcome data were gathered from more than 900 youths to determine whether prevention program participation would, across 2 years, moderate genetic risk for increased alcohol use conferred by the dopaminergic and GABAergic systems. Results: We found that (a) variance in dopaminergic (DRD2, DRD4, ANKK1) and GABAergic (GABRG1, GABRA2) genes forecast increases in alcohol use across 2 years, and (b) youths at genetic risk who were assigned to the control condition displayed greater increases in alcohol use across 2 years than did youths at genetic risk who were assigned to the prevention condition or youths without genetic risk who were assigned to either condition. Conclusions: This study is unique in combining data from two large prevention trials to test hypotheses regarding genetic main effects and gene × prevention interactions. Focusing on gene systems purported to confer risk for alcohol use and abuse, the study demonstrated that participation in efficacious prevention programs can moderate genetic risk. The results also support the differential susceptibility hypothesis that some youths, for genetic reasons, are more susceptible than others to both positive and negative contextual influences. En ligne : http://dx.doi.org/10.1111/jcpp.12042 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=210 [article] Differential susceptibility to prevention: GABAergic, dopaminergic, and multilocus effects [Texte imprimé et/ou numérique] / Gene H. BRODY, Auteur ; Yi-Fu CHEN, Auteur ; Steven R. H. BEACH, Auteur . - p.863-871. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 54-8 (August 2013) . - p.863-871 Mots-clés : Alcohol use  African American  genetics  prevention  risk Index. décimale : PER Périodiques Résumé : Background: Randomized prevention trials provide a unique opportunity to test hypotheses about the interaction of genetic predispositions with contextual processes to create variations in phenotypes over time. Methods: Using two longitudinal, randomized prevention trials, molecular genetic and alcohol use outcome data were gathered from more than 900 youths to determine whether prevention program participation would, across 2 years, moderate genetic risk for increased alcohol use conferred by the dopaminergic and GABAergic systems. Results: We found that (a) variance in dopaminergic (DRD2, DRD4, ANKK1) and GABAergic (GABRG1, GABRA2) genes forecast increases in alcohol use across 2 years, and (b) youths at genetic risk who were assigned to the control condition displayed greater increases in alcohol use across 2 years than did youths at genetic risk who were assigned to the prevention condition or youths without genetic risk who were assigned to either condition. Conclusions: This study is unique in combining data from two large prevention trials to test hypotheses regarding genetic main effects and gene × prevention interactions. Focusing on gene systems purported to confer risk for alcohol use and abuse, the study demonstrated that participation in efficacious prevention programs can moderate genetic risk. The results also support the differential susceptibility hypothesis that some youths, for genetic reasons, are more susceptible than others to both positive and negative contextual influences. En ligne : http://dx.doi.org/10.1111/jcpp.12042 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=210

Exploring genetic moderators and epigenetic mediators of contextual and family effects: From Gene × Environment to epigenetics / Steven R. H. BEACH in Development and Psychopathology, 28-4 pt2 (November 2016)  

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Family-centered prevention ameliorates the longitudinal association between risky family processes and epigenetic aging / Gene H. BRODY in Journal of Child Psychology and Psychiatry, 57-5 (May 2016)  

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Is serotonin transporter genotype associated with epigenetic susceptibility or vulnerability? Examination of the impact of socioeconomic status risk on African American youth / Steven R. H. BEACH in Development and Psychopathology, 26-2 (May 2014)  

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Life stress, the dopamine receptor gene, and emerging adult drug use trajectories: A longitudinal, multilevel, mediated moderation analysis / Gene H. BRODY in Development and Psychopathology, 24-3 (August 2012)  

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Measuring the biological embedding of racial trauma among Black Americans utilizing the RDoC approach / Sierra E. CARTER in Development and Psychopathology, 33-5 (December 2021)  

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Methylation of the oxytocin receptor gene mediates the effect of adversity on negative schemas and depression / Ronald L. SIMONS in Development and Psychopathology, 29-3 (August 2017)  

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Neighborhood × Serotonin Transporter Linked Polymorphic Region (5-HTTLPR) interactions for substance use from ages 10 to 24 years using a harmonized data set of African American children / Michael WINDLE in Development and Psychopathology, 28-2 (May 2016)  

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Perceived discrimination, serotonin transporter linked polymorphic region status, and the development of conduct problems / Gene H. BRODY in Development and Psychopathology, 23-2 (May 2011)  

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Resilience to adversity and the early origins of disease / Gene H. BRODY in Development and Psychopathology, 28-4 pt2 (November 2016)  

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Smoking in young adulthood among African Americans: Interconnected effects of supportive parenting in early adolescence, proinflammatory epitype, and young adult stress / Steven R. H. BEACH in Development and Psychopathology, 29-3 (August 2017)  

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